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List of works by Fernando Queiroz Cunha

-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice

scientific article published on 02 October 2018

15d-PGJ-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice

scientific article published in Scientific Reports

15d-prostaglandin J2 inhibits inflammatory hypernociception: involvement of peripheral opioid receptor

scientific article

5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection

scientific article published on 4 February 2013

5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality

scientific article published on 31 October 2013

5-lipoxygenase is a key determinant of acute myocardial inflammation and mortality during Trypanosoma cruzi infection

scientific article published on 8 April 2010

9The PI3Kγ/AKT signaling pathway mediates peripheral antinociceptive action of dipyrone

scientific article published on 26 September 2020

A controversial role for IL-12 in immune response and bone resorption at apical periodontal sites.

scientific article published on January 2010

A crucial role for IL-6 in the CNS of rats during fever induced by the injection of live E. coli

scientific article published on 5 June 2011

A novel model of megavoltage radiation-induced oral mucositis in hamsters: Role of inflammatory cytokines and nitric oxide

scientific article published on 20 March 2015

A novel technique to perform direct intraganglionar injections in rats

scientific article published on 14 September 2006

ATP-Sensitive Potassium Channel Blockage Attenuates Cisplatin-Induced Renal Damage

scientific article published on 17 July 2007

Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.

scientific article published on 28 January 2012

Activation of peripheral kappa/delta opioid receptors mediates 15-deoxy-(Delta12,14)-prostaglandin J2 induced-antinociception in rat temporomandibular joint

scientific article

Activation pattern of neutrophils from blood of elderly individuals with Candida-related denture stomatitis

scientific article published on 26 November 2011

Acute and persistent nociceptive paw sensitisation in mice: the involvement of distinct signalling pathways

scientific article published on 5 November 2009

Adhesion molecules and Differentiation Syndrome: phenotypic and functional analysis of the effect of ATRA, As2O3, phenylbutyrate, and G-CSF in acute promyelocytic leukemia

scientific article published in December 2007

Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice.

scientific article

Adjunctive Benefits of Systemic Etoricoxib in Non-Surgical Treatment of Aggressive Periodontitis: Short-Term Evaluation

scientific article published in September 2008

Agglutinin isolated from the red marine alga Hypnea cervicornis J. Agardh reduces inflammatory hypernociception: involvement of nitric oxide

scientific article published on 30 June 2010

Amifostine (Wr-2721) Prevents Indomethacin-Induced Gastric Damage in Rats: Role of Non-Protein Sulfhydryl Groups and Leukocyte Adherence

scientific article published on 08 December 2006

Amifostine and glutathione prevent ifosfamide- and acrolein-induced hemorrhagic cystitis

scientific article published on 17 May 2006

An anti-inflammatory lectin from Luetzelburgia auriculata seeds inhibits adhesion and rolling of leukocytes and modulates histamine and PGE2 action in acute inflammation models

scientific article published on 12 September 2009

An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice

scientific article published on 16 July 2013

Angiotensin II potentiates inflammatory edema in rats: Role of mast cell degranulation

scientific article published on 26 April 2006

Anti-inflammatory activity and possible mechanism of extract from Mikania laevigata in carrageenan-induced peritonitis

Anti-inflammatory activity and possible mechanism of extract from Mikania laevigata in carrageenan-induced peritonitis.

scientific article published in August 2009

Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands.

scientific article

Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: Inhibition of cytokine production-dependent mechanism

scientific article published on 01 February 2007

Anti-inflammatory and anti-nociceptive activity of risedronate in experimental pain models in rats and mice

scientific article published on 01 July 2006

Anti-inflammatory effects of LASSBio-998, a new drug candidate designed to be a p38 MAPK inhibitor, in an experimental model of acute lung inflammation ⬇️

scientific article published on 01 January 2011

Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation

scientific article published in April 2008

Anti-nociceptive effect of thalidomide on zymosan-induced experimental articular incapacitation

scientific article published on 10 March 2006

Anticoagulant and fibrinogenolytic properties of the venom of Polybia occidentalis social wasp

scientific article published in October 2010

Antigen-induced inflammatory mechanical hypernociception in mice is mediated by IL-18.

scientific article published on 27 December 2006

Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain.

scientific article

Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes☆

scientific article published on 12 June 2010

Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats.

scientific article

Aorta Remodeling Due to Stretch or Turbulent Flow/Low Wall Shear Stress: Distinctly Different Biological Phenomena?

Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state.

scientific article published on 04 October 2016

Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect

scientific article published on 23 March 2017

Aryl hydrocarbon receptor (AhR) activation contributes to high‐fat diet‐induced vascular dysfunction

scientific article published on 17 February 2022

B cells are involved in the modulation of pathogenic gut immune response in food-allergic enteropathy.

scientific article

B lymphocyte-induced maturation protein 1 controls TH9 cell development, IL-9 production, and allergic inflammation

scientific article published on 07 August 2018

Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses asthma-like responses via nitric oxide synthase 2 activity

scientific article published in July 2003

Baroreflex activation in conscious rats modulates the joint inflammatory response via sympathetic function.

scientific article

Biomass smoke COPD has less tomographic abnormalities but worse hypoxemia compared with tobacco COPD

scientific article published on 25 April 2019

Blockade of Bradykinin Receptors or Angiotensin II Type 2 Receptor Prevents Paclitaxel-Associated Acute Pain Syndrome in Mice

scientific article published on 23 September 2020

Blockage of Eosinopoiesis by IL-17A Is Prevented by Cytokine and Lipid Mediators of Allergic Inflammation

scientific article published on 23 June 2015

Bosentan, a mixed endothelin receptor antagonist, inhibits superoxide anion-induced pain and inflammation in mice.

scientific article

Bosentan, an endothelin receptor antagonist, ameliorates collagen-induced arthritis: the role of TNF-α in the induction of endothelin system genes

scientific article

Bothrops jararacussu snake venom-induces a local inflammatory response in a prostanoid- and neutrophil-dependent manner.

scientific article published on 12 August 2014

Brain Stimulation Differentially Modulates Nociception and Inflammation in Aversive and Non-aversive Behavioral Conditions

scientific article published on 18 May 2018

Budlein A, a Sesquiterpene Lactone From , Alleviates Pain and Inflammation in a Model of Acute Gout Arthritis in Mice

scholarly article by Victor Fattori et al published 2018 in Frontiers in Pharmacology

CCR2 Expression in Neutrophils Plays a Critical Role in Their Migration Into the Joints in Rheumatoid Arthritis.

scientific article published in July 2015

CCR2 Plays a Protective Role in Rocio Virus-Induced Encephalitis by Promoting Macrophage Infiltration Into the Brain

scientific article published on 01 May 2019

CCR2-deficient mice are protected to sepsis by the disruption of the inflammatory monocytes emigration from the bone marrow

scientific article published on 05 October 2020

CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis

scientific article published on 21 July 2015

CCR5-Positive Inflammatory Monocytes are Crucial for Control of Sepsis

scientific article published on 01 November 2019

CD28 is required for T cell activation and IFN-gamma production by CD4+ and CD8+ T cells in response to Trypanosoma cruzi infection

article

CXCR2‐specific chemokines mediate leukotriene B4–dependent recruitment of neutrophils to inflamed joints in mice with antigen‐induced arthritis

scientific article published on 01 July 2008

Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats

scientific article

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

scientific article published on 17 April 2018

Carbon monoxide and nitric oxide modulate hyperosmolality-induced oxytocin secretion by the hypothalamus in vitro

scientific article published on 3 June 2010

Carbon monoxide and nitric oxide modulate hyperosmolality-induced oxytocin secretion by the hypothalamusin vitro

scientific article published in 2010

Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxide-dependent activation of G protein receptor kinase.

scientific article published on 19 May 2017

Cardiovascular and inflammatory response to cholecystokinin during endotoxemic shock

scientific article published in January 2013

Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation

scientific article published on 24 July 2017

Caspase-1 is involved in the genesis of inflammatory hypernociception by contributing to peripheral IL-1β maturation

scientific article published on 4 October 2010

Chemical Composition and Acaricidal Activity againstTetranychus urticaeof Essential Oil fromMarsypianthes chamaedrys(Vahl.) Kuntze

article

Chemical composition, antinociceptive and anti-inflammatory effects in rodents of the essential oil of Peperomia serpens (Sw.) Loud

article

Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages

scientific article

Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway

scientific article published on 26 November 2019

Chronic Toxoplasma gondii Infection Exacerbates Secondary Polymicrobial Sepsis.

scientific article published on 07 April 2017

Cinnamoyloxy-mammeisin Isolated from Geopropolis Attenuates Inflammatory Process by Inhibiting Cytokine Production: Involvement of MAPK, AP-1, and NF-κB.

scientific article published in July 2016

Circulating neutrophils may play a role in the host response in cervical cancer

scientific article published on 26 March 2007

Collagen induced arthritis (CIA) in mice features regulatory transcriptional network connecting major histocompatibility complex (MHC H2) with autoantigen genes in the thymus

article

Comparative expression of RANK, RANKL, and OPG in keratocystic odontogenic tumors, ameloblastomas, and dentigerous cysts

scientific article published on 03 December 2007

Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice

scientific article published on 28 May 2019

Correction: T Cell Post-Transcriptional miRNA-mRNA Interaction Networks Identify Targets Associated with Susceptibility/Resistance to Collagen-induced Arthritis.

correction of a scientific article

Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis

scientific article

Crucial role of neutrophils in the development of mechanical inflammatory hypernociception

scientific article

Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation

scientific article

Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow

scientific article

Cytokine-induced neutrophil chemoattractant 1 (CINC-1) mediates the sympathetic component of inflammatory mechanical hypersensitivitiy in rats.

scientific article

DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain

scientific article published on 16 November 2015

DMH-CBD, a cannabidiol analog with reduced cytotoxicity, inhibits TNF production by targeting NF-kB activity dependent on A2A receptor

scientific article published on 20 February 2019

Decreased levels of alpha-1-acid glycoprotein are related to the mortality of septic patients in the emergency department

scientific article published on January 2013

Detrimental role of endogenous nitric oxide in host defence against Sporothrix schenckii.

scientific article

Development of a lethal model of peritonitis for assessment of laparoscopic and laparotomic treatments in rats

scientific article published in January 2007

Diabetes Mellitus and Sepsis: A Challenging Association.

scientific article

Different inflammatory mediators induce inflammation and pain after application of liquid nitrogen to the skin

Differential expression of osteoblast and osteoclast chemmoatractants in compression and tension sides during orthodontic movement

scientific article published on 11 April 2008

Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice

scientific article published on 24 October 2016

Diosmin reduces chronic constriction injury-induced neuropathic pain in mice

scientific article published on 15 June 2017

Direct blockade of inflammatory hypernociception by peripheral A1 adenosine receptors: involvement of the NO/cGMP/PKG/KATP signaling pathway

scientific article published on September 2010

Disruption of sarcolemmal dystrophin and beta-dystroglycan may be a potential mechanism for myocardial dysfunction in severe sepsis.

scientific article

Divergent Role OF Heme Oxygenase Inhibition in the Pathogenesis of Sepsis

scientific article published on 01 June 2011

Docking, synthesis and pharmacological activity of novel urea-derivatives designed as p38 MAPK inhibitors.

scientific article

Down-regulation of CXCR2 on Neutrophils in Severe Sepsis Is Mediated by Inducible Nitric Oxide Synthase–derived Nitric Oxide

scientific article published on 30 November 2006

Down-regulation of expression of osteoblast and osteocyte markers in periodontal tissues associated with the spontaneous alveolar bone loss of interleukin-10 knockout mice.

scientific article published in February 2010

Dual effect of Lutzomyia longipalpis saliva on Leishmania braziliensis infection is mediated by distinct saliva-induced cellular recruitment into BALB/c mice ear

scientific article

Dual effect of local application of nitric oxide donors in a model of incision pain in rats

scientific article

Dual function of the long pentraxin PTX3 in resistance against pulmonary infection with Klebsiella pneumoniae in transgenic mice

scientific article published on 24 March 2006

Dual role of CCL3/CCR1 in oral squamous cell carcinoma: implications in tumor metastasis and local host defense

scientific article published on 01 November 2007

Dual role of hydrogen sulfide in mechanical inflammatory hypernociception

scientific article published on 7 June 2008

Dynamic changes of the Th17/Tc17 and regulatory T cell populations interfere in the experimental autoimmune diabetes pathogenesis

scientific article published on 23 May 2012

Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice

scientific article

Effect of endogenous hydrogen sulfide inhibition on structural and functional renal disturbances induced by gentamicin ⬇️

scientific article published on February 16, 2012

Effect of gedunin on acute articular inflammation and hypernociception in mice

scientific article published on 3 February 2015

Effect of mast cells depletion on the failure of neutrophil migration during sepsis

scientific article published on 2 November 2005

Effect of salivary gland extract of Leishmania vector, Lutzomyia longipalpis, on leukocyte migration in OVA-induced immune peritonitis.

scientific article published in August 2005

Effects of lidocaine infusion during experimental endotoxemia in horses.

scientific article published on July 2010

Effects of the treatment with glibenclamide, an ATP-sensitive potassium channel blocker, on intestinal ischemia and reperfusion injury

scientific article published on 3 November 2006

Endothelin-1 induces neutrophil recruitment in adaptive inflammation via TNFα and CXCL1/CXCR2 in mice

scientific article published on 09 February 2012

Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1.

scientific article

Eotaxin-2 in sputum cell culture to evaluate asthma inflammation.

scientific article published in November 2006

Erratum to: The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-κB and Cytokines

scientific article published on 6 September 2017

Erratum to: The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia

scholarly article published in Naunyn-Schmiedeberg's Archives of Pharmacology

Essential role of CCR2 in neutrophil tissue infiltration and multiple organ dysfunction in sepsis

scientific article published on 23 August 2010

Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection

scientific article

Essential roles of PKA, iNOS, CD95/CD95L, and terminal caspases in suppression of eosinopoiesis by PGE2 and other cAMP-elevating agents

Estradiol and thermoregulation in adult endotoxemic rats exposed to lipopolysaccharide in neonatal life

scientific article published on 12 August 2011

Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice

scientific article published on 02 May 2019

Exposure to low doses of malathion during juvenile and peripubertal periods impairs testicular and sperm parameters in rats: Role of oxidative stress and testosterone

scientific article published on 29 May 2020

Factors involved in the T helper type 1 and type 2 cell commitment and osteoclast regulation in inflammatory apical diseases.

scientific article published in February 2009

Failure of neutrophil chemotactic function in breast cancer patients treated with chemotherapy

scientific article published on 27 August 2005

Failure of neutrophil chemotactic function in septic patients.

scientific article

Failure of neutrophil migration toward infectious focus in severe sepsis: a critical event for the outcome of this syndrome

scientific article published in March 2005

Feedback inhibition of nitric oxide synthase activity by nitric oxide ⬇️

scientific article published on March 1, 1993

Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms

article

Fractalkine mediates inflammatory pain through activation of satellite glial cells

scientific article published on 17 June 2013

Frontline Science: Blood-circulating leukocytes fail to infiltrate the spinal cord parenchyma after spared nerve injury

scientific article published on 31 May 2019

Fructose 1,6-bisphosphate inhibits osteoclastogenesis by attenuating RANKL-induced NF-κB/NFATc-1

scientific article published on 29 March 2019

Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway

scientific article

Galectin-3 aggravates experimental polymicrobial sepsis by impairing neutrophil recruitment to the infectious focus

scientific article published on 04 July 2018

Gastric damage induced by different doses of indomethacin in rats is variably affected by inhibiting iNOS or leukocyte infiltration

scientific article published in January 2008

Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils

scientific article published on 27 December 2011

Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei

scientific article published in March 2014

Gastroprotective effect of heme-oxygenase 1/biliverdin/CO pathway in ethanol-induced gastric damage in mice

scientific article published on September 2010

Genetic selection for susceptibility to oral tolerance leads to a profound reduction of the acute inflammatory response

scientific article published on 01 December 2004

Glutamine depletion potentiates leucocyte-dependent inflammatory events induced by carrageenan or Clostridium difficile toxin A in rats

scientific article published in November 2005

Granulocyte-Colony Stimulating Factor (G-CSF) induces mechanical hyperalgesia via spinal activation of MAP kinases and PI3K in mice

scientific article published on 12 January 2011

Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10

scientific article published on 10 January 2015

Green propolis increases myeloid suppressor cells and CD4+Foxp3+ cells and reduces Th2 inflammation in the lungs after allergen exposure

scientific article published on 21 December 2019

HPV16, HPV18, and HIV infection may influence cervical cytokine intralesional levels

scientific article published in April 2005

Haeme oxygenase activity protects the host against excessive cardiac inflammation during experimental Trypanosoma cruzi infection.

scientific article

Heat-killed Enterococcus faecalis Alters Nitric Oxide and CXCL12 Production but not CXCL8 and CCL3 Production by Cultured Human Dental Pulp Fibroblasts

article

Hematopoietic SCT modulates gut inflammation in experimental inflammatory bowel disease.

scientific article published on 15 March 2010

Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis

scientific article published in April 2013

Hepatic Osteodystrophy: The Mechanism of Bone Loss in Hepatocellular Disease and the Effects of Pamidronate Treatment.

scientific article

Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation

scientific article published on 13 June 2018

High serum nitric oxide levels in patients with severe leptospirosis

scientific article published on December 2006

Histamine h2 receptor signaling in the pathogenesis of sepsis: studies in a murine diabetes model

scientific article

Histological and molecular temporomandibular joint analyses after mandibular advancement surgery: study in minipigs.

scientific article

Hydrogen sulfide augments neutrophil migration through enhancement of adhesion molecule expression and prevention of CXCR2 internalization: role of ATP-sensitive potassium channels

scientific article published in September 2008

Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activation

scientific article published on 25 March 2010

Hydrogen sulfide prevents ethanol-induced gastric damage in mice: role of ATP-sensitive potassium channels and capsaicin-sensitive primary afferent neurons.

scientific article published on 2 June 2009

Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats.

scientific article published on 16 April 2015

Hypernociception elicited by tibio-tarsal joint flexion in mice: a novel experimental arthritis model for pharmacological screening

scientific article published on 21 June 2006

Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?

scientific article

IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production

scientific article published in December 2007

IL-15 mediates immune inflammatory hypernociception by triggering a sequential release of IFN-gamma, endothelin, and prostaglandin

scholarly article

IL-17 mediates articular hypernociception in antigen-induced arthritis in mice

scientific article published on 6 December 2009

IL-17 receptor signaling is required to control polymicrobial sepsis

scientific article

IL-18 Enhances Collagen-Induced Arthritis by Recruiting Neutrophils Via TNF- and Leukotriene B4

scientific article published on 01 July 2003

IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10

scientific article published on 01 January 2019

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population.

scientific article published on 4 April 2017

IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis

scientific article published on 04 September 2020

IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy

scientific article published on 14 May 2010

IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice

scholarly article

IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system

scientific article

IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice.

scientific article

IL-4 regulates susceptibility to intestinal inflammation in murine food allergy.

scientific article

Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation.

scientific article

In-depth Analysis of Laboratory Parameters Reveals the Interplay Between Sex, Age and Systemic Inflammation in Individuals with COVID-19

scholarly article by Felipe ten-Caten published in 2021

In-plane behavior of cavity masonry infills and strengthening with textile reinforced mortar

article by Farhad Akhoundi et al published February 2018 in Engineering Structures

Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System

scientific article

Increased activities of cardiac matrix metalloproteinases matrix metalloproteinase (MMP)-2 and MMP-9 are associated with mortality during the acute phase of experimental Trypanosoma cruzi infection.

scientific article

Increased sarcolemmal permeability as an early event in experimental septic cardiomyopathy: a potential role for oxidative damage to lipids and proteins

scientific article

Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania

Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania.

scientific article published on 17 April 2018

Induction of bone-marrow eosinophilia in mice submitted to surgery is dependent on stress-induced secretion of glucocorticoids

scientific article published on 20 September 2004

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

scientific article published on 01 March 2021

Inflammation, myocardial dysfunction, and mortality in children with septic shock: an observational study

scientific article published on 4 October 2013

Inflammatory intestinal damage induced by 5-fluorouracil requires IL-4.

scientific article published on 26 October 2012

Inhibition of guanylyl cyclase restores neutrophil migration and maintains bactericidal activity increasing survival in sepsis.

scientific article

Inhibition of hydrogen sulphide formation reduces cisplatin-induced renal damage

scientific article published on 23 July 2010

Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence

scientific article

Inhibition of leukocyte rolling by nitric oxide during sepsis leads to reduced migration of active microbicidal neutrophils.

scientific article

Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice

scientific article

Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain

scientific article published on 27 May 2014

Innovative technique for the study of pneumoperitoneum in the evaluation of abdominal pain after chemical irritation with zymozan

scientific article published on 01 May 2008

Interference of a neutrophil recruitment inhibitory factor upon the accumulation of inflammatory cells and airway hyperreactivity in sensitized guinea‐pigs after intranasal antigen challenge ⬇️

scientific article published on February 1, 1993

Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice

scientific article published on April 2004

Interleukin 6 concentration in ascitic fluid of cirrhotic patients: relationship with previous episodes of spontaneous bacterial peritonitis

scientific article published on 01 January 2003

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages

scientific article published on February 14, 1992

Interleukin-10 limits intense acute swimming-induced muscle mechanical hyperalgesia in mice.

scientific article

Interleukin-10 rs2227307 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock

scientific article published on 2 June 2015

Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis.

scientific article published in September 2007

Interleukin-17 and kidney allograft outcome

scientific article published in June 2009

Interleukin-18 induces mechanical hypernociception in rats via endothelin acting on ETB receptors in a morphine-sensitive manner

scientific article published on 29 March 2004

Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis.

scientific article

Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

scientific article published on 16 May 2010

Interleukin-4 Modulates the Inflammatory Response in Ifosfamide-Induced Hemorrhagic Cystitis

article

Investigations on the biology, epidemiology, pathology and control of Tunga penetrans in Brazil. V. Cytokine concentrations in experimentally infected Wistar rats

scientific article published on 2 October 2004

Involvement of LTB4 in zymosan-induced joint nociception in mice: participation of neutrophils and PGE2.

scientific article published on 3 October 2007

Involvement of NO in the inhibitory effect of Calotropis procera latex protein fractions on leukocyte rolling, adhesion and infiltration in rat peritonitis model

scientific article published on 30 July 2009

Involvement of nitric oxide on the pathogenesis of irinotecan-induced intestinal mucositis: role of cytokines on inducible nitric oxide synthase activation

scientific article published on 20 November 2011

Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception.

scientific article

Irinotecan- and 5-fluorouracil-induced intestinal mucositis: insights into pathogenesis and therapeutic perspectives.

scientific article

Joint NOD2/RIPK2 signaling regulates IL-17 axis and contributes to the development of experimental arthritis

scientific article

Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production

scientific article

Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.

scientific article published on 10 May 2012

LPS from Escherichia coli protects against indomethacin-induced gastropathy in rats--role of ATP-sensitive potassium channels

scientific article published on 25 July 2006

Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis

scientific article published on 7 March 2017

Lectin extracted from Canavalia grandiflora seeds presents potential anti-inflammatory and analgesic effects

scientific article published on 20 January 2009

Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo.

scientific article

Leishmania infantum Parasites Subvert the Host Inflammatory Response through the Adenosine A2A Receptor to Promote the Establishment of Infection

scientific article

Leukotriene B4 is essential for selective eosinophil recruitment following allergen challenge of CD4+ cells in a model of chronic eosinophilic inflammation

scientific article published on 15 June 2008

Lipopolysaccharide from Escherichia coli prevents indomethacin-induced gastric damage in rats: role of non-protein sulfhydryl groups and leukocyte adherence.

scientific article published on 29 April 2009

Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw

scientific article

Lipoxin A(4) attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects

scientific article published on October 2010

Lippia sidoides and Myracrodruon urundeuva gel prevents alveolar bone resorption in experimental periodontitis in rats.

scientific article

Liver X Receptor Activation Impairs Neutrophil Functions and Aggravates Sepsis

scientific article published on 01 April 2020

Local profile of cytokines and nitric oxide in patients with bacterial vaginosis and cervical intraepithelial neoplasia.

scientific article published in August 2007

Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production

scientific article published on 05 March 2007

Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis

scientific article

MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression

scientific article published on 03 August 2020

MIP-1alpha[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4

scientific article published on 14 April 2005

Mast cells control insulitis and increase Treg cells to confer protection against STZ-induced type 1 diabetes in mice

scientific article published on 14 August 2015

Mast cells phagocyte Candida albicans and produce nitric oxide by mechanisms involving TLR2 and Dectin-1.

scientific article published on 7 September 2015

Mechanisms affecting neutrophil migration capacity in breast cancer patients before and after chemotherapy.

scientific article

Mechanisms underlying the hyperalgesic responses triggered by joint activation of TLR4.

scientific article published on 24 August 2016

Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization

scientific article published on 27 May 2016

Mice lacking interleukin-18 gene display behavioral changes in animal models of psychiatric disorders: Possible involvement of immunological mechanisms.

scientific article

Microbicidal activity of eosinophils is associated with activation of the arginine‐NO pathway ⬇️

scientific article published on September 1, 1998

Modulation of monocytes in septic patients: preserved phagocytic activity, increased ROS and NO generation, and decreased production of inflammatory cytokines

scientific article published on 16 February 2016

Modulation of mucosal immunity in a murine model of food-induced intestinal inflammation

scientific article published on 13 November 2007

Modulation of toll-like receptor expression: a further effect of statins?

scientific article published on 01 July 2006

Molecular basis of carrageenan-induced cytokines production in macrophages

scientific article published on 07 September 2020

Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway

scientific article

Morphologic evaluation and expression of matrix metalloproteinases-2 and 9 and nitric oxide during experimental periodontal disease in rat

scientific article published on 05 February 2008

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

scientific journal article

Myenteric denervation in gastric carcinogenesis: differential modulation of nitric oxide and annexin-A1 ⬇️

scientific article published on November 20, 2012

NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection.

scientific article

NLRP12 Attenuates Inflammatory Bone Loss in Experimental Apical Periodontitis

scientific article published on 25 January 2019

NLRP12 controls arthritis severity by acting as a checkpoint inhibitor of Th17 cell differentiation

scientific article published on 07 July 2020

NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B4 in a murine model of gout

article

NOD2 contributes to Porphyromonas gingivalis-induced bone resorption.

scientific article

NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory pain

scientific article published on 8 May 2015

Naringenin mitigates titanium dioxide (TiO)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB

scholarly article by Marília F Manchope et al published 28 October 2018 in Inflammation Research

Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB

scholarly article by Marília F. Manchope et al published 28 October 2018 in Inflammation Research

Neuraminidase inhibitors rewire neutrophil function in murine sepsis and COVID-19 patient cells

scientific article published on 12 November 2020

Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia

scientific article published on 2 June 2017

Neutrophil Extracellular Traps Effectively Control Acute Chikungunya Virus Infection

scientific article published on 01 January 2019

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

scientific article

Neutrophil Migration Induced by IL-1β Depends upon LTB4 Released by Macrophages and upon TNF-α and IL-1β Released by Mast Cells

scientific article published on 01 February 2008

Neutrophil Recruitment and Articular Hyperalgesia in Antigen-Induced Arthritis are Modulated by the Cholinergic Anti-Inflammatory Pathway

scientific article

Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis

scientific article published on 08 April 2019

Neutrophil extracellular traps mediate joint hyperalgesia induced by immune inflammation

scientific article published on 26 December 2020

Neutrophil paralysis in Plasmodium vivax malaria.

scientific article

Neutrophil paralysis in sepsis

scientific article published on September 2010

Neutrophil recruitment in immunized mice depends on MIP-2 inducing the sequential release of MIP-1α, TNF-α and LTB4

scientific article published on 01 August 2006

Neutrophils contribute to the pathogenesis of hemorrhagic cystitis induced by ifosfamide

scientific article published on 06 July 2018

Nitric Oxide and Hydrogen Sulfide Interact When Modulating Gastric Physiological Functions in Rodents.

scientific article

Nitric oxide inhibits neutrophil migration by a mechanism dependent on ICAM-1: role of soluble guanylate cyclase

scientific article published on 18 April 2006

Nitric oxide synthase-mediated phytoalexin accumulation in soybean cotyledons in response to the Diaporthe phaseolorum f. sp. meridionalis elicitor

scientific article published in November 2002

Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway

scientific article

Nociceptive effect of subcutaneously injected interleukin-12 is mediated by endothelin (ET) acting on ETB receptors in rats

scientific journal article

Non-Peptidergic Nociceptive Neurons Are Essential for Mechanical Inflammatory Hypersensitivity in Mice

scientific article published on 23 January 2019

Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis.

scientific article

Nucleosides from Phlebotomus papatasi salivary gland ameliorate murine collagen-induced arthritis by impairing dendritic cell functions.

scientific article

Nucleosides present on phlebotomine saliva induce immunossuppression and promote the infection establishment.

scientific article

Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis

scientific article published in February 2005

Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients

scientific article published on 10 June 2019

PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation

scientific article published on 01 October 2020

PPAR-gamma agonist rosiglitazone prevents inflammatory periodontal bone loss by inhibiting osteoclastogenesis

scientific article

PPAR-γ agonists, mainly 15d-PGJ2, reduce eosinophil recruitment following allergen challenge

scientific article published on 08 December 2011

PPAR-γ/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis

scientific article published on 31 January 2014

Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner

scientific article published on 13 August 2018

Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious

scientific article

Paradoxical interaction between cancer and long-term postsepsis disorder: impairment of de novo carcinogenesis versus favoring the growth of established tumors

scientific article published on 01 May 2020

Pericytes modulate myelination in the central nervous system

scientific article published on 7 December 2017

Periodontal pathogens amplify arthritic bone erosion by reducing the TH2 response and promoting a toll-like receptor 2-dependent TH17 phenotype

Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 response

scientific article published on 28 March 2014

Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain

scientific article published on 01 March 2015

Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway

scholarly article

Peripheral antinociceptive effect of pertussis toxin: activation of the arginine/NO/cGMP/PKG/ ATP-sensitive K channel pathway

scientific article published on 01 August 2006

Peripheral hyperalgesic cytokines.

scientific article

Peripheral nitric oxide signaling directly blocks inflammatory pain

scientific article published on 18 February 2020

Perivascular adipose tissue contributes to lethal sepsis-induced vasoplegia in rats

scientific article published on 27 September 2019

Peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J2, reduces neutrophil migration via a nitric oxide pathway

scientific article published on 01 January 2008

Peroxynitrite mediates neutrophil migration failure in severe polymicrobial sepsis

scientific article published on 26 September 2007

Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in mice

scientific article published on 16 July 2007

Pharmacological Beta-Adrenergic Receptor Activation Attenuates Neutrophil Recruitment by a Mechanism Dependent on Nicotinic Receptor and the Spleen

scientific article

Pharmacological analysis of the neutrophil migration induced by D. rostrata lectin: Involvement of cytokines and nitric oxide

scientific article published on 09 June 2009

Pharmacological opportunities to control inflammatory diseases through inhibition of the leukocyte recruitment

scientific article

Pharmacologically active chemical mediators in plasmodium berghei malaria

article by Renato S. B. Cordeiro et al published 1986 in Memórias do Instituto Oswaldo Cruz

Phlebotomine salivas inhibit immune inflammation-induced neutrophil migration via an autocrine DC-derived PGE2/IL-10 sequential pathway

scientific article

Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.

scientific article published on 27 May 2010

Platelets Fuel the Inflammasome Activation of Innate Immune Cells

scientific article published on 01 May 2020

Porcine spermadhesin PSP-I/PSP-II stimulates macrophages to release a neutrophil chemotactic substance: modulation by mast cells

scientific article published on 11 December 2002

Post-Sepsis State Induces Tumor-Associated Macrophage Accumulation through CXCR4/CXCL12 and Favors Tumor Progression in Mice.

scientific article published on 27 January 2016

Predictive Value of Matrix Metalloproteinases and Their Inhibitors for Mortality in Septic Patients: A Cohort Study

scientific article published in January 2017

Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production

scientific article published on 10 May 2017

Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects

scientific article published on 6 April 2017

Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production

scientific journal article

Protective effect of RC-3095, an antagonist of the gastrin-releasing peptide receptor, in experimental arthritis

scientific article published on 01 October 2011

Protective effect of an extract from Ascaris suum in experimental arthritis models

scientific article published on 14 April 2008

Protective effects of atorvastatin in rat models of acute pulmonary embolism: involvement of matrix metalloproteinase-9.

scientific article published in January 2007

Protective role of 5-lipoxigenase during Leishmania infantum infection is associated with Th17 subset

scientific article

Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-κB and oxidative stress

scientific article published on 09 May 2016

Quercetin Reduces Neutrophil Recruitment Induced by CXCL8, LTB4, and fMLP: Inhibition of Actin Polymerization

scientific article published on 28 January 2011

Quercetin reduces inflammatory pain: inhibition of oxidative stress and cytokine production

scientific article published in November 2009

Reduction of ICAM-1 expression by carbon monoxide via soluble guanylate cyclase activation accounts for modulation of neutrophil migration.

scientific article published on 27 March 2010

Reduction of gap and adherens junction proteins and intercalated disc structural remodeling in the hearts of mice submitted to severe cecal ligation and puncture sepsis.

scientific article published on September 2007

Reduction of gap junction proteins and intercalated disc structural remodeling in the hearts of mice submitted to sepsis.

scientific article published on 26 September 2007

Regulation of angiotensin II receptors levels during rat induced pulpitis.

scientific article

Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis

scholarly article

Regulation of type 17 helper T-cell function by nitric oxide during inflammation

scientific article

Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury

scientific article published on 26 March 2020

Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury.

scientific article

Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation

scientific article published on 31 March 2019

Rheumatoid Arthritis Exacerbates the Severity of Osteonecrosis of the Jaws (ONJ) in Mice. A Randomized, Prospective, Controlled Animal Study

scientific article published on 7 March 2016

Role of CCR2 in orthodontic tooth movement

scientific article published on February 2012

Role of IL-18 in overt pain-like behaviour in mice

scientific article published on 9 April 2008

Role of KATP channels and TRPV1 receptors in hydrogen sulfide-enhanced gastric emptying of liquid in awake mice

scientific article published on 2 August 2012

Role of NOX2-derived ROS in the development of cognitive impairment after sepsis.

scientific article published on 5 November 2013

Role of TNF-α/TNFR1 in intense acute swimming-induced delayed onset muscle soreness in mice

scientific article published on 08 February 2014

Role of cytokines (TNF-α, IL-1β and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide

scientific article published on 12 July 2007

Role of cytokines in mediating mechanical hypernociception in a model of delayed-type hypersensitivity in mice

scientific article published on 26 March 2008

Role of lipocortin‐1 in the anti‐hyperalgesic actions of dexamethasone ⬇️

scientific article published on July 1, 1997

Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice.

scientific article

Role of regulatory T cells in long-term immune dysfunction associated with severe sepsis

scientific article published in August 2010

Routine abdominal drains after Roux-en-Y gastric bypass: a prospective evaluation of the inflammatory response

scientific article published on 6 October 2009

S100A9 plays a pivotal role in a mouse model of herpetic neuralgia via TLR4/TNF pathway

scientific article published on 31 March 2020

SARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability

scientific article

SARS-CoV-2 triggered neutrophil extracellular traps (NETs) mediate COVID-19 pathology

scientific article published on 9 June 2020

SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology

scientific article published on 01 December 2020

SN-38, the active metabolite of irinotecan, inhibits the acute inflammatory response by targeting toll-like receptor 4

scientific article published on 22 April 2019

Serotonin synthesis protects the mouse colonic crypt from DNA damage and colorectal tumorigenesis

scientific article published on 27 June 2019

Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis

scientific article published on 01 July 2006

Sildenafil prevents indomethacin-induced gastropathy in rats: role of leukocyte adherence and gastric blood flow

scientific article published on October 2005

Skin vasodilation and analgesic effect of a topical nitric oxide-releasing hydrogel

scientific article published on 12 June 2013

Sleep restriction during peripuberty unbalances sexual hormones and testicular cytokines in rats

scientific article published on 01 January 2019

Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells.

scientific article published on 8 June 2018

Spermadhesin PSP-I/PSP-II heterodimer and its isolated subunits induced neutrophil migration into the peritoneal cavity of rats

scientific article published in December 2002

Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis

scientific article published on 23 April 2016

Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain

scientific article published on 26 August 2015

Stimulation of peripheral kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway

scientific article published on 8 February 2012

Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes

scientific article published on 12 June 2018

Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice

scientific article published on 18 August 2015

T cell post-transcriptional miRNA-mRNA interaction networks identify targets associated with susceptibility/resistance to collagen-induced arthritis

scientific article (publication date: 2013)

TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis.

scientific article published on 6 February 2018

TGFβ1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of T17 cells by an AHR-independent mechanism

scientific article published on 13 November 2018

TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model

scientific article published on 13 February 2017

TLR2 signaling downregulates chemokine receptor CXCR2 and impairs neutrophil migration in severe polymicrobial sepsis.

scientific article published on 26 September 2007

TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection

scientific article published on 25 March 2020

TNF-alpha mediates the induction of nitric oxide synthase in macrophages but not in neutrophils in experimental cutaneous leishmaniasis

scientific article published on 01 August 2003

TNF-α and IL-1β mediate inflammatory hypernociception in mice triggered by B1 but not B2 kinin receptor

scientific article published on 13 July 2007

Tadalafil analgesia in experimental arthritis involves suppression of intra‐articular TNF release ⬇️

scientific article published on September 1, 2011

Target Inhibition of IL-1 Receptor Prevents Ifosfamide Induced Hemorrhagic Cystitis in Mice.

scientific article published on 26 July 2015

Targeted inhibition of IL-18 attenuates irinotecan-induced intestinal mucositis in mice.

scientific article published on May 2014

Targeting IL-33/ST2 signaling: regulation of immune function and analgesia

scientific article

Targeting endothelin ETA and ETB receptors inhibits antigen-induced neutrophil migration and mechanical hypernociception in mice

scientific article

Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice.

scientific article

Targeting neutrophils in sepsis

scientific article published on 28 May 2014

Targeting nitric oxide as a key modulator of sepsis, arthritis and pain

scientific article published on 30 April 2019

Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief

scientific article

Taurine supplementation increases irisin levels after high intensity physical training in obese women

scientific article published on 18 June 2019

Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron

scholarly article

The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats.

scientific article

The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis

scientific article

The Atypical Chemokine Receptor ACKR2 is Protective Against Sepsis

scientific article published on 24 August 2017

The Effect of Laparoscopy Access and Antibiotics on the Outcome of Severe Bacterial Peritonitis in Rats

scientific article published on 01 February 2008

The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus

scientific article published on 03 September 2019

The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development

scientific article published on 01 January 2019

The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-κB and Cytokines

scientific article published on 01 December 2017

The acute phase of Trypanosoma cruzi infection is attenuated in 5-lipoxygenase-deficient mice

scientific article (publication date: 2014)

The aggravation of arthritis by periodontitis is dependent of IL-17 receptor A activation.

scientific article published on 12 May 2017

The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β

The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation

scientific article published in April 2016

The critical role of heme oxygenase in neutrophil migration impairment in polymicrobial sepsis.

scientific article published on 26 September 2007

The critical role of leukotriene B4 in antigen-induced mechanical hyperalgesia in immunised rats

scientific article

The endogenous cytokine profile and nerve fibre density in mouse ear Leishmania major-induced lesions related to nociceptive thresholds

scientific article published on 30 November 2012

The essential role of IFN-γ in the control of lethal Aggregatibacter actinomycetemcomitans infection in mice

scientific article published on 25 January 2008

The galactose-binding lectin from Vatairea macrocarpa seeds induces in vivo neutrophil migration by indirect mechanism

scientific article published in December 2003

The host control of a clinical isolate strain of P. aeruginosa infection is independent of Nod-1 but depends on MyD88.

scientific article published on 15 February 2018

The influence of glutathione modulators on the course of Leishmania major infection in susceptible and resistant mice

scientific article published in March 2008

The intravenous administration of tumor necrosis factor alpha, interleukin 8 and macrophage‐derived neutrophil chemotactic factor inhibits neutrophil migration by stimulating nitric oxide production ⬇️

scientific article published on August 1, 1998

The involvement of CD4+CD25+ T cells in the acute phase of Trypanosoma cruzi infection.

scientific article

The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice

scientific article published on 20 November 2012

The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats

scientific article published on 27 March 2013

The nitroxyl donor, Angeli's salt, reduces chronic constriction injury-induced neuropathic pain

scientific article published on 7 June 2016

The pattern of immune cell infiltration in chromoblastomycosis: involvement of macrophage inflammatory protein-1 alpha/CCL3 and fungi persistence

scientific article published on 01 January 2007

The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila

scientific article published on 2 June 2010

The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia ⬇️

scientific article published on November 1, 1992

The protein LJM 111 from Lutzomyia longipalpis salivary gland extract (SGE) accounts for the SGE-inhibitory effects upon inflammatory parameters in experimental arthritis model

scientific article

The quassinoid isobrucein B reduces inflammatory hyperalgesia and cytokine production by post-transcriptional modulation.

scientific article published on 10 February 2015

The role of Nox2-derived ROS in the development of cognitive impairment after sepsis

scientific article

The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia

scientific article published on 28 November 2012

The role of PKA and PKCepsilon pathways in prostaglandin E2-mediated hypernociception

scientific article published on 13 February 2009

The role of carbon monoxide and nitric oxide in hyperosmolality-induced atrial natriuretic peptide release by hypothalamus in vitro.

scientific article published in July 2004

The role of neutrophils in neuro-immune modulation

scientific article published on 28 November 2019

The role of neutrophils in severe sepsis

Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 (15d-PGJ2) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4+CD25-FOXP3+ Cells.

scientific article published on 31 October 2016

Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis.

scientific article published on 12 December 2016

Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice Phenotype Characterization

scientific article published on 19 August 2019

Thirty days after anterior cruciate ligament transection is sufficient to induce signs of knee osteoarthritis in rats: pain, functional impairment, and synovial inflammation

scientific article published on 31 January 2020

Toll-Like Receptor 2 Is Required for Inflammatory Process Development during Leishmania infantum Infection.

scientific article published on 23 February 2017

Toll-like receptor 2/MyD88 signaling mediates zymosan-induced joint hypernociception in mice: Participation of TNF-α, IL-1β and CXCL1/KC

scientific article published on 25 October 2011

Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis

scientific article published in February 2006

Toll-like receptor 9 activation in neutrophils impairs chemotaxis and reduces sepsis outcome

scientific article published in September 2012

Toll-like receptor 9 signaling in dendritic cells regulates neutrophil recruitment to inflammatory foci following Leishmania infantum infection.

scientific article

Trypanosoma cruzi adjuvants potentiate T cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine

scientific article

Tumour necrosis factor-alpha mediates neutrophil migration to the knee synovial cavity during immune inflammation.

scientific article

Tumour necrosis factor-alpha, interleukin-1beta and interleukin-8 induce persistent mechanical nociceptor hypersensitivity

scientific article

Turbulent flow/low wall shear stress and stretch differentially affect aorta remodeling in rats

scientific article published in March 2006

Typical and atypical carcinoid tumors of the lung: a clinicopathological correlation of 783 cases with emphasis on histological features

scientific article published on 05 March 2020

Uncaria tomentosa reduces osteoclastic bone loss in vivo

scientific article published on 02 September 2020

Use of dexamethasone with mesna for the prevention of ifosfamide-induced hemorrhagic cystitis.

scientific article

Vatairea macrocarpa (Leguminosae) lectin activates cultured macrophages to release chemotactic mediators

scientific article published on 15 December 2006

Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB.

scientific article published on 14 May 2015

Xenogeneic Mesenchymal Stromal Cells Improve Wound Healing and Modulate the Immune Response in an Extensive Burn Model.

scientific article published on 7 May 2015

[Indications for penetrating keratoplasty in Pernambuco]

scientific article published on 01 September 2005

[Limbal relaxing incisions during cataract surgery: one-year follow-up]

scientific article published on 01 May 2006

iNOS-derived nitric oxide modulates infection-stimulated bone loss.

scientific article published in December 2008

α-Galactosylceramide suppresses murine eosinophil production through interferon-γ-dependent induction of NO synthase and CD95.

scientific article published on 24 April 2015

α1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice

scientific article published on 13 March 2012

α1D-adrenoceptor-induced relaxation on rat carotid artery is impaired during the endothelial dysfunction evoked in the early stages of hyperhomocysteinemia

scientific article published on 10 June 2006

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