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List of works by Andreas Hecht

4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin

scientific article published on 3 October 2009

Analysis of regulatory elements of E-cadherin with reporter gene constructs in transgenic mouse embryos

scientific article

Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT

scientific article published on 24 January 2022

Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes

scientific article published on 12 June 2008

Canonical Wnt signaling transiently stimulates proliferation and enhances neurogenesis in neonatal neural progenitor cultures

scientific article published on 10 November 2006

Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer.

scientific article

Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors

scientific article

Dynamic chromatin: The regulatory domain organization of eukaryotic gene loci ⬇️

scientific article published on October 1, 1991

E-cadherin intron 2 contains cis-regulatory elements essential for gene expression.

scientific article published on 26 January 2005

Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing

scientific article published on 05 August 2016

Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro

scientific article published on June 1999

Genome-wide mapping of DNA-binding sites identifies stemness-related genes as directly repressed targets of SNAIL1 in colorectal cancer cells

scientific article published on 07 August 2019

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast

scientific article (publication date: 24 February 1995)

Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis

scientific article published on 31 December 2007

Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression

scientific article

Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells

scientific article published on 20 March 2020

Mapping DNA interaction sites of chromosomal proteins using immunoprecipitation and polymerase chain reaction.

scientific article published in January 1999

Mathematical modelling suggests a differential impact of β-transducin repeat-containing protein paralogues on Wnt/β-catenin signalling dynamics

scientific article published on 7 February 2015

Mediator is a transducer of Wnt/beta-catenin signaling.

scientific article published on 24 March 2006

Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions

scientific article published on 25 February 2013

Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1.

scientific article

Oncogenic transformation by beta-catenin: deletion analysis and characterization of selected target genes

scientific article published in October 2002

Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways.

scientific article published in November 2006

Rat antibodies as probes for the characterization of progesterone receptor A and B proteins from laying hen oviduct cytosol

scientific article published on 01 January 1988

SMAD4 mutations do not preclude epithelial-mesenchymal transition in colorectal cancer

scientific article published on 03 December 2021

SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer

scientific article published on 16 September 2014

SNAIL1 employs β-Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation

scientific article published on 18 September 2019

SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells.

scientific article published on 20 November 2017

Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer

scientific article published on 18 March 2014

Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions

scientific article published on 4 March 2011

Spreading of transcriptional repressor SIR3 from telomeric heterochromatin

scientific article (publication date: 5 September 1996)

The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevis

scientific article (publication date: March 1999)

The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression

scientific article published on 25 September 2006

Trans-repression of beta-catenin activity by nuclear receptors

scientific article published on 12 September 2003

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