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List of works by Xaralabos Varelas

A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma

scientific article published on 20 March 2015

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

scientific article published on 19 November 2020

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

scientific article published on 01 January 2021

Altered RNA editing in 3' UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors

scientific article published on 16 March 2016

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

scientific article

Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.

scientific article published on 22 June 2017

CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features

scientific article published on 19 February 2019

Cdc34 self-association is facilitated by ubiquitin thiolester formation and is required for its catalytic activity

scientific article

Coordinating developmental signaling: novel roles for the Hippo pathway.

scientific article published on 05 December 2011

Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap.

scientific article

Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced Smad signaling

scientific article published on March 2015

Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells.

scientific article published on 18 September 2017

Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer

scientific article published on 20 July 2018

Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells

scientific article published on 16 April 2018

Head and neck cancer: from research to therapy and cure

scientific article published on 01 December 2014

Hsp70-Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation

article published in the Proceedings of the National Academy of Sciences of the United States of America

Identification of candidate cancer drivers by integrative Epi-DNA and Gene Expression (iEDGE) data analysis

scientific article published on 15 November 2019

Immunofluorescence Microscopy to Study Endogenous TAZ in Mammalian Cells

scientific article published on 01 January 2019

Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis.

scientific article published on 27 July 2017

Integrating developmental signals: a Hippo in the (path)way ⬇️

scientific article published on August 29, 2011

Integrin-FAK-CDC42-PP1A signaling gnaws at YAP/TAZ activity to control incisor stem cells

scientific article

Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling

scientific article published on 01 January 2020

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

scientific article

N-glycosylation induces the CTHRC1 protein and drives oral cancer cell migration

scientific article published on 23 May 2013

Naturally-occurring hotspot cancer mutations in Gα13 promote oncogenic signaling

scientific article published on 27 October 2020

Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors

scientific article

Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease

scientific article published on 01 August 2021

Phosphatidic Acid Signals via the Hippo Pathway

scientific article published on 01 October 2018

Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown.

scientific article

Protein N-glycosylation in oral cancer: dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling

scientific article

Purification and properties of the ubiquitin-conjugating enzymes Cdc34 and Ubc13.Mms2.

scientific article

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

scientific article published on 01 October 2019

Stem cell regulation by the Hippo pathway.

scientific article published on 20 July 2012

Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells.

scientific article published on 12 December 2013

Systematic morphological profiling of human gene and allele function via Cell Painting.

scientific article published on 18 March 2017

TAZ Forces Lateral Inhibition

scientific article published on 01 March 2019

TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression.

scientific article

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

scientific article

TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression

scientific article published on 18 October 2019

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

scientific article published in December 2017

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

scientific article published on 17 June 2020

The Cdc34/SCF ubiquitination complex mediates Saccharomyces cerevisiae cell wall integrity

scientific article

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway

scientific article published in December 2010

The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland.

scientific article

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

scientific article

The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7

scientific article published on 9 December 2013

The Hippo pathway regulates Wnt/beta-catenin signaling

scientific article

The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome

scientific article published on 30 September 2013

The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGF Signaling

scientific article published on 24 July 2020

The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors

scientific journal article

The in vivo genetic program of murine primordial lung epithelial progenitors

scientific article published on 31 January 2020

The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells

scientific article

The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates

scientific article

Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis.

scientific article

Yap suppresses T-cell function and infiltration in the tumor microenvironment

scientific article published on 13 January 2020

Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis

scientific article published on 01 July 2021

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