List of works - Sylvain Latour

A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.

scientific article published on 15 February 2016

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

scientific article published on 20 April 2022

A mutation in X-linked inhibitor of apoptosis (G466X) leads to memory inflation of Epstein-Barr virus-specific T cells

scientific article published on December 2014

A novel XIAP mutation in a Japanese boy with recurrent pancytopenia and splenomegaly

scientific article published on 16 December 2009

A novel hypomorphic mutation in STIM1 results in a late-onset immunodeficiency.

scientific article

A recurrent clonally distinct Burkitt lymphoma case highlights genetic key events contributing to oncogenesis

scientific article published on 27 March 2019

A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling

scientific article

Aggressive large B-cell lymphoma triggered by a parvovirus B19 infection in a previously healthy child

scientific article published on 25 August 2019

Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes

scientific article

Allogeneic hematopoietic stem cell transplant outcomes for patients with dominant negative IKZF1/IKAROS mutations

scientific article published on 06 April 2019

An atypical case of X-linked lymphoproliferative disease revealed as a late cerebral lymphoma

scientific article published on 10 November 2009

Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor

scientific journal article

Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation

scientific article (publication date: September 2001)

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

scientific article

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

scientific article

Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans

scientific article published on 3 December 2012

Characterization of Crohn disease in X-linked inhibitor of apoptosis-deficient male patients and female symptomatic carriers.

scientific article published on 15 June 2014

Chimeric immunoglobulin E reactive with tumor-associated antigen activates human Fc epsilon RI bearing cells

scientific article published on January 1997

Chronic Active Gastritis in X-linked Lymphoproliferative Disease

scientific article published on 01 February 2008

Clinical and genetic characteristics of XIAP deficiency in Japan

scientific article published on 8 January 2012

Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency).

scientific article published on 30 November 2010

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study ⬇️

scientific article published on 16 July 2016

Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells

scientific journal article

Comprehensive molecular diagnosis of Epstein-Barr virus-associated lymphoproliferative diseases using next-generation sequencing

scientific article published on 18 May 2018

Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells

scientific article published on 19 September 2019

Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes

scientific article

Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

scientific article

Diagnostic Yield of Next-generation Sequencing in Very Early-onset Inflammatory Bowel Diseases: A Multicentre Study

scientific article published on 01 August 2018

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

scientific journal article

Distinct intracytoplasmic sequences are required for endocytosis and phagocytosis via murine FcγRII in mast cells

scientific article published on 01 November 1993

Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling

scientific article

Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency.

scientific article published on 11 June 2018

EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.

scientific article published on 31 March 2014

Efficacy of gene therapy for X-linked severe combined immunodeficiency

scientific article

Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells

scientific journal article

Genetic defects affecting lymphocyte cytotoxicity

scientific article published on 12 April 2007

HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease

scientific article published on 01 July 2020

Hematopoietic stem cell transplantation for cytidine triphosphate synthase 1 (CTPS1) deficiency

scientific article published on 08 June 2018

High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages

scientific article

Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG

Human iNKT and MAIT cells exhibit a PLZF-dependent proapoptotic propensity that is counterbalanced by XIAP

scientific article published on 06 December 2012

IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

scientific article

Identification of FcγRIIa, a product of the murine αFcγR gene

article

Identification of SLAMF3 (CD229) as an inhibitor of hepatocellular carcinoma cell proliferation and tumour progression

scientific article

Identification, in mouse macrophages and in serum, of a soluble receptor for the Fc portion of IgG (Fc gamma R) encoded by an alternatively spliced transcript of the Fc gamma RII gene

scientific article published on August 1993

Identification, molecular cloning, biologic properties, and tissue distribution of a novel isoform of murine low-affinity IgG receptor homologous to human Fc gamma RIIB1.

scientific article published in July 1996

Impaired Ig class switch in mice deficient for the X-linked lymphoproliferative disease gene Sap

article

In hematopoietic cells with a germline mutation of CBL, loss of heterozygosity is not a signature of juvenile myelo-monocytic leukemia.

scientific article published on 4 July 2013

Induction of tumor necrosis factor-alpha production by mast cells via Fc gamma R. Role of the Fc gamma RIII gamma subunit

scientific article published on September 1992

Inherited Immunodeficiencies With High Predisposition to Epstein–Barr Virus-Driven Lymphoproliferative Diseases.

scientific article published on 4 June 2018

Inherited defects causing hemophagocytic lymphohistiocytic syndrome

scientific article published on 01 December 2011

Interactions of CD45-associated Protein with the Antigen Receptor Signaling Machinery in T-lymphocytes

scientific article published in Journal of Biological Chemistry

Intestinal dysbiosis in Inflammatory Bowel Disease associated with primary immunodeficiency

scientific article published on 10 October 2018

Life-threatening pulmonary interstitial lung disease complicating pediatric nonhumoral immunodeficiencies

scientific article published on 03 April 2019

Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.

scientific article published on 27 December 2017

Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases

article

Membrane and soluble Fc gamma RII/III modulate the antigen-presenting capacity of murine dendritic epidermal Langerhans cells for IgG-complexed antigens.

scientific article published on August 1995

Molecular and immunological basis of X-linked lymphoproliferative disease

scientific article

Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors

scientific article

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

scientific article

Murine Fc gamma RII and III in mast cell activation

scientific article

Murine recombinant Fc gamma RIII, but not Fc gamma RII, trigger serotonin release in rat basophilic leukemia cells.

scientific article

Natural killer T cells and X-linked lymphoproliferative syndrome

scientific article published on December 2007

Negative regulation of immunoreceptor signaling

scientific article

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

scientific journal article

Occurrence of nodular lymphocyte-predominant hodgkin lymphoma in hermansky-pudlak type 2 syndrome is associated to natural killer and natural killer T cell defects.

scientific article

Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency.

scientific article

Proximal protein tyrosine kinases in immunoreceptor signaling

scientific article

RASGRP1 mutation in autoimmune lymphoproliferative syndrome-like disease.

scientific article published on 15 November 2017

Refractory monogenic Crohn's disease due to X-linked inhibitor of apoptosis deficiency.

scientific article published on 19 November 2015

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

scientific article (publication date: August 2001)

Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase

scientific article published on August 1997

Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.

scientific article published on February 1995

Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.

scientific article

Regulation of tyrosine-containing activation motif-dependent cell signalling by Fc gamma RII.

scientific article published on January 1995

SLAM-associated protein favors the development of iNKT2 over iNKT17 cells

scientific article published on 24 June 2016

SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signaling

scientific article published on 14 July 2015

Signaling pathways involved in the T-cell-mediated immunity against Epstein-Barr virus: Lessons from genetic diseases

scientific article published on 01 September 2019

Stepwise development of MAIT cells in mouse and human

scientific article

TCR density in early iNKT cell precursors regulates agonist selection and subset differentiation in mice

scientific article published on 02 April 2019

TLR-Induced Cytokines Promote Effective Proinflammatory Natural Th17 Cell Responses

article

The SAP family of adaptors in immune regulation

scientific article

The SLAM family of immune-cell receptors

scientific article (publication date: June 2003)

The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils

scientific article

The murine alpha Fc gamma R gene product: identification, expression and regulation

scientific article published on December 1990

The same tyrosine-based inhibition motif, in the intra-cytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation

scientific article published on 01 November 1995

Tyrosine-containing activation motif-dependent phagocytosis in mast cells

scientific article published on January 1994

Variable expression of CD3-ζ chain in tumor-infiltrating lymphocytes (TIL) derived from renal-cell carcinoma: Relationship with til phenotype and function

scientific article published on 01 October 1995

Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation

scientific article published on 21 March 2013

X-linked inhibitor of apoptosis protein deficiency: more than an X-linked lymphoproliferative syndrome

scientific article published on 4 March 2015

X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease

scientific article

X-linked lymphoproliferative syndromes and related autosomal recessive disorders.

scientific article published on December 2013

XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome

scientific article

XIAP deficiency syndrome in humans

scientific article published on 07 February 2015

XIAP, un gène anti-apoptotique muté dans un nouveau syndrome lymphoprolifératif lié à l’X (XLP)

article

List of works by Sylvain Latour

A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

A mutation in X-linked inhibitor of apoptosis (G466X) leads to memory inflation of Epstein-Barr virus-specific T cells

A novel XIAP mutation in a Japanese boy with recurrent pancytopenia and splenomegaly

A novel hypomorphic mutation in STIM1 results in a late-onset immunodeficiency.

A recurrent clonally distinct Burkitt lymphoma case highlights genetic key events contributing to oncogenesis

A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling

Aggressive large B-cell lymphoma triggered by a parvovirus B19 infection in a previously healthy child

Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes

Allogeneic hematopoietic stem cell transplant outcomes for patients with dominant negative IKZF1/IKAROS mutations

An atypical case of X-linked lymphoproliferative disease revealed as a late cerebral lymphoma

Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor

Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans

Characterization of Crohn disease in X-linked inhibitor of apoptosis-deficient male patients and female symptomatic carriers.

Chimeric immunoglobulin E reactive with tumor-associated antigen activates human Fc epsilon RI bearing cells

Chronic Active Gastritis in X-linked Lymphoproliferative Disease

Clinical and genetic characteristics of XIAP deficiency in Japan

Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency).

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study ⬇️

Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells

Comprehensive molecular diagnosis of Epstein-Barr virus-associated lymphoproliferative diseases using next-generation sequencing

Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells

Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes

Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

Diagnostic Yield of Next-generation Sequencing in Very Early-onset Inflammatory Bowel Diseases: A Multicentre Study

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

Distinct intracytoplasmic sequences are required for endocytosis and phagocytosis via murine FcγRII in mast cells

Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling

Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency.

EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.

Efficacy of gene therapy for X-linked severe combined immunodeficiency

Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells

Genetic defects affecting lymphocyte cytotoxicity

HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease

Hematopoietic stem cell transplantation for cytidine triphosphate synthase 1 (CTPS1) deficiency

High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages

Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG

Human iNKT and MAIT cells exhibit a PLZF-dependent proapoptotic propensity that is counterbalanced by XIAP

IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

Identification of FcγRIIa, a product of the murine αFcγR gene

Identification of SLAMF3 (CD229) as an inhibitor of hepatocellular carcinoma cell proliferation and tumour progression

Identification, in mouse macrophages and in serum, of a soluble receptor for the Fc portion of IgG (Fc gamma R) encoded by an alternatively spliced transcript of the Fc gamma RII gene

Identification, molecular cloning, biologic properties, and tissue distribution of a novel isoform of murine low-affinity IgG receptor homologous to human Fc gamma RIIB1.

Impaired Ig class switch in mice deficient for the X-linked lymphoproliferative disease gene Sap

In hematopoietic cells with a germline mutation of CBL, loss of heterozygosity is not a signature of juvenile myelo-monocytic leukemia.

Induction of tumor necrosis factor-alpha production by mast cells via Fc gamma R. Role of the Fc gamma RIII gamma subunit

Inherited Immunodeficiencies With High Predisposition to Epstein–Barr Virus-Driven Lymphoproliferative Diseases.

Inherited defects causing hemophagocytic lymphohistiocytic syndrome

Interactions of CD45-associated Protein with the Antigen Receptor Signaling Machinery in T-lymphocytes

Intestinal dysbiosis in Inflammatory Bowel Disease associated with primary immunodeficiency

Life-threatening pulmonary interstitial lung disease complicating pediatric nonhumoral immunodeficiencies

Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.

Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases

Membrane and soluble Fc gamma RII/III modulate the antigen-presenting capacity of murine dendritic epidermal Langerhans cells for IgG-complexed antigens.

Molecular and immunological basis of X-linked lymphoproliferative disease

Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

Murine Fc gamma RII and III in mast cell activation

Murine recombinant Fc gamma RIII, but not Fc gamma RII, trigger serotonin release in rat basophilic leukemia cells.

Natural killer T cells and X-linked lymphoproliferative syndrome

Negative regulation of immunoreceptor signaling

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

Occurrence of nodular lymphocyte-predominant hodgkin lymphoma in hermansky-pudlak type 2 syndrome is associated to natural killer and natural killer T cell defects.

Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency.

Proximal protein tyrosine kinases in immunoreceptor signaling

RASGRP1 mutation in autoimmune lymphoproliferative syndrome-like disease.

Refractory monogenic Crohn's disease due to X-linked inhibitor of apoptosis deficiency.

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase

Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.

Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.

Regulation of tyrosine-containing activation motif-dependent cell signalling by Fc gamma RII.

SLAM-associated protein favors the development of iNKT2 over iNKT17 cells

SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signaling

Signaling pathways involved in the T-cell-mediated immunity against Epstein-Barr virus: Lessons from genetic diseases

Stepwise development of MAIT cells in mouse and human