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List of works by Roger Schibli

"Click-to-chelate": design and incorporation of triazole-containing metal-chelating systems into biomolecules of diagnostic and therapeutic interest

scientific article published in January 2008

"Click-to-chelate": in vitro and in vivo comparison of a 99mTc(CO)3-labeled N(tau)-histidine folate derivative with its isostructural, clicked 1,2,3-triazole analogue

scientific article

(64)Cu- and (68)Ga-Based PET Imaging of Folate Receptor-Positive Tumors: Development and Evaluation of an Albumin-Binding NODAGA-Folate

scientific article published on 4 May 2016

165Er: A new candidate for Auger electron therapy and its possible cyclotron production from natural holmium targets

scientific article published on 12 February 2020

18F-AzaFol for Detection of Folate Receptor-β Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study

scientific article published on 22 November 2019

44Sc-PSMA-617 for radiotheragnostics in tandem with 177Lu-PSMA-617-preclinical investigations in comparison with 68Ga-PSMA-11 and 68Ga-PSMA-617.

scientific article published on 19 January 2017

5-(2-18F-fluoroethoxy)-L-tryptophan as a substrate of system L transport for tumor imaging by PET.

scientific article

99mTc-labeling and in vivo studies of a bombesin analogue with a novel water-soluble dithiadiphosphine-based bifunctional chelating agent

scientific article published on March 1999

A "click chemistry" approach to the efficient synthesis of multiple imaging probes derived from a single precursor

scientific article published on 5 October 2009

A 99mTc(I)-postlabeled high affinity bombesin analogue as a potential tumor imaging agent

scientific article published on May 2002

A Novel Organometallic Aqua Complex of Technetium for the Labeling of Biomolecules:  Synthesis of [99mTc(OH2)3(CO)3]+from [99mTcO4]-in Aqueous Solution and Its Reaction with a Bifunctional Ligand

scientific article (publication date: August 1998)

A Short-Term Biological Indicator for Long-Term Kidney Damage after Radionuclide Therapy in Mice

scientific article published on 21 June 2017

A click approach to structurally diverse conjugates containing a central di-1,2,3-triazole metal chelate

scientific article

A comparison of three (67/68)Ga-labelled exendin-4 derivatives for β-cell imaging on the GLP-1 receptor: the influence of the conjugation site of NODAGA as chelator

scientific article

A first-in-man PET study of [18F]PSS232, a fluorinated ABP688 derivative for imaging metabotropic glutamate receptor subtype 5.

scientific article published on 27 November 2017

A new 18F-labeled folic acid derivative with improved properties for the PET imaging of folate receptor-positive tumors

scientific article published on 18 October 2010

A unique matched quadruplet of terbium radioisotopes for PET and SPECT and for α- and β- radionuclide therapy: an in vivo proof-of-concept study with a new receptor-targeted folate derivative

scientific article published on 8 November 2012

Albumin-Binding PSMA Ligands: Optimization of the Tissue Distribution Profile

scientific article

Albumin-Binding PSMA Radioligands: Impact of Minimal Structural Changes on the Tissue Distribution Profile

scientific article published on 29 May 2020

Alpha-PET for Prostate Cancer: Preclinical investigation using 149Tb-PSMA-617

scientific article published on 28 November 2019

Alpha-PET with terbium-149: evidence and perspectives for radiotheragnostics

Anti-L1CAM radioimmunotherapy is more effective with the radiolanthanide terbium-161 compared to lutetium-177 in an ovarian cancer model.

scientific article

Assessment of an elastin binding molecule for PET imaging of atherosclerotic plaques

scientific article published on 10 July 2013

Biodistribution and dosimetry of a single dose of albumin-binding ligand [177Lu]Lu-PSMA-ALB-56 in patients with mCRPC

scientific article published on 19 September 2020

Bis(thiosemicarbazones) as bifunctional chelators for the room temperature 64-copper labeling of peptides

scientific article published on 03 March 2010

Brain glucose transport and phosphorylation under acute insulin-induced hypoglycemia in mice: an 18F-FDG PET study

scientific article published on 24 October 2013

CD80 Is Upregulated in a Mouse Model with Shear Stress-Induced Atherosclerosis and Allows for Evaluating CD80-Targeting PET Tracers

scientific article published on 18 July 2016

Can Nuclear Imaging of Activated Macrophages with Folic Acid-Based Radiotracers Serve as a Prognostic Means to Identify COVID-19 Patients at Risk?

scientific article published on 09 September 2020

Can animal data predict human outcome? Problems and pitfalls of translational animal research

scientific article published in September 2012

Cannabinoid receptor type 2 (CB2) as one of the candidate genes in human carotid plaque imaging: Evaluation of the novel radiotracer [11C]RS-016 targeting CB2 in atherosclerosis.

scientific article published on 8 January 2017

Catabolism of neurotensins. Implications for the design of radiolabeling strategies of peptides

scientific article published on 01 June 1999

Characterization of different osteosarcoma phenotypes by PET imaging in preclinical animal models

scientific article published on 25 June 2013

Charge dependent substrate activity of C3' and N3 functionalized, organometallic technetium and rhenium-labeled thymidine derivatives toward human thymidine kinase 1.

scientific article published in April 2010

Chemoselective 18F-incorporation into pyridyl acyltrifluoroborates for rapid radiolabelling of peptides and proteins at room temperature

scientific article published on 01 January 2020

Cholecystokinin 2 Receptor Agonist 177Lu-PP-F11N for Radionuclide Therapy of Medullary Thyroid Carcinoma: Results of the Lumed Phase 0a Study

scientific article published on 13 September 2019

Clinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with 152Tb-DOTATOC.

scientific article published on 21 August 2017

Combination of Proton Therapy and Radionuclide Therapy in Mice: Preclinical Pilot Study at the Paul Scherrer Institute

scientific article published on 02 September 2019

Combination of lutetium-177 labelled anti-L1CAM antibody chCE7 with the clinically relevant protein kinase inhibitor MK1775: a novel combination against human ovarian carcinoma

Combination of terbium-161 with somatostatin receptor antagonists-a potential paradigm shift for the treatment of neuroendocrine neoplasms

scientific article published on 08 October 2021

Combined Application of Albumin-Binding [177Lu]Lu-PSMA-ALB-56 and Fast-Cleared PSMA Inhibitors: Optimization of the Pharmacokinetics

scientific article published on 08 May 2020

Combining Albumin-Binding Properties and Interaction with Pemetrexed to Improve the Tissue Distribution of Radiofolates

scientific article published on 16 June 2018

Comparative Studies of Three Pairs of α- and γ-Conjugated Folic Acid Derivatives Labeled with Fluorine-18.

scientific article published on 4 December 2015

Comparative studies of substitution reactions of rhenium(I) dicarbonyl-nitrosyl and tricarbonyl complexes in aqueous media

scientific article

Comparison of desferrioxamine and NODAGA for the gallium-68 labeling of exendin-4

scientific article published on 16 May 2019

Comparison of recombinant human haptocorrin expressed in human embryonic kidney cells and native haptocorrin

scientific article

Complete Carbonylation of fac-

scientific article published on 01 January 2000

Contribution of Auger/conversion electrons to renal side effects after radionuclide therapy: preclinical comparison of (161)Tb-folate and (177)Lu-folate.

scientific article published on 9 February 2016

Corrigendum concerning "Methoxinine-An alternative stable amino acid substitute for oxidation-sensitive methionine in radiolabelled peptide conjugates"

scientific article published on 26 January 2020

Cu(I)-catalyzed intramolecular cyclization of alkynoic acids in aqueous media: a "click side reaction".

scientific article published on 29 November 2007

Current use and future potential of organometallic radiopharmaceuticals.

scientific article

Cyclotron production of (44)Sc: From bench to bedside.

scientific article published on 30 May 2015

DOTA conjugate with an albumin-binding entity enables the first folic acid-targeted 177Lu-radionuclide tumor therapy in mice

scientific article published on 12 December 2012

DOTA-functionalized polylysine: a high number of DOTA chelates positively influences the biodistribution of enzymatic conjugated anti-tumor antibody chCE7agl

scientific article

Delivery of BMP-2 by two clinically available apatite materials: in vitro and in vivo comparison

scientific article published on 09 May 2014

Design and Preclinical Evaluation of an Albumin-Binding PSMA Ligand for Cu-Based PET Imaging

scientific article published on 30 October 2018

Design of Radiolabeled Analogs of Minigastrin by Multiple Amide-to-Triazole Substitutions

scientific article published on 17 April 2020

Design, synthesis, and initial evaluation of a high affinity positron emission tomography probe for imaging matrix metalloproteinases 2 and 9.

scientific article published on 7 June 2013

Development and evaluation of novel PET tracers for imaging cannabinoid receptor type 2 in brain

scientific article published on January 2014

Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ₂ receptors

scientific article published on 20 September 2013

Development of [(18)F]-PSS223 as a PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGluR5).

scientific article published in January 2012

Development of a new class of PSMA radioligands comprising ibuprofen as an albumin-binding entity

scientific article published on 01 January 2020

Diastereomerically Pure 6R- and 6S-3'-Aza-2'-18F-Fluoro-5-Methyltetrahydrofolates Show Unprecedentedly High Uptake in Folate Receptor-Positive KB Tumors

scientific article published on 24 July 2018

Direct in vitro and in vivo comparison of (161)Tb and (177)Lu using a tumour-targeting folate conjugate

scientific article published on 8 October 2013

Discovery of a fluorinated 4-oxo-quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2.

scientific article published on 6 July 2016

Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor.

scientific article

Distance-Dependent Cellular Uptake of Oligoproline-Based Homobivalent Ligands Targeting GPCRs-An Experimental and Computational Analysis

scientific article published on 13 October 2020

Dose-dependent effects of (anti)folate preinjection on 99mTc-radiofolate uptake in tumors and kidneys

scientific article published on 01 August 2007

Dosimetry and first clinical evaluation of the new 18F-radiolabeled bombesin analogue BAY 864367 in patients with prostate cancer.

scientific article published on 12 February 2015

Dual, Site-Specific Modification of Antibodies by Using Solid-Phase Immobilized Microbial Transglutaminase

scientific article published on 3 August 2017

Effects of antifolate drugs on the cellular uptake of radiofolates in vitro and in vivo.

scientific article published on December 2006

Effects of the antifolates pemetrexed and CB3717 on the tissue distribution of (99m)Tc-EC20 in xenografted and syngeneic tumor-bearing mice

scientific article

Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size

scientific article

Elucidating the Structure-Activity Relationship of the Pentaglutamic Acid Sequence of Minigastrin with Cholecystokinin Receptor Subtype 2

scientific article published on 14 January 2019

Enzymatic antibody modification by bacterial transglutaminase

scientific article published in January 2013

Erratum: Longitudinal in vivo evaluation of bone regeneration by combined measurement of multi-pinhole SPECT and micro-CT for tissue engineering

scientific article published on 12 November 2015

Evaluation of 4-oxo-quinoline-based CB2 PET radioligands in R6/2 chorea huntington mouse model and human ALS spinal cord tissue

scientific article published on 5 January 2018

Evaluation of 5H-thiazolo[3,2-a]pyrimidin-5-ones as potential GluN2A PET tracers

scientific article published on 16 June 2020

Evaluation of Actinium-225 Labeled Minigastrin Analogue [225Ac]Ac-DOTA-PP-F11N for Targeted Alpha Particle Therapy

scientific article published on 12 November 2020

Evaluation of Tc-rhAnnexin V-128 SPECT/CT as a diagnostic tool for early stages of interstitial lung disease associated with systemic sclerosis

scientific article published on 16 August 2018

Evaluation of [11C]Me-NB1 as a potential PET radioligand for measuring GluN2B-containing NMDA receptors, drug occupancy and receptor crosstalk

scientific article published on 30 November 2017

Evaluation of a Novel Tc-99m Labelled Vitamin B12 Derivative for Targeting Escherichia coli and Staphylococcus aureus In Vitro and in an Experimental Foreign-Body Infection Model

scientific article

Evaluation of a novel radiofolate in tumour-bearing mice: promising prospects for folate-based radionuclide therapy

scientific article

Evaluation of anti-VEGFR-3 specific scFv antibodies as potential therapeutic and diagnostic tools for tumor lymph-angiogenesis.

scientific article

Evaluation of the first 44Sc-labeled Affibody molecule for imaging of HER2-expressing tumors

scientific article published on 18 October 2016

Evaluation of the radiolabeled boronic acid-based FAP inhibitor MIP-1232 for atherosclerotic plaque imaging.

scientific article published on 27 January 2015

Evaluation of ¹¹¹in-labelled exendin-4 derivatives containing different meprin β-specific cleavable linkers

scientific article

Ex vivo differential phase contrast and magnetic resonance imaging for characterization of human carotid atherosclerotic plaques

scientific article

Exendin-4 Derivatives with an Albumin-Binding Moiety Show Decreased Renal Retention and Improved GLP-1 Receptor Targeting

scientific article published on 21 August 2019

Expression of functional folate receptors by human parathyroid cells.

scientific article published on 25 October 2013

FDG kinetic modeling in small rodent brain PET: optimization of data acquisition and analysis

scientific article published on 6 August 2013

Facile and Improved Precursor Synthesis for the Next Generation Cardiac Positron Emission Tomography Imaging Agent [18F]Flurpiridaz

scientific article published on 23 April 2020

First Clinicopathologic Evidence of a Non-PSMA-Related Uptake Mechanism for 68Ga-PSMA-11 in Salivary Glands

scientific article published on 08 February 2019

First clinical results of (D)-18F-Fluoromethyltyrosine (BAY 86-9596) PET/CT in patients with non-small cell lung cancer and head and neck squamous cell carcinoma

scientific article published on 25 September 2014

First-in-Human PET/CT Imaging of Metastatic Neuroendocrine Neoplasms with Cyclotron-Produced 44Sc-DOTATOC: A Proof-of-Concept Study

scientific article published in May 2017

Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression.

scientific article published on 24 November 2012

Fluorine-18 click radiosynthesis and preclinical evaluation of a new 18F-labeled folic acid derivative

scientific article published in December 2008

Folate Receptor-Positive Gynecological Cancer Cells: In Vitro and In Vivo Characterization

scientific article published on 15 August 2017

Folate receptor targeted alpha-therapy using terbium-149.

scientific article published on 13 March 2014

Folate receptor-targeted multimodality imaging of ovarian cancer in a novel syngeneic mouse model

scientific article

Folate receptor-targeted radionuclide therapy: preclinical investigation of anti-tumor effects and potential radionephropathy

scientific article

Folic acid conjugates for nuclear imaging of folate receptor-positive cancer

scientific article published on 13 December 2010

Functionalization of glucose at position C-3 for transition metal coordination: organo-rhenium complexes with carbohydrate skeletons

scientific article

Future prospects for SPECT imaging using the radiolanthanide terbium-155 - production and preclinical evaluation in tumor-bearing mice

scientific article published on 15 November 2013

GABAA receptor subtypes in the mouse brain: Regional mapping and diazepam receptor occupancy by in vivo [18F]flumazenil PET.

scientific article published on 10 February 2017

Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability

scientific article published on 21 April 2014

Glycation methods for bombesin analogs containing the (NalphaHis)Ac chelator for 99mTc(CO)3 radiolabeling

scientific article published on 5 November 2008

HAX1 deficiency: Impact on lymphopoiesis and B-cell development

article

High-Resolution SPECT Imaging of Stimuli-Responsive Soft Microrobots

scientific article published on 15 July 2019

High-sensitivity ICP-MS – an alternative for in vitro and in vivo characterization of future radiometal-based theranostic candidates

scientific article published in 2022

Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

scientific article published on 11 August 2020

Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor

scientific article published on 20 July 2018

Identification, characterization and suppression of side-products formed during the synthesis of high dose ⁶⁸Ga-DOTA-TATE

scientific article published on 05 August 2012

Imaging atherosclerotic plaque inflammation via folate receptor targeting using a novel 18F-folate radiotracer

scientific article

Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomography/computed tomography

scientific article published on 01 July 2011

Imaging quality of (44)Sc in comparison with five other PET radionuclides using Derenzo phantoms and preclinical PET.

scientific article

Imaging tumour ATB0,+ transport activity by PET with the cationic amino acid O-2((2-[18F]fluoroethyl)methyl-amino)ethyltyrosine.

scientific article published on 5 December 2013

ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo

scientific article

Implementation of a new separation method to produce qualitatively improved 64 Cu

scientific article published on 01 June 2019

Improved PET imaging of tumors in mice using a novel (18) F-folate conjugate with an albumin-binding entity

scientific article published on December 2013

Improved Syntheses of the Mglu₅ Antagonists MMPEP and MTEP Using Sonogashira Cross-Coupling.

scientific article published on 20 February 2018

In Vivo Imaging of Local Inflammation: Monitoring LPS-Induced CD80/CD86 Upregulation by PET

scientific article published on 28 September 2020

In Vivo Labeling of Plasma Proteins for Imaging of Enhanced Vascular Permeability in the Lungs

scientific article published on 28 September 2018

In vitro and in vivo evaluation of an innocuous drug cocktail to improve the quality of folic acid targeted nuclear imaging in preclinical research.

scientific article published on 8 February 2013

In vitro and in vivo evaluation of bidentate, water-soluble phosphine ligands as anchor groups for the organometallic fac-[99mTc(CO)3]+-core

scientific article published on 01 August 1999

In vitro and in vivo targeting of different folate receptor-positive cancer cell lines with a novel 99mTc-radiofolate tracer

scientific article published on 24 May 2006

In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography

scientific article

In vivo imaging of prostate cancer using [68Ga]-labeled bombesin analog BAY86-7548.

scientific article published on 9 August 2013

Influence of the denticity of ligand systems on the in vitro and in vivo behavior of (99m)Tc(I)-tricarbonyl complexes: a hint for the future functionalization of biomolecules

scientific article

Influence of the molecular charge on the biodistribution of bombesin analogues labeled with the [99mTc(CO)3]-core

scientific article

Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy

scientific article published on 8 June 2016

Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma.

scientific article published on 21 January 2018

Investigation of the chick embryo as a potential alternative to the mouse for evaluation of radiopharmaceuticals

scientific article published on 28 October 2014

Isostructural folate conjugates radiolabeled with the matched pair 99mTc/188Re: a potential strategy for diagnosis and therapy of folate receptor-positive tumors

scientific article published on August 2007

Ketamine and Ceftriaxone-Induced Alterations in Glutamate Levels Do Not Impact the Specific Binding of Metabotropic Glutamate Receptor Subtype 5 Radioligand [F]PSS232 in the Rat Brain

scientific article published on 29 August 2018

L1 Cell Adhesion Molecule Confers Radioresistance to Ovarian Cancer and Defines a New Cancer Stem Cell Population

scientific article published on 15 January 2020

L1-CAM-targeted antibody therapy and 177Lu-radioimmunotherapy of disseminated ovarian cancer

scientific article published on 29 August 2011

Liquid Chromatography ICP-MS to Assess the Stability of 175Lu- and natGa-Based Tumor-Targeting Agents towards the Development of 177Lu- and 68Ga-Labeled Radiopharmaceuticals

scientific article published on 21 February 2024

Longitudinal in vivo evaluation of bone regeneration by combined measurement of multi-pinhole SPECT and micro-CT for tissue engineering

scientific article published on 19 May 2015

MRS glucose mapping and PET joining forces: re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia

scientific article

Management of chronic obstructive pulmonary disease: the Swiss guidelines. Official Guidelines of the Swiss Respiratory Society.

scientific article

Metabotropic glutamate receptor subtype 5 is altered in LPS-induced murine neuroinflammation model and in the brains of AD and ALS patients

scientific article published on 05 October 2018

Metal chelating systems synthesized using the copper(I) catalyzed azide-alkyne cycloaddition.

scientific article

Methoxinine - an alternative stable amino acid substitute for oxidation-sensitive methionine in radiolabelled peptide conjugates

scientific article published on 5 January 2017

Microbial transglutaminase and c-myc-tag: a strong couple for the functionalization of antibody-like protein scaffolds from discovery platforms.

scientific article

Modification of different IgG1 antibodies via glutamine and lysine using bacterial and human tissue transglutaminase

scientific article

Molecular assembly of multifunctional ⁹⁹(m)Tc radiopharmaceuticals using "clickable" amino acid derivatives.

scientific article published on December 2010

Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain

scientific article published in 2022

Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27).

scientific article published on 13 July 2012

Neuroimaging with Radiopharmaceuticals Targeting the Glutamatergic System

scientific article published on 01 December 2020

New derivatives of vitamin B12 show preferential targeting of tumors

scientific article

Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering

scientific article published on 19 May 2016

Novel chemoselective (18)F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions.

scientific article published on 4 April 2016

Novel glycated [99mTc(CO)3]-labeled bombesin analogues for improved targeting of gastrin-releasing peptide receptor-positive tumors

scientific article

Novel peptide probes to assess the tensional state of fibronectin fibers in cancer

scientific article published on 27 November 2017

On the consensus nomenclature rules for radiopharmaceutical chemistry - Reconsideration of radiochemical conversion

scientific article published on 18 November 2020

Organometallic 99mTc-aquaion labels peptide to an unprecedented high specific activity

scientific article published on 01 November 1999

Organometallic [Re(CO)3]+ and [Re(CO)2(NO)]2+ labeled substrates for human thymidine kinase 1.

scientific article

PEGylation of (99m)Tc-labeled bombesin analogues improves their pharmacokinetic properties

scientific article published on 21 April 2011

PEGylation, increasing specific activity and multiple dosing as strategies to improve the risk-benefit profile of targeted radionuclide therapy with 177Lu-DOTA-bombesin analogues.

scientific article

Paclitaxel improved anti-L1CAM lutetium-177 radioimmunotherapy in an ovarian cancer xenograft model

scientific article published on 3 October 2014

Pemetrexed improves tumor selectivity of 111In-DTPA-folate in mice with folate receptor-positive ovarian cancer

scientific article

Pharmacological inhibition of mTORC1 increases CCKBR-specific tumor uptake of radiolabeled minigastrin analogue [177Lu]Lu-PP-F11N

scientific article published on 29 August 2020

Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice.

scientific article

Preclinical Comparison of Albumin-Binding Radiofolates: Impact of Linker Entities on the in Vitro and in Vivo Properties

scientific article published on 17 January 2017

Preclinical Development of 18F-OF-NB1 for Imaging GluN2B-Containing N-Methyl-D-Aspartate Receptors and its Utility as a Biomarker for Amyotrophic Lateral Sclerosis

scientific article published on 31 July 2020

Preclinical Development of Novel PSMA-Targeting Radioligands: Modulation of Albumin-Binding Properties To Improve Prostate Cancer Therapy.

scientific article published on 23 April 2018

Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor-Targeted PET Imaging

scientific article published on 25 January 2019

Preclinical evaluation and test-retest studies of [(18)F]PSS232, a novel radioligand for targeting metabotropic glutamate receptor 5 (mGlu5).

scientific article published on 20 August 2014

Preclinical evaluation of 5-methyltetrahydrofolate-based radioconjugates-new perspectives for folate receptor-targeted radionuclide therapy

scientific article published on 15 October 2020

Preclinical evaluation of novel organometallic 99mTc-folate and 99mTc-pteroate radiotracers for folate receptor-positive tumour targeting

scientific article published on 9 June 2006

Preclinical imaging of the co-stimulatory molecules CD80 and CD86 with indium-111-labeled belatacept in atherosclerosis.

scientific article

Preclinical investigations and first-in-human application of 152Tb-PSMA-617 for PET/CT imaging of prostate cancer

scientific article published on 25 July 2019

Production and characterization of no-carrier-added 161Tb as an alternative to the clinically-applied 177Lu for radionuclide therapy

scientific article published on 10 July 2019

Production and separation of Sc for radiopharmaceutical purposes

article published in 2017

Promises of cyclotron-produced 44Sc as a diagnostic match for trivalent β--emitters: in vitro and in vivo study of a 44Sc-DOTA-folate conjugate

scientific article published on 6 November 2013

Promising potential of [177Lu]Lu-DOTA-folate to enhance tumor response to immunotherapy-a preclinical study using a syngeneic breast cancer model

scientific article published on 19 October 2020

Promising prospects for 44Sc-/47Sc-based theragnostics: application of 47Sc for radionuclide tumor therapy in mice.

scientific article

Prospects in folate receptor-targeted radionuclide therapy

scientific article published on 24 September 2013

Quantification of brain glucose metabolism by 18F-FDG PET with real-time arterial and image-derived input function in mice

scientific article

Quantitative positron emission tomography of mGluR5 in rat brain with [(18) F]PSS232 at minimal invasiveness and reduced model complexity

scientific article published on 28 January 2015

Radiation dosimetry of 18F-AzaFol: A first in-human use of a folate receptor PET tracer

scientific article published on 08 April 2020

Radiation dosimetry of [18F]-PSS232-a PET radioligand for imaging mGlu5 receptors in humans

scientific article published on 25 June 2019

Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies.

scientific article

Radioiodinated folic acid conjugates: evaluation of a valuable concept to improve tumor-to-background contrast

scientific article

Radiolabeled 111In-FGF-2 Is Suitable for In Vitro/Ex Vivo Evaluations and In Vivo Imaging.

scientific article published on 21 February 2017

Radiolabeling and in vitro /in vivo evaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor.

scientific article published on 19 July 2013

Radiolabeling of rituximab with (188)Re and (99m)Tc using the tricarbonyl technology

scientific article published on 22 September 2010

Radiometal labeling of antibodies and antibody fragments for imaging and therapy.

scientific article published in January 2004

Radiosynthesis and evaluation of an 18F-labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma

scientific article published on 02 January 2018

Radiosynthesis and preclinical evaluation of 3'-Aza-2'-[(18)F]fluorofolic acid: a novel PET radiotracer for folate receptor targeting

scientific article

Recent progress in allosteric modulators for GluN2A subunit and development of GluN2A-selective nuclear imaging probes

scientific article published on 01 June 2019

Recording intracellular molecular events from the outside: glycosylphosphatidylinositol-anchored avidin as a reporter protein for in vivo imaging

scientific article published on 14 February 2011

Reduced 18F-Folate Conjugates as a New Class of PET Tracers for Folate Receptor Imaging.

scientific article published on 7 February 2018

Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner

scientific article

SPECT study of folate receptor-positive malignant and normal tissues in mice using a novel 99mTc-radiofolate

scientific article

SUN-334 Evaluation of the CCK-2 Receptor Agonist 177Lu-PP-F11N for PRRT of Medullary Thyroid Carcinoma: Results of a Phase 0 "Lumed" Study.

scientific article

Sc as useful β-emitter for the radiotheragnostic paradigm: a comparative study of feasible production routes

article published in 2017

Sc for labeling of DOTA- and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations

Simultaneous Visualization of 161Tb- and 177Lu-Labeled Somatostatin Analogues Using Dual-Isotope SPECT Imaging

scientific article published on 12 April 2021

Single Photon Emission Computed Tomography Tracer

scientific article published on 01 January 2020

Single photon emission computed tomography tracer.

scientific article published on January 2013

Single-step radiofluorination of peptides using continuous flow microreactor

scientific article published on 01 May 2012

Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models

scientific article

Site-specific and stoichiometric modification of antibodies by bacterial transglutaminase

scientific article published on December 2010

Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex

scientific article published on 01 September 1999

Steps toward high specific activity labeling of biomolecules for therapeutic application: preparation of precursor [(188)Re(H(2)O)(3)(CO)(3)](+) and synthesis of tailor-made bifunctional ligand systems

scientific article

Strategies for the Development of Novel Tumor Targeting Technetium and Rhenium Radiopharmaceuticals

article

Structural Basis for Universal Corrinoid Recognition by the Cobalamin Transport Protein Haptocorrin

scientific article

Structural and (99)Tc NMR Investigations of Complexes with fac-[Tc(CO)(3)](+) Moieties and Macrocyclic Thioethers of Various Ring Sizes: Synthesis and X-ray Structure of the Complexes fac-[Tc(9-ane-S(3))(CO)(3)]Br, fac-[Tc(2)(tosylate)(2)(18-ane-S(6

scientific article published on 01 July 1998

Structure-Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

scientific article published on 05 December 2019

Structure-Affinity Relationships of 2,3,4,5-Tetrahydro-1H-3-benzazepine and 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-amine Analogues and the Discovery of a Radiofluorinated 2,3,4,5-Tetrahydro-1H-3-benzazepine Congener for Imaging GluN2B Subunit-Conta

scientific article published on 28 October 2019

Studies toward the development of new silicon-containing building blocks for the direct (18)F-labeling of peptides

scientific article

Syntheses and characterization of dicarbonyl-nitrosyl complexes of technetium(I) and rhenium(I) in aqueous media: spectroscopic, structural, and DFT analyses.

scientific article

Synthesis and Biological Evaluation of Thiophene-Based Cannabinoid Receptor Type 2 Radiotracers for PET Imaging

scientific article published on 27 July 2016

Synthesis and In Vitro Evaluation of E- and Z-Geometrical Isomers of PSS232 as Potential Metabotropic Glutamate Receptors Subtype 5 (mGlu5) Binders

Synthesis and Pharmacological Evaluation of [11C]Granisetron and [18F]Fluoropalonosetron as PET Probes for 5-HT3 Receptor Imaging

scientific article published on 29 August 2016

Synthesis and Preliminary Evaluation of a 2-Oxoquinoline Carboxylic Acid Derivative for PET Imaging the Cannabinoid Type 2 Receptor

scientific article published on 06 March 2014

Synthesis and Structure-Affinity Relationship of Small Molecules for Imaging Human CD80 by Positron Emission Tomography

scientific article published on 29 August 2019

Synthesis and biological evaluation of (18)F-labeled Fluoroethoxy tryptophan analogues as potential PET tumor imaging agents.

scientific article

Synthesis and biological evaluation of ¹⁸F-labeled fluoropropyl tryptophan analogs as potential PET probes for tumor imaging.

scientific article published on 30 October 2013

Synthesis and evaluation of biphenyl compounds as kinesin spindle protein inhibitors

scientific article published on April 2013

Synthesis and evaluation of bombesin analogues conjugated to two different triazolyl-derived chelators for (99m)Tc labeling

scientific article published on October 2010

Synthesis and evaluation of novel α-fluorinated (E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyl oxime (ABP688) derivatives as metabotropic glutamate receptor subtype 5 PET radiotracers

scientific article published on 9 August 2012

Synthesis and in vitro characterization of organometallic rhenium and technetium glucose complexes against Glut 1 and hexokinase.

scientific article

Synthesis and in vitro/in vivo evaluation of novel 99mTc(CO)3-folates

scientific article published in May 2006

Synthesis and in vitro/in vivo pharmacological evaluation of [11C]-ThioABP, a novel radiotracer for imaging mGluR5 with PET

scholarly article by Selena Milicevic Sephton et al published 2013 in MedChemComm

Synthesis and pharmacological evaluation of ¹¹C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging.

scientific article

Synthesis and preclinical evaluation of a folic acid derivative labeled with 18F for PET imaging of folate receptor-positive tumors.

scientific article published on July 2006

Synthesis and preliminary biological evaluation of O-2((2-[(18)F]fluoroethyl)methylamino)ethyltyrosine ([(18)F]FEMAET) as a potential cationic amino acid PET tracer for tumor imaging.

scientific article published on 7 May 2014

Synthesis and properties of boranocarbonate: a convenient in situ CO source for the aqueous preparation of [(99m)Tc(OH(2))3(CO)3]+.

scientific article published in April 2001

Synthesis of a Novel γ-Folic Acid-N τ-Histidine Conjugate Suitable for Labeling with 99mTc and 188Re

Synthesis, Radiolabeling, and Biological Evaluation of 5-Hydroxy-2-[(18)F]fluoroalkyl-tryptophan Analogues as Potential PET Radiotracers for Tumor Imaging.

scientific article published on 18 May 2016

Synthesis, Radiolabeling, and Characterization of Plasma Protein-Binding Ligands: Potential Tools for Modulation of the Pharmacokinetic Properties of (Radio)Pharmaceuticals.

scientific article published on 12 September 2017

Synthesis, in vitro, and in silico evaluation of organometallic technetium and rhenium thymidine complexes with retained substrate activity toward human thymidine kinase type 1.

scientific article published on 7 October 2008

Synthesis, radiolabeling and evaluation of novel 4-oxo-quinoline derivatives as PET tracers for imaging cannabinoid type 2 receptor

scientific article published on 13 January 2015

Synthesis, radiolabelling and in vitro and in vivo evaluation of a novel fluorinated ABP688 derivative for the PET imaging of metabotropic glutamate receptor subtype 5.

scientific article published on 10 December 2011

Targeted 64 Cu-labeled gold nanoparticles for dual imaging with positron emission tomography and optical imaging

scientific article published on 28 May 2019

Targeted Radiotherapeutics from 'Bench-to-Bedside'

scientific article published on 01 December 2020

Targeting Cancer Stem Cells with Radioimmunotherapy: The Case of the Ovarian Cancer Stemness-Associated Biomarker L1CAM

scientific article published on 18 July 2024

Targets and probes for non-invasive imaging of β-cells

scientific article published on 26 December 2016

Terbium-161 for PSMA-targeted radionuclide therapy of prostate cancer

scientific article published on 27 May 2019

The biodistribution of self-assembling protein nanoparticles shows they are promising vaccine platforms

scientific article

The influence of physical work upon decompression time after simulated oxy-helium dives

scientific article published on 01 January 1972

The low-energy β− and electron emitter 161Tb as an alternative to 177Lu for targeted radionuclide therapy

scientific article published in August 2011

The soluble form of the cancer-associated L1 cell adhesion molecule is a pro-angiogenic factor.

scientific article published on 20 January 2009

Therapeutic Potential of 47Sc in Comparison to 177Lu and 90Y: Preclinical Investigations

scientific article published on 20 August 2019

Therapeutic Radiometals Beyond 177Lu and 90Y: Production and Application of Promising α-Particle, β--Particle, and Auger Electron Emitters.

scientific article published in September 2017

Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo.

scientific article published on 11 August 2017

Towards non-invasive imaging of vulnerable atherosclerotic plaques by targeting co-stimulatory molecules.

scientific article published on 13 April 2014

Transglutaminase-based chemo-enzymatic conjugation approach yields homogeneous antibody-drug conjugates.

scientific article published on 12 February 2014

Transplantation and tracking of human-induced pluripotent stem cells in a pig model of myocardial infarction: assessment of cell survival, engraftment, and distribution by hybrid single photon emission computed tomography/computed tomography of sodi

scientific article published on 5 July 2012

Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting

scientific article published on 17 April 2020

Tumor imaging in patients with advanced tumors using a new (99m) Tc-radiolabeled vitamin B12 derivative

scientific article published on 12 December 2013

Tumor targeting using 67Ga-DOTA-Bz-folate--investigations of methods to improve the tissue distribution of radiofolates

scientific article published on 03 March 2011

Unexpected reactivity of cyclic perfluorinated iodanes with electrophiles

scientific article published on 01 August 2018

Versatile routes to C-2- and C-6-functionalized glucose derivatives of iminodiacetic acid

scientific article published in January 2003

Versatile synthetic approach to new bifunctional chelating agents tailor made for labeling with the fac-[M(CO)(3)](+) core (M = Tc, (99m)Tc, Re): synthesis, in vitro, and in vivo behavior of the model complex [M(APPA)(CO)(3)] (APPA = [(5-amino-penty

scientific article published in July 2003

Visualisation of interstitial lung disease by molecular imaging of integrin αvβ3 and somatostatin receptor 2

scientific article published on 17 November 2018

Water-exchange study revealed unexpected substitution behavior of [(CO)2(NO)Re(H2O)3]2+ in aqueous media.

scientific article

[(3)H]metyrapol and 4-[(131)i]iodometomidate label overlapping, but not identical, binding sites on rat adrenal membranes

scientific article published on 20 February 2013

[11C]mHED PET follows a two-tissue compartment model in mouse myocardium with norepinephrine transporter (NET)-dependent uptake, while [18F]LMI1195 uptake is NET-independent

scientific article published on 29 September 2020

[18F]Fluoro-Deoxy-Glucose Folate: A Novel PET Radiotracer with Improved in Vivo Properties for Folate Receptor Targeting

scientific article published on 13 March 2012

“Click to Chelate”: Synthesis and Installation of Metal Chelates into Biomolecules in a Single Step

scientific article published on 01 November 2006

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