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List of works by Luis F. Santana

A G-coupled purinergic receptor boosts Ca influx and vascular contractility during diabetic hyperglycemia

scientific article published on 01 March 2019

A New Mutation in FIG4 Causes a Severe Form of CMT4J Involving TRPV4 in the Pathogenic Cascade

scientific article published in September 2017

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

scientific article

A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics.

scientific article published on 16 January 2018

A stochastic model of ion channel cluster formation in the plasma membrane

scientific article published on 01 August 2019

A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons

scientific article published on 30 September 2019

A-kinase anchoring proteins: getting to the heart of the matter.

scientific article published on March 2010

AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus.

scientific article published on 09 December 2013

AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension

scientific article published on 03 January 2008

AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction.

scientific article published on 24 December 2015

AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension

scientific article

Activation of NFATc3 Down-regulates the β1 Subunit of Large Conductance, Calcium-activated K+Channels in Arterial Smooth Muscle and Contributes to Hypertension

scientific article published in Journal of Biological Chemistry

Adding accessories for hypertension: α2δ-1 subunits upregulate CaV1.2 channels in arterial myocytes in a model of genetic hypertension

scientific article published on 4 September 2012

Alterations in Early Action Potential Repolarization Causes Localized Failure of Sarcoplasmic Reticulum Ca 2+ Release

scientific article published on 10 February 2005

An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria

scientific journal article

Anchored phosphatases modulate glucose homeostasis

scientific journal article

BIN1 Induces the Formation of T-Tubules and Adult-Like Ca2+ Release Units in Developing Cardiomyocytes.

article

Ca(2+) entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels

scientific article published on 17 May 2016

Ca2+ flux through promiscuous cardiac Na+ channels: slip-mode conductance

scientific article published in February 1998

Calcium Channels in Vascular Smooth Muscle.

scientific article published on 14 October 2016

Calcium sparklets in arterial smooth muscle ⬇️

scientific article published on 21 January 2008

Calcium sparklets regulate local and global calcium in murine arterial smooth muscle

scientific article

Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes.

scientific article published on August 1997

Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice

scientific article (publication date: 2012)

Cav1.3 channels produce persistent calcium sparklets, but Cav1.2 channels are responsible for sparklets in mouse arterial smooth muscle

scientific article published in September 2007

Cellular mechanisms of ventricular arrhythmias in a mouse model of Timothy syndrome (long QT syndrome 8).

scientific article published on 9 November 2013

Constitutively active L-type Ca2+ channels

scientific article

Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure

scientific article published on 01 May 1997

Differential calcineurin/NFATc3 activity contributes to the Ito transmural gradient in the mouse heart

scientific article published on 13 April 2006

Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity

scientific article published on 10 October 2019

Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes.

scientific article published on 15 May 2017

Down-regulation of CaV1.2 channels during hypertension: how fewer CaV1.2 channels allow more Ca(2+) into hypertensive arterial smooth muscle

scientific article published on 28 October 2013

Downregulation of the BK Channel β1 Subunit in Genetic Hypertension ⬇️

scientific article published on October 9, 2003

Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating

scientific article published on 28 June 2018

Dynamic changes in sarcoplasmic reticulum structure in ventricular myocytes

scientific article published on November 2011

Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery.

scientific article

Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells

scientific article

Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes.

scientific article

Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels

scientific article (publication date: 25 February 2015)

How does the shape of the cardiac action potential control calcium signaling and contraction in the heart?

scientific article

Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes.

scientific article published on 25 October 2017

Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome

scientific article

Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes

scientific article published on 22 January 2020

Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure

scientific article

Kv2 channels oppose myogenic constriction of rat cerebral arteries.

scientific article

Kv2.1 channels play opposing roles in regulating membrane potential, Ca2+ channel function, and myogenic tone in arterial smooth muscle

scientific article published on 03 February 2020

Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

scientific article published on 30 October 2019

Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle

scientific article

Local control of excitation-contraction coupling in human embryonic stem cell-derived cardiomyocytes

scientific article

Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve.

scientific article published on 17 November 2016

Maladaptive response of arterial myocytes to chronic exposure to Ca2+ channel blockers

scientific article published on 17 July 2020

Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle

scientific article

Mechanisms underlying variations in excitation-contraction coupling across the mouse left ventricular free wall

scientific article published on 19 January 2006

Metabolic-electrical control of coronary blood flow

scientific article published on 01 April 2020

Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.

scientific article published on 11 February 2014

Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure

scientific article published on 10 February 2011

Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy

scientific article published on 27 May 2011

Myostatin represses physiological hypertrophy of the heart and excitation-contraction coupling

scientific article

NFAT-dependent excitation-transcription coupling in heart

scientific article published in September 2008

NFATc3 regulates Kv2.1 expression in arterial smooth muscle

scientific article published on 22 August 2004

NFATc3-dependent loss of I(to) gradient across the left ventricular wall during chronic beta adrenergic stimulation

scientific article published on 5 November 2008

NFATc3-induced reductions in voltage-gated K+ currents after myocardial infarction

scientific article published on 15 April 2004

Natural inequalities: why some L-type Ca2+ channels work harder than others

scientific article

On the loose: uncaging Ca2+ -induced Ca2+ release in smooth muscle.

scientific article

Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.

scientific article

Oxidative stress decreases microtubule growth and stability in ventricular myocytes

scientific article

Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes

scientific article

Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane.

scientific article

Probing the effects of membrane cholesterol in the Torpedo californica acetylcholine receptor and the novel lipid-exposed mutation alpha C418W in Xenopus oocytes

scientific article published on 20 September 2001

Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage.

scientific article published on 30 June 2017

Regulation of L-type calcium channel sparklet activity by c-Src and PKC-α.

scientific article published on 26 June 2013

Relationship between Ca2+ sparklets and sarcoplasmic reticulum Ca2+ load and release in rat cerebral arterial smooth muscle

scientific article published on 7 October 2011

Restoration of normal L-type Ca2+ channel function during Timothy syndrome by ablation of an anchoring protein

scientific article published on 23 June 2011

Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure.

scientific article

SMAKing Ca2+ sparks in arterial myocytes

scientific article published on 23 August 2007

Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins

scientific article published on 19 November 2018

Sodium current and arrhythmogenesis in heart failure.

scientific article published on July 2005

Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels

scientific article published on 29 July 2010

The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension

scholarly article

The long and winding road home: how junctin and triadin find their way to the junctional SR.

scientific article published on 2 February 2015

Two mechanisms of quantized calcium release in skeletal muscle

scientific article published in Nature

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