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List of works by James L. Manley

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

scientific article

A UV-crosslinkable interaction in human U6 snRNA.

scientific article published in May 1998

A complex protein assembly catalyzes polyadenylation of mRNA precursors

scientific article

A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock

scientific article

A human homologue of theEscherichia coliDnaJ heatshock protein ⬇️

scientific article published on December 11, 1991

A journey to the end of the message

scientific article published on April 2015

A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy

scientific article published on 01 August 2003

A nuclear micrococcal-sensitive, ATP-dependent exoribonuclease degrades uncapped but not capped RNA substrates

scientific article

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

scientific article published on July 1990

A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins)

scientific article

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint

scientific article published in June 2009

ALS mutations in TLS/FUS disrupt target gene expression

scientific article

ASAP, a novel protein complex involved in RNA processing and apoptosis

scientific article

Accurate and specific polyadenylation of mRNA precursors in a soluble whole-cell lysate ⬇️

scientific article published on 01 June 1983

Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1

scientific article published on 9 January 2012

Allosteric regulation of even-skipped repression activity by phosphorylation

scientific article published in January 1999

Alternative cleavage and polyadenylation: the long and short of it

scientific article

Alternative polyadenylation blooms

scientific article published in February 2010

Alternative polyadenylation of mRNA precursors.

scientific article

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

scientific article

An intronic element contributes to splicing repression in spinal muscular atrophy.

scholarly article

An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72

scientific article

Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase

scientific article (publication date: 14 June 2002)

BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.

scientific article

Base substitution in an intervening sequence of a beta+-thalassemic human globin gene

scientific article

CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processing

scientific article

Cell signalling and the control of pre-mRNA splicing.

scientific article

Cell-cycle related regulation of poly(A) polymerase by phosphorylation

scientific article

Cell-free synthesis of SU + 3 tyrosyl transfer RNA: characterization of the 4S product

scientific article

Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues

scientific article

Characterization of the catalytic activity of U2 and U6 snRNAs

scientific article

Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation

scientific article published in February 2009

Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2)

scientific article

Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins

scientific article published on 5 February 2012

Concurrent splicing and transcription are not sufficient to enhance splicing efficiency

scientific article published on 13 July 2007

Cooperation between core promoter elements influences transcriptional activity in vivo

scientific article

Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates

scientific article published on October 2003

Cotranscriptional processes and their influence on genome stability.

scientific article published on July 2006

Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors

scientific article

Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex

scientific article

DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.

scientific article

DNA-protein complexes spread on N2-discharged carbon film and characterized by molecular weight and its projected distribution

scientific article published in September 1982

Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery

scientific article

Determinants of SR protein specificity.

scientific article

Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities

scientific article

Drosophila Pelle phosphorylates Dichaete protein and influences its subcellular distribution in developing oocytes

scientific article published in January 2010

Ectopic expression of the Drosophila tramtrack gene results in multiple embryonic defects, including repression of even-skipped and fushi tarazu

scientific article

Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease.

scientific article

Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination

scientific article published in May 2001

From transcription to mRNA: PAF provides a new path.

scientific article

Function and control of RNA polymerase II C-terminal domain phosphorylation in vertebrate transcription and RNA processing

scientific article published on 21 April 2014

Generation and functional analyses for base-substitution mutants of the adenovirus 2 major late promoter.

scientific article published on December 1984

Heat shock-induced SRSF10 dephosphorylation displays thermotolerance mediated by Hsp27.

scientific article published on 6 December 2010

Heterozygous disruption of the TATA-binding protein gene in DT40 cells causes reduced cdc25B phosphatase expression and delayed mitosis.

scientific article

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

scientific article

How bidirectional becomes unidirectional

scientific article published on 01 September 2013

Hsp27 enhances recovery of splicing as well as rephosphorylation of SRp38 after heat shock.

scientific article

Human Tra2 Proteins Are Sequence-Specific Activators of Pre-mRNA Splicing ⬇️

scientific article published on April 3, 1998

Human capping enzyme promotes formation of transcriptional R loops in vitro

scholarly article

Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors

scientific article

Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors

scientific article

In vitro analysis of transcriptional activators and polyadenylation

scientific article published in January 2014

In vitro splicing of simian virus 40 early pre mRNA.

scientific article published on February 1986

In vitro sumoylation of recombinant proteins and subsequent purification for use in enzymatic assays

scientific article published on January 2009

In vitro transcription: whole-cell extract

scientific article published in January 1983

Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability

scientific article

Inhibition of poly(A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non-consensus sites

scientific article

Intrinsic metal binding by a spliceosomal RNA

scientific article published on 01 July 2002

Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair.

scientific article published on 03 March 2014

Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation

scientific article

Mdm2 and MdmX as Regulators of Gene Expression ⬇️

scientific article published on March 1, 2012

MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress

scientific article published on 30 January 2012

Mechanisms and consequences of alternative polyadenylation

scientific article

Messenger RNA polyadenylylation: a universal modification

scientific article

Misregulation of pre-mRNA alternative splicing in cancer

scientific article

Molecular architecture of the human pre-mRNA 3' processing complex

scientific article published on February 2009

Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins.

scientific article

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells

scientific article

New links between mRNA polyadenylation and diverse nuclear pathways

scientific article published on August 2014

Nuclear coupling: RNA processing reaches back to transcription

scientific article published on 01 November 2002

Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization

scientific article published on October 2003

PARP1 represses PAP and inhibits polyadenylation during heat shock

scientific article published on 6 December 2012

PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins

scientific article published on 01 September 2006

Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator.

scientific article published on 14 September 2008

Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2 ⬇️

scientific article published on November 2, 1998

Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation.

scientific article published on 10 July 2001

Pin1 modulates RNA polymerase II activity during the transcription cycle

scientific article

Pin1 modulates the structure and function of human RNA polymerase II.

scientific article published on 4 November 2003

Poly(A) polymerase phosphorylation is dependent on novel interactions with cyclins

scientific article

Polyadenylation of mRNA precursors

scientific article published on May 1988

Polyoma virus small tumor antigen pre-mRNA splicing requires cooperation between two 3' splice sites

scientific article

Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing

scientific article published on 16 October 2007

R Loops and Links to Human Disease

scientific article published on 3 September 2016

RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs

scientific article

RNA polymerase II is an essential mRNA polyadenylation factor ⬇️

scientific article (publication date: 3 September 1998)

RNA polymerase II terminates transcription in vitro in the SV40 origin region

scientific article published on June 1987

RNA splicing. Question of commitment

scientific article published in September 1993

RNA synthesis in isolated nuclei: identification and comparison of adenovirus 2 encoded transcripts synthesized in vitro and vivo

scientific article published on 01 November 1979

RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing

scientific article

RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells.

scientific article

Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing

scientific article published on November 2007

Regulation and substrate specificity of the SR protein kinase Clk/Sty

scientific article

Regulation of adenovirus mRNA synthesis

scientific article published on January 1980

Regulation of plant developmental processes by a novel splicing factor

scientific article published on 30 May 2007

Regulation of pre-mRNA splicing in metazoa

scientific article published on April 1997

Repression of simian virus 40 early transcription by viral DNA replication in human 293 cells

scientific article

Requirements of the RNA polymerase II C-terminal domain for reconstituting pre-mRNA 3' cleavage.

scientific article

Rna synthesis in isolated nuclei processing of adenovirus serotype 2 late messenger rna precursors

scientific article published in August 1982

Roles of Sumoylation in mRNA Processing and Metabolism

scientific article published on January 2017

SELEX to identify protein-binding sites on RNA.

scientific article

SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors

scientific article published on November 2016

SUMO functions in constitutive transcription and during activation of inducible genes in yeast.

scientific article

SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3

scientific journal article

SV40 T-antigen-binding sites within the 5'-flanking regions of human U1 and U2 genes

scientific article

Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation

scientific article published on 01 March 1988

Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites

scientific article published on 01 July 1987

Splicing of mRNA precursors: the role of RNAs and proteins in catalysis

scientific article published on 26 January 2009

Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs

scientific article published on 01 July 1984

Splicing-related catalysis by protein-free snRNAs

scientific article

Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins

scientific article

Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1

scientific article

Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase

scientific article

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

scientific article

Structure and function of the 5′→3′ exoribonuclease Rat1 and its activating partner Rai1

scientific article

Structure and function of the S1 nuclease-sensitive site in the adenovirus late promoter

scientific article published on 01 June 1986

Sub1 functions in osmoregulation and in transcription by both RNA polymerases II and III

scientific article

Sub1 globally regulates RNA polymerase II C-terminal domain phosphorylation.

scientific article

Sumoylation controls the timing of Tup1-mediated transcriptional deactivation.

scientific article

Sumoylation modulates the assembly and activity of the pre-mRNA 3' processing complex

scientific article published on 8 October 2007

Sumoylation of transcription factor Gcn4 facilitates its Srb10-mediated clearance from promoters in yeast

scientific article published on February 2012

Sumoylation regulates multiple aspects of mammalian poly(A) polymerase function

scientific article

Suppression of amber mutants in vitro induced by low temperature

scientific article published on November 1978

Synthesis and degradation of termination and premature-termination fragments of β-galactosidase in vitro and in vivo ⬇️

scientific article published on November 15, 1978

Synthesis in vitro of an exceptionally long RNA transcript promoted by an AluI sequence

scientific article published on 01 November 1982

Synthesis of internal re-initiation fragments of β-galactosidase in vitro and in vivo ⬇️

scientific article published on November 15, 1978

Systematic profiling of poly(A)+ transcripts modulated by core 3' end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylation

scientific article published on 23 April 2015

TLS inhibits RNA polymerase III transcription

scientific article

TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements ⬇️

scientific article published on March 29, 2012

TLS/FUS: a protein in cancer and ALS.

scientific article published on 23 August 2012

Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity

scientific article published on October 2001

The C-terminal domain of RNA polymerase II functions as a phosphorylation-dependent splicing activator in a heterologous protein

scientific article published on January 2005

The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains.

scientific article

The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability

scientific article

The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex

scientific article

The RNA polymerase II CTD coordinates transcription and RNA processing.

scientific article

The SR protein SRp38 represses splicing in M phase cells

scientific article (publication date: November 2002)

The end of the message--another link between yeast and mammals.

scientific article

The ends of the affair: capping and polyadenylation.

scientific article

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

scientific article published in December 1989

The human papillomavirus type 16 negative regulatory RNA element interacts with three proteins that act at different posttranscriptional levels.

scholarly article

The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3' end formation

scientific article published in October 2005

The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination

scientific article

The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation

scientific article

The prolyl isomerase Pin1 functions in mitotic chromosome condensation.

scientific article

The search for alternative splicing regulators: new approaches offer a path to a splicing code

scientific article

The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy

scientific article

The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription.

scientific article

The use of simple model systems to study spliceosomal catalysis

scientific article published on 24 November 2008

The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity ⬇️

scientific article published on July 10, 2012

Threonine-4 of the budding yeast RNAP II CTD couples transcription with Htz1-mediated chromatin remodeling.

scientific article

Transcription of methylated eukaryotic viral genes in a solublein vitrosystem ⬇️

scientific article published on June 11, 1984

Transcription termination by nuclear RNA polymerases

scientific article (publication date: June 2009)

Transcriptional activators enhance polyadenylation of mRNA precursors.

scientific article published on November 2011

Transcriptional regulators of Drosophila embryogenesis.

scientific article published on December 1992

Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein

scientific article

Transcriptional repression of eukaryotic promoters

scientific article

Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation

scientific article published on 17 January 2014

Tumor metabolism: hnRNP proteins get in on the act

scientific article

Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA.

scientific article published on 26 October 2010

U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.

scientific article published on August 1995

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

scientific article published on 13 July 2018

Variations in intracellular levels of TATA binding protein can affect specific genes by different mechanisms.

scientific article published on 22 October 2007

XRN2 Links Transcription Termination to DNA Damage and Replication Stress

scientific article

cFLIP expression is altered in severe corticosteroid-resistant asthma

scientific article

hnRNP A1 functions with specificity in repression of SMN2 exon 7 splicing

scientific article published on 19 September 2007

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