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List of works by Michael Roth

A 340 kDa hyaluronic acid secreted by human vascular smooth muscle cells regulates their proliferation and migration

scientific article published in August 1998

A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus hypersecretion.

scientific article published in June 2005

A granulocyte inhibitory protein overexpressed in chronic renal disease regulates expression of interleukin 6 and interleukin 8.

scientific article

Aclidinium bromide combined with formoterol inhibits remodeling parameters in lung epithelial cells through cAMP.

scientific article published on 4 November 2015

Acute Exacerbations of COPD Are Associated With Increased Expression of Heparan Sulfate and Chondroitin Sulfate in BAL.

scientific article published on 30 July 2015

Acute exacerbations of COPD are associated with significant activation of matrix metalloproteinase 9 irrespectively of airway obstruction, emphysema and infection

scientific article

Adenovirus-specific IgG maturation as a surrogate marker in acute exacerbations of COPD.

scientific article published on August 2014

Adrenomedullin mediates pro-angiogenic and pro-inflammatory cytokines in asthma and COPD

scientific article published on 25 January 2019

Age-related decrease in an early step of DNA-repair of normal human lymphocytes exposed to ultraviolet-irradiation

scientific article published in January 1989

Airway and lung remodelling in chronic pulmonary obstructive disease: a role for muscarinic receptor antagonists?

scientific article

Airway epithelium-derived transforming growth factor-beta is a regulator of fibroblast proliferation in both fibrotic and normal subjects

scientific article published on 22 May 2008

Airway smooth muscle cell proliferation is increased in asthma

scientific article

Airway smooth muscle cells respond directly to inhaled environmental factors.

scientific article published on 27 August 2010

An imbalance in C/EBPs and increased mitochondrial activity in asthmatic airway smooth muscle cells: novel targets in asthma therapy?

scientific article published on 03 April 2009

Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis.

scientific article published on 12 December 2014

Anti-inflammatory dimethylfumarate: a potential new therapy for asthma?

scientific article

Antihypertensive drugs and risk of COVID-19? - Authors' reply

scientific article published on 26 March 2020

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

scientific article published on 12 March 2020

Assay for cell migration and invasion of vascular smooth muscle cells

scientific article published on 01 January 2001

Association of the glucocorticoid receptor D641V variant with steroid-resistant asthma: a case-control study

scientific article published in June 2015

Asthma and COPD - The C/EBP Connection

scientific article

Asthma and the CCAAT-enhancer binding proteins: a holistic view on airway inflammation and remodeling

scientific article

Asthma and the regulated retrotransposon transcriptome

scientific article published on 01 September 2012

Asthma: is it due to an abnormal airway smooth muscle cell?

scientific article published on 11 May 2006

Biomarkers and personalised medicine for asthma

scientific article published on 03 January 2019

Bronchial smooth muscle cells of asthmatics promote angiogenesis through elevated secretion of CXC-chemokines (ENA-78, GRO-α, and IL-8).

scientific article

Bronchial thermoplasty decreases airway remodelling by blocking epithelium-derived heat shock protein-60 secretion and protein arginine methyltransferase-1 in fibroblasts

scientific article published on 04 December 2019

Broncho Vaxom (OM-85) modulates rhinovirus docking proteins on human airway epithelial cells via Erk1/2 mitogen activated protein kinase and cAMP.

scientific article published on 28 November 2017

COPD Exacerbations Are Associated With Proinflammatory Degradation of Hyaluronic Acid

scientific article published on 30 July 2015

Ca(2+)-channel blockers modulate expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and low density lipoprotein receptor genes stimulated by platelet-derived growth factor

scientific article published on October 1991

Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix

scientific article

Calcineurin inhibitors in bronchiolitis obliterans syndrome following stem cell transplantation.

scientific article

Calcium channel blockers activate the interleukin-6 gene via the transcription factors NF-IL6 and NF-kappaB in primary human vascular smooth muscle cells

scientific article published on 01 May 1999

Calreticulin is a negative regulator of bronchial smooth muscle cell proliferation

scientific article published on 21 February 2012

Cell cultures from cryopreserved human lung tissue

scientific article published in January 1992

Cell density and serum exposure modify the function of the glucocorticoid receptor C/EBP complex

scientific article published on 07 November 2007

Cell type-specific effect of hypoxia and platelet-derived growth factor-BB on extracellular matrix turnover and its consequences for lung remodeling.

scientific article published on 10 November 2006

Characterization of angiotensin II receptors in cultured adult rat cardiac fibroblasts. Coupling to signaling systems and gene expression

scientific article

Chlamydia pneumoniae activates epithelial cell proliferation via NF-kappaB and the glucocorticoid receptor

scientific article published on October 2003

Chlamydia pneumoniae infection after lung transplantation.

scientific article published on February 2005

Chlamydia pneumoniae infections in asthma: clinical implications.

scientific article published on January 2003

Cigarette smoke inhibits lung fibroblast proliferation by translational mechanisms

scientific article published on 18 August 2011

Clinical potential of aclidinium bromide in chronic obstructive pulmonary disease

scientific article published on 13 June 2014

Co-Loading of Isoniazid-Grafted Phthalocyanine-in-Cyclodextrin and Rifampicin in Crude Soybean Lecithin Liposomes: Formulation, Spectroscopic and Biological Characterization

scientific article published on 01 January 2020

Collagenase expression and activity is modulated by the interaction of collagen types, hypoxia, and nutrition in human lung cells

scientific article published in July 2005

Combined Activation of Guanylate Cyclase and Cyclic AMP in Lung Fibroblasts as a Novel Therapeutic Concept for Lung Fibrosis

scientific article published on 07 March 2019

Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma.

scientific article

Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling.

scientific article published on 9 January 2017

Corticosteroids inhibit the expression of the vascular endothelial growth factor gene in human vascular smooth muscle cells

scientific article published on 01 January 1998

Culture of human alveolar epithelial type II cells by sprouting

article

Cyclosporine A mediates fibroproliferation through epithelial cells.

scientific article published on June 2004

DMF inhibits PDGF-BB induced airway smooth muscle cell proliferation through induction of heme-oxygenase-1.

scientific article

Defects of airway smooth muscle cell function are important in asthma

scientific article

Dimethylfumarate inhibits CXCL10 via haem oxygenase-1 in airway smooth muscle.

scientific article

Dimethylfumarate inhibits NF-{kappa}B function at multiple levels to limit airway smooth muscle cell cytokine secretion.

scientific article published on 22 May 2009

Disease-specific expression and regulation of CCAAT/enhancer-binding proteins in asthma and chronic obstructive pulmonary disease

scientific article

Distinct effects of Broncho-Vaxom (OM-85 BV) on gp130 binding cytokines

scientific article published on August 2000

Distinct endobronchial expression of matrix-metalloproteinases (MMP) and their endogenous inhibitors in lung cancer

scientific article published in May 2001

Dual ERK and phosphatidylinositol 3‐kinase pathways control airway smooth muscle proliferation: Differences in asthma

scientific article published on 01 September 2008

Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells

scientific article

ERK activation and mitogenesis in human airway smooth muscle cells

scientific article published in May 2001

ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: a comparison between mesothelioma and mesothelial cells

scientific article published on May 2006

Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle

scientific article published on 25 August 2006

Effects of amlodipine on gene expression and extracellular matrix formation in human vascular smooth muscle cells and fibroblasts: implications for vascular protection

scientific article published on December 1997

Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation.

scientific article published in January 2004

Expression of connective tissue growth factor in asthmatic airway smooth muscle cells.

scientific article

Extracellular matrix composition is modified by β₂-agonists through cAMP in COPD.

scientific article published on 12 August 2014

Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-beta1 and TGF-beta3

scientific article published on 01 May 1999

Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism

scientific article published in April 2004

Familial cancer. Initial results of an inquiry into its occurrence in Basel

scientific article published on 01 January 1985

Fast beneficial systemic anti-inflammatory effects of inhaled budesonide and formoterol on circulating lymphocytes in asthma

scientific article published in July 2013

Glucocorticoids and β2-agonists regulate the pathologic metabolism of hyaluronic acid in COPD

scientific article published on 17 August 2017

HGF Expressing Stem Cells in Usual Interstitial Pneumonia Originate from the Bone Marrow and Are Antifibrotic

scientific article

Hepatocyte growth factor secreted by bone marrow stem cell reduce ER stress and improves repair in alveolar epithelial II cells.

scientific article

House dust mite extract downregulates C/EBPα in asthmatic bronchial smooth muscle cells

scientific article published on 25 November 2010

Human airway smooth muscle cell proliferation from asthmatics is negatively regulated by semaphorin3A.

scientific article published on 25 October 2016

Hyaluronic acid: A key molecule in skin aging

scientific article

Hypoxia differentially enhances the effects of transforming growth factor-beta isoforms on the synthesis and secretion of glycosaminoglycans by human lung fibroblasts

scientific article published in June 2002

Hypoxia modifies the effect of PDGF on glycosaminoglycan synthesis by primary human lung cells

scientific article published on 01 November 2000

Hypoxia modulates the effects of transforming growth factor-beta isoforms on matrix-formation by primary human lung fibroblasts

scientific article published on 01 October 2003

Hypoxia-induced interleukin-6 and interleukin-8 production is mediated by platelet-activating factor and platelet-derived growth factor in primary human lung cells

scientific article published on 01 October 1998

IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes.

scientific article published on 21 March 2018

Identification of a novel IL-6 isoform binding to the endogenous IL-6 receptor

scientific article published in July 2002

IgE Downregulates PTEN through MicroRNA-21-5p and Stimulates Airway Smooth Muscle Cell Remodeling

scientific article published on 18 February 2019

Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma

scientific article published on 23 January 2020

Impaired translation of CCAAT/enhancer binding protein alpha mRNA in bronchial smooth muscle cells of asthmatic patients

scientific article published on 03 January 2009

Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection

scientific article

Induction of interleukin 6 and interleukin 8 expression by Broncho-Vaxom (OM-85 BV) via C-Fos/serum responsive element

scientific article

Inhibition of NF-κB and AP-1 by dimethylfumarate correlates with down-regulated IL-6 secretion and proliferation in human lung fibroblasts

scientific article published on 7 December 2010

Inhibition of receptor-mediated platelet activation by nedocromil sodium

scientific article published on 01 June 1993

Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling

scientific article published in October 2002

Interaction of C/EBPalpha and the glucocorticoid receptor in vivo and in nontransformed human cells

scientific article published on February 2002

Intracellular interleukin 6 mediates platelet-derived growth factor-induced proliferation of nontransformed cells.

scientific article

Intrinsic asthma: is it intrinsic to the smooth muscle?

scientific article published on 04 May 2009

Is There a Regulatory Role of Immunoglobulins on Tissue Forming Cells Relevant in Chronic Inflammatory Lung Diseases? ⬇️

scientific article published on November 2, 2011

Isolation and Characterization of Glycosaminoglycans from Human Atheromatous Vessels

scientific article published on January 1, 2001

IκBα glutathionylation and reduced histone H3 phosphorylation inhibit eotaxin and RANTES.

scientific article published on 30 June 2011

Ligand-independent activation of the glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells

scientific journal article

Long acting β2-agonist's activation of cyclic AMP cannot halt ongoing mitogenic stimulation in airway smooth muscle cells

scientific article published on 12 March 2019

Longitudinal Measurement of Serum Vascular Endothelial Growth Factor in Patients with Chronic Obstructive Pulmonary Disease

scientific article

Lung remodeling mechanisms in chronic lung diseases.

scientific article published on February 2014

MMP and TIMP expression pattern in pleural effusions of different origins

scientific article published in December 1997

Manidipine affects rPDGF-BB-induced gene transcription of low-density lipoprotein receptors and 3-hydroxy-3-methylglutaryl coenzyme A reductase in human mesangial cells

scientific article published on February 1993

Manidipine regulates the transcription of cytokine genes ⬇️

scientific article published on May 1, 1992

Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study

scientific article published on 18 December 2015

Mechanism of anti-remodelling action of treprostinil in human pulmonary arterial smooth muscle cells

scientific article published in PLoS ONE

Mechanisms of airway remodeling. Airway smooth muscle

scientific article published on 01 November 2001

Mesothelioma cells escape heat stress by upregulating Hsp40/Hsp70 expression via mitogen-activated protein kinases

scientific article

Molecular mechanisms of combination therapy with inhaled corticosteroids and long-acting beta-agonists.

scientific article published on October 2009

Multipotent mesenchymal stem cells in lung fibrosis

scientific article published on 21 August 2017

Neuronal chemorepellent Semaphorin 3E inhibits human airway smooth muscle cell proliferation and migration

scientific article published on 6 August 2013

Noncanonical WNT-5A signaling regulates TGF-β-induced extracellular matrix production by airway smooth muscle cells

scientific article published on 19 December 2012

Opposite effect of corticosteroids and long-acting beta(2)-agonists on serum- and TGF-beta(1)-induced extracellular matrix deposition by primary human lung fibroblasts

scientific article published on 01 January 2007

Opposite effect of fluticasone and salmeterol on fibronectin and tenascin-C expression in primary human lung fibroblasts.

scientific article published on 20 March 2009

PAF-dependent phosphatidylinositol turnover in platelets: differences between asthmatics and normal individuals

scientific article published on January 1990

PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts.

scientific article published on 18 January 2016

PRMT1 Modulates Processing of Asthma-Related Primary MicroRNAs (Pri-miRNAs) into Mature miRNAs in Lung Epithelial Cells

scientific article published on 25 November 2020

PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation.

scientific article published on 29 May 2015

Pelargonium sidoides radix extract EPs 7630 reduces rhinovirus infection through modulation of viral binding proteins on human bronchial epithelial cells

scientific article published in PLoS ONE

Platelet-activating factor exerts mitogenic activity and stimulates expression of interleukin 6 and interleukin 8 in human lung fibroblasts via binding to its functional receptor

scientific article published on July 1996

Platelet-derived growth factor stimulates the secretion of hyaluronic acid by proliferating human vascular smooth muscle cells

scientific article

Prevention of New Respiratory Episodes in Children with Recurrent Respiratory Infections: An Expert Consensus Statement

scientific article published on 17 November 2020

Primary fibroblast cell cultures from transbronchial biopsies of lung transplant recipients.

scientific article

Procoagulant activity of PPD-stimulated human lymphocytes after cryopreservation

scientific article published on 01 December 1994

Proinflammatory Cytokine Levels in Patients with Lung Cancer and Carcinomatous Pleurisy ⬇️

scientific article published on January 1, 1998

Proliferation of human non-small-cell lung cancer cell lines: role of interleukin-6

scientific article published on 01 October 1998

Rat mesothelioma cell proliferation requires p38δ mitogen activated protein kinase and C/EBP-α.

scientific article published on 11 January 2011

Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages

article

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

scientific article published in Nature Communications

Serum IgE Induced Airway Smooth Muscle Cell Remodeling Is Independent of Allergens and Is Prevented by Omalizumab

scientific article published on 2 September 2015

Serum levels of hyaluronic acid are associated with COPD severity and predict survival

scientific article published on 07 March 2019

Single and multiple viral infections in lower respiratory tract infection

scientific article

Sirtuin 3 Inhibits Airway Epithelial Mitochondrial Oxidative Stress in Cigarette Smoke-Induced COPD

scientific article published on 11 September 2020

Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation.

scientific article

Steroids and β2-agonists regulate hyaluronan metabolism in asthmatic airway smooth muscle cells

scientific article published on 03 August 2012

Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients

scientific article published on 01 May 1994

Systemic Biomarkers of Collagen and Elastin Turnover Are Associated With Clinically Relevant Outcomes in COPD.

scientific article published on 26 August 2016

TGF-β Upregulated Mitochondria Mass through the SMAD2/3→C/EBPβ→PRMT1 Signal Pathway in Primary Human Lung Fibroblasts

scientific article published on 10 December 2018

Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator.

scientific article

The MNK-1/eIF4E pathway as a new therapeutic pathway to target inflammation and remodelling in asthma

scientific article published on 11 July 2016

The differential distribution of hyaluronic acid in the layers of human atheromatic aortas is associated with vascular smooth muscle cell proliferation and migration

scientific article published on 01 May 1998

The effect of short-term withdrawal from continuous positive airway pressure therapy on sympathetic activity and markers of vascular inflammation in subjects with obstructive sleep apnoea.

scientific article published in June 2007

The effects of omalizumab on IgE-induced cytokine synthesis by asthmatic airway smooth muscle cells.

scientific article published in February 2010

The interaction of endothelin-1 and TGF-β1 mediates vascular cell remodeling

scientific article

The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling

scientific article

Thymine dimer repair in fibroblasts of patients with dysplastic naevus syndrome (DNS)

scientific article published on 01 February 1988

Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis

scientific article

Tiotropium sustains the anti-inflammatory action of olodaterol via the cyclic AMP pathway

scientific article

Transcription factors in asthma: are transcription factors a new target for asthma therapy?

scientific article

Transcriptional activation of low density lipoprotein receptor gene by angiotensin-converting enzyme inhibitors and Ca(2+)-channel blockers involves protein kinase C isoforms

scientific article

Transforming growth factor-beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts.

scientific article

Treatment with long acting muscarinic antagonists stimulates serum levels of irisin in patients with COPD.

scientific article published on 21 October 2017

Treprostinil inhibits proliferation and extracellular matrix deposition by fibroblasts through cAMP activation

scientific article published on 18 January 2018

Urokinase potentiates PDGF-induced chemotaxis of human airway smooth muscle cells

scientific article published on 7 February 2003

Urokinase signal transduction and its role in cell migration.

scientific article published on February 2005

Vasoactive Intestinal Peptide for Diagnosing Exacerbation in Chronic Obstructive Pulmonary Disease

scientific article published on 9 October 2015

[Fundamentals of chronic inflammatory lung diseases (asthma, COPD, fibrosis)]

scientific article published on 01 May 2014

[Matrix metalloproteases and their inhibitors in the pleura]

scientific article published on 01 September 1998

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