List of works - Romain Roncagalli

A THEMIS:SHP1 complex promotes T-cell survival

scientific article

A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.

scientific article published on 15 February 2016

ARHGAP45 controls naïve T- and B-cell entry into lymph nodes and T-cell progenitor thymus seeding

scientific article published on 15 March 2021

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

scientific article

CD5, an Undercover Regulator of TCR Signaling

scientific article published on 07 December 2018

CD6 modulates thymocyte selection and peripheral T cell homeostasis

scientific article published on 04 July 2016

Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation

scientific journal article

Computational modeling of the main signaling pathways involved in mast cell activation

scientific article published on January 2014

Control of CD8 T cell proliferation and terminal differentiation by active STAT5 and CDKN2A/CDKN2B.

scientific article published on 15 June 2015

Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.

scientific article published on 19 September 2016

EAT-2 : un nouveau régulateur de la fonction des cellules NK

EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.

scientific article published on 31 March 2014

Fit αβ T-cell receptor suppresses leukemogenesis of Pten-deficient thymocytes

scientific article published on 22 March 2018

In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation.

scientific article published on March 2015

Integrative biology of T cell activation

scientific article

LAT signaling pathology: an "autoimmune" condition without T cell self-reactivity

scientific article published on 09 June 2010

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor

scientific article published on 13 August 2009

LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN2 as a regulator of effector functions

scientific article published on 01 July 2020

Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes

scientific article published on 28 January 2010

Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors

scientific article

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

scientific journal article

Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics

scientific article published on 02 November 2020

Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry.

scientific article published on March 2017

Proteomic Analysis of the SH2 Domain-containing Leukocyte Protein of 76 kDa (SLP76) Interactome in Resting and Activated Primary Mast Cells

scientific article

Proteomic analysis of the SH2 domain-containing leukocyte protein of 76 kDa (SLP76) interactome in resting and activated primary mast cells [corrected].

scientific article published on 2 July 2013

Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy

scientific article published on 01 June 2019

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

scientific article published on 07 October 2019

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub

scientific journal article

Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells

scientific journal article

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells

scientific article published on 10 July 2018

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

scientific journal article

The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

scientific article published on 13 April 2008

The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.

scientific article published on 19 September 2016

The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells

scientific article

List of works by Romain Roncagalli

A THEMIS:SHP1 complex promotes T-cell survival

A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.

ARHGAP45 controls naïve T- and B-cell entry into lymph nodes and T-cell progenitor thymus seeding

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

CD5, an Undercover Regulator of TCR Signaling

CD6 modulates thymocyte selection and peripheral T cell homeostasis

Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation

Computational modeling of the main signaling pathways involved in mast cell activation

Control of CD8 T cell proliferation and terminal differentiation by active STAT5 and CDKN2A/CDKN2B.

Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.

EAT-2 : un nouveau régulateur de la fonction des cellules NK

EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.

Fit αβ T-cell receptor suppresses leukemogenesis of Pten-deficient thymocytes

In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation.

Integrative biology of T cell activation

LAT signaling pathology: an "autoimmune" condition without T cell self-reactivity

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor

LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN2 as a regulator of effector functions

Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes

Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics

Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry.

Proteomic Analysis of the SH2 Domain-containing Leukocyte Protein of 76 kDa (SLP76) Interactome in Resting and Activated Primary Mast Cells

Proteomic analysis of the SH2 domain-containing leukocyte protein of 76 kDa (SLP76) interactome in resting and activated primary mast cells [corrected].

Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub

Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.

The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells