List of works - Einar M Sigurdsson

A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice

scientific article published on 08 February 2007

A safer vaccine for Alzheimer's disease?

scientific article

A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.

scientific article

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.

scientific article

Alzheimer's disease: challenges ahead

scientific article published on February 2010

Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds.

scientific article

Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice.

scientific article published in February 2001

Amyloid fibril formation by macrophage migration inhibitory factor

scientific article

Amyloid-beta injection in rat amygdala alters tau protein but not mRNA expression.

scientific article published in March 2000

An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives.

scientific article published on July 2004

Anti-prion antibodies for prophylaxis following prion exposure in mice

scientific article published on 01 January 2003

Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance.

scientific article published on 25 October 2013

Antibody-derived in vivo imaging of tau pathology

scientific article

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy

scientific article published in July 1998

Bilateral injections of amyloid-beta 25-35 into the amygdala of young Fischer rats: behavioral, neurochemical, and time dependent histopathological effects

scientific article published on November 1997

Cognitive and Sensorimotor Tasks for Assessing Functional Impairments in Mouse Models of Alzheimer’s Disease and Related Disorders ⬇️

scientific article published on January 1, 2012

Conformation as therapeutic target in the prionoses and other neurodegenerative conditions

scientific article

Copper chelation delays the onset of prion disease

scientific article published on 30 September 2003

Corrigendum to "Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging" EBioMedicine 35 (2018) 270-278

scientific article published on 29 September 2018

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

scientific article published in August 2003

Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type

scientific article published in April 2001

Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging

scientific article published on 23 August 2018

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

scientific article published on 20 January 2016

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Harnessing the immune system for treatment and detection of tau pathology.

scientific article published on January 2014

High titers of mucosal and systemic anti-PrP antibodies abrogate oral prion infection in mucosal-vaccinated mice.

scientific article published on 6 March 2008

Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau

scientific article published on 14 October 2018

Histological staining of amyloid and pre-amyloid peptides and proteins in mouse tissue

scientific article published on January 2012

Histological staining of amyloid-beta in mouse brains

scientific article published in January 2005

Immunization delays the onset of prion disease in mice.

scientific article published on July 2002

Immunization treatment approaches in Alzheimer's and prion diseases.

scientific article

Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice

scientific article published on August 2001

Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model ⬇️

scientific article published on December 8, 2010

Immunotherapy for conformational diseases.

scientific article published on January 2006

Immunotherapy for tauopathies.

scientific article published on 08 July 2011

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

scientific article published on August 2007

Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies.

scientific article published on October 2008

In Vivo Evaluation of Neuronal Transport in Murine Models of Neurodegeneration Using Manganese-Enhanced MRI

scientific article published on 01 January 2018

In Vivo Imaging of Tauopathy in Mice

scientific article published on 01 January 2018

In vivo magnetic resonance imaging of amyloid-β plaques in mice

scientific article published on January 2012

In vivo reversal of amyloid-beta lesions in rat brain.

scientific article published in January 2000

Infectivity of amyloid diseases

scientific article published on 01 September 2002

Internalization of tau antibody and pathological tau protein detected with a flow cytometry multiplexing approach

scientific article published on 22 March 2016

Laterality in the histological effects of injections of amyloid-beta 25-35 into the amygdala of young Fischer rats.

scientific article published in June 1997

Live Imaging of Pathological Tau Protein and Tau Antibodies in a Neuron-Like Cellular Model

scientific article published on 01 January 2018

Local and distant histopathological effects of unilateral amyloid-beta 25-35 injections into the amygdala of young F344 rats

scientific article

Magnetic resonance imaging of amyloid plaques in transgenic mice

scientific article published in January 2005

Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model

scientific article published on 21 October 2011

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

scientific article published in September 2008

Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging

scientific article

Mucosal vaccination delays or prevents prion infection via an oral route.

scientific article

Murine models of Alzheimer's disease and their use in developing immunotherapies.

scientific article published on 13 May 2010

New directions towards safer and effective vaccines for Alzheimer's disease.

scientific article

Non-invasive, in vivo monitoring of neuronal transport impairment in a mouse model of tauopathy using MEMRI ⬇️

scientific article published on August 31, 2012

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

scientific article

Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology

scientific article published in October 2006

Promising developments in prion immunotherapy

scientific article published on 01 October 2005

Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice

scientific article published on 6 December 2017

Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice

scientific article

Specific amyloid β clearance by a catalytic antibody construct

scientific article

Structural characterization of monoclonal antibodies targeting C-terminal Ser404 region of phosphorylated tau protein

scientific article published on 26 February 2019

Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein.

scientific article

Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Progress and Potential Pitfalls

scientific article published on 01 January 2018

Tau Immunotherapy

scientific article

Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy

scientific article published on 22 March 2019

Tau as a Therapeutic Target for Alzheimers Disease ⬇️

scientific article published on September 1, 2011

Tau immunotherapy and imaging.

scientific article published on 11 September 2013

Tau immunotherapy for Alzheimer's disease

scientific article published on 03 April 2015

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments.

scientific article

Tau-focused immunotherapy for Alzheimer's disease and related tauopathies.

scientific article published on October 2009

Tau-targeting therapies for Alzheimer disease

scientific article published on 01 July 2018

Therapeutic applications of antibodies in non-infectious neurodegenerative diseases

scientific article published on 05 April 2011

Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology

scientific article published on 02 October 2013

Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages

scientific article published on November 2006

beta-Amyloid 25-35 and/or quinolinic acid injections into the basal forebrain of young male Fischer-344 rats: behavioral, neurochemical and histological effects

scientific article published in December 1995

List of works by Einar M Sigurdsson

A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice

A safer vaccine for Alzheimer's disease?

A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.

Alzheimer's disease: challenges ahead

Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds.

Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice.

Amyloid fibril formation by macrophage migration inhibitory factor

Amyloid-beta injection in rat amygdala alters tau protein but not mRNA expression.

An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives.

Anti-prion antibodies for prophylaxis following prion exposure in mice

Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance.

Antibody-derived in vivo imaging of tau pathology

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy

Bilateral injections of amyloid-beta 25-35 into the amygdala of young Fischer rats: behavioral, neurochemical, and time dependent histopathological effects

Cognitive and Sensorimotor Tasks for Assessing Functional Impairments in Mouse Models of Alzheimer’s Disease and Related Disorders ⬇️

Conformation as therapeutic target in the prionoses and other neurodegenerative conditions

Copper chelation delays the onset of prion disease

Corrigendum to "Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging" EBioMedicine 35 (2018) 270-278

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type

Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Harnessing the immune system for treatment and detection of tau pathology.

High titers of mucosal and systemic anti-PrP antibodies abrogate oral prion infection in mucosal-vaccinated mice.

Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau

Histological staining of amyloid and pre-amyloid peptides and proteins in mouse tissue

Histological staining of amyloid-beta in mouse brains

Immunization delays the onset of prion disease in mice.

Immunization treatment approaches in Alzheimer's and prion diseases.

Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice

Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model ⬇️

Immunotherapy for conformational diseases.

Immunotherapy for tauopathies.

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies.

In Vivo Evaluation of Neuronal Transport in Murine Models of Neurodegeneration Using Manganese-Enhanced MRI

In Vivo Imaging of Tauopathy in Mice

In vivo magnetic resonance imaging of amyloid-β plaques in mice

In vivo reversal of amyloid-beta lesions in rat brain.

Infectivity of amyloid diseases

Internalization of tau antibody and pathological tau protein detected with a flow cytometry multiplexing approach

Laterality in the histological effects of injections of amyloid-beta 25-35 into the amygdala of young Fischer rats.

Live Imaging of Pathological Tau Protein and Tau Antibodies in a Neuron-Like Cellular Model

Local and distant histopathological effects of unilateral amyloid-beta 25-35 injections into the amygdala of young F344 rats

Magnetic resonance imaging of amyloid plaques in transgenic mice

Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging

Mucosal vaccination delays or prevents prion infection via an oral route.

Murine models of Alzheimer's disease and their use in developing immunotherapies.

New directions towards safer and effective vaccines for Alzheimer's disease.

Non-invasive, in vivo monitoring of neuronal transport impairment in a mouse model of tauopathy using MEMRI ⬇️

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology

Promising developments in prion immunotherapy

Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice

Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice

Specific amyloid β clearance by a catalytic antibody construct

Structural characterization of monoclonal antibodies targeting C-terminal Ser404 region of phosphorylated tau protein

Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein.

Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Progress and Potential Pitfalls

Tau Immunotherapy

Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy

Tau as a Therapeutic Target for Alzheimers Disease ⬇️

Tau immunotherapy and imaging.

Tau immunotherapy for Alzheimer's disease

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments.

Tau-focused immunotherapy for Alzheimer's disease and related tauopathies.

Tau-targeting therapies for Alzheimer disease

Therapeutic applications of antibodies in non-infectious neurodegenerative diseases

Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology

Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages

beta-Amyloid 25-35 and/or quinolinic acid injections into the basal forebrain of young male Fischer-344 rats: behavioral, neurochemical and histological effects