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List of works by Thomas C. Darton

A 23-year retrospective investigation of Salmonella Typhi and Salmonella Paratyphi isolated in a tertiary Kathmandu hospital

scientific article published on 27 November 2017

Advancing the management and control of typhoid fever: a review of the historical role of human challenge studies

scientific article published on 31 January 2014

An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever

scientific article published on 24 May 2017

An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella Typhi challenge delivered in sodium bicarbonate solution

scientific article published on 10 February 2014

Are we good at thromboembolic disease prophylaxis - an audit of the use of risk assessment forms in emergency medical admissions

scientific article published on May 2005

Assessment and Translation of the Antibody-in-Lymphocyte Supernatant (ALS) Assay to Improve the Diagnosis of Enteric Fever in Two Controlled Human Infection Models and an Endemic Area of Nepal

scientific article published on 23 October 2017

Azithromycin resistance in Shigella spp. in Southeast Asia.

scientific article

Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics

scientific article published on 27 July 2011

Baseline factors predicting the duration of intravenous antibiotic therapy for cellulitis in an outpatient setting

scientific article published on March 2010

Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia

scientific article published on 24 January 2017

Burden of enteric fever at three urban sites in Africa and Asia: a multicentre population-based study

scientific article published on 01 December 2021

Challenge of Humans with Wild-type Salmonella enterica Serovar Typhi Elicits Changes in the Activation and Homing Characteristics of Mucosal-Associated Invariant T Cells

scientific article published on 6 April 2017

Changing Antimicrobial Resistance Trends in Kathmandu, Nepal: A 23-Year Retrospective Analysis of Bacteraemia

scholarly article by Raphaël M Zellweger et al published 2018 in Frontiers in Medicine

Characterizing altruistic motivation in potential volunteers for SARS-CoV-2 challenge trials

Clinical features, antimicrobial susceptibility patterns and genomics of bacteria causing neonatal sepsis in a children's hospital in Vietnam: protocol for a prospective observational study

scientific article

Compositional and Functional Differences in the Human Gut Microbiome Correlate with Clinical Outcome following Infection with Wild-Type Salmonella enterica Serovar Typhi.

scientific article

Control of Invasive Salmonella Disease in Africa: Is There a Role for Human Challenge Models?

scientific article

Current challenges and possible solutions to improve access to care and treatment for hepatitis C infection in Vietnam: a systematic review

scientific article

Design, recruitment, and microbiological considerations in human challenge studies.

scientific article

Development and Evaluation of a Blood Culture PCR Assay for Rapid Detection of Salmonella Paratyphi A in Clinical Samples

scientific article

Diagnostic host gene signature for distinguishing enteric fever from other febrile diseases

scientific article published on 30 August 2019

Epidemiology and control of tuberculosis in Western European cities

scientific article published on 01 August 2003

Ethics of controlled human infection to study COVID-19

scientific article published on 07 May 2020

Evaluation of an agar-gradient minimum-inhibitory-concentration method (the Etest) as a rapid and direct measure of antimicrobial susceptibility in Gram-negative bacteraemia

scientific article published on 18 November 2008

Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model

scientific article

Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers

scientific article published on 07 March 2022

Genetic material should be routinely collected in clinical vaccine trials--high consent rates can be achieved across all age groups

scientific article

Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model

scientific article published on 20 October 2020

Identification of Novel Serodiagnostic Signatures of Typhoid Fever Using a Salmonella Proteome Array

scientific article published on 19 September 2017

Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever

scientific article published on 12 October 2017

Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever

scientific article published on 23 May 2016

MBL2 deficiency is associated with higher genomic bacterial loads during meningococcemia in young children

scientific article published on 18 December 2014

Managing and monitoring tuberculosis using web-based tools in combination with traditional approaches

scientific article

Non-typhoidal Salmonella serovars associated with invasive and non-invasive disease in the Lao People's Democratic Republic

scientific article published on 12 January 2018

Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease

scientific article published on 11 June 2015

Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans

scientific article published on 22 September 2015

Reply to Farmakiotis et al.

scientific article published on 30 July 2014

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

scientific article published on 08 December 2020

Salmonella Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model

scientific article published in January 2017

Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans

scientific article published on March 2016

Seasonal influenza programme expansion

scientific article published on 07 December 2020

Severity of meningococcal disease associated with genomic bacterial load

scientific article published in March 2009

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

scientific article published in February 2021

Systematic telephone triage of possible 'swine' influenza leads to potentially serious misdiagnosis of infectious diseases.

scientific article published on 10 September 2009

The Impact of Vaccination and Prior Exposure on Stool Shedding of Salmonella Typhi and Salmonella Paratyphi in 6 Controlled Human Infection Studies

scientific article published on 01 April 2019

The STRATAA study protocol: a programme to assess the burden of enteric fever in Bangladesh, Malawi and Nepal using prospective population census, passive surveillance, serological studies and healthcare utilisation surveys

scientific article published on 2 July 2017

The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs: Accelerating the introduction of typhoid conjugate vaccines and reducing the global burden of enteric fever. Report from a meeting held on 26–27 October 2016,

scientific article published in September 2017

The challenge of enteric fever

scientific article published on 8 October 2013

The serodominant secreted effector protein of Salmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles

scientific article

Tourniquet Test for Dengue Diagnosis: Systematic Review and Meta-analysis of Diagnostic Test Accuracy.

scientific article

Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance: An Individual Patient Data Analysis of 2092 Participants Enrolled into 4 Randomized, Controlled Trials in Nepal

scientific article

Typhoid epidemiology, diagnostics and the human challenge model.

scientific article published on January 2014

Understanding paratyphoid infection: study protocol for the development of a human model of Salmonella enterica serovar Paratyphi A challenge in healthy adult volunteers

scientific article published on 16 June 2015

Unnecessary hesitancy on human vaccine tests-Response

scientific article

Use of direct Etest in the management of ventilator-associated pneumonia due to resistant Gram-negative pathogens

scientific article published on 18 November 2008

Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a

scientific article

Why the development of effective typhoid control measures requires the use of human challenge studies.

scientific article

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