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List of works by Muralidhar L. Hegde

8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1.

scientific article published on 21 April 2013

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization.

scientific article

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging.

scientific article published on 21 June 2016

A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis

scientific article published on 10 October 2019

A new evidence for DNA nicking property of amyloid beta-peptide (1-42): relevance to Alzheimer's disease

scientific article published on 4 April 2007

Activation of Ras Signaling Pathway by 8-Oxoguanine DNA Glycosylase Bound to Its Excision Product, 8-Oxoguanine ⬇️

scientific article published on May 8, 2012

Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

scientific article published on 25 July 2013

Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective

scientific article published on 24 April 2020

Aluminium in Alzheimer's disease: are we still at a crossroad?

scientific article

Amyloid beta and neuromelanin--toxic or protective molecules? The cellular context makes the difference.

scientific article

An algorithmic approach to understand trace elemental homeostasis in serum samples of Parkinson disease

scientific article published on 01 July 2005

Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis

scientific article published on 07 November 2019

Challenges and complexities of alpha-synuclein toxicity: new postulates in unfolding the mystery associated with Parkinson's disease

scientific article published on October 2003

Challenges associated with metal chelation therapy in Alzheimer's disease

scientific article

Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?

scientific article published on 20 September 2016

Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways

scientific article

DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease

scientific article published on January 2010

DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes

scientific article published on 26 April 2007

Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis

scientific article published on 23 March 2020

Evidence of altered DNA integrity in the brain regions of suicidal victims of Bipolar Depression

scientific article

First evidence for helical transitions in supercoiled DNA by amyloid Beta Peptide (1-42) and aluminum: a new insight in understanding Alzheimer's disease.

scientific article published on January 2004

Hexahydropyrrolo[2,3-b]indole Compounds as Potential Therapeutics for Alzheimer's Disease

scientific article published on 07 October 2019

Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes

scientific article published on 21 November 2007

Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription

scientific article published on 21 August 2020

Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients.

scientific article published on 13 June 2019

MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.

scientific article

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

scientific article published in Nature Communications

New Mechanisms of DNA Repair Defects in Fused in Sarcoma-Associated Neurodegeneration: Stage Set for DNA Repair-Based Therapeutics?

scientific article published on 10 June 2019

New evidence on α-synuclein and Tau binding to conformation and sequence specific GC* rich DNA: Relevance to neurological disorders

scientific article

New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.

scientific article

New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases

scientific article

Oxidative Genome Damage and its Repair in Neurodegenerative Diseases: Function of Transition Metals as a Double-Edged Sword ⬇️

scientific article published on January 1, 2011

Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.

scientific article

Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression.

scientific article published on 18 October 2016

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle

scientific article published on 21 February 2020

Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase

scientific article published on 30 June 2017

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

scientific article

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

scientific article

RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures

scientific article

RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease

scientific article published on 04 December 2019

Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease

scientific article published on 26 August 2012

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome

scientific article published on 30 November 2011

Role of protein conformational dynamics and DNA integrity in relevance to neuronal cell death in neurodegeneration

scientific article published on September 2006

Serum trace element levels and the complexity of inter-element relations in patients with Parkinson's disease

scientific article published on 01 January 2004

Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases

scientific article

Studies on genomic DNA topology and stability in brain regions of Parkinson's disease

scientific article published on 10 March 2006

The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: DOMINANT NEGATIVE FUNCTION OF THE CTD.

scientific article

The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions

scientific article published on 27 March 2013

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

scientific article

The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites

scientific article

The role of 8-oxoguanine DNA glycosylase-1 in inflammation

scientific article

The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis

scientific article published on 29 January 2015

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

scientific article published on 14 July 2015

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells

scientific article published on 01 August 2020

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