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List of works by Maria G. Castro

A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics

scientific article

A novel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells in vitro and coronary arteries in vivo after adenovirus-mediated gene transfer

scientific article published on September 2003

ANGI-16IN VIVO AND IN VITRO STUDIES SHOW THAT BRAIN DERIVED ENDOTHELIAL CELLS STIMULATE MIGRATION OF HUMAN, MOUSE AND RAT GLIOMA CELLS.

scientific article

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

scientific article published on March 2016

ATRX mutations and glioblastoma: Impaired DNA damage repair, alternative lengthening of telomeres, and genetic instability.

scientific article published on 27 April 2016

Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain

scientific article published in January 2001

Adenoviral vector-mediated gene therapy for gliomas: coming of age.

scientific article

Adenoviral vectors encoding tumor necrosis factor-alpha and FasL induce apoptosis of normal and tumoral anterior pituitary cells

scientific article published on June 2006

Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types

scientific article published on April 2002

Adenovirus expression of IL-1 and NF-kappaB inhibitors does not inhibit acute adenoviral-induced brain inflammation, but delays immune system-mediated elimination of transgene expression.

scientific article published on September 2003

Adenovirus vector-mediated delivery of the prodrug-converting enzyme carboxypeptidase G2 in a secreted or GPI-anchored form: High-level expression of this active conditional cytotoxic enzyme at the plasma membrane

scientific article published in November 2002

Adenovirus vectors to transfer genes into neurones: implications for gene therapy of neurological disorders.

scientific article published in January 1994

Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes

scientific article

Adenovirus-mediated expression of HSV1-TK or Fas ligand induces cell death in primary human glioma-derived cell cultures that are resistant to the chemotherapeutic agent CCNU.

scientific article published in August 2001

Adenovirus-mediated gene transfer in the ovine pituitary gland is associated with hypophysitis

scientific article

Adenovirus-mediated gene transfer of a secreted transforming growth factor-beta type II receptor inhibits luminal loss and constrictive remodeling after coronary angioplasty and enhances adventitial collagen deposition

scientific article

Adenovirus-mediated gene transfer of transforming growth factor-beta3, but not transforming growth factor-beta1, inhibits constrictive remodeling and reduces luminal loss after coronary angioplasty.

scientific article published on 24 November 2003

Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas

scientific article

Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium

scientific article published in December 1999

Antibodies to neuropeptide precursors expressed as fusion proteins in E. coli their use to examine neuropeptide biosynthetic pathways, intracellular trafficking and physiological activities ⬇️

scientific article published on June 1, 1992

Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression

scientific article

Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM

scientific article

B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma.

scientific article

Biocontrol and PGPR Features in Native Strains Isolated from Saline Soils of Argentina

article

Biosynthesis of corticotrophin-releasing hormone (CRH) in mouse corticotrophic tumour cells expressing the human proCRH gene: intracellular storage and regulated secretion

scientific article published on October 1991

Biosynthesis of corticotropin-releasing hormone in human T-lymphocytes

scientific article published on 01 April 1993

Blockade of cell volume regulatory protein NKCC1 increases TMZ-induced glioma apoptosis and reduces astrogliosis

scientific article published on 11 May 2020

Blockade of mTOR signaling via rapamycin combined with immunotherapy augments antiglioma cytotoxic and memory T-cell functions.

scientific article

Blocking immunosuppressive checkpoints for glioma therapy: the more the Merrier!

scientific article

CD20, CD3, and CD40 ligand microclusters segregate three-dimensionally in vivo at B-cell-T-cell immunological synapses after viral immunity in primate brain

scientific article published on 06 August 2008

CXCR4 increases in-vivo glioma perivascular invasion, and reduces radiation induced apoptosis: A genetic knockdown study.

scientific article

Cell type-specific adenoviral transgene expression in the intact ovine pituitary gland after stereotaxic delivery: an in vivo system for long-term multiple parameter evaluation of human pituitary gene therapy.

scientific article published in February 2001

Cell type-specific expression from viral promoters within replication-deficient adenovirus recombinants in primary neocortical cultures.

scientific article

Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors

scientific article

Cell-type specific expression in the pituitary: physiology and gene therapy.

scientific article

Cell-type-specific and regulatable transgenesis in the adult brain: adenovirus-encoded combined transcriptional targeting and inducible transgene expression

scientific article published in December 2000

Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK.

scientific article published in April 2000

Challenges in the evaluation, consent, ethics and history of early clinical trials - Implications of the Tuskegee 'trial' for safer and more ethical clinical trials

scientific article

Characterizing and targeting PDGFRA alterations in pediatric high-grade glioma

scientific article published on 25 August 2016

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

scientific article

Co-localisation of autoimmune antibodies specific for double stranded DNA with procorticotrophin-releasing hormone within the nucleus of stably transfected CHO-K1 cells.

scientific article published on December 1995

Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.

scientific article

Combining cytotoxic and immune-mediated gene therapy to treat brain tumors

scientific article

Consensus guidelines for the detection of immunogenic cell death

scientific article published on October 2014

Corticotrophin-releasing hormone receptor type 1: generation and characterization of polyclonal antipeptide antibodies and their localization in pituitary cells and cortical neurones in vitro

scientific article published on July 1996

Corticotropin-releasing (CRH) activity of thymic peptides on CRH-insensitive corticotropic tumor cells.

scientific article published on January 1993

Cracking the glioma-NK inhibitory code: toward successful innate immunotherapy

scientific article published in November 2014

Current and future strategies for the treatment of malignant brain tumors.

scientific article

Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells.

scientific article

Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells

scientific article published in March 2001

Dendritic cell-based immunotherapy for glioma: multiple regimens and implications in clinical trials

scientific article

Differential Effect of Aging on Serum Levels of Prolactin and -Melanotropin in Rats

scientific article published on 01 February 1991

Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration.

scientific article

Diminished Diurnal Secretion of Corticosterone in Aging Female but Not Male Rats

scientific article published on 01 January 1989

Direct regulation of GnRH transcription by CRF-like peptides in an immortalized neuronal cell line

scientific article published on October 1998

Effect of the corticotrophin releasing hormone precursor on interleukin-6 release by human mononuclear cells

scientific article published on October 1997

Effective high-capacity gutless adenoviral vectors mediate transgene expression in human glioma cells.

scientific article

Effectiveness and preclinical safety profile of doxycycline to be used "off-label" to induce therapeutic transgene expression in a phase I clinical trial for glioma

scientific article published on September 2013

Effects of corticotrophin-releasing factor and arginine-vasopressin on proopiomelanocortin (POMC) mRNA levels, release and storage of adrenocorticotrophin from mouse anterior pituitary cells

scientific article published on 01 January 1993

Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model

scientific article published on November 2004

Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination

scientific article

Electrophysiological evidence against a neurotransmitter role of corticotropin-releasing hormone (CRH) in primary somatosensory cortex

scientific article published in May 1998

Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design.

scientific article published on June 2011

Estrogens sensitize anterior pituitary gland to apoptosis

scientific article

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

article

Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology

scientific article

Expression and partial purification of human prolactin in Escherichia coli.

scientific article published in January 1991

Expression of Biologically Active Procorticotrophin-Releasing Hormone (proCRH) in Stably Transfected CHO-K1 Cells: Characterization of Nuclear proCRH

scientific article published on 01 April 1995

Expression of biologically active human pre-procorticotropin releasing hormone in E. coli: characterization and purification

scientific article published in January 1990

Expression of prolactin receptors and regulation of cell proliferation by prolactin, corticotropin-releasing factor, and corticosterone in a neuroblastoma cell line

scientific article published on January 2002

Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion

scientific article

Fas ligand-transfected myoblasts and islet cell transplantation.

scientific article

FasL induces Fas/Apo1-mediated apoptosis in human embryonic kidney 293 cells routinely used to generate E1-deleted adenoviral vectors.

scientific article published on April 1998

Fitness, insulin sensitivity, and frontal lobe integrity in adults with overweight and obesity.

scientific article published on 28 April 2016

Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model.

scientific article published on 13 December 2007

Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.

scientific article published on 19 February 2008

Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain

scientific article

Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms.

scientific article

Gene therapy and targeted toxins for glioma

article

Gene therapy and virotherapy: novel therapeutic approaches for brain tumors ⬇️

scientific article published on October 1, 2010

Gene therapy continues to make progress: clinical and regulatory perspectives

scientific article published on October 2009

Gene therapy for Parkinson's disease: recent achievements and remaining challenges.

scientific article

Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safety.

scientific article

Gene therapy for brain tumors: basic developments and clinical implementation

scientific article

Gene therapy for inherited neurological disorders: towards therapeutic intervention in the Lesch-Nyhan syndrome.

scientific article published in January 1998

Gene therapy for liver transplantation using adenoviral vectors: CD40-CD154 blockade by gene transfer of CD40Ig protects rat livers from cold ischemia and reperfusion injury

scientific article published on January 2004

Gene therapy for pituitary tumors.

scientific article

Gene therapy for pituitary tumours.

scientific article

Gene therapy strategies for intracranial tumours: glioma and pituitary adenomas.

scientific article

Gene therapy strategies for the treatment of pituitary tumours

scientific article published in February 1999

Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics.

scientific article

Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model

scientific article

Gene transfer into cultured bovine ciliary epithelial cells using adenovirus vectors

scientific article published in August 1996

Gene transfer into enteric neurons of the rat small intestine in organ culture using a replication defective recombinant herpes simplex virus type 1 (HSV1) vector, but not recombinant adenovirus vectors

scientific article published in April 1997

Gene transfer into neural cells in vitro using adenoviral vectors

scientific article published in October 2008

Gene transfer into rat brain using adenoviral vectors.

scientific article

Generation and characterization of an antiserum reactive with a proteolytic processing site within rat procorticotrophin-releasing hormone

scientific article published in October 1995

Generation of a recombinant herpes simplex virus type 1 expressing the rat corticotropin- releasing hormone precursor: endoproteolytic processing, intracellular targeting and biological activity

scientific article

Glioma trials and viral tribulations: can anything be concluded from non-controlled trials?

scientific article published on 3 October 2014

HG-02ATRX LOSS PROMOTES TUMOR GROWTH AND IMPAIRS GENETIC STABILITY IN GLIOBLASTOMA.

scientific article published on 21 April 2015

HG-03A NOVEL MOUSE MODEL OF YOUNG ADULT GLIOBLASTOMA: IN VIVO EXPRESSION OF MUTATED IDH1 (R132H) GENE USING THE SLEEPING BEAUTY TRANSPOSASE SYSTEM.

scientific article published on 21 April 2015

HSV1 vectors to study protein targeting in neurones: are glycosyl-phosphatidylinositol anchors polarized targeting signals in neurones?

scientific article published in January 1994

Hemispherical Pediatric High-Grade Glioma: Molecular Basis and Therapeutic Opportunities

scientific article published on 17 December 2020

Herpes simplex virus 1 (HSV-1) helper co-infection affects the distribution of an amplicon encoded protein in glia.

scientific article

Herpes simplex virus type 1 thymidine kinase sequence fused to the lacz gene increases levels of {beta}-galactosidase activity per genome of high-capacity but not first-generation adenoviral vectors in vitro and in vivo.

scientific article published on 10 December 2008

High-Capacity Adenovirus Vector-Mediated Anti-Glioma Gene Therapy in the Presence of Systemic Antiadenovirus Immunity.

scientific article published in June 2008

High-Density Lipoprotein-Mimicking Nanodiscs for Chemo-immunotherapy against Glioblastoma Multiforme

scientific article published on 11 February 2019

High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity.

scientific article published on 20 February 2008

High-capacity, helper-dependent, "gutless" adenoviral vectors for gene transfer into brain

scientific article

Histones and related preparations interfere with immunoassays for peptide hormones

scientific article published on 01 July 1993

Human Flt3L generates dendritic cells from canine peripheral blood precursors: implications for a dog glioma clinical trial

scientific article

Human gene therapy and imaging in neurological diseases

scientific article

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

scientific article published on 01 February 2019

IL-1beta (+3954C/T) polymorphism could protect human immunodeficiency virus (HIV)-infected patients on highly active antiretroviral treatment (HAART) against lipodystrophic syndrome.

scientific article published in March 2008

Identification and Visualization of CD8+ T Cell Mediated IFN-γ Signaling in Target Cells during an Antiviral Immune Response in the Brain ⬇️

scientific article published on August 29, 2011

Immature myeloid cells in the tumor microenvironment: Implications for immunotherapy

scientific article

Immune regulation of transgene expression in the brain: B cells regulate an early phase of elimination of transgene expression from adenoviral vectors

scientific article published on January 2006

Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions

scientific article

Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells

scientific article published on 10 January 2012

Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells.

scientific article

Immunology of neurological gene therapy: how T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapses

scientific article

Immunoreactive delta sleep-inducing peptide secretion from mouse dissociated, anterior pituitary cells: regulation by corticotropin-releasing factor and arginine vasopressin

scientific article

Immunosuppressive Myeloid Cells' Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy

scientific article published on 4 January 2017

Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter.

scientific article published on September 2007

In vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells.

scientific article

In vivo transgene expression from an adenoviral vector is altered following a 6-OHDA lesion of the dopamine system.

scientific article published on 18 April 2005

Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells

scientific article published on 23 July 2009

Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression.

scientific article

Inhibition of 2-Hydroxyglutarate Elicits Metabolic-reprograming and Mutant IDH1 Glioma Immunity in Mice

scientific article published on 17 December 2020

Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain.

scientific article published on February 1999

Intracellular Retention of the Corticotrophin-releasing Hormone (CRH) Precursor Within COS-7 Cells

scientific article published on 01 October 1998

Intracellular compartmentalisation of procorticotrophin releasing hormone

scientific article published on February 1993

Intracellular trafficking of prohormones and proneuropeptides: cell type-specific sorting and targeting

scientific article published on July 1997

Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression.

scientific article published on 15 September 2007

Intrapituitary adenoviral administration of 7B2 can extend life span and reverse endocrinological deficiencies in 7B2 null mice

scientific article published in June 2002

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

scientific article

Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo.

scientific article

Lack of humoral immune response to the tetracycline (Tet) activator in rats injected intracranially with Tet-off rAAV vectors

scientific article

Lentiviral-induced high-grade gliomas in rats: the effects of PDGFB, HRAS-G12V, AKT, and IDH1-R132H.

scientific article

Marmosets as a preclinical model for testing "off-label" use of doxycycline to turn on Flt3L expression from high-capacity adenovirus vectors

scientific article

Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1.

scientific article published on 4 January 2017

Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy.

scientific article

Mitochondrial haplogroup T is negatively associated with the status of elite endurance athlete

scientific article published on 27 June 2007

Molecular therapy in a model neuroendocrine disease: developing clinical gene therapy for pituitary tumours.

scientific article

Multiple Expressed Endogenous Glioma Epitopes as Novel Vaccines for Gliomas

scientific article published on 12 August 2016

Mutant ATRX: uncovering a new therapeutic target for glioma.

scientific article

Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer

scientific article published on 06 January 2017

Native Chromatin Immunoprecipitation Using Murine Brain Tumor Neurospheres

scientific article published on 29 January 2018

Natural killer cells eradicate galectin-1-deficient glioma in the absence of adaptive immunity

scientific article

Natural killer cells require monocytic Gr-1(+)/CD11b(+) myeloid cells to eradicate orthotopically engrafted glioma cells

scientific article published on 16 March 2016

Neocortical neuronal polarity: targeting of a foreign protein linked to a glycosyl-phosphatidylinositol (GPI) anchor in postmitotic neurons and polarized distribution of a marker of the trans-Golgi network (TGN 38).

scientific article

Neuro-oncology: The long and winding road--gene therapy for glioma

scientific article published on 24 September 2013

Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity

scientific article published in March 1999

Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease.

scientific article

Neuropeptide gene transfer into neuronal and glial cell lines

scientific article published in January 1994

Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders

scientific article

Normalization of wound healing and diabetic markers in organ cultured human diabetic corneas by adenoviral delivery of c-Met gene

scientific article

Nuclear and cytoplasmic localisation of procorticotrophin releasing hormone in transfected CHO-K1 cells.

scientific article published in January 1994

Nuclear localisation of corticotrophin releasing hormone (CRH) in transfected CHO-K1 cells

scientific article published on 01 August 1993

Nuclear translocation of neuropeptides: possible nuclear roles

scientific article published on 01 July 1995

On the stimulatory nature of the control of MSH secretion in ducks

scientific article published in December 1986

One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.

scientific article

Overview of current immunotherapeutic strategies for glioma

scientific article

PTPS-15ATRX LOSS PROMOTES TUMOR GROWTH AND IMPAIRS NON-HOMOLOGOUS END JOINING DNA REPAIR IN GLIOMA.

scientific article

Photoperiodic regulation of prolactin gene expression in the Syrian hamster by a pars tuberalis-derived factor.

scientific article

Piry virus antibodies in inhabitants of Rio de Janeiro

scientific article published in October 1993

Platelets mediate cytotoxic T lymphocyte-induced liver damage

scientific article

Polarity development and synaptogenesis in low density primary cultures of neocortex. Use of herpes simplex virus-1 vectors to transfer genes into postmitotic neurons

scientific article published in February 1993

Polarized Distribution of the Trans-Golgi Network Marker TGN38 During the In Vitro Development of Neocortical Neurons: Effects of Nocodazole and Brefeldin A

article

Politically correct gene therapy? A "clean environment" improves gene delivery to the brain!

scientific article published in April 1999

Post-translational processing of proopiomelanocortin in the pituitary and in the brain

scientific article published on January 1997

Potential impact of a presumed increase in the biting activity of dengue-virus-infected Aedes aegypti (Diptera: Culicidae) females on virus transmission dynamics.

scientific article published on September 2011

Preclinical Efficacy and Safety Profile of Allometrically Scaled Doses of Doxycycline Used to Turn "On" Therapeutic Transgene Expression from High-Capacity Adenoviral Vectors in a Glioma Model

scientific article published on 08 April 2016

Preclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapy

scientific article

Prediction of protein antigenic sites in human corticotrophin-releasing hormone precursor

scientific article published in March 1993

Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors

scientific article

Presence of pro-vasopressin mRNA, neurophysin and arginine vasopressin in mouse anterior pituitary cells and the AtT-20 corticotrophic tumour cell line

scientific article published on July 1988

Pro-opiomelanocortin and pro-vasopressin converting enzyme in pituitary secretory vesicles

scientific article

Processing of Procorticotropin-Releasing Hormone (Pro-CRH): Molecular Forms of CRH in Normal and Preeclamptic Pregnancy1

scientific article published on 01 February 2000

Procorticotrophin releasing hormone is endoproteolytically processed by the prohormone convertase PC2 but not by PC1 within stably transfected CHO-K1 cells

scientific article published on 01 August 1996

Procorticotrophin-releasing hormone: endoproteolytic processing and differential release of its derived peptides within AtT20 cells.

scientific article

Production and release of corticotropin releasing hormone (CRH) from AtT-20 cells stably transfected with the human CRH gene

scientific article published on December 1990

Progesterone antagonizes the permissive action of estradiol on tumor necrosis factor-alpha-induced apoptosis of anterior pituitary cells.

scientific article

Progress and challenges in viral vector-mediated gene transfer to the brain.

scientific article published on August 2002

Progress in gene therapy for neurological disorders.

scientific article published on 23 April 2013

Prohormone and proneuropeptide synthesis and secretion.

scientific article published on October 1997

Prospects of biological and synthetic pharmacotherapies for glioblastoma

scientific article published on 20 January 2020

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

scientific article published on 30 July 2020

Pushing the limits of glioma resection using electrophysiologic brain mapping

scientific article published on 23 April 2012

Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction.

scientific article

Real-time imaging of gene promoter activity using an adenoviral reporter construct demonstrates transcriptional dynamics in normal anterior pituitary cells.

scientific article published in July 2003

Recent advances and future of immunotherapy for glioblastoma

scientific article published on 13 July 2016

Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.

scientific article

Regulated, adenovirus-mediated delivery of tyrosine hydroxylase suppresses growth of estrogen-induced pituitary prolactinomas

scientific article published in December 2001

Reversibility of glioma stem cells' phenotypes explains their complex in vitro and in vivo behavior: Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells as a disco

scientific article published on 24 August 2016

Safety Profile of Gutless Adenovirus Vectors Delivered into the Normal Brain Parenchyma: Implications for a Glioma Phase 1 Clinical Trial ⬇️

scientific article published on September 5, 2012

Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma ⬇️

scientific article published on February 9, 2013

Simultaneous detection of amplicon and HSV-1 helper encoded proteins reveals that neurons and astrocytoma cells do express amplicon-borne transgenes in the absence of synthesis of virus immediate early proteins

scientific article

Single vs. combination immunotherapeutic strategies for glioma.

scientific article

Sphingosine-1 Phosphate: A New Modulator of Immune Plasticity in the Tumor Microenvironment

scientific article

Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses

scientific article published on June 2005

Strong promoters are the key to highly efficient, noninflammatory and noncytotoxic adenoviral-mediated transgene delivery into the brain in vivo

scientific article published in October 2000

Studies on the prolactin-releasing mechanism of histones H2A and H2B

scientific article published on 01 April 2000

Subcellular post-transcriptional targeting: delivery of an intracellular protein to the extracellular leaflet of the plasma membrane using a glycosyl-phosphatidylinositol (GPI) membrane anchor in neurons and polarised epithelial cells

scientific article published in November 2000

Survival and Proliferation of Neural Progenitor-Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

scientific article published on 19 August 2016

Switching on and off transgene expression within lactotrophic cells in the anterior pituitary gland in vivo

scientific article published on June 2001

Synaptogenesis and distribution of presynaptic axonal varicosities in low density primary cultures of neocortex: an immunocytochemical study utilizing synaptic vesicle-specific antibodies, and an electrophysiological examination utilizing whole cell

article

Synthetic HDL Nanoparticles Delivering Docetaxel and CpG for Chemoimmunotherapy of Colon Adenocarcinoma

scientific article published on 05 March 2020

Synthetic high-density lipoprotein nanodiscs for personalized immunotherapy against gliomas

scientific article published on 21 May 2020

Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

scientific article published on 10 November 2020

T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury

scientific article

Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation.

scientific article

Temozolomide does not impair gene therapy-mediated antitumor immunity in syngeneic brain tumor models

scientific article published on 05 February 2014

The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas

scientific article published on 01 January 2020

The Long and Winding Road: From the High-Affinity Choline Uptake Site to Clinical Trials for Malignant Brain Tumors

scientific article published on 23 April 2016

The regulation of the corticomelanotropic cell activity in Aves--II. Effect of various peptides on the release of ACTH from dispersed, perfused duck pituitary cells

scientific article published in January 1986

The regulation of the corticomelanotropic cell activity in aves. III--Effect of various peptides on the release of MSH from dispersed, perfused duck pituitary cells. Cosecretion of ACTH with MSH.

scientific article

The use of inclusion bodies, isolated from Escherichia coli expressing corticotrophin-releasing hormone precursor, to raise specific antibodies against the neuropeptide moiety

scientific article

The value of EGFRvIII as the target for glioma vaccines.

scientific article published on January 2014

Therapeutic efficacy of immune stimulatory thymidine kinase and fms-like tyrosine kinase 3 ligand (TK/Flt3L) gene therapy in a mouse model of high grade brainstem glioma

scientific article published on 24 April 2020

Thymosin peptides stimulate corticotropin release by a calcium-dependent mechanism

scientific article published on January 1993

Thymus-pituitary interactions during ageing

scientific article published in January 1993

Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus-mediated CTLA4Ig expression

scientific article

Towards global and long-term neurological gene therapy: unexpected transgene dependent, high-level, and widespread distribution of HSV-1 thymidine kinase throughout the CNS.

scientific article published in November 2001

Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride-induced hyperplastic anterior pituitaries

scientific article published on September 2000

Transmembrane signals mediating adrenocorticotropin release from mouse anterior pituitary cells

scientific article

Transposon mediated integration of plasmid DNA into the subventricular zone of neonatal mice to generate novel models of glioblastoma

scientific article

Treatment of experimental glioma by administration of adenoviral vectors expressing Fas ligand

scientific article published in July 1999

Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials

scientific article

Uptake of alpha-(L)-iduronidase produced by retrovirally transduced fibroblasts into neuronal and glial cells in vitro

scientific article published on January 1997

Use of gene transfer to study post-translational modifications of neuropeptides in cell lines

scientific article published on January 1994

Use of recombinant adenovirus for gene transfer into the rat brain. Evaluation of gene transfer efficiency, toxicity, and inflammatory and immune reactions

scientific article published in January 2003

Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells

scientific article published in April 1998

Use of recombinant vectors derived from herpes simplex virus 1 mutant tsK for short-term expression of transgenes encoding cytoplasmic and membrane anchored proteins in postmitotic polarized cortical neurons and glial cells in vitro

scientific article

γ-Glutamyl transferase: a marker of nonalcoholic fatty liver disease in patients with the metabolic syndrome.

scientific article published in July 2012

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