List of works - Xuejun Wang

A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment ⬇️

scientific article published on 22 February 2016

A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers.

scientific article published on 28 June 2017

A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy

scientific article published on 18 April 2016

A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases

scientific article

A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin

scientific article published on 27 September 2005

A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome.

scientific article published on 31 October 2008

Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes

scientific article published on 14 February 2006

Activation of the ubiquitin-proteasome system in doxorubicin cardiomyopathy.

scientific article

Alpha B-crystallin suppresses pressure overload cardiac hypertrophy

scientific journal article

AlphaB-crystallin modulates protein aggregation of abnormal desmin

scientific article published on 23 October 2003

Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure

scientific article published on 31 May 2013

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

scientific article

Auranofin lethality to prostate cancer includes inhibition of proteasomal deubiquitinases and disrupted androgen receptor signaling

scientific article published on 09 January 2019

Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes

scientific article

Autophagy Controls Nrf2-Mediated Dichotomy in Pressure Overloaded Hearts

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

scientific article published on 18 September 2020

Autophagy and p62 in cardiac protein quality control

scientific article

Autophagy and p62 in cardiac proteinopathy.

scientific article

Autophagy and the ubiquitin-proteasome system in cardiac dysfunction.

scientific article

Autophagy modulation: a potential therapeutic approach in cardiac hypertrophy.

scientific article published on 2 June 2017

Bilirubin neurotoxicity is associated with proteasome inhibition

scientific article published on 15 June 2017

Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats

scientific article

COP9 Signalosome Promotes Neointimal Hyperplasia via Deneddylation and CSN5-Mediated Nuclear Export

COP9 Signalosome Suppresses RIPK1-RIPK3 mediated Cardiomyocyte Necroptosis in Mice

scientific article published on 24 June 2020

COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity

scientific article

COP9 signalosome regulates autophagosome maturation

scientific article

COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation.

scientific article published on 6 August 2010

COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase

scientific article

CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes

scientific article published on 14 June 2020

Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase.

scientific article

Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy

scientific article

Cardiac-specific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction.

scientific article

Catecholamine Surges Cause Cardiomyocyte Necroptosis a RIPK1-RIPK3-Dependent Pathway in Mice

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: I. Regional hemodynamics and myocyte remodeling

scientific article published in February 1999

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling

scientific article published in February 1999

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: III. Intercalated disc remodeling

scientific article (publication date: February 1999)

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

scientific article

Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes

Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer

scientific article

Desmin Filaments and Desmin-Related Myopathy

Desmin filaments and cardiac disease: establishing causality.

scientific article

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons

scientific article published on December 2008

Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy

scientific article published on October 2010

Editorial: Targeting Cardiac Proteotoxicity

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice ⬇️

scientific article published on August 15, 2011

Enhancement of proteasome function by PA28α overexpression protects against oxidative stress.

scientific article

Entangled in a heart-ailing quandary: could modified cofilin-2 be a culprit of Alzheimer's disease of the heart?

scientific article published on 01 March 2015

Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice

scientific article published on 01 July 2001

Formation of binucleated cardiac myocytes in rat heart: I. Role of actin-myosin contractile ring

scientific article published on 01 June 1997

Formation of binucleated cardiac myocytes in rat heart: II. Cytoskeletal organisation

scientific article published on 01 June 1997

FoxO3 hastens autophagy and shrinks the heart but does not curtail pathological hypertrophy in adult mice

scientific article published on 8 July 2011

GFP reporter mouse models of UPS proteolytic function

scientific article published in May 2006

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo ⬇️

scientific article published on December 21, 2012

Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition

scientific article published on 08 April 2015

Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation

scientific article published on 12 December 2013

Gambogic acid suppresses pressure overload cardiac hypertrophy in rats

scientific article

Genetically Induced Moderate Inhibition of the Proteasome in Cardiomyocytes Exacerbates Myocardial Ischemia-Reperfusion Injury in Mice ⬇️

scientific article published on June 26, 2012

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

scientific article published on 25 June 2015

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Heart failure and protein quality control

scientific article published on December 2006

Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers.

scientific article

Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress

scientific article published on 26 June 2019

Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells.

scientific article published on 5 September 2017

In situ dynamically monitoring the proteolytic function of the ubiquitin-proteasome system in cultured cardiac myocytes

scientific article published on 22 April 2004

Inadequate ubiquitination-proteasome coupling contributes to myocardial ischemia-reperfusion injury

scientific article published on 22 October 2018

Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy

scientific article published on 01 December 2001

Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer

scientific article published on 11 April 2019

Inhibition of Proteasomal Deubiquitinase by Silver Complex Induces Apoptosis in Non-Small Cell Lung Cancer Cells

scientific article published on 30 August 2018

Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide

scientific article published on 24 May 2019

Interplay between the ubiquitin-proteasome system and autophagy in proteinopathies.

scientific article

Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake

scientific article published on 6 October 2005

L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro

scientific article

Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction

scientific article published on 7 November 2005

Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors.

scientific article published on 17 May 2016

Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways

scientific article published on 17 August 2017

Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner

scientific article published on 05 February 2014

Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure

scientific article published on 10 July 2017

NEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins

scientific article

Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms.

scientific article

Novel use of old drug: Anti-rheumatic agent auranofin overcomes imatinib-resistance of chronic myeloid leukemia cells

scientific article published on November 2014

Nrf2-Mediated Cardiac Maladaptive Remodeling and Dysfunction in a Setting of Autophagy Insufficiency

scientific article published on 16 November 2015

Nuclear compartmentalization of FAK and FRNK in cardiac myocytes

scientific journal article

Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes.

scientific article published on January 2016

PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy

scientific article published on 22 May 2019

PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice

scientific article published on 01 July 2001

Pathological Significance and Prognostic Roles of Indirect Bilirubin/Albumin Ratio in Hepatic Encephalopathy

Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury

scientific article published on 20 January 2021

Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.

scientific article

Physiological levels of ATP negatively regulate proteasome function.

scientific article

Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation.

scientific article

Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy.

scientific article published on 02 July 2016

Posttranslational Modification and Quality Control ⬇️

scientific article published on January 18, 2013

Priming the Proteasome to Protect against Proteotoxicity

scientific article published on 26 March 2020

Priming the proteasome by protein kinase G: a novel cardioprotective mechanism of sildenafil

scientific article

Proteasomal and lysosomal protein degradation and heart disease

scientific article

Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

scientific article

Proteasome malfunction activates the PPP3/calcineurin-TFEB-SQSTM1/p62 pathway to induce macroautophagy in the heart

scientific article published on 22 September 2020

Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor

scientific article published on 02 February 2017

Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins.

scientific article published on 14 June 2013

Protein quality control and degradation in cardiomyocytes

scientific article published on 20 May 2008

Protein quality control in protection against systolic overload cardiomyopathy: the long term role of small heat shock proteins

scientific article

Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development

scientific article published on 01 August 1996

Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy

scientific article published in August 2005

Repeated intermittent administration of a ubiquitous proteasome inhibitor leads to restrictive cardiomyopathy ⬇️

scientific article published on May 2, 2013

Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases.

scientific article published on 10 January 2017

Sanggenon C decreases tumor cell viability associated with proteasome inhibition

scientific article published in June 2011

Ser14-RPN6 Phosphorylation Mediates the Activation of 26S Proteasomes by cAMP and Protects against Cardiac Proteotoxic Stress in Mice

Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo.

scientific article published on May 2009

Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition ⬇️

scientific article published on March 24, 2011

Structural basis of ventricular remodeling: role of the myocyte.

scientific article

Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium

scientific article published on 5 May 2003

Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease.

scientific article published on 18 January 2014

Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes

scientific article published on 5 August 2014

Synergistic effects of gefitinib and thalidomide treatment on EGFR-TKI-sensitive and -resistant NSCLC

scientific article published on 25 May 2019

Systemic inhibition of neddylation by 3-day MLN4924 treatment regime does not impair autophagic flux in mouse hearts and brains

scientific article published on 20 December 2017

TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux

scientific article

Targeting proteasome-associated deubiquitinases as a novel strategy for the treatment of estrogen receptor-positive breast cancer

scholarly article by Xiaohong Xia published in September 2018

The COP9 signalosome and cullin-RING ligases in the heart

scientific article published on 20 March 2015

The COP9 signalosome and vascular function: intriguing possibilities?

scientific article published on 20 March 2015

The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart

scientific article published on 13 January 2016

The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice.

scientific article published on 19 July 2013

The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription.

scientific article published on 25 July 2008

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction

scientific article published on 05 May 2020

The Interplay Between Autophagy and Regulated Necrosis

The Ubiquitin–Proteasome System and Cardiovascular Disease ⬇️

scientific article published on January 1, 2012

The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity

scientific article

The role of the proteasome in heart disease

scientific article published on 15 September 2010

The role of the ubiquitin-proteasome pathway in cardiovascular disease

scientific article published on 05 November 2009

The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective

scientific article

Transcription Factor 7-like 2 Mediates Canonical Wnt/β-Catenin Signaling and c-Myc Upregulation in Heart Failure.

scientific article published on 14 June 2016

Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo

scientific article published on 28 November 2015

UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells

scholarly article by Sanam Sane et al published October 2018 in Molecular Oncology

UCHL1 protects against ischemic heart injury via activating HIF-1α signal pathway

UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle

scientific article published on 26 July 2019

Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice.

scientific article published on February 2014

Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure

scientific article published on 07 April 2022

Ubiquitin receptors and protein quality control

scientific article published on 6 October 2012

Unraveling enigma in the z-disks

scientific article published on 01 August 2010

Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes

scientific article published on 25 August 2006

Vascular Spasm: A Newly Unraveled Cause for Cardiovascular Adversity of Proteasome Inhibition

scientific article published on 13 June 2017

p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress

scientific article

List of works by Xuejun Wang

A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment ⬇️

A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers.

A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy

A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases

A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin

A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome.

Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes

Activation of the ubiquitin-proteasome system in doxorubicin cardiomyopathy.

Alpha B-crystallin suppresses pressure overload cardiac hypertrophy

AlphaB-crystallin modulates protein aggregation of abnormal desmin

Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

Auranofin lethality to prostate cancer includes inhibition of proteasomal deubiquitinases and disrupted androgen receptor signaling

Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes

Autophagy Controls Nrf2-Mediated Dichotomy in Pressure Overloaded Hearts

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

Autophagy and p62 in cardiac protein quality control

Autophagy and p62 in cardiac proteinopathy.

Autophagy and the ubiquitin-proteasome system in cardiac dysfunction.

Autophagy modulation: a potential therapeutic approach in cardiac hypertrophy.

Bilirubin neurotoxicity is associated with proteasome inhibition

Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats

COP9 Signalosome Promotes Neointimal Hyperplasia via Deneddylation and CSN5-Mediated Nuclear Export

COP9 Signalosome Suppresses RIPK1-RIPK3 mediated Cardiomyocyte Necroptosis in Mice

COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity

COP9 signalosome regulates autophagosome maturation

COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation.

COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase

CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes

Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase.

Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy

Cardiac-specific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction.

Catecholamine Surges Cause Cardiomyocyte Necroptosis a RIPK1-RIPK3-Dependent Pathway in Mice

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: I. Regional hemodynamics and myocyte remodeling

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: III. Intercalated disc remodeling

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes

Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer

Desmin Filaments and Desmin-Related Myopathy

Desmin filaments and cardiac disease: establishing causality.

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons

Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy

Editorial: Targeting Cardiac Proteotoxicity

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice ⬇️

Enhancement of proteasome function by PA28α overexpression protects against oxidative stress.

Entangled in a heart-ailing quandary: could modified cofilin-2 be a culprit of Alzheimer's disease of the heart?

Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice

Formation of binucleated cardiac myocytes in rat heart: I. Role of actin-myosin contractile ring

Formation of binucleated cardiac myocytes in rat heart: II. Cytoskeletal organisation

FoxO3 hastens autophagy and shrinks the heart but does not curtail pathological hypertrophy in adult mice

GFP reporter mouse models of UPS proteolytic function

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo ⬇️

Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition

Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation

Gambogic acid suppresses pressure overload cardiac hypertrophy in rats

Genetically Induced Moderate Inhibition of the Proteasome in Cardiomyocytes Exacerbates Myocardial Ischemia-Reperfusion Injury in Mice ⬇️

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

Guidelines for the use and interpretation of assays for monitoring autophagy

Heart failure and protein quality control

Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers.

Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress

Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells.

In situ dynamically monitoring the proteolytic function of the ubiquitin-proteasome system in cultured cardiac myocytes

Inadequate ubiquitination-proteasome coupling contributes to myocardial ischemia-reperfusion injury

Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy

Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer

Inhibition of Proteasomal Deubiquitinase by Silver Complex Induces Apoptosis in Non-Small Cell Lung Cancer Cells

Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide

Interplay between the ubiquitin-proteasome system and autophagy in proteinopathies.

Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake

L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro

Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction

Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors.

Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways

Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner

Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure

NEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins

Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms.