List of works - Victor V Maltsev

A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.

scientific article

A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells.

scientific article

A negative resistance region underlies the triggering property of membrane potential in human T-lymphocytes

scientific article published on November 1, 1992

A novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins.

scientific article

Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells

scientific article (publication date: 2013)

Beat-to-beat Ca(2+)-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm.

scientific article published on 14 September 2011

Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate

scientific article

Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size

scientific article published on 24 May 2007

Calcium signalling in individual T-cells measured by confocal microscopy.

scientific article published on September 1994

Calpain inhibition reduces amplitude and accelerates decay of the late sodium current in ventricular myocytes from dogs with chronic heart failure

scientific article

Cardiac pacemaker cell failure with preserved I(f), I(CaL), and I(Kr): a lesson about pacemaker function learned from ischemia-induced bradycardia

scientific article published on 22 December 2006

Cardiomyocyte-like cells differentiated in vitro from embryonic carcinoma cells P19 are characterized by functional expression of adrenoceptors and Ca2+ channels

scientific article published on 01 July 1994

Cardiomyocytes derived from embryonic stem cells.

scientific article published in January 2005

Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents

scientific article published on August 1994

Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).

scientific article published on 19 June 2009

Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability.

scientific article published on 24 October 2006

Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts

scientific article published on 17 November 2014

Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity

scientific article

Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance

scientific article

Cytochalasin D alters kinetics of Ca2+ transient in rat ventricular cardiomyocytes: an effect of altered actin cytoskeleton?

scientific article published on 01 August 1998

Cytoskeleton modulates coupling between availability and activation of cardiac sodium channel

scientific article published on 01 October 1997

Development of cardiomyocytes expressing cardiac-specific genes, action potentials, and ionic channels during embryonic stem cell-derived cardiogenesis

scientific article published on March 1995

Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process.

scientific article published in April 2004

Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions

scientific article published on 25 January 2005

Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin

scientific journal article

Down-regulation of sodium current in chronic heart failure: effect of long-term therapy with carvedilol

scientific article published in September 2002

Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types

scientific article published in November 1993

Embryonic stem cells: a model to study structural and functional properties in cardiomyogenesis

scientific article

Establishment of beta-adrenergic modulation of L-type Ca2+ current in the early stages of cardiomyocyte development

scientific article

Gating of the late Na+ channel in normal and failing human myocardium

scientific article published on 01 November 2002

High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells

scientific article published on 19 January 2006

In vitro cellular models for cardiac development and pharmacotoxicology

scientific article published in August 1995

In vitro differentiation of embryonic stem cells into cardiomyocytes or skeletal muscle cells is specifically modulated by retinoic acid

scientific article published on 01 October 1994

In vitro differentiation of embryonic stem cells into cardiomyocytes or skeletal muscle cells is specifically modulated by retinoic acid

scientific article published on 01 January 1994

Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its beta1 subunit.

scientific article published on 03 March 2009

Late sodium current in failing heart: friend or foe?

scientific article

Late sodium current is a novel target for amiodarone: studies in failing human myocardium

scientific article

Letter to the editor: "Validating the requirement for beat-to-beat coupling of the Ca2+ clock and M clock in pacemaker cell normal automaticity".

scientific article published on June 2011

Life and death of a cardiac calcium spark

scientific article (publication date: September 2013)

Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca²⁺ cycling dynamics.

scientific article published on October 2013

Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state

scientific article published on 28 September 2006

Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility".

scientific article published on 13 March 2013

Modern concepts concerning the origin of the heartbeat.

scientific article

Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: developmentally regulated expression of myogenic determination genes and functional expression of ionic currents

scientific article published on July 1994

Na+ channel function, regulation, structure, trafficking and sequestration

scientific article

New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.

scientific article published on 05 May 2013

Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cells

scientific article

Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes

scientific article

Numerical Modeling Calcium and CaMKII Effects in the SA Node

scientific article published on April 2014

Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking

scientific article

Oscillating and triggering properties of T cell membrane potential

scientific article published in December 1990

Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.

scientific article published on 11 November 2004

Post-transcriptional alterations in the expression of cardiac Na+ channel subunits in chronic heart failure.

scientific article published on July 2004

Post-transcriptional silencing of SCN1B and SCN2B genes modulates late sodium current in cardiac myocytes from normal dogs and dogs with chronic heart failure ⬇️

scientific article published on June 24, 2011

Rebuttal: What If the shoe doesn't fit? “The funny current has a major pacemaking role in the sinus node” ⬇️

scientific article published on September 16, 2011

Relationship between action potential, contraction-relaxation pattern, and intracellular Ca2+ transient in cardiomyocytes of dogs with chronic heart failure

scientific article published in June 1998

Relationship between steady-state activation and availability of cardiac sodium channel: evidence of uncoupling

scientific article published on 01 February 1998

Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: role of sustained inward current

scientific article published in March 1999

Reprogramming paces the heart

scientific article

Rhythmic Ca2+ oscillations drive sinoatrial nodal cell pacemaker function to make the heart tick.

scientific article

Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization

scientific article published on 12 February 2004

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells

scientific article published on 25 September 2017

Stabilization of diastolic calcium signal via calcium pump regulation of complex local calcium releases and transient decay in a computational model of cardiac pacemaker cell with individual release channels

scientific article published on 8 August 2017

Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.

scientific article published on 09 January 2009

The funny current in the context of the coupled-clock pacemaker cell system ⬇️

scientific article published on September 16, 2011

The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker.

scientific article published on October 2006

The missing link in the mystery of normal automaticity of cardiac pacemaker cells.

scientific article published on March 2008

List of works by Victor V Maltsev

A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.

A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells.

A negative resistance region underlies the triggering property of membrane potential in human T-lymphocytes

A novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins.

Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells

Beat-to-beat Ca(2+)-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm.

Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate

Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size

Calcium signalling in individual T-cells measured by confocal microscopy.

Calpain inhibition reduces amplitude and accelerates decay of the late sodium current in ventricular myocytes from dogs with chronic heart failure

Cardiac pacemaker cell failure with preserved I(f), I(CaL), and I(Kr): a lesson about pacemaker function learned from ischemia-induced bradycardia

Cardiomyocyte-like cells differentiated in vitro from embryonic carcinoma cells P19 are characterized by functional expression of adrenoceptors and Ca2+ channels

Cardiomyocytes derived from embryonic stem cells.

Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents

Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).

Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability.

Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts

Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity

Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance

Cytochalasin D alters kinetics of Ca2+ transient in rat ventricular cardiomyocytes: an effect of altered actin cytoskeleton?

Cytoskeleton modulates coupling between availability and activation of cardiac sodium channel

Development of cardiomyocytes expressing cardiac-specific genes, action potentials, and ionic channels during embryonic stem cell-derived cardiogenesis

Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process.

Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions

Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin

Down-regulation of sodium current in chronic heart failure: effect of long-term therapy with carvedilol

Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types

Embryonic stem cells: a model to study structural and functional properties in cardiomyogenesis

Establishment of beta-adrenergic modulation of L-type Ca2+ current in the early stages of cardiomyocyte development

Gating of the late Na+ channel in normal and failing human myocardium

High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells

In vitro cellular models for cardiac development and pharmacotoxicology

In vitro differentiation of embryonic stem cells into cardiomyocytes or skeletal muscle cells is specifically modulated by retinoic acid

In vitro differentiation of embryonic stem cells into cardiomyocytes or skeletal muscle cells is specifically modulated by retinoic acid

Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its beta1 subunit.

Late sodium current in failing heart: friend or foe?

Late sodium current is a novel target for amiodarone: studies in failing human myocardium

Letter to the editor: "Validating the requirement for beat-to-beat coupling of the Ca2+ clock and M clock in pacemaker cell normal automaticity".

Life and death of a cardiac calcium spark

Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca²⁺ cycling dynamics.

Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state

Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility".

Modern concepts concerning the origin of the heartbeat.

Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: developmentally regulated expression of myogenic determination genes and functional expression of ionic currents

Na+ channel function, regulation, structure, trafficking and sequestration

New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.

Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cells

Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes

Numerical Modeling Calcium and CaMKII Effects in the SA Node

Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking

Oscillating and triggering properties of T cell membrane potential

Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.

Post-transcriptional alterations in the expression of cardiac Na+ channel subunits in chronic heart failure.

Post-transcriptional silencing of SCN1B and SCN2B genes modulates late sodium current in cardiac myocytes from normal dogs and dogs with chronic heart failure ⬇️

Rebuttal: What If the shoe doesn't fit? “The funny current has a major pacemaking role in the sinus node” ⬇️

Relationship between action potential, contraction-relaxation pattern, and intracellular Ca2+ transient in cardiomyocytes of dogs with chronic heart failure

Relationship between steady-state activation and availability of cardiac sodium channel: evidence of uncoupling

Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: role of sustained inward current

Reprogramming paces the heart

Rhythmic Ca2+ oscillations drive sinoatrial nodal cell pacemaker function to make the heart tick.

Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells

Stabilization of diastolic calcium signal via calcium pump regulation of complex local calcium releases and transient decay in a computational model of cardiac pacemaker cell with individual release channels

Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.

The funny current in the context of the coupled-clock pacemaker cell system ⬇️

The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker.

The missing link in the mystery of normal automaticity of cardiac pacemaker cells.