List of works by Michael Gale

2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo

scientific article

2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members

scientific journal article

A Trypanosoma brucei gene family encoding protein kinases with catalytic domains structurally related to Nek1 and NIMA.

scientific article published in May 1993

A short hairpin RNA screen of interferon-stimulated genes identifies a novel negative regulator of the cellular antiviral response

scientific article published on 18 June 2013

A summary of the 18th International Symposium on Hepatitis C Virus and Related Viruses

scientific article published in January 2012

A systems biology approach reveals that tissue tropism to West Nile virus is regulated by antiviral genes and innate immune cellular processes

scientific article published on 7 February 2013

Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication

scientific article

An alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

scientific article published on 20 July 2020

An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo

scientific article published on 17 October 2012

Antiviral and inflammatory crosstalk in the control of RNA virus infection

Antiviral innate immunity: editorial overview.

scientific article published on 22 January 2014

Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor

scientific article (publication date: 10 November 2009)

Author Correction: Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control

scientific article published on 13 December 2019

Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease

scientific article published on January 2012

Beta interferon controls West Nile virus infection and pathogenesis in mice

scientific article published on 4 May 2011

CARD games between virus and host get a new player

scientific article

CD22 is required for protection against West Nile virus Infection

scientific article published on 9 January 2013

CD4 and CD8 T cells from SIV-infected macaques have defective signaling responses after perturbation of either CD3 or CD2 receptors

scientific article published on January 1990

Cell type- and replication stage-specific influenza virus responses in vivo

scientific article published on 13 August 2020

Cell-Specific IRF-3 Responses Protect against West Nile Virus Infection by Interferon-Dependent and -Independent Mechanisms

scientific article (publication date: 27 July 2007)

Cell-intrinsic innate immune control of West Nile virus infection

scientific article

Class A Scavenger Receptor-Mediated Double-Stranded RNA Internalization Is Independent of Innate Antiviral Signaling and Does Not Require Phosphatidylinositol 3-Kinase Activity

scientific article published on 11 September 2015

Coexpressed RIG-I agonist enhances humoral immune response to influenza virus DNA vaccine

scientific article

Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0.

scientific article published on 11 January 2012

Convergent evolution of escape from hepaciviral antagonism in primates

scientific article (publication date: 2012)

Correction: Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission

scientific article

Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux

scientific article

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

scientific article published on 05 November 2020

Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis

scientific article

Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses

scientific article published on 3 March 2013

Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.

scientific article published on July 2008

Direct, interferon-independent activation of the CXCL10 promoter by NF-κB and interferon regulatory factor 3 during hepatitis C virus infection

scientific article

Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation

scientific article

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

scientific article (publication date: 2008)

Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes

scientific article

Dynamics of innate immunity are key to chronic immune activation in AIDS.

scientific article published on January 2012

Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling

scientific article

Editorial overview: Antiviral strategies

scientific article published on 23 May 2015

Effector genes of interferon action against hepatitis C virus ⬇️

scientific article published on May 1, 2003

Effects of the hepatitis C virus core protein on innate cellular defense pathways

scientific article published on July 2004

Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity

scientific article published on 20 May 2015

Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition

scientific article published on 12 March 2020

Erratum: Evasion of intracellular host defence by hepatitis C virus

scientific article published in Nature

Establishment and Maintenance of the Innate Antiviral Response to West Nile Virus Involves both RIG-I and MDA5 Signaling through IPS-1

scientific article

Evasion and disruption of innate immune signalling by hepatitis C and West Nile viruses

scientific article published on 31 March 2009

Evasion of intracellular host defence by hepatitis C virus

scientific article (publication date: 18 August 2005)

Evolution of hepatitis C virus NS5A region in breakthrough patients during pegylated interferon and ribavirin therapy*

scientific article

Expression of human PKR protein kinase in transgenic mice

scientific article

Femur-Sparing Pattern of Abnormal Fetal Growth in Pregnant Women from New York City After Maternal Zika Virus Infection.

scientific article

Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

scientific article published on 12 September 2016

Fighting the flu with inflammasome signaling

scientific article

Functional SARS-CoV-2-specific immune memory persists after mild COVID-19

scientific article published on 13 August 2020

Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense

scientific article published on 8 February 2007

GB virus type C NS5A sequence polymorphisms: association with interferon susceptibility and inhibition of PKR-mediated eIF2alpha phosphorylation

scientific article published in May 2005

Genetic diversity in the collaborative cross model recapitulates human West Nile virus disease outcomes.

scientific article published on 5 May 2015

HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production

scientific article

Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity

scientific article published on January 2010

Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission

scientific article

Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression.

scientific article

Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication

scientific article published on 4 November 2014

Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells

scientific article

Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins

scientific article (publication date: 3 April 2007)

Hepatitis regulation by the inflammasome signaling pathway

scientific article published on May 2015

Human DNA-PK activates a STING-independent DNA sensing pathway

scientific article published on 01 January 2020

Human immunodeficiency virus type 1 mediates global disruption of innate antiviral signaling and immune defenses within infected cells

scientific article published on 12 August 2009

IFITM1 is a tight junction protein that inhibits hepatitis C virus entry

scientific article published on 12 December 2012

IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease

scientific article

IL-1β signaling promotes CNS-intrinsic immune control of West Nile virus infection

scientific article

IPS-1 Is Essential for the Control of West Nile Virus Infection and Immunity

scientific article

IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling

scientific article

IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice

scientific article published on 13 April 2014

Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication

scientific article

Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I.

scientific article

Identifying protective host gene expression signatures within the spleen during West Nile virus infection in the collaborative cross model

scientific article (publication date: December 2016)

Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

scientific article (publication date: 22 February 2005)

Immune signaling by RIG-I-like receptors

scientific article

Immunoprofiles of human Sertoli cells infected with Zika virus reveals unique insights into host-pathogen crosstalk.

scientific article published on 7 June 2018

In vitro and in vivo characterization of a West Nile virus MAD78 infectious clone

scientific article

Inactivation of the PKR protein kinase and stimulation of mRNA translation by the cellular co-chaperone P58(IPK) does not require J domain function

scientific article

Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection

article

Infectious clones of novel lineage 1 and lineage 2 West Nile virus strains WNV-TX02 and WNV-Madagascar

scientific article published on 9 May 2012

Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis

scientific journal article

Influenza: fatal immunity and the 1918 virus

scientific article published in January 2007

Inhibition of cellular autophagy deranges dengue virion maturation

scientific article published on 21 November 2012

Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus

scientific article

Inhibitor of κB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection

scientific article published on 7 November 2011

Innate antiviral immune signaling, viral evasion and modulation by HIV-1.

scientific article published on 08 December 2013

Innate immune evasion by hepatitis C virus and West Nile virus

scientific article (publication date: 2007)

Innate immune tolerance and the role of kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection

scientific article

Innate immunity against HIV-1 infection

scientific article published on June 2015

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

scientific article

Interference with Virus Infection

scientific article published on September 2015

Interferon Regulatory Factor IRF-7 Induces the Antiviral Alpha Interferon Response and Protects against Lethal West Nile Virus Infection

scientific article

Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection

scientific article

Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection

scientific journal article

Interferon regulatory factor-3 activation, hepatic interferon-stimulated gene expression, and immune cell infiltration in hepatitis C virus patients

scientific article published in March 2008

Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock

scientific article

Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus

scientific article published on 24 June 2019

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

scientific article published on April 2015

Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy

scientific article published on 06 July 2021

Intracellular innate immune cascades and interferon defenses that control hepatitis C virus

scientific article

Isoflavone agonists of IRF-3 dependent signaling have antiviral activity against RNA viruses

scientific article

LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3.

scientific article

Long double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-beta promoter stimulator 1, and IFN

scientific article

MAVS Expressed by Hematopoietic Cells Is Critical for Control of West Nile Virus Infection and Pathogenesis

scientific article published on 25 May 2016

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D.

scientific article published on 27 January 2017

Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control

scientific article published on 08 November 2019

Measure and countermeasure: type I IFN (IFN-alpha/beta) antiviral response against West Nile virus

scientific article published on 24 June 2009

Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop

scientific article

Membrane Perturbation-Associated Ca2+ Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry

scientific article published on 30 December 2015

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

scholarly article by Dawn M Dudley et al published August 2018 in Nature Medicine

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

scientific article

Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation

scientific article published on 27 February 2019

Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase

scientific article published on April 1998

New ways of initiating translation in eukaryotes.

scientific article published on December 2001

Nitric oxide controls an inflammatory-like Ly6C(hi)PDCA1+ DC subset that regulates Th1 immune responses

scientific article

Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses

scientific article

Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.

scientific article published on 21 January 2014

Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross.

scientific article

P52rIPK regulates the molecular cochaperone P58IPK to mediate control of the RNA-dependent protein kinase in response to cytoplasmic stress

scientific article published on October 2002

PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons

scientific article (publication date: July 2006)

Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length

scientific article

Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the central nervous system

scientific article published on 21 August 2013

Pegylated interferon and ribavirin promote early evolution of nonstructural 5A protein in individuals with hepatitis C who demonstrate a response to treatment

scientific article

Principles of intracellular viral recognition.

scientific article published on 21 November 2006

Proteome-Wide Zika Virus CD4 T Cell Epitope and HLA Restriction Determination

scientific article published on 04 August 2020

Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking

scientific article

Pushing to a cure by harnessing innate immunity against hepatitis C virus

scientific article

RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid Interferon Gene Expression

scientific article

RIG-I in RNA virus recognition

scientific article

RIG-I like receptors and their signaling crosstalk in the regulation of antiviral immunity.

scientific article published on September 2011

RIG-I like receptors in antiviral immunity and therapeutic applications

scientific article published on 23 June 2011

RIG-I mediated hepatic innate immune signaling that controls HCV infection

scientific article published in December 2008

RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection

scientific article published on 13 August 2019

RNA-Seq in the Collaborative Cross

scientific article published on January 2017

RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions

scientific article published on 18 November 2019

RNase L activates the NLRP3 inflammasome during viral infections

scientific article

RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.

scientific article

Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling

scientific article

RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

scientific article

Rapid generation of a mouse model for Middle East respiratory syndrome

scientific article

Recognition of viruses by cytoplasmic sensors

scientific article published on 12 January 2010

Reemergence of hepatitis C virus after 8.5 years in a patient with hypogammaglobulinemia: evidence for an occult viral reservoir

scientific article published on 10 August 2005

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

scientific article

Regulation of CXCL-8 (Interleukin-8) Induction by Double-Stranded RNA Signaling Pathways during Hepatitis C Virus Infection

scientific article

Regulation of Innate Immunity and Interferon Defenses by Hepatitis C Virus

Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease ⬇️

scientific article (publication date: 16 May 2003)

Regulation of PKR and IRF-1 during hepatitis C virus RNA replication

scientific article

Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6

scientific article

Regulation of hepatic innate immunity by hepatitis C virus

scientific article

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

scientific article

Regulation of innate immunity against hepatitis C virus infection.

scientific article published on 16 November 2007

Regulation of interferon production and innate antiviral immunity through translational control of IRF-7

article

Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance

scientific article published on July 1998

Resistance to Alpha/Beta Interferon Is a Determinant of West Nile Virus Replication Fitness and Virulence

scientific article

Risk of Zika microcephaly correlates with features of maternal antibodies

scientific article published on 14 August 2019

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

scientific article

STING is required for host defense against neuropathological West Nile virus infection

scientific article published on 15 August 2019

Single-cell transcriptomic analyses of T cells in chronic HCV-infected patients dominated by DAA-induced interferon signaling changes

scientific article published on 09 August 2021

Small self-RNA generated by RNase L amplifies antiviral innate immunity

scientific article published on 25 July 2007

SnapShot: Interferon Signaling

scientific article published on December 2015

Sterol-izing innate immunity

scientific article

Strategies for hepatitis C therapeutic intervention: now and next

scientific article published in October 2004

Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy

scientific article published on 01 November 2019

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

scientific article

Systematic Profiling of Full-Length Ig and TCR Repertoire Diversity in Rhesus Macaque through Long Read Transcriptome Sequencing

scientific article published on 06 May 2020

T-Cell Alterations in Late Postpoliomyelitis

scientific article published on 01 May 1989

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway

scientific article

The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites

scientific article published on 10 February 2016

The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness

scientific article published on 26 July 2012

The accelerating pace of HCV research: a summary of the 15th International Symposium on Hepatitis C Virus And Related Viruses

scientific article published on 19 November 2008

The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection

scientific article published on 21 August 2013

The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs

scientific article

The herpesvirus accessory protein γ134.5 facilitates viral replication by disabling mitochondrial translocation of RIG-I

scientific article published on 26 March 2021

The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway

scientific article

The innate immune adaptor molecule MyD88 restricts West Nile virus replication and spread in neurons of the central nervous system

scientific article published on 29 September 2010

The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.

scientific article published on May 2012

The oncogenic potential of hepatitis C virus NS5A sequence variants is associated with PKR regulation

scientific article

The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins

scientific article published on March 2003

Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection

scientific article

Tissue specific expression of PKR protein kinase in aging B6D2F1 mice

article

Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

scientific article

Transcriptional analysis of antiviral small molecule therapeutics as agonists of the RLR pathway

scientific article published on February 2016

Two new monoclonal antibodies for biochemical and flow cytometric analyses of human interferon regulatory factor-3 activation, turnover, and depletion

scientific article published on 13 June 2012

Unveiling viral enablers.

scientific article

Uridine composition of the poly-U/UC tract of HCV RNA defines non-self recognition by RIG-I.

scientific article

Viral Protein Accumulation of Zika Virus Variants Links with Regulation of Innate Immunity for Differential Control of Viral Replication, Spread, and Response to Interferon

scientific article published in 2023

Viral and cellular gene expression in CD4+ human lymphoid cell lines infected by the simian immunodeficiency virus, SIV/Mne

scientific article published on July 1991

Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection

scientific article

Viral evasion of the interferon system

scientific article published on September 2009

Viral evolution and interferon resistance of hepatitis C virus RNA replication in a cell culture model

scientific article

Viruses and interferon: a fight for supremacy

scientific article (publication date: September 2002)

Vpu mediates depletion of interferon regulatory factor 3 during HIV infection by a lysosome-dependent mechanism

scientific article published on 16 May 2012

Vpu-deficient HIV strains stimulate innate immune signaling responses in target cells

scientific article

West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and -independent pathways without antagonizing host defense signaling

scientific article

West Nile virus infection and immunity

scientific article published on February 2013

What happens inside lentivirus or influenza virus infected cells: insights into regulation of cellular and viral protein synthesis

scientific article published on April 1997

ZAPS electrifies RIG-I signaling.

scientific article

ZIKV can infect human term placentas in the absence of maternal factors

scientific article published on 18 March 2022

Zika Virus and the Non-Microcephalic Fetus: Why We Should Still Worry

scientific article published on 29 August 2018

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