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List of works by Imre Kovesdi

"Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype

article

A factor discriminating between the wild-type and a mutant polyomavirus enhancer

scientific article published on July 1987

A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy ⬇️

scientific article published on September 1, 1998

Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo

scientific article published on December 1997

Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity

scientific article published in February 2004

Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining

scientific article published on 01 May 2000

Adenoviral producer cells

scientific article published on 16 August 2010

Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis

scientific article published on August 1997

Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws

scientific article published in March 1999

Adenoviral vectors for gene transfer

scientific article published on October 1997

Adenovirus as a gene therapy vector for hematopoietic cells.

scientific article published in June 2000

Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression

scientific article

Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types

scientific article

Adenovirus type 9 fiber knob binds to the coxsackie B virus-adenovirus receptor (CAR) with lower affinity than fiber knobs of other CAR-binding adenovirus serotypes

scientific article published on August 2001

Adenovirus vectors targeting alphaV integrin or heparan sulfate receptors display different distribution of transgene activity after intramuscular injection.

scientific article published in March 2004

Adenovirus-mediated E2F-1 gene transfer in nonsmall-cell lung cancer induces cell growth arrest and apoptosis.

scientific article published in September 2002

Adenovirus-mediated VEGF(121) gene transfer stimulates angiogenesis in normoperfused skeletal muscle and preserves tissue perfusion after induction of ischemia

scientific article published in August 2000

Adenovirus-mediated gene transfer of human inducible nitric oxide synthase in porcine vein grafts inhibits intimal hyperplasia

article

Adenovirus-mediated increase of HNF-3 levels stimulates expression of transthyretin and sonic hedgehog, which is associated with F9 cell differentiation toward the visceral endoderm lineage

scientific article

Adenovirus-mediated inducible nitric oxide synthase gene transfer inhibits hepatocyte apoptosis

scientific article published on August 1998

Adenovirus-mediated transduction of intestinal cells in vivo

scientific article

Augmentation of pulmonary host defense against Pseudomonas by FcgammaRIIA cDNA transfer to the respiratory epithelium.

scientific article

Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart

article

CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts.

scientific article

Chromosomal assignment of the heparin-binding cytokine genes MDK and PTN in mouse and man

scientific article

Chromosomal localization and nucleoside diphosphate kinase activity of human metastasis-suppressor genes NM23-1 and NM23-2

scientific article

Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype

scientific article published on 01 January 1997

Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins

scientific article (publication date: 1991)

Coarse spray delivery to a localized region of the pulmonary airways for gene therapy.

scientific article

Comparative analysis of adenovirus fiber-cell interaction: adenovirus type 2 (Ad2) and Ad9 utilize the same cellular fiber receptor but use different binding strategies for attachment

scientific article

Construction of a pseudoreceptor that mediates transduction by adenoviruses expressing a ligand in fiber or penton base.

scientific article published on November 1999

Dendritic cell based PSMA immunotherapy for prostate cancer using a CD40-targeted adenovirus vector

scientific article

Development of an Ad7 cosmid system and generation of an Ad7deltaE1deltaE3HIV(MN) env/rev recombinant virus

scientific article published on February 2003

Developmental control of a promoter-specific factor that is also regulated by the E1A gene product

scientific article

Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees

article

E1A transcription induction: enhanced binding of a factor to upstream promoter sequences

scientific article published in February 1986

Effective multiple oral administration of reverse genetics engineered infectious bursal disease virus in mice in the presence of neutralizing antibodies

scientific article published on 30 April 2015

Effective repeat administration with adenovirus vectors to the muscle

scientific article published in April 2000

Efficient activation of viral genomes by levels of herpes simplex virus ICP0 insufficient to affect cellular gene expression or cell survival.

scientific article

Efficient adenoviral gene transfer to kidney cortical vasculature utilizing a fiber modified vector

scientific article

Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo

scientific article

Electromagnetic guidance for catheter-based transendocardial injection: a platform for intramyocardial angiogenesis therapy. Results in normal and ischemic porcine models

scientific article published in March 2000

Endothelial nitric oxide synthase protects aortic allografts from the development of transplant arteriosclerosis

scientific article published in March 2000

Enhanced liver uptake of opsonized red blood cells after in vivo transfer of FcgammaRIIA cDNA to the liver

scientific article

Epitopes expressed in different adenovirus capsid proteins induce different levels of epitope-specific immunity

scientific article

Ex vivo adenovirus mediated gene transfection of human conjunctival epithelium

scientific article published on July 2001

Expression and function of recombinant S1179D endothelial nitric oxide synthase in canine cerebral arteries

scientific article

Expression of gp19K increases the persistence of transgene expression from an adenovirus vector in the mouse lung and liver ⬇️

scientific article published on October 1, 1997

Expression of the HBNF (heparin-binding neurite-promoting factor) gene in the brain of fetal, neonatal and adult rat: an in situ hybridization study

scientific article published on December 18, 1992

Extended tropism of an adenoviral vector does not circumvent the maturation-dependent transducibility of mouse skeletal muscle

scientific article published in November 1999

Gene therapy for collateral vessel development.

scientific article published on September 1997

Gene therapy with angiogenic factors: a new potential approach to the treatment of ischemic diseases

scientific article

Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension

scientific article published on 18 August 2003

Genetic incorporation of human metallothionein into the adenovirus protein IX for non-invasive SPECT imaging

scientific article (publication date: 9 February 2011)

Genomic organization of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant

scientific article

HBNF and MK, members of a novel gene family of heparin-binding proteins with potential roles in embryogenesis and brain function.

scientific article

Heparin-binding neurotrophic factor (HBNF) and MK, members of a new family of homologous, developmentally regulated proteins ⬇️

scientific article published on October 30, 1990

Identification of a cellular transcription factor involved in E1A trans-activation

scientific article published in April 1986

Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae

scientific article

Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein

scientific article published on March 2000

Improved production of adenovirus vectors expressing apoptotic transgenes

scientific article

In vivo expression and function of recombinant GTPCH I in the rabbit carotid artery

scientific article published on 9 October 2003

In vivo gene transfer of inducible nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits

scientific article published on 10 April 2003

Increased gene transfer in acute myeloid leukemic cells by an adenovirus vector containing a modified fiber protein.

scientific article published on March 1999

Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins.

scientific article

Increased revascularization efficacy after administration of an adenovirus encoding VEGF(121).

scientific article

Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate

scientific article published on 01 June 2000

Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis.

scientific article published on October 1997

Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12.

scientific article published in January 1999

Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization

scientific article

Inhibitory effect of recombinant iNOS gene expression on vasomotor function of canine basilar artery

scientific article

Interaction of the adenovirus 14.7-kDa protein with FLICE inhibits Fas ligand-induced apoptosis

scientific article published on 01 March 1998

Isolation from bovine brain and structural characterization of HBNF, a heparin-binding neurotrophic factor

scientific article published in January 1991

Local adenoviral-mediated inducible nitric oxide synthase gene transfer inhibits neointimal formation in the porcine coronary stented model

article

Marked inhibition of retinal neovascularization in rats following soluble-flt-1 gene transfer

scientific article published in September 2004

Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses

scientific article published on March 2004

Modifications in adenoviral coat fiber proteins and transcriptional regulatory sequences enhance transgene expression

scientific article published in August 2002

Modifications of the fiber in adenovirus vectors increase tropism for malignant glioma models

scientific article published in January 2000

Muscle stem cells can act as antigen-presenting cells: implication for gene therapy

scientific article published in September 2004

Nitric oxide prevents p21 degradation with the ubiquitin-proteasome pathway in vascular smooth muscle cells

scientific article published on 01 February 2000

Optimization of ex vivo inducible nitric oxide synthase gene transfer to vein grafts

scientific article published in August 1999

Optimizing cardiovascular gene therapy: increased vascular gene transfer with modified adenoviral vectors

scientific article published in February 2000

Periocular gene transfer of sFlt-1 suppresses ocular neovascularization and vascular endothelial growth factor-induced breakdown of the blood-retinal barrier

scientific article

Polylysine modification of adenoviral fiber protein enhances muscle cell transduction

scientific article published on July 1999

Potentiation of nitric oxide-induced apoptosis in p53-/- vascular smooth muscle cells

scientific article

Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex

scientific article published on July 1987

Promoters influence the kinetics of transgene expression following adenovector gene delivery

scientific article published on February 2008

Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid.

scientific article

Protection from reoxygenation injury by inhibition of rac1.

scientific article published on May 1998

Quantitative assessment of actin transcript number in eggs, embryos, and tube feet of the sea star Pisaster ochraceus.

scientific article published on November 1985

Rapid construction of adenoviral vectors by lambda phage genetics

scientific article published on April 2002

Rat sponge implant model: a new system for evaluating angiogenic gene transfer.

scientific article published in December 2000

Recombinant infectious bursal disease virus carrying hepatitis C virus epitopes

scientific article published on 24 November 2010

Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions

scientific article

Refolding and characterization of human recombinant heparin-binding neurite-promoting factor

scientific article published on February 1994

Regional suppression of tumor growth by in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the flt-1 vascular endothelial growth factor receptor

scientific article published on April 1998

Regulation of tissue factor expression in smooth muscle cells with nitric oxide

scientific article published in March 2003

Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer

scientific article published on March 1998

Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen.

scientific article published on September 2000

Sequence complexity in the maternal RNA of the starfish Pisaster ochraceus (Brandt)

scientific article published on 01 January 1982

Structure of the gene coding for the human retinoic acid-inducible factor, MK

scientific article

Structure/activity relationships in basic FGF

scientific article published on 01 January 1991

Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies

scientific article published in October 1996

Targeted adenovirus-mediated gene delivery to T cells via CD3.

scientific article published in October 1997

Targeting an adenoviral gene vector to cytokine-activated vascular endothelium via E-selectin

scientific article published in May 1999

Targeting endothelium for gene therapy via receptors up-regulated during angiogenesis and inflammation

scientific article

Targeting of adenovirus penton base to new receptors through replacement of its RGD motif with other receptor-specific peptide motifs.

scientific article

The HIV-1 nef protein does not have guanine nucleotide binding, GTPase, or autophosphorylating activities

scientific article published on 01 December 1991

The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F

scientific article published on October 1998

The role of receptors in the maturation-dependent adenoviral transduction of myofibers

scientific article

Transactivation by the adenovirus E1A gene.

scientific article published on June 1988

Transduction of bone marrow cells by the AdZ.F(pK7) modified adenovirus demonstrates preferential gene transfer in myeloma cells.

scientific article published in November 1999

VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases

scientific article published on 01 February 1999

Vascular permeability effect of adenovirus-mediated vascular endothelial growth factor gene transfer to the rabbit and rat skeletal muscle

scientific article published in August 1999

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