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List of works by Paul Declerck

A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior

scientific article published on 23 May 2016

A Genome-wide Study of Common and Rare Genetic Variants Associated with Circulating Thrombin Activatable Fibrinolysis Inhibitor

scientific article published on 29 January 2018

A model of the reactive form of plasminogen activator inhibitor-1

scientific article published on 01 November 1994

A peptide accelerating the conversion of plasminogen activator inhibitor-1 to an inactive latent state

scientific article

Accelerated conversion of human plasminogen activator inhibitor-1 to its latent form by antibody binding

scientific article published on 01 June 1999

Activated thrombin activatable fibrinolysis inhibitor levels are associated with the risk of cardiovascular death in patients with coronary artery disease: the AtheroGenestudy

scientific article published on 01 January 2009

Activation of both coagulation and fibrinolysis in childhood hemolytic uremic syndrome.

scientific article

Activation of the zymogen to urokinase-type plasminogen activator is associated with increased interdomain flexibility.

scientific article published on 6 June 2011

Active PAI-1 as marker for venous thromboembolism: Case–control study using a comprehensive panel of PAI-1 and TAFI assays

scientific article published on 20 August 2014

Additivity in effects of vitronectin and monoclonal antibodies against alpha-helix F of plasminogen activator inhibitor-1 on its reactions with target proteinases

scientific article published on 29 October 2004

Advances in understanding pectin methylesterase inhibitor in kiwi fruit: an immunological approach.

scientific article published on 3 November 2010

Age-dependent spontaneous coronary arterial thrombosis in transgenic mice that express a stable form of human plasminogen activator inhibitor-1.

scientific article published on July 2002

Amplified endogenous plasmin activity resolves acute thrombotic thrombocytopenic purpura in mice.

scientific article published on 5 October 2017

An echistatin-like Arg-Gly-Asp (RGD)-containing sequence in the heavy chain CDR3 of a murine monoclonal antibody that inhibits human platelet glycoprotein IIb/IIIa function

scientific article published in July 1994

Announcing a TAFIa mutant with a 180-fold increased half-life and concomitantly a strongly increased antifibrinolytic potential

scientific article published on 16 November 2006

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis.

scientific article published on 29 January 2018

Base specific interaction of reductively activated nitroimidazoles with DNA

scientific article published on 01 November 1983

Bioavailability of different artemisinin tablet formulations in rabbit plasma--correlation with results obtained by an in vitro dissolution method

scientific article published in October 1997

Biochemical importance of glycosylation in thrombin activatable fibrinolysis inhibitor

scientific article published on 6 December 2007

Biochemical importance of glycosylation of plasminogen activator inhibitor-1.

scientific article

Biopharmaceuticals: Reference Products and Biosimilars to Treat Inflammatory Diseases.

scientific article published on 20 February 2017

Biosimilar monoclonal antibodies: a science-based regulatory challenge ⬇️

scientific article published on January 4, 2013

Biosimilarity Versus Manufacturing Change: Two Distinct Concepts

scientific article published on 17 September 2015

Biosimilars - terms of use.

scientific article published on 23 September 2015

Biosimilars: controversies as illustrated by rhGH.

scientific article published on May 2010

Biotherapeutics in the era of biosimilars: what really matters is patient safety.

scientific article published on January 2007

Bispecific targeting of thrombin activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 by a heterodimer diabody

scientific article published on 22 August 2008

Bridging the Clinical Gap for DNA-Based Antibody Therapy Through Translational Studies in Sheep

scientific article published on 10 September 2019

Characterization of a panel of monoclonal antibodies toward mouse PAI-1 that exert a significant profibrinolytic effect in vivo

scientific article published on 09 March 2011

Characterization of common neoantigenic epitopes generated in plasminogen activator inhibitor-1 after cleavage of the reactive center loop or after complex formation with various serine proteinases

scientific article published on 01 December 1995

Characterization of plasminogen activator inhibitor 1 mutants containing the P13 to P10 region of ovalbumin or antithrombin III: evidence that the P13 residue contributes significantly to the active to substrate transition

scientific article published on 01 September 1998

Characterization of recombinant rat plasminogen activator inhibitor-1 and development of immunological tools for its quantitation

scientific article published on July 1, 1997

Clearance of plasmin-PN-1 complexes by vascular smooth muscle cells in human aneurysm of the ascending aorta.

scientific article published on 24 October 2017

Cloning and paratope analysis of an antibody fragment, a rational approach for the design of a PAI-1 inhibitor

scientific article published in February 2004

Cloning of a single-chain variable fragment (scFv) switching active plasminogen activator inhibitor-1 to substrate

scientific article published on 01 April 1997

Clot stability and fibrin deposition is strongly reduced in mice in which mouse TAFI is replaced by human TAFI

scientific article published on 02 April 2014

Comparative analysis of the proteinase specificity in wild-type and stabilized plasminogen activator inhibitor-1: evidence for contribution of intramolecular flexibility

scientific article published in August 2004

Comparative evaluation of stable TAFIa variants: importance of alpha-helix 9 and beta-sheet 11 for TAFIa (in)stability

scientific article published on 31 July 2007

Comparative study of inhibitory antibody derivatives towards thrombin activatable fibrinolysis inhibitor

scientific article published on 01 July 2009

Comparison of random and oriented immobilisation of antibody fragments on mixed self-assembled monolayers

scientific article

Conformational (in)stability of rat vs. human activated thrombin activatable fibrinolysis inhibitor

scientific article published on 28 May 2008

Conformational Studies on Plasminogen Activator Inhibitor (PAI-1) in Active, Latent, Substrate, and Cleaved Forms

scientific article published on 01 January 1995

Convalescent plasma levels of TAFI activation peptide predict death and recurrent vascular events in ischemic stroke survivors

scientific article

Correlations between t-PA and PAI-1 antigen and activity and t-PA/PAI-1 complexes in plasma of control subjects and of patients with increased t-PA or PAI-1 levels

scientific article published in December 1990

Corrigendum: PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin

scientific article published on 01 May 2015

DNA-Based Delivery of Checkpoint Inhibitors in Muscle and Tumor Enables Long-Term Responses with Distinct Exposure

scientific article published on 13 February 2020

DNA-based delivery of anti-DR5 Nanobodies improves exposure and anti-tumor efficacy over protein-based administration

scientific article published on 30 July 2020

Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding

scientific article published on 19 July 2018

Demystifying biosimilars: development, regulation and clinical use

scientific article published on 30 November 2018

Development and evaluation of monoclonal antibodies as probes to assess the differences between two tomato pectin methylesterase isoenzymes

scientific article published on 15 August 2009

Development of ELISAs measuring the extent of TAFI activation

scientific article published on 08 December 2005

Development of a genotype 325-specific proCPU/TAFI ELISA.

scientific article published in May 2003

Development of a liquid chromatography/mass spectrometry assay for the bacterial transglycosylation reaction through measurement of Lipid II

scientific article published on 07 October 2015

Development of a universal anti-adalimumab antibody standard for interlaboratory harmonization

scientific article

Development of anti-matrix metalloproteinase-2 (MMP-2) nanobodies as potential therapeutic and diagnostic tools

scientific article published on 24 October 2019

Development of sandwich-type ELISAs for the quantification of rat and murine thrombin activatable fibrinolysis inhibitor in plasma

scientific article published on 08 October 2007

Different Policy Measures and Practices between Swedish Counties Influence Market Dynamics: Part 1-Biosimilar and Originator Infliximab in the Hospital Setting.

scientific article

Different Policy Measures and Practices between Swedish Counties Influence Market Dynamics: Part 2-Biosimilar and Originator Etanercept in the Outpatient Setting.

scientific article

Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.

scientific article

Dynamic structural and functional relationships in recombinant plasminogen activator inhibitor-1 (rPAI-1).

scientific article

Effect of Reteplase and PAI-1 antibodies on postoperative adhesion formation in a laparoscopic mouse model

scientific article

Effectiveness of the electronic cigarette: An eight-week Flemish study with six-month follow-up on smoking reduction, craving and experienced benefits and complaints.

scientific article

Elucidation of a novel epitope of a substrate-inducing monoclonal antibody against the serpin PAI-1.

scientific article published in May 2003

Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity

scientific article

Enhanced expression of plasminogen activator inhibitor-1 by dedifferentiated thyrocytes

scientific article published on 01 July 2002

Enhancement of endogenous fibrinolysis does not reduce local fibrin deposition, but modulates inflammation upon intestinal ischemia and reperfusion

scientific article published in March 2004

Evaluation of the profibrinolytic properties of a bispecific antibody-based inhibitor against human and mouse thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1.

scientific article

Evaluation of the profibrinolytic properties of an anti-TAFI monoclonal antibody in a mouse thromboembolism model

scientific article published on 22 February 2011

Evidence for a pre-latent form of the serpin plasminogen activator inhibitor-1 with a detached beta-strand 1C

scientific article published on 03 October 2006

Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor

scientific article published on 23 November 2011

Function-stabilizing mechanism of plasminogen activator inhibitor type 1 induced upon binding to alpha1-acid glycoprotein

scientific article published in September 2005

Generation and characterization of inhibitory nanobodies towards thrombin activatable fibrinolysis inhibitor

scientific article published on 17 February 2010

Generation and characterization of monoclonal antibodies against the N-terminus of alpha-2-antiplasmin.

scientific article published on 3 May 2018

Generation and in vitro characterisation of inhibitory nanobodies towards plasminogen activator inhibitor 1.

scientific article published on 8 September 2016

Generation of a Highly Specific Monoclonal Anti-Infliximab Antibody for Harmonization of TNF-Coated Infliximab Assays

scientific article published on 01 August 2015

Generation of a stable activated thrombin activable fibrinolysis inhibitor variant

scientific article published on 4 April 2006

Generation of a stable thrombin-activatable fibrinolysis inhibitor deletion mutant exerting full carboxypeptidase activity without activation

scientific article published on 06 April 2015

Glycosylation influences the stability of human plasminogen activator inhibitor-1

scientific article published on 01 September 2012

Haemostatic biomarkers are associated with long-term recurrent vascular events after ischaemic stroke

scientific article published on 30 June 2016

Harmonization of Infliximab and Anti-Infliximab Assays Facilitates the Comparison Between Originators and Biosimilars in Clinical Samples

scientific article published on 7 March 2016

High quality structure of cleaved PAI-1-stab

scientific article

High thrombin activatable fibrinolysis inhibitor levels are associated with an increased risk of premature peripheral arterial disease

scientific article published on 30 December 2010

His374 of wheat endoxylanase inhibitor TAXI-I stabilizes complex formation with glycoside hydrolase family 11 endoxylanases

scientific article

Homogeneity versus diversity: inhibition of plasma PAI-1 in murine sepsis proved lethal in homogeneous cohorts but not in all-inclusive populations.

scientific article published on 14 November 2012

Hormonal control of plasminogen activator inhibitor-1 gene expression and production in human adipose tissue: stimulation by glucocorticoids and inhibition by catecholamines

scientific article published on November 1999

Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth

scientific article published on 01 September 2004

Hydrogenosomal ATP:AMP phosphotransferase of Trichomonas vaginalis

scientific article published on 01 January 1987

Identification and characterisation of monoclonal antibodies that impair the activation of human thrombin activatable fibrinolysis inhibitor through different mechanisms

scientific article published on 05 May 2011

Identification of a bacterial inhibitor against g-type lysozyme

scientific article published on 25 August 2010

Identification of a functional epitope in plasminogen activator inhibitor-1, not localized in the reactive center loop

scientific article published on March 1, 1998

Identification of a novel, nanobody-induced, mechanism of TAFI inactivation and its in vivo application

scientific article published in February 2014

Identification of a target site in plasminogen activator inhibitor-1 that allows neutralization of its inhibitor properties concomitant with an allosteric up-regulation of its antiadhesive properties

scientific article published on 07 May 2001

Identification of functional synergism between monoclonal antibodies. Application to the enhancement of plasminogen activator inhibitor-1 neutralizing effects

scientific article published on 01 October 1997

Identification of positively charged residues contributing to the stability of plasminogen activator inhibitor 1

scientific article published on 01 September 1997

Immobilization of the distal hinge in the labile serpin plasminogen activator inhibitor 1: identification of a transition state with distinct conformational and functional properties

scientific article published on 09 April 2003

Immunogenicity of immunomodulatory, antibody-based, oncology therapeutics

scientific article published on 15 April 2019

Importance of the hinge region between alpha-helix F and the main part of serpins, based upon identification of the epitope of plasminogen activator inhibitor type 1 neutralizing antibodies

scientific article published on 01 March 2000

In vitro and in vivo characterisation of the profibrinolytic effect of an inhibitory anti-rat TAFI nanobody

scientific article published on 09 January 2014

In vitro reductive activation of nitroimidazoles

scientific article published on 01 January 1986

Inactivation of plasminogen activator inhibitor-1 by specific proteolysis with stromelysin-1 (MMP-3).

scientific article published in December 2000

Increased zymogen activity of thrombin-activatable fibrinolysis inhibitor prolongs clot lysis

scientific article published in June 2012

Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice.

scientific article published on 28 July 2016

Inhibition of plasminogen activator inhibitor-1: antibody fragments and their unique sequences as a tool for the development of profibrinolytic drugs

scientific article published in February 2004

Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke

scientific article published on 24 December 2014

Letter: dry blood spots for anti-TNF treatment monitoring in IBD

scientific article published on 01 May 2013

Long-term in vivo expression of trastuzumab following intramuscular electrotransfer of the encoding DNA in mice.

scientific article

Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential

scientific article published on 22 June 2017

Lysozyme inhibitor conferring bacterial tolerance to invertebrate type lysozyme

scientific article published on 5 January 2010

Maximal PAI-1 inhibition in vivo requires neutralizing antibodies that recognize and inhibit glycosylated PAI-1

scientific article published on 16 December 2011

Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1

scientific article

Mechanisms of conversion of plasminogen activator inhibitor 1 from a suicide inhibitor to a substrate by monoclonal antibodies

scientific article published on 9 September 2002

Migration of the activation peptide of thrombin-activatable fibrinolysis inhibitor (TAFI) during SDS-polyacrylamide gel electrophoresis

scientific article published in May 2004

Modulation of TAFI function through different pathways--implications for the development of TAFI inhibitors

scientific article published on 01 December 2005

Modulation of plasminogen activator inhibitor 1 by Triton X-100--identification of two consecutive conformational transitions

scientific article published on August 1, 1998

Modulation of serpin reaction through stabilization of transient intermediate by ligands bound to alpha-helix F.

scientific article published on 5 July 2007

Molecular forms of plasminogen activator inhibitor-1 (PAI-1) and tissue-type plasminogen activator (t-PA) in human plasma

scientific article published on 01 May 1991

Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction

scientific article published on 20 February 2020

Monoclonal Antibody Biosimilars in Oncology: Critical Appraisal of Available Data on Switching

scientific article published on 24 April 2018

Monoclonal antibodies targeting the antifibrinolytic activity of activated thrombin-activatable fibrinolysis inhibitor but not the anti-inflammatory activity on osteopontin and C5a.

scientific article published in December 2013

Monoclonal antibody-based immunoassays for the specific quantitation of rat PAI-1 antigen and activity in biological samples

scientific article published on April 1, 1998

Multimeric vitronectin. Identification and characterization of conformation-dependent self-association of the adhesive protein ⬇️

scientific article published on October 25, 1993

Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury

scientific article

Neutralization of plasminogen activator inhibitor-1 inhibitory properties: identification of two different mechanisms

scientific article published on 01 February 1997

Nonmedical Switching From Originators to Biosimilars: Does the Nocebo Effect Explain Treatment Failures and Adverse Events in Rheumatology and Gastroenterology?

scientific article published on 16 January 2020

Novel or expanding current targets in fibrinolysis.

scientific article published on 02 June 2014

Overcoming Barriers to the Market Access of Biosimilars in the European Union: The Case of Biosimilar Monoclonal Antibodies

scientific article

PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin.

scientific article

Pathophysiology of fibrinolysis

scientific article published on 01 June 1995

Plasmin and the thrombin-thrombomodulin complex both contribute to thrombin-activatable fibrinolysis inhibitor activation in whole blood model thrombi.

scientific article

Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation

scientific article

Plasminogen activator inhibitor-1 modulates adipocyte differentiation.

scientific article published on 6 September 2005

Prevention of Serpin Misfolding by RNA Aptamers

scientific article published on 01 June 2016

Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies.

scientific article published on 6 February 2018

Proteinase specificity and functional diversity in point mutants of plasminogen activator inhibitor 1

scientific article published on 01 May 1997

Protonation state of a single histidine residue contributes significantly to the kinetics of the reaction of plasminogen activator inhibitor-1 with tissue-type plasminogen activator

scientific article published on 19 March 2004

Purification and characterization of natural and recombinant human plasminogen activator inhibitor-1 (PAI-1)

scientific article published on 01 August 1988

Quantitation of Vervet monkey (Chlorocebus aethiops) plasminogen activator inhibitor-1 in plasma and platelets

scientific article published on 01 May 2006

Rational design of complex formation between plasminogen activator inhibitor-1 and its target proteinases

scientific article published on 01 April 1997

Reactive site-dependent phenotypic alterations in plasminogen activator inhibitor-1 transgenic mice.

scientific article published on 16 April 2007

Realization and characterization of porous gold for increased protein coverage on acoustic sensors

scientific article

Reciprocal regulation of tissue-type and urokinase-type plasminogen activators in the differentiation of murine preadipocyte line 3T3-L1 and the hormonal regulation of fibrinolytic factors in the mature adipocytes

scientific article published on October 2001

Redirection of the reaction between activated protein C and a serpin to the substrate pathway

scientific article published on 28 November 2007

Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex.

scientific article published on 25 June 2013

Selective neutralization of the serpin protease nexin-1 by a specific monoclonal antibody

scientific article published on 26 May 2015

Site-directed targeting of plasminogen activator inhibitor-1 as an example for a novel approach in rational drug design

scientific article published on 26 February 2004

Species-dependent molecular drug targets in plasminogen activator inhibitor-1 (PAI-1)

scientific article published on 01 September 2009

State of play and clinical prospects of antibody gene transfer

scientific article published on 07 June 2017

Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity

scientific article published on 15 August 2020

Structural determinants in the stability of the serpin/proteinase complex

scientific article published in August 2003

Structure-function relationships in serpins: current concepts and controversies

scientific article published on 01 October 1998

Study of recombinant antibody fragments and PAI-1 complexes combining protein-protein docking and results from site-directed mutagenesis

scientific article published in September 2007

Substrate behavior of plasminogen activator inhibitor-1 is not associated with a lack of insertion of the reactive site loop

scientific article

Systemic inhibition and liver-specific over-expression of PAI-1 failed to improve survival in all-inclusive populations or homogenous cohorts of CLP mice

scientific article published on 01 June 2014

TAFIa inhibiting nanobodies as profibrinolytic tools and discovery of a new TAFIa conformation.

scientific article

Targeting of plasminogen activator inhibitor 1 improves fibrinolytic therapy for tetracycline-induced pleural injury in rabbits.

scientific article published in April 2015

Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits.

scientific article published on 31 August 2017

Targeting the autolysis loop of urokinase-type plasminogen activator with conformation-specific monoclonal antibodies

scientific article

The Biochemistry, Physiology and Pathological roles of PAI-1 and the requirements for PAI-1 inhibition in vivo.

scientific article published on 15 July 2012

The Language of Biosimilars: Clarification, Definitions, and Regulatory Aspects

scientific article published on 04 March 2017

The Market of Biopharmaceutical Medicines: A Snapshot of a Diverse Industrial Landscape

scientific article

The Occurrence of Thrombosis in Inflammatory Bowel Disease Is Reflected in the Clot Lysis Profile

scientific article

The arrival of biosimilar monoclonal antibodies in oncology: clinical studies for trastuzumab biosimilars

scientific article published on 01 July 2019

The conversion of active to latent plasminogen activator inhibitor-1 is an energetically silent event.

scientific article published on 14 January 2005

The distal hinge of the reactive site loop and its proximity: a target to modulate plasminogen activator inhibitor-1 activity

scientific article

The hyperfibrinolytic state of mice with combined thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen activator inhibitor-1 gene deficiency is critically dependent on TAFI deficiency

scientific article published on 01 December 2012

The importance of helix F in plasminogen activator inhibitor-1

scientific article published on 01 January 2000

The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent

scientific journal article

The rise of oncology biosimilars: from process to promise

scientific article published on 23 August 2019

The road from development to approval: evaluating the body of evidence to confirm biosimilarity

scientific article published in August 2017

The role of thrombin activatable fibrinolysis inhibitor in arterial thrombosis at a young age: the ATTAC study

scientific article published on 23 March 2009

The roles of selected arginine and lysine residues of TAFI (Pro-CPU) in its activation to TAFIa by the thrombin-thrombomodulin complex

scientific article

The story of the serpin plasminogen activator inhibitor 1: is there any need for another mutant?

scientific article published on 01 November 2004

The structural basis for the pathophysiological relevance of PAI-I in cardiovascular diseases and the development of potential PAI-I inhibitors

scientific article published in March 2004

Thrombin activatable fibrinolysis inhibitor activation peptide shows association with all major subtypes of ischemic stroke and with TAFI gene variation

scientific article published in February 2007

Thrombin activatable fibrinolysis inhibitor.

scientific article published on June 2011

Thrombin activatable fibrinolysis inhibitor: a putative target to enhance fibrinolysis.

scientific article published on 02 March 2013

Thrombin-activatable fibrinolysis inhibitor is associated with severity and outcome of severe meningococcal infection in children

scientific article published on 15 November 2007

Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via Mac-1, but independently of urokinase-type plasminogen activator receptor

scientific article published on 03 October 2011

Use of mouse models to study plasminogen activator inhibitor-1.

scientific article published on January 2011

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