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List of works by Ettore Novellino

(1S,3R,4S,5R)5-O-Caffeoylquinic acid: isolation, stereo-structure characterization and biological activity

scientific article

(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation

scientific article published on 16 February 2018

1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB1 or CB2 receptor ligands

13C-NMR and1H-NMR Chemical Shifts in a Correlation Analysis of Benzotriazole Derivatives Active as Plant Growth Regulators

article

1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators

scientific article published on 24 September 2008

2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching

scientific article published in December 2005

2-Amino-6-[(1'R,2'S)-1',2'-dihydroxypropyl]-3-methyl-pterin-4-one, a biologically active metabolite from the anthozoanAstroides calycularis Pallas

3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: tricyclic heteroaromatic derivatives as a new class of benzodiazepine receptor ligands

scientific article

3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.

scientific article published on February 2001

3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists

scientific article published on 7 February 2012

4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors

scientific article published on 27 June 2018

4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor

scientific article

5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists

scientific article published on 27 February 2015

5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives

scientific article

5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.

scientific article published on 10 October 2007

6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach

scientific article published on 5 November 2013

A Convenient One Step Synthesis of 5-Cystein-S-yldopa Using Ceric Ammonium Nitrate

article by Francesco Chioccara & Ettore Novellino published June 1986 in Synthetic Communications

A Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome

scientific article published on 22 December 2015

A Fhit-mimetic peptide suppresses annexin A4-mediated chemoresistance to paclitaxel in lung cancer cells

scientific article published on 04 May 2016

A Healthy Balance of Plasma Cholesterol by a Novel Annurca Apple-Based Nutraceutical Formulation: Results of a Randomized Trial

scientific article published on 17 February 2017

A Pilot Screening of Agro-Food Waste Products as Sources of Nutraceutical Formulations to Improve Simulated Postprandial Glycaemia and Insulinaemia in Healthy Subjects

scientific article published on 01 May 2020

A Practical Synthesis of 5-Aroyl-1-aryltetrazoles Using an Ugi-Like 4-Component Reaction Followed by a Biomimetic Transamination

A Round Trip from Medicinal Chemistry to Predictive Toxicology

scientific article published on January 2016

A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids

scientific article published on 26 October 2016

A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability

scientific article (publication date: 24 January 2017)

A decade of nutraceutical patents: where are we now in 2018?

scientific article published on 29 November 2018

A different molecular mechanism underlying antimicrobial and hemolytic actions of temporins A and L.

scientific article

A membrane-permeable peptide containing the last 21 residues of the G alpha(s) carboxyl terminus inhibits G(s)-coupled receptor signaling in intact cells: correlations between peptide structure and biological activity.

scientific article

A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies

scientific article published on 30 May 2011

A negative allosteric modulator of the WNT receptor Frizzled 4 switches into an allosteric agonist

scientific article published on 2 January 2018

A new efficient synthetic methodology for tetrahydroisoquinoline and tetrahydro-beta-carboline derivatives using the Pictet-Spengler reaction

scientific article

A new series of 1,3-dihidro-imidazo[1,5-c]thiazole-5,7-dione derivatives: synthesis and interaction with Abeta(25-35) amyloid peptide

scientific article published in September 2009

A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands

scientific article published on January 2015

A new, potent urotensin II receptor peptide agonist containing a Pen residue at the disulfide bridge

scientific article published in September 2002

A novel approach to the synthesis of diaza-bridged heterocycle derivatives

A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach.

scientific article

A novel quinone-based derivative (DTNQ-Pro) induces apoptotic death via modulation of heat shock protein expression in Caco-2 cells

scientific article published on June 2010

A novel route to synthesize Freidinger lactams by micowave irradiation*

scientific article published on 01 November 2005

A practical, green, and selective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems using alumina-catalyzed Michael addition reaction

article

A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents.

scientific article published in August 2001

A regioselective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems

scholarly article by Sabrina Castellano et al published December 2009 in Tetrahedron Letters

A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex

scientific article

A stereoselective approach to peptidomimetic BACE1 inhibitors.

scientific article published on 6 October 2013

A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues

A structure-activity relationship study on position-2 of the Galpha(s) C-terminal peptide able to inhibit G(s) activation by A2A adenosine receptor

scientific article published in January 2003

A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides

A unique capsular polysaccharide structure from the psychrophilic marine bacterium Colwellia psychrerythraea 34H that mimics antifreeze (glyco)proteins ⬇️

scientific article

A1 adenosine receptor antagonists, 3-aryl[1,2,4]triazino[4,3-a]benzimidazol-4-(10H)-ones (ATBIs) andN-alkyl andN-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs): Different recognition of bovine and human binding sites

Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model.

scientific article published on 2 May 2008

Alanine scanning analysis and structure-function relationships of the frog-skin antimicrobial peptide temporin-1Ta

article

Allosteric modulators of human A2B adenosine receptor

scientific article published on 19 December 2013

An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of multiple sclerosis

scientific article

An alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes

scientific article published on 13 November 2013

An antibody-free strategy for screening putative HDM2 inhibitors using crude bacterial lysates expressing GST-HDM2 recombinant protein

scientific article

An assessment of the nutraceutical potential of Juglans regia L. leaf powder in diabetic rats

scientific article published on 30 March 2017

An efficient approach for monosulfide bridge formation in solid-phase peptide synthesis

An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds

scientific article

An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald–Hartwig intramolecular cyclization

scholarly article in RSC Advances, vol. 6 no. 41, 2016

An investigation into the origin of the biased agonism associated with the urotensin II receptor activation

scientific article

Annurca (Malus pumila Miller cv. Annurca) apple as a functional food for the contribution to a healthy balance of plasma cholesterol levels: results of a randomized clinical trial

scientific article

Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial

scientific article

Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells

scientific article

Anthocyanin composition and extractability in berry skin and wine of Vitis vinifera L. cv. Aglianico

scientific article published on 28 July 2011

Antifungal peptides at membrane interaction

scientific article published on 2 March 2012

Antioxidant and antimicrobial properties of polyphenolic fractions from selected Moroccan red wines

scientific article published on November 2011

Antioxidant and antimicrobial properties of traditional green and purple "Napoletano" basil cultivars (Ocimum basilicum L.) from Campania region (Italy).

scientific article published on 27 December 2016

Antioxidant peptides from “Mozzarella di Bufala Campana DOP” after simulated gastrointestinal digestion: In vitro intestinal protection, bioavailability, and anti-haemolytic capacity

Antioxidant peptides released from gastrointestinal digestion of “Stracchino” soft cheese: Characterization, in vitro intestinal protection and bioavailability

Antitumor agents 4. Characterization of free radicals produced during reduction of the antitumor drug 5H-pyridophenoxazin-5-one: an EPR study

scientific article published in October 2003

Antitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative

scientific article

Antitumor agents. 1. Synthesis, biological evaluation, and molecular modeling of 5H-pyrido[3,2-a]phenoxazin-5-one, a compound with potent antiproliferative activity

scientific article published in November 2002

Antitumor agents. 2. Synthesis, structure-activity relationships, and biological evaluation of substituted 5H-pyridophenoxazin-5-ones with potent antiproliferative activity

scientific article published in November 2002

Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity

scientific article published on February 2004

Antitumor agents. 5. synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5h-benzopyridophenoxazin-5-ones, and 5h-benzopyridophenoxazin-5-ones with potent antiproliferative activit

scientific article published on August 2006

Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis

scientific article

Apoptosis therapy in cancer: the first single-molecule co-activating p53 and the translocator protein in glioblastoma.

scientific article published on 23 April 2014

Application of “magnetic tongue” to the sensory evaluation of extra virgin olive oil

scholarly article by Ilaria Lauri et al published October 2013 in Food Chemistry

Architecture of the Human Urotensin II Receptor: Comparison of the Binding Domains of Peptide and Non-Peptide Urotensin II Agonists

scientific article published on 01 April 2005

Architecture of the Human Urotensin II Receptor: Comparison of the Binding Domains of Peptide and Non-Peptide Urotensin II Agonists

Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: A critical review of in vitro and in vivo animal-based studies

scientific article published on 24 June 2019

Aryl Azides as Forgotten Electrophiles in the Van Leusen Reaction: A Multicomponent Transformation Affording 4-Tosyl-1-arylimidazoles

scientific article published on 10 December 2019

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation

scientific article

Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.

scientific article published on 12 May 2007

Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 1).

scientific article published on December 2006

Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 2).

scientific article published on December 2006

Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase

scientific article

Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells

scientific article published on 7 September 2012

Benzodiazepine Scaffold as Drug-like Molecular Simplification of FR235222: A Chemical Tool for Exploring HDAC Inhibition

scientific article published on 24 August 2016

Benzofuroxane Derivatives as Multi-Effective Agents for the Treatment of Cardiovascular Diabetic Complications. Synthesis, Functional Evaluation, and Molecular Modeling Studies ⬇️

scientific article published on November 20, 2012

Benzothiopyranoindole-Based Antiproliferative Agents: Synthesis, Cytotoxicity, Nucleic Acids Interaction, and Topoisomerases Inhibition Properties

scientific article published on 01 September 2009

Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors

scientific article published on 01 December 2019

Beyond radio-displacement techniques for identification of CB1 ligands: the first application of a fluorescence-quenching assay

scientific article published on 20 January 2014

Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.

scientific article

Binding of the hemopressin peptide to the cannabinoid CB1 receptor: structural insights

scientific article published on 19 November 2010

Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors

scientific article

Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives

scientific article published on 10 July 2019

Bioactive Compounds for the Management of Hypertriglyceridemia: Evidence From Clinical Trials and Putative Action Targets

scientific article published on 30 November 2020

Bioassay-guided identification of the antihyperglycaemic constituents of walnut ( Juglans regia ) leaves

Biological activity of 3-chloro-azetidin-2-one derivatives having interesting antiproliferative activity on human breast cancer cell lines

scientific article published on 25 September 2013

Biomimetic Synthesis of 5,6-Dihydroxyindole-2-Carboxylic Acid and of its Benzyl Ester

Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent

scientific article published on December 2008

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex

scientific article

Biselectivity of isoDGR peptides for fibronectin binding integrin subtypes α5β1 and αvβ6: conformational control through flanking amino acids

scientific article

Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication

scientific article published on 30 July 2019

Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity

scientific article

CDC25 phosphatase inhibitors: an update

scientific article published on January 2012

CDC25A and B dual-specificity phosphatase inhibitors: potential agents for cancer therapy.

scientific article published on January 2009

Calmodulin-dependent kinase II mediates vascular smooth muscle cell proliferation and is potentiated by extracellular signal regulated kinase

scientific article

Canned bluefin tuna, an in vitro cardioprotective functional food potentially safer than commercial fish oil based pharmaceutical formulations

scientific article published on 24 June 2014

Cardioprotective Effects of Taurisolo® in Cardiomyoblast H9c2 Cells under High-Glucose and Trimethylamine N-Oxide Treatment <i>via De Novo</i> Sphingolipid Synthesis

scientific article published on 12 November 2020

Carprofen analogues as sirtuin inhibitors: enzyme and cellular studies

scientific article published on November 2012

Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity

scientific article

Characterization of a selective CaMKII peptide inhibitor

scientific article published on 22 January 2013

Characterization of monovarietal extra virgin olive oils from the province of Béjaïa (Algeria)

scholarly article by Firdousse Laincer et al published November 2016 in Food Research International

Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties

scientific article

Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: model construction and docking calculations

scientific article published on 3 March 2007

Chemical behaviour of 1,4-benzoxazine

Chemical composition, antioxidant and antimicrobial properties of Rapa Catozza Napoletana (Brassica rapa L. var. rapa DC.) seed meal, a promising protein source of Campania region (southern Italy) horticultural germplasm

article

Chemical modifications in the seed region of miRNAs 221/222 increase the silencing performances in gastrointestinal stromal tumor cells

scientific article published on 27 January 2016

Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents.

scientific article published on 19 June 2017

Cinnamoyl Compounds as Simple Molecules that Inhibit p300 Histone Acetyltransferase

scientific article published on 10 March 2007

Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies

scientific article published on 16 February 2008

Co-polymerization of dopa and cysteinyldopa in melanogenesis in vitro

scientific article published on 01 July 1980

Colon Bioaccessibility and Antioxidant Activity of White, Green and Black Tea Polyphenols Extract after In Vitro Simulated Gastrointestinal Digestion

scientific article published on 08 November 2018

Combined Use of Factorial Design and Comparative Molecular Field Analysis (CoMFA): a Case Study

scholarly article by Giuseppe Caliendo et al published 1994 in QSAR and Combinatorial Science

Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells

scientific article published on 21 April 2015

Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials

scientific article

Comparative Molecular Field Analysis on a Set of Muscarinic Agonists

scholarly article by Giovanni Greco et al published 1991 in QSAR and Combinatorial Science

Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity

scientific article published on 18 September 2017

Computer-aided structure-affinity relationships in a set of piperazine and 3,8-diazabicyclo[3.2.1]octane derivatives binding to the mu-opioid receptor

scientific article

Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors.

scientific article

Conformation-activity relationship of designed glycopeptides as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis

scientific article published in August 2006

Conformational Control of Integrin-Subtype Selectivity in isoDGR Peptide Motifs: A Biological Switch

scientific article published on 01 November 2010

Conformational Stability of A?-(25?35) in the Presence of Thiazolidine Derivatives

scientific article published on 01 February 2007

Conformational analysis of furanoid epsilon-sugar amino acid containing cyclic peptides by NMR spectroscopy, molecular dynamics simulation, and X-ray crystallography: evidence for a novel turn structure

scientific article published in September 2003

Conformational analysis of the G?s proteinC-terminal region

scientific article published on 01 August 2002

Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor

scientific article

Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1.

scientific article

Continuous Flow Synthesis of Thieno[2,3-c]isoquinolin-5(4H)-one Scaffold: A Valuable Source of PARP-1 Inhibitors

Correction to New Anticancer Agents Mimicking Protein Recognition Motifs

scientific article published on 30 April 2015

Corrigendum to “Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors” [Eur. J. Pharmacol. 477 (2003) 227–234]

scholarly article published in European Journal of Pharmacology

Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design

scientific article

Cycloaddition reactions of thiazolidine derivatives. An approach to the synthesis of new functionalized heterocyclic systems

article published in 2001

Cyclotides: a natural combinatorial peptide library or a bioactive sequence player?

scientific article published on 22 September 2014

DOTA-Derivatives of Octreotide Dicarba-Analogs with High Affinity for Somatostatin sst2,5 Receptors

scientific article published on 23 February 2017

DPP-4 inhibitors: a patent review (2012 - 2014).

scientific article

DTNQ-Pro, a Mimetic Dipeptide, Sensitizes Human Colon Cancer Cells to 5-Fluorouracil Treatment

scientific article published on 21 April 2013

Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity.

scientific article published on 26 June 2017

Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides

scientific article published on 28 July 2015

Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists

scientific article published on 13 February 2008

Derivatives of Benzimidazol-2-ylquinoline and Benzimidazol-2-ylisoquinoline as Selective A1 Adenosine Receptor Antagonists with Stimulant Activity on Human Colon Motility

scientific article published on 27 July 2011

Design and Synthesis of Melanocortin Peptides with Candidacidal and Anti-TNF-α Properties

scientific article published on 01 March 2005

Design and Synthesis of New Cell Penetrating Peptides: Diffusion and Distribution Inside the Cornea.

scientific article published on 27 September 2016

Design and Synthesis of Small Libraries of Peptidomimetics Based on a Thiazolidine Moiety

Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists

scientific article published on 15 April 2008

Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

scientific article published on 21 November 2011

Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore

scientific article published on 31 January 2007

Design and synthesis of spirotryprostatin-inspired diketopiperazine systems from prolyl spirooxoindolethiazolidine derivatives

scientific article published on 29 April 2010

Design of novel nicotinic ligands through 3D database searching

scientific article published in February 2005

Design, Molecular Modeling, Synthesis, and Anti-HIV-1 Activity of New Indolyl Aryl Sulfones. Novel Derivatives of the Indole-2-carboxamide

article

Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands

scientific article published on 8 December 2014

Design, Synthesis, Biological Activity, and Structural Analysis of Lactam-Constrained PTPRJ Agonist Peptides

scientific article published on 04 July 2018

Design, Synthesis, Conformational Analysis, and Biological Studies of Urotensin-II Lactam Analogues

article

Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1).

scientific article published in March 2010

Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists

scientific article published in November 2002

Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors

scientific article

Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors

scientific article

Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor

scientific article published on 25 March 2015

Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.

scientific article published on 21 October 2008

Design, synthesis, and cytotoxic evaluation of a new series of 3-substituted spiro[(dihydropyrazine-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)] derivatives

scientific article published on 22 March 2007

Design, synthesis, and cytotoxic evaluation of acyl derivatives of 3-aminonaphtho[2,3-b]thiophene-4,9-dione, a quinone-based system

scientific article published on 23 May 2011

Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents

scientific article published on 16 February 2008

Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors

scientific article published on January 2006

Designed glucopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis.

scientific article published on 3 December 2012

Designed glycopeptides with different beta-turn types as synthetic probes for the detection of autoantibodies as biomarkers of multiple sclerosis

scientific article published on 20 August 2008

Detailed peptide profiling of “Scotta”: from a dairy waste to a source of potential health-promoting compounds

article

Detailed polyphenolic profiling of Annurca apple (M. pumila Miller cv Annurca) by a combination of RP-UHPLC and HILIC, both hyphenated to IT-TOF mass spectrometry

scientific article published on 29 May 2015

Development and Identification of a Novel Anti-HIV-1 Peptide Derived by Modification of the N-Terminal Domain of HIV-1 Integrase.

scientific article

Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors.

scientific article

Development of Novel Amides as Noncovalent Inhibitors of Immunoproteasomes

scientific article published on 26 March 2019

Development of a practical and scalable route for the preparation of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and analogs

Development of an Optimized Protocol for NMR Metabolomics Studies of Human Colon Cancer Cell Lines and First Insight from Testing of the Protocol Using DNA G-Quadruplex Ligands as Novel Anti-Cancer Drugs

scientific article published on 15 January 2016

Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies

scientific article

Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors

scientific article

Development of novel cyclic peptides as pro-apoptotic agents

scientific article published on 5 April 2016

Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation.

scientific article published on 21 September 2015

Development of novel selective peptidomimetics containing a boronic acid moiety, targeting the 20S proteasome as anticancer agents

scientific article

Development of peptidomimetic boronates as proteasome inhibitors

article

Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling

scientific article published on 29 April 2007

Diarylheterocycle Core Ring Features Effect in Selective COX-1 Inhibition

scientific article published on 25 January 2012

Differential scanning calorimetry to investigate G-quadruplexes structural stability

scientific article published on 14 March 2013

Dihydrithieno[2,3-b]naphto-4,9-dione analogues as anticancer agents: Synthesis and in cell pharmacological studies

scientific article published on 26 July 2015

Discovery of Huperzine A−Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Midgorge Recognition Sites

scientific article published on 01 June 2006

Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.

scientific article published on 22 June 2015

Discovery of New Inhibitors of Cdc25B Dual Specificity Phosphatases by Structure-Based Virtual Screening

scientific article published on 01 May 2012

Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor

scientific article published on 24 November 2015

Discovery of PTPRJ agonist peptides that effectively inhibit in vitro cancer cell proliferation and tube formation

scientific article

Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure

scientific article published on 26 February 2019

Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior

scientific article published in January 2009

Discovery of a novel small molecule inhibitor targeting the frataxin/ubiquitin interaction via structure-based virtual screening and bioassays

scientific article

Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors

scientific article published in June 2010

Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria

scientific article

Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase

scientific article published on 6 September 2010

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

scientific article

Disease-modifying anti-Alzheimer's drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation.

scientific article

Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design

scientific article published in October 2003

Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data

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Driving forces in the delivery of penetratin conjugated G protein fragment

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Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells.

scientific article published on 31 October 2016

Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer

scientific article published on 8 August 2017

Effect of Annurca Apple Polyphenols on Intermittent Claudication in Patients With Peripheral Artery Disease

scientific article published on 03 December 2018

Effect of Grape Pomace Polyphenols With or Without Pectin on TMAO Serum Levels Assessed by LC/MS-Based Assay: A Preliminary Clinical Study on Overweight/Obese Subjects

scientific article published on 21 May 2019

Effects of Annurca apple polyphenols on lipid metabolism in HepG2 cell lines: A source of nutraceuticals potentially indicated for the metabolic syndrome

article by Gian Carlo Tenore et al published September 2014 in Food Research International

Effects of Grape Pomace Polyphenolic Extract (Taurisolo) in Reducing TMAO Serum Levels in Humans: Preliminary Results from a Randomized, Placebo-Controlled, Cross-Over Study

scientific article published on 10 January 2019

Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action

scientific article

Effects of variable selection on CoMFA coefficient contour maps in a set of triazines inhibiting DHFR

scientific article published on 01 April 1994

Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids

scientific article published on 01 August 2006

Emerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancer

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Enantiomeric 4-Acylamino-6-alkyloxy-2 Alkylthiopyrimidines As Potential A3 Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy.

scientific article published on 20 April 2016

Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants

article

Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column

scientific article published in February 2003

Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments

scientific article

Ensemble-Docking Approach on BACE-1: Pharmacophore Perception and Guidelines for Drug Design

scholarly article by Vittorio Limongelli et al published 11 June 2007 in ChemMedChem

Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design

scientific article published in May 2007

Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent

scientific article published on 19 July 2008

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates.

scientific article published on 11 April 2016

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

scientific article published on 11 December 2013

Evidence for G-quadruplex in the promoter of VEGFR-2 and its targeting to inhibit tumor angiogenesis.

scientific article

Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors

scientific article published on 15 May 2008

Exploiting the 4-Phenylquinazoline Scaffold for the Development of High Affinity Fluorescent Probes for the Translocator Protein (TSPO).

scientific article

Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones

scientific article published on 5 August 2015

Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors

scientific article published in March 2009

Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents

scientific article published on 5 September 2015

Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists

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Exploring the biological consequences of conformational changes in aspartame models containing constrained analogues of phenylalanine

article

Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence

scientific article published on 27 November 2013

Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors

scientific article

Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: a docking and molecular dynamics study

scientific article published on 8 August 2006

Exploring the nutraceutical potential of polyphenols from black, green and white tea infusions - an overview

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Facile Baeyer–Villiger oxidation of cyclic ketones: conventional versus microwave-assisted approach

article

Fermentation of Foods and Beverages as a Tool for Increasing Availability of Bioactive Compounds. Focus on Short-Chain Fatty Acids

scientific article published on 25 July 2020

Fluorescence enhancement upon G-quadruplex folding: synthesis, structure, and biophysical characterization of a dansyl/cyclodextrin-tagged thrombin binding aptamer.

scientific article published on 25 October 2013

Formation of [4Fe-4S] clusters in the mitochondrial iron-sulfur cluster assembly machinery

scientific article published on 7 November 2014

Free protein amino acids of some Mediterranean Siphonales

scientific article published in 1984

From (+)-epigallocatechin gallate to a simplified synthetic analogue as a cytoadherence inhibitor for P. falciparum

scholarly article in RSC Advances, vol. 4 no. 9, 2014

From pharmaceuticals to nutraceuticals: bridging disease prevention and management

scientific article published on 30 November 2018

From the pharmacophore to the homology model of the benzodiazepine receptor: the indolyglyoxylamides affair

scientific article published on January 2012

Fruit-based juices: Focus on antioxidant properties-Study approach and update

scientific article published on 02 June 2019

Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides

scientific article published on 23 January 2019

Further caulerpenyne-like esters from the green algaCaulerpa prolifera

Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors

scientific article published in September 2003

Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5

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G-Quadruplex on Oligo Affinity Support (G4-OAS): An Easy Affinity Chromatography-Based Assay for the Screening of G-Quadruplex Ligands

scientific article published on 14 April 2014

G-triplex structure and formation propensity

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GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1.

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Galphas protein C-terminal alpha-helix at the interface: does the plasma membrane play a critical role in the Galphas protein functionality?

scientific article published in October 2005

Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.

scientific article published on October 1998

Geometrically constrained analogues of N-benzylindolylglyoxylylamides: [1, 2, 4]triazino[4, 3-a]benzimidazol-4(10H)-one derivatives as potential new ligands at the benzodiazepine receptor.

scientific article published in September 2003

Grape Polyphenols Ameliorate Muscle Decline Reducing Oxidative Stress and Oxidative Damage in Aged Rats

scientific article published on 30 April 2020

HCV-targeted antivirals: current status and future challenges

scientific article published on January 2014

Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition

scholarly article in RSC Advances, vol. 6 no. 69, 2016

Hemopressin Peptides as Modulators of the Endocannabinoid System and their Potential Applications as Therapeutic Tools

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High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives.

scientific article

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity

scientific article

Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding

scientific article published on October 2007

Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase

scientific article published in April 2003

How are thermodynamically stable G-quadruplex–duplex hybrids?

Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor

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Human integrin alphavbeta5: homology modeling and ligand binding

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Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library

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Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists

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Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications

scientific article published on 08 April 2011

Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells

scientific article

Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity

scientific article published on 10 July 2018

Identification of a new series of amides as non-covalent proteasome inhibitors.

scientific article published on 25 January 2014

Identification of an acetal derivative of the piperonyl methyl ketone in tablets seized for suspected drug trafficking

Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor

scientific article

Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.

scientific article published in June 2009

Identification of cysteinyldopa-derived units in eumelanins from mammalian eyes

scientific article published on 01 March 1981

Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.

scientific article published on May 2012

Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by Diketo acid derivatives

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Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening.

scientific article

Identification of novel indole derivatives acting as inhibitors of the Keap1-Nrf2 interaction.

scientific article

Identification of novel interactors of human telomeric G-quadruplex DNA

Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening

scientific article published on 14 September 2016

Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization

article

Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.

scientific article

Identification of structural features of 2-alkylidene-1,3-dicarbonyl derivatives that induce inhibition and/or activation of histone acetyltransferases KAT3B/p300 and KAT2B/PCAF.

scientific article

Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells.

scientific article

Identification of the spiro(oxindole-3,3'-thiazolidine)-based derivatives as potential p53 activity modulators

scientific article published on 8 November 2010

Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5).

scientific article published on 11 August 2009

Imidazo[2,1-b]thiazole system: a scaffold endowing dihydropyridines with selective cardiodepressant activity

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Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study

scientific article published on 01 December 2019

In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors

scientific article published on 19 January 2016

In vitro Bioaccessibility, Bioavailability, and Plasma Protein Interaction of New Oral Anticoagulants in the Presence of Macronutrients

scientific article published on 01 January 2018

In vitro bioaccessibility, bioavailability and plasma protein interaction of polyphenols from Annurca apple (M. pumila Miller cv Annurca)

scientific article published on 20 June 2013

In vitro hypoglycaemic and hypolipidemic potential of white tea polyphenols

scientific article published on 24 May 2013

Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation.

scientific article

Indole-2-carboxamides as allosteric modulators of the cannabinoid CB₁ receptor.

scientific article published on 17 May 2012

Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity

scientific article published on 6 September 2007

Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide

scientific article

Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus

scientific article published on April 2009

Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on 24 November 2014

Inherent desensitisation-preventing properties of a novel, subtype-selective AMPA receptor agonist, (S)-CPW 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells

scientific article

Inhibition of ocular aldose reductase by a new benzofuroxane derivative ameliorates rat endotoxic uveitis

scientific article

Inhibitors of Cdc25 phosphatases as anticancer agents: a patent review

scientific article published on March 2010

Insights into amyloid-like aggregation of H2 region of the C-terminal domain of nucleophosmin

scientific article

Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

scientific article

Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges.

scientific article

Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode

scientific article published on 13 November 2015

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors

scientific article published on 9 January 2018

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

scientific article published on 27 October 2015

Investigating the mechanism of substrate uptake and release in the glutamate transporter homologue Glt(Ph) through metadynamics simulations

scientific article

Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2.

scientific article published on 14 August 2015

Investigational drugs targeting cyclin-dependent kinases for the treatment of cancer: an update on recent findings (2013-2016).

scientific article published on 8 September 2016

Isolation and functional characterization of peptide agonists of PTPRJ, a tyrosine phosphatase receptor endowed with tumor suppressor activity

scientific article

L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives

scientific article

Lactofermented Annurca Apple Puree as a Functional Food Indicated for the Control of Plasma Lipid and Oxidative Amine Levels: Results from a Randomised Clinical Trial

scientific article published on 09 January 2019

Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas.

scientific article

Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor

scientific article published on 10 July 2014

Ligand based approach to L-type calcium channel by imidazo[2,1-b]thiazole-1,4-dihydropyridines: from heart activity to brain affinity

scientific article published on 9 May 2013

Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists

scientific article published in June 2005

Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations

scientific article published on 23 February 2017

Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells

scientific article published on 9 March 2018

Linking CoMFA and protein homology models of enzyme-inhibitor interactions: an application to non-steroidal aromatase inhibitors

article

Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma

scientific article published on 20 April 2016

Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells

scientific article published on 09 January 2016

Long non-coding RNA containing ultraconserved genomic region 8 promotes bladder cancer tumorigenesis

scientific article published on March 2016

Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules

scientific article

Lower incidence of macrovascular complications in patients on insulin glargine versus those on basal human insulins: a population-based cohort study in Italy

scientific article published on 24 June 2013

Lower rate of cardiovascular complications in patients on bolus insulin analogues: a retrospective population-based cohort study

scientific article (publication date: 2013)

Malaria chemotherapy: recent advances in drug development

scientific article

Manadoperoxides A-D from the Indonesian sponge Plakortis cfr. simplex. Further insights on the structure-activity relationships of simple 1,2-dioxane antimalarials

scientific article published in June 2010

Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation

scientific article

May Polyphenols Have a Role Against Coronavirus Infection? An Overview of in vitro Evidence

scientific article published on 15 May 2020

Mechanistic insight into ligand binding to G-quadruplex DNA

scientific article

Melanocortin MC₄ receptor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral ischemia

scientific article

Melanocortins counteract inflammatory and apoptotic responses to prolonged myocardial ischemia/reperfusion through a vagus nerve-mediated mechanism

scientific article published on 10 April 2010

Membrane charge dependent states of the beta-amyloid fragment Abeta (16-35) with differently charged micelle aggregates

scientific article published on 4 January 2010

Microwave-Assisted Synthesis of KN-93, a Potent and Selective Inhibitor of Ca²+/Calmoduline-Dependent Protein Kinase II

Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.

scientific article

Modeling of Cdc25B Dual Specifity Protein Phosphatase Inhibitors: Docking of Ligands and Enzymatic Inhibition Mechanism

article

Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)

scientific article published on 07 September 2014

Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives

scientific article published on 8 September 2013

Modulation of the JAK/ERK/STAT signaling in melanocortin-induced inhibition of local and systemic responses to myocardial ischemia/reperfusion.

scientific article published on 25 March 2013

Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition

scientific article

Molecular signaling involving intrinsically disordered proteins in prostate cancer

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Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

scientific article published on 18 March 2020

Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma

scientific article published on 2 June 2016

Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor

scientific article published in May 2005

Multicomponent Reaction of Z-Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One-Pot Route to Aminodioximes and Their Transformation into 5-Amino-1,2,4-oxadiazoles by Mitsunobu–Beckmann Rearrangement

scientific article published on 30 September 2015

Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation

scientific article

Mycosporine aminoacids and related compounds from the eggs of fishes

N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.

scientific article published in September 1998

N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor.

scientific article published on March 2004

N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis

article

N-O-Isopropyl sulfonamido-based hydroxamates: Kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors

scientific article published in 2012

N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase

scientific article

NMR Spectrometers as “Magnetic Tongues”: Prediction of Sensory Descriptors in Canned Tomatoes

Naphtho[1,2-d]isothiazole acetic acid derivatives as a novel class of selective aldose reductase inhibitors.

scientific article

Native PAGE to study the interaction between the oncosuppressor p53 and its protein ligands

scientific article published on 02 January 2015

Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases

scientific article

New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function

scientific article

New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists

scientific article published on 28 June 2011

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer

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New alpha-(N)-heterocyclichydrazones: evaluation of anticancer, anti-HIV and antimicrobial activity

scientific article published on February 2004

New anticancer agents mimicking protein recognition motifs

scientific article published on 19 August 2013

New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.

scientific article

New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives: synthesis and biological evaluation as potential antitumoral agents

scientific article published in August 2003

New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation.

scientific article published on January 2007

New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on 12 April 2014

New insight into the binding mode of peptide ligands at Urotensin-II receptor: structure-activity relationships study on P5U and urantide

scientific article

New insight into the binding mode of peptides at urotensin-II receptor by Trp-constrained analogues of P5U and urantide

scientific article published on 25 March 2013

New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds

scientific article published on 27 July 2011

New insight into the mechanism of action of the temporin antimicrobial peptides

scientific article

New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H.

scientific article

New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article

New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target

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New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer

scientific article

New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity

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New pyrrolobenzothiazepine derivatives as molecular probes of the ‘peripheral-type’ benzodiazepine receptor (PBR) binding site

New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53

scientific article

Nitrile N-Oxides and Nitrile Imines as New Fuels for the Discovery of Novel Isocyanide-Based Multicomponent Reactions

Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.

scientific article published on 14 February 2011

Noncanonical DNA secondary structures as drug targets: the prospect of the i-motif

scientific article published on 24 June 2014

Nondenaturing polyacrylamide gel electrophoresis to study the dissociation of the p53·MDM2/X complex by potentially anticancer compounds

scientific article published on 18 September 2015

Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies

scientific article published on 01 December 2019

Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.

scientific article

Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands

scientific article

Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.

scientific article published on May 2010

Novel Peptide-Based PET Probe for Non-invasive Imaging of C-X-C Chemokine Receptor Type 4 (CXCR4) in Tumors

scientific article published in 2021

Novel alpha-melanocyte stimulating hormone peptide analogues with high candidacidal activity

scientific article published in February 2003

Novel and Selective αvβ3Receptor Peptide Antagonist: Design, Synthesis, and Biological Behavior

scientific article published on 01 June 2006

Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action

scientific article published on March 2006

Novel cyclic biphalin analogue with improved antinociceptive properties.

scientific article published on 14 July 2014

Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.

scientific article

Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors

scientific article published on August 2010

Novel peptidomimetics as BACE-1 inhibitors: Synthesis, molecular modeling, and biological studies

scientific article published on 14 November 2012

Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities

scientific article published on 23 July 2008

Novel route in the synthesis of ψ[CH2NH] amide bond surrogate

Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships

scientific article published on 23 January 2008

Novel temporin L antimicrobial peptides: promoting self-assembling by lipidic tags to tackle superbugs

scientific article published on 01 December 2020

Novel α-MSH peptide analogues with broad spectrum antimicrobial activity

scientific article

Novel, highly potent adenosine deaminase inhibitors containing the pyrazolo[3,4-d]pyrimidine ring system. Synthesis, structure-activity relationships, and molecular modeling studies.

scientific article published in August 2005

Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives

scientific article

Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization

scientific article published in November 2009

Nutraceutical potential and antioxidant benefits of red pitaya (Hylocereus polyrhizus) extracts

article by Gian Carlo Tenore et al published January 2012 in Journal of Functional Foods

Nutraceutical potential of monofloral honeys produced by the Sicilian black honeybees (Apis mellifera ssp. sicula).

scientific article published in April 2012

Nutraceutical potential of polyphenolic fractions from Annurca apple (M. pumila Miller cv Annurca).

scientific article published on 12 November 2012

Nutraceutical value and toxicological profile of selected red wines from Morocco

scientific article published on 11 May 2011

Nutraceuticals - shedding light on the grey area between pharmaceuticals and food

scientific article published on 23 April 2018

Nutraceuticals: A paradigm of proactive medicine

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Nutraceuticals: Beyond the Diet Before the Drugs

article by Antonello Santini & Ettore Novellino published 31 July 2014 in Current Bioactive Compounds

Nutraceuticals: opening the debate for a regulatory framework.

scientific article published on 12 February 2018

Obestatin conformational features: a strategy to unveil obestatin's biological role?

scientific article

Occurrence of mycosporine related compounds in sea urchin eggs

scientific article published in 1986

Occurrence of two new mycosporine-like aminoacids, mytilins A and B in the edible mussel, mytilus galloprovincialis

Online Comprehensive RPLC × RPLC with Mass Spectrometry Detection for the Analysis of Proteome Samples

article

Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge.

scientific article published on 14 March 2017

Opposite modulation of cell migration by distinct subregions of urokinase connecting peptide

scientific article published on 20 March 2013

Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling

scientific article

Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors

scientific article

Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators

scientific article published on 18 September 2014

Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals

scientific article

Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue

scientific article published on 01 July 2014

Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.

scientific article

Petiodial, a new monocyclic diterpenoid from the Mediterranean green algaUdotea petiolata

Pharmacological folding chaperones act as allosteric ligands of Frizzled4.

scientific article

Pharmacophoric modifications lead to superpotent αvβ3 integrin ligands with suppressed α5β1 activity

scientific article

Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of noncamptothecin topoisomerase I (Top1) inhibitors

scientific article published on 16 September 2013

Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies

scientific article published on 24 August 2016

Photocatalytic Isocyanide-Based Multicomponent Domino Cascade toward the Stereoselective Formation of Iminofurans

scientific article published on 10 January 2020

Plasmodium falciparum subtilisin-like protease 1: discovery of potent difluorostatone-based inhibitors

scholarly article in RSC Advances, vol. 5 no. 29, 2015

Polyphenols: A concise overview on the chemistry, occurrence, and human health

scientific article published on 29 July 2019

Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models

scientific article

Potent, Efficacious, and Stable Cyclic Opioid Peptides with Long Lasting Antinociceptive Effect after Peripheral Administration

scientific article published on 27 December 2019

Predictive Structure-Based Toxicology Approaches To Assess the Androgenic Potential of Chemicals.

scientific article

Preliminary finding on a new calcium channel entry blocker chemotype: 5,6-diamino-4-hydroxy-2-mercaptopyrimidine derivatives

scientific article

Preparation of Constrained Unnatural Aromatic Amino AcidsviaUnsaturated Diketopiperazine Intermediate

article by Adriano Mollica et al published 7 September 2015 in Journal of Heterocyclic Chemistry

Production of enniatins A, A1, B, B1, B4, J1 by Fusarium tricinctum in solid corn culture: structural analysis and effects on mitochondrial respiration

scientific article

Progresses in the pursuit of aldose reductase inhibitors: The structure-based lead optimization step

scientific article published on 05 March 2012

Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity

scientific article

Protein flexibility in virtual screening: the BACE-1 case study

scientific article

Pursuing Aldose Reductase Inhibitors through in Situ Cross-Docking and Similarity-Based Virtual Screening

scientific article published on 01 September 2009

Pyrido[1,2-a]pyrimidin-4-one Derivatives as a Novel Class of Selective Aldose Reductase Inhibitors Exhibiting Antioxidant Activity

scientific article published on 11 September 2007

Pyroglutamic Acid Derivatives: Building Blocks for Drug Discovery

article published in 2014

Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A New Class of Agents with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Who Were Imatinib-Resistant

article

Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A New Class of Agents with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Who Were Imatinib-Resistant

Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target

scientific article published on June 2005

Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity.

scientific article published on July 1996

Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity

scientific article

Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies

scientific article published in October 1999

Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils

scientific article published on 01 June 2011

Quantitative structure-activity relationships in a set of thiazolidin-4-ones acting as H1-histamine antagonists

scientific article published on 01 January 1995

Quinoline-Based p300 Histone Acetyltransferase Inhibitors with Pro-apoptotic Activity in Human Leukemia U937 Cells

scientific article published on 06 February 2014

Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.

scientific article

Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.

scientific article

REACH and in silico methods: an attractive opportunity for medicinal chemists

scientific article

Rapid Screening of Antioxidant Anthocyanins in Autochthonous Nero d’Avola Grape Clones by Pre-column DPPH Reaction Coupled to UHPLC-UV/Vis-IT-TOF: a Strategy to Combine Chemical data and Genetic Diversity

article published in 2016

Rational design of the first difluorostatone-based PfSUB1 inhibitors

scientific article published on 23 May 2014

Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides

scientific article

Reaction between (Z)-Arylchlorooximes and α-Isocyanoacetamides: A Procedure for the Synthesis of Aryl-α-ketoamide Amides

scientific article published on 20 June 2014

Reaction between quinone and thiazolidine. A study on the formation mechanism of new antiproliferative quinolindiones

Recent structure-activity studies of the peptide hormone urotensin-II, a potent vasoconstrictor

scientific article published on April 2004

Recent trends and advances in food chemistry and analysis: research highlights from the IX Italian Congress of Food Chemistry

scientific article

Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure

scientific article published on 22 September 2014

Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides

scientific article published on April 2006

Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation

scientific article published on 28 November 2010

Response to Keith et al. Re: "Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial"

scientific article published on 08 November 2019

Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview

scholarly article by Giuseppe Annunziata published in September 2018

Retracted: Endogenous Urotensin II Selectively Modulates Erectile Function through eNOS

retracted article

Reversible formation of cyclic 1,4-benzothiazine oligomers

Revisiting a receptor-based pharmacophore hypothesis for human A(2A) adenosine receptor antagonists

scientific article published on 20 June 2013

Role of Lipoylation of the Immunodominant Epitope of Pyruvate Dehydrogenase Complex: Toward a Peptide-Based Diagnostic Assay for Primary Biliary Cirrhosis

scientific article published on 06 August 2015

SAR study and conformational analysis of a series of novel peptide G protein-coupled receptor kinase 2 inhibitors

scientific article published in January 2014

STAT-3 inhibitors: state of the art and new horizons for cancer treatment.

scientific article published on January 2011

Sampling protein motion and solvent effect during ligand binding

scientific article published on 11 January 2012

Screening Platform toward New Anti-HIV Aptamers Set on Molecular Docking and Fluorescence Quenching Techniques

scientific article published on 25 January 2016

Selective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)](4).

scientific article

Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models

scientific article published on 4 October 2013

Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization

scientific article

Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage

scientific article published on 22 January 2007

Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells

scientific article published on 15 January 2014

Shading the TRF2 Recruiting Function: A New Horizon in Drug Development

article

Shape-dependent effects in a series of aromatic nitro compounds acting as mutagenic agents on S. typhimurium TA98.

scientific article published in January 1995

Shooting for Selective Druglike G-Quadruplex Binders: Evidence for Telomeric DNA Damage and Tumor Cell Death

article

Simulated gastrointestinal digestion, intestinal permeation and plasma protein interaction of white, green, and black tea polyphenols

scientific article published on 10 August 2014

Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme.

scientific article

Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors.

scientific article

Solution-phase parallel synthesis of aryloxyimino amides via a novel multicomponent reaction among aromatic (Z)-chlorooximes, isocyanides, and electron-deficient phenols

scientific article

Some new aspects on the chemistry of 1,4-benzoxazines

Specific Targeting of Acetylcholinesterase and Butyrylcholinesterase Recognition Sites. Rational Design of Novel, Selective, and Highly Potent Cholinesterase Inhibitors

scientific article published on 01 January 2003

Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity

scientific article published in November 2005

Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.

scientific article published in July 2005

Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations

scientific article published in February 2009

Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

scientific article published in June 2009

Spiro[(dihydropyrazin-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)]-based cytotoxic agents: structure-activity relationship studies on the substituent at N4-position of the diketopiperazine domain

scientific article

Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors.

scientific article published in January 2005

Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands

scientific article published on 9 December 2015

State of the art of Ready-to-Use Therapeutic Food: a tool for nutraceuticals addition to foodstuff

scientific article

State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders.

scientific article published on January 2012

Sterol composition of some mediterranean green algae

article

Sterols of four Mediterranean hydroids

scientific article published in 1985

Structural Evidence of N6-Isopentenyladenosine As a New Ligand of Farnesyl Pyrophosphate Synthase

article

Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle

scientific article

Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis

scientific article published on June 2010

Structural studies on Hgr3 orphan receptor ligand prolactin-releasing peptide

scientific article

Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands

scientific article published on 06 April 2017

Structure-Activity Relationship Studies, SPR Affinity Characterization, and Conformational Analysis of Peptides That Mimic the HNK-1 Carbohydrate Epitope.

scientific article published on 12 April 2017

Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist

scientific article published on 10 November 2017

Structure-Activity Study of the Peptides P5U and Urantide by the Development of Analogues Containing Uncoded Amino Acids at Position 9

article

Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme

scientific article

Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection

scientific article (publication date: 20 January 2017)

Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors

scientific article published on 17 March 2014

Structure-activity relationship studies optimizing the antiproliferative activity of novel cyclic somatostatin analogues containing a restrained cyclic beta-amino acid

scientific article

Structure-activity relationship, conformational and biological studies of temporin L analogues

scientific article

Structure-activity studies of peptidomimetics based on kinase-inhibitory region of suppressors of cytokine signaling 1.

scientific article published on 20 November 2017

Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase

scientific article

Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrations

scientific article

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking

scientific article published on 7 May 2015

Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism

scientific article published on 16 November 2015

Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents.

scientific article published on 25 February 2015

Structure-based optimization of tyrosine kinase inhibitor CLM3. Design, synthesis, functional evaluation, and molecular modeling studies

scientific article published on 5 February 2014

Structure-based virtual screening and biological evaluation of Mycobacterium tuberculosis adenosine 5'-phosphosulfate reductase inhibitors

scientific article published on 15 October 2008

Structure?function Relationships and Conformational Properties of ?-MSH(6?13) Analogues with Candidacidal Activity

scientific article published on 01 January 2007

Structure—affinity relationship studies on benzotriazole derivatives binding to 5-HT receptor subtypes

Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A adenosine receptor

scientific article published on 09 November 2017

Study of Benzodiazepines Receptor Sites Using a Combined QSAR-CoMFA Approach

Switchable Protecting Strategy for Solid Phase Synthesis of DNA and RNA Interacting Nucleopeptides.

scientific article

Syntheses, biological evaluation, and molecular modeling of 18F-labeled 4-anilidopiperidines as mu-opioid receptor imaging agents

scientific article published in December 2005

Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues

scientific article published on 29 July 2011

Synthesis and Pharmacological Activity of 2-(substituted)-3-{2-[(4-phenyl-4-cyano)piperidino]ethyl}-1,3-thiazolidin-4-ones

scientific article published on 01 June 2006

Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators

scientific article published on 24 December 2019

Synthesis and antiinflammatory—analgesic profile of 1-methyl-2-(4-X-benzoyl) imidazole-5-carboxylic acids

article published in 1995

Synthesis and antimicrobial activities of 5-amidobenzotriazole derivatives

Synthesis and biological activity of benzotriazole derivatives structurally related to trazodone

Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors

scientific article published on 2 April 2011

Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein

scientific article

Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis

scientific article published on 2 August 2012

Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands

scientific article published on October 2010

Synthesis and biological evaluation of new N-alkylcarbazole derivatives as STAT3 inhibitors: Preliminary study

scientific article published on 04 December 2012

Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines

scientific article

Synthesis and cytotoxic evaluation of novel spirohydantoin derivatives of the dihydrothieno[2,3-b]naphtho-4,9-dione system.

scientific article published on February 2005

Synthesis and gene silencing properties of siRNAs containing terminal amide linkages

scientific article

Synthesis and pharmacological evaluation of a set of N-[2-(alkylamino)ethyl]benzotriazol-X-yl isobutyramides acting as local anesthetics

scholarly article by Giuseppe Caliendo et al published January 1996 in European Journal of Medicinal Chemistry

Synthesis and pharmacological evaluation of analogs of indole-based cannabimimetic agents

scientific article published on 4 November 2009

Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors

scientific article published in August 2003

Synthesis and pharmacological evaluation of some 4-oxo-quinoline-2-carboxylic acid derivatives as anti-inflammatory and analgesic agents

scientific article published on October 2010

Synthesis and structure-activity relationships of antiinflammatory 1-methyl-2-(4-X-benzoyl)imidazole-5-acetic acids

Synthesis of 3-phenyl-2H-1,4-benzoxazin-2-one. Revision of some structural assignments

Synthesis of Novel Indole-Based Ring Systems by Acid-Catalysed Condensation from α-Amino Aldehydes andL-Trp-OMe

Synthesis of Quinolindione Derivatives Assisted by Microwave Irradiation

Synthesis of aminocarbonyl N-acylhydrazones by a three-component reaction of isocyanides, hydrazonoyl chlorides, and carboxylic acids

scientific article

Synthesis of conformationally constrained β-turn thiazolidine mimetic

article by Paolo Grieco et al published February 2002 in Tetrahedron Letters

Synthesis of dicarba-cyclooctapeptide Somatostatin analogs by conventional and MW-assisted RCM: A study about the impact of the configuration at C α of selected amino acids

Synthesis of dihydroplakortin, 6-epi-dihydroplakortin, and their C10-desethyl analogues

scientific article published in April 2010

Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR).

scientific article published on September 2002

Synthesis of new β-turn dipeptide mimetic based on tetrahydroisoquinoline moiety

Synthesis, Characterization, and DNA Binding Profile of a Macrocyclic β-Sheet Analogue of ARC Protein

scientific article

Synthesis, antimicrobial data and correlation analysis in a set of 2-alkyl-5-amidobenzotriazoles

Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands

scientific article published on 02 December 2014

Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands.

scientific article published on August 1996

Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists

scientific article

Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.

scientific article published on 19 September 2008

Synthesis, biological evaluation, and molecular modeling investigation of chiral phenoxyacetic acid analogues with PPARalpha and PPARgamma agonist activity.

scientific article published on May 2007

Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity

scientific article published on August 2005

Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists

scientific article published in March 2005

Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides

scientific article

Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selec

scientific article published on 21 June 2009

Synthesis, in vitro, and in cell studies of a new series of [indoline-3,2'-thiazolidine]-based p53 modulators

scientific article published on 26 June 2013

Synthesis, local anesthetic activity and QSAR studies for a set of N-[2-(alkylamino)ethyl]benzotriazol-x-yl acetamides

Synthesis, pharmacological evaluation, and molecular modeling studies of novel peptidic CAAX analogues as farnesyl-protein-transferase inhibitors

scientific article published on March 2006

Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor.

scientific article published in December 1996

Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials

Tacrine based human cholinesterase inhibitors: Synthesis of peptidic-tethered derivatives and their effect on potency and selectivity

scientific article published on 26 August 2008

Tailoring of Integrin Ligands: Probing the Charge Capability of the Metal Ion-Dependent Adhesion Site

scientific article published on 09 January 2012

Tandem Application of Virtual Screening and NMR Experiments in the Discovery of Brand New DNA Quadruplex Groove Binders

scientific article published in 2009

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

scientific article

Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors

scientific article

Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies

scientific article published on 7 November 2014

Targeting the BCL2 Gene Promoter G-Quadruplex with a New Class of Furopyridazinone-Based Molecules

scientific article published on 18 January 2018

Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.

scientific article

The First Sphingosine 1-Phosphate Lyase Inhibitors against Multiple Sclerosis: A Successful Drug Discovery Tale

scientific article published on 10 June 2014

The G-Triplex DNA

The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARγ ligands

scientific article published on 16 March 2016

The design of multitarget ligands for chronic and neuropathic pain

scientific article

The effect of d-amino acid substitution on the selectivity of temporin L towards target cells: identification of a potent anti-Candida peptide

scientific article published on 10 September 2012

The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc)

scientific article

The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II

scientific article

The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: Biophysical and molecular modeling studies

scientific article published in 2011

Thiazolidin-4-one formation. Mechanistic and synthetic aspects of the reaction of imines and mercaptoacetic acid under microwave and conventional heating

scientific article published on 3 September 2004

Three-dimensional structure of the alpha-MSH-derived candidacidal peptide [Ac-CKPV]2.

scientific article published in July 2005

To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis

scientific article published on 16 December 2016

Topological Characterization of Nucleic Acid G-Quadruplexes by UV Absorption and Circular Dichroism

scholarly article by Andreas Ioannis Karsisiotis et al published 16 September 2011 in Angewandte Chemie International Edition

Toward a quantitative comparative toxicology of organic compounds.

scientific article published on January 1989

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors

scientific article published on 27 December 2012

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives

article

Toxicity of aflatoxin B1 towards the vitamin D receptor (VDR).

scientific article

Trichoderma harzianum strain T-22 induces changes in phytohormone levels in cherry rootstocks (Prunus cerasus × P. canescens)

Trimeric aldolization product of 1,4-benzothiazine

Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators

article

Tuning RNA Interference by Enhancing siRNA/PAZ Recognition

scientific article

Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations

scientific article published on 03 July 2019

Unprecedented synthesis of a novel amino quinone ring system via oxidative decarboxylation of quinone-based alpha,alpha-amino esters

scientific article published on 8 December 2009

Unraveling the Active Conformation of Urotensin II

Unraveling the active conformation of urotensin II.

scientific article published in March 2004

Unusual reaction of a substituted benzothiazoline with sulphuryl chloride: formation of a 2,2′-(ethane-1,2-diylidene)bis-1,4-benzothiazine dye

Urantide conformation and interaction with the urotensin-II receptor.

scientific article

Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta

scientific article published on December 2003

Urotensin II receptor determines prognosis of bladder cancer regulating cell motility/invasion

scientific article

Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer

scientific article published on 18 September 2015

Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells

scientific article

Urotensin II: A Novel Target in Human Corpus Cavernosum

Urotensin-II Receptor: A Double Identity Receptor Involved in Vasoconstriction and in the Development of Digestive Tract Cancers and other Tumors.

scientific article published on 20 June 2016

Urotensin-II receptor antagonists.

scientific article

Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans.

scientific article published on 22 January 2014

Urotensin-II receptor ligands. From agonist to antagonist activity

scientific article published in November 2005

Urotensin-II receptor peptide agonists

scientific article published in September 2004

Use of Integrated Computational Approaches in the Search for New Therapeutic Agents

scientific article

Use of NMR in profiling of cocaine seizures

scientific article published on 17 May 2013

Use of comparative molecular field analysis and cluster analysis in series design

article

Use of the Hydrophobic Substituent Constant in a Comparative Molecular Field Analysis (CoMFA) on a Set of Anilides Inhibiting the Hill Reaction

Use of the hydrogen bond potential function in a comparative molecular field analysis (CoMFA) on a set of benzodiazepines

scientific article published in June 1993

Visible-Light Photocatalytic Functionalization of Isocyanides for the Synthesis of Secondary Amides and Ketene Aminals

scientific article published on 19 October 2020

WNT Inhibitory Activity of Malus Pumila miller cv Annurca and Malus domestica cv Limoncella Apple Extracts on Human Colon-Rectal Cells Carrying Familial Adenomatous Polyposis Mutations.

scientific article published on 18 November 2017

[1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors.

scientific article published in December 2001

p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells

scientific article published on 28 March 2014

tert-Butylcarbamate-containing histone deacetylase inhibitors: apoptosis induction, cytodifferentiation, and antiproliferative activities in cancer cells

scientific article published on 25 March 2013

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