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List of works by Robert S Chapkin

5-Series peptido-leukotriene synthesis in mouse peritoneal macrophages: Modulation by dietary n-3 fatty acids

article

A chemoprotective fish oil- and pectin-containing diet temporally alters gene expression profiles in exfoliated rat colonocytes throughout oncogenesis.

scientific article

A chemoprotective fish oil/pectin diet enhances apoptosis via Bcl-2 promoter methylation in rat azoxymethane-induced carcinomas.

scientific article published on December 2012

A high legume low glycemic index diet improves serum lipid profiles in men.

scientific article

A macrophage-smooth muscle cell co-culture model: Applications in the study of atherogenesis

article

A metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune response.

scientific article published on 30 April 2012

A novel role for nutrition in the alteration of functional microdomains on the cell surface.

scientific article published on January 2009

A rapid RT-PCR method for detection of intact RNA in formalin-fixed paraffin-embedded tissues

scientific article published on August 1995

A two-stage normalization method for partially degraded mRNA microarray data.

scientific article

Aberrant crypt foci and semiparametric modeling of correlated binary data.

scientific article

Ability of 15-hydroxyeicosatrienoic acid (15-OH-20:3) to modulate macrophage arachidonic acid metabolism

scientific article published in June 1988

Alteration of EGFR spatiotemporal dynamics suppresses signal transduction.

scientific article

Alteration of glycerolipid and sphingolipid-derived second messenger kinetics in ras transformed 3T3 cells

scientific article

Alteration of in vitro murine peritoneal macrophage function by dietary enrichment with eicosapentaenoic and docosahexaenoic acids in menhaden fish oil.

scientific article published in October 1989

Analysis of epidermal growth factor receptor dimerization by BS³ cross-linking

scientific article published on January 2015

Anatomical site-specific response to DNA damage is related to later tumor development in the rat azoxymethane colon carcinogenesis model

article

Antagonizing arachidonic acid-derived eicosanoids reduces inflammatory Th17 and Th1 cell-mediated inflammation and colitis severity.

scientific article

Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs)

scientific article published on 11 September 2020

Assessing the Multivariate Relationship between the Human Infant Intestinal Exfoliated Cell Transcriptome (Exfoliome) and Microbiome in Response to Diet

scientific article published on 18 December 2020

Bioactive dietary long-chain fatty acids: emerging mechanisms of action.

scientific article published on 20 May 2008

Cell cycle related inhibition of mouse vascular smooth muscle cell proliferation by prostaglandin E1: relationship between prostaglandin E1 and intracellular cAMP levels

scientific article published on 01 February 1996

Chain elongation of eicosapentaenoic acid in the macrophage

article

Chemoprotective epigenetic mechanisms in a colorectal cancer model: Modulation by n-3 PUFA in combination with fermentable fiber

scientific article

Chemotherapeutic Properties of n-3 Polyunsaturated Fatty Acids - Old Concepts and New Insights.

scientific article published on March 2009

Classification of diet-modulated gene signatures at the colon cancer initiation and progression stages

scientific article published on 16 March 2011

Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation.

scientific article published on 04 February 2014

Comparing automatic and manual image processing in FLARE assay analysis for colon carcinogenesis.

scientific article

Composition of mouse peritoneal macrophage phospholipid molecular species

article

Diacylglycerol and ceramide kinetics in primary cultures of activated T-lymphocytes

scientific article published in January 1996

Diet and carcinogen alter luminal butyrate concentration and intracellular pH in isolated rat colonocytes

article

Dietary Fat and Fiber Modulate the Effect of Carcinogen on Colonic Protein Kinase C λ Expression in Rats , , ⬇️

scientific article published on October 1, 1997

Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice.

scientific article published on 25 March 2009

Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 production

scientific article published in November 2004

Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation.

scientific article published on 06 June 2009

Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells

scientific article

Dietary fat and fiber differentially alter intracellular second messengers during tumor devolopment in rat colon

article

Dietary fat and fiber interact to uniquely modify global histone post-translational epigenetic programming in a rat colon cancer progression model.

scientific article published on 16 April 2018

Dietary fat and fiber modulate colonic cell proliferation in an interactive site‐specific manner

article

Dietary fiber differentially alters cellular fatty acid‐binding protein expression in exfoliated colonocytes during tumor development

article

Dietary fish oil and DHA down-regulate antigen-activated CD4+ T-cells while promoting the formation of liquid-ordered mesodomains.

scientific article

Dietary fish oil and curcumin combine to modulate colonic cytokinetics and gene expression in dextran sodium sulphate-treated mice.

scientific article published on 15 March 2011

Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPARdelta/PGE2 and elevation of PGE3

scientific article

Dietary manipulation of macrophage phospholipid classes: selective increase of dihomogammalinolenic acid

scientific article

Dietary modulation of rat colonic cAMP-dependent protein kinase activity

article

Dietary n-3 PUFA affect TcR-mediated activation of purified murine T cells and accessory cell function in co-cultures

scientific article published in October 2002

Dietary n-3 PUFA alter colonocyte mitochondrial membrane composition and function

scientific article published in February 2002

Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis

scientific article

Dietary n-3 polyunsaturated fatty acids modulate purified murine T-cell subset activation

scientific article

Dietary n-3 polyunsaturated fatty acids suppress splenic CD4(+) T cell function in interleukin (IL)-10(-/-) mice.

scientific article published in February 2005

Dietary polyunsaturated fatty acids modulate resistance to Mycobacterium tuberculosis in guinea pigs

scientific article

Dietary γ-Linolenic Acid Enhances Mouse Macrophage-Derived Prostaglandin E1 Which Inhibits Vascular Smooth Muscle Cell Proliferation , ⬇️

scientific article published on 01 September 1997

Dietary γ-Linolenic Acid Modulates Macrophage–Vascular Smooth Muscle Cell Interactions

article

Differential effects of 2- and 3-series E-prostaglandins on in vitro expansion of Lgr5+ colonic stem cells.

scientific article published on 11 December 2013

Disruption of inducible 6-phosphofructo-2-kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response.

scientific article

Docosahexaenoic acid alters the size and distribution of cell surface microdomains

scientific article published on 17 November 2007

Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulation

scientific article

Effect of dietary linseed oil on tumoricidal activity and eicosanoid production in murine macrophages.

scientific article

Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes

scientific article published in April 1998

Effects of dietary n-3 polyunsaturated fatty acids on T-cell membrane composition and function.

scientific article

Effects of dietary n−3 and n−6 polyunsaturated fatty acids on macrophage phospholipid classes and subclasses

article

Effects of fatty acids on benzo[a]pyrene uptake and metabolism in human lung adenocarcinoma A549 cells

scientific article

Evaluation of fecal mRNA reproducibility via a marginal transformed mixture modeling approach

scientific article

Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil.

scientific article published in April 1988

Fecal microbiota composition of breast-fed infants is correlated with human milk oligosaccharides consumed.

scientific article published on June 2015

Fish Oil Enhances Targeted Apoptosis During Colon Tumor Initiation in Part by Downregulating Bcl-2

article

Fish oil decreases oxidative DNA damage by enhancing apoptosis in rat colon

scientific article

GROWTH-RELATED SIGNALING IN VASCULAR SMOOTH MUSCLE CELLS OS DEREGULATED BY TCDD DURING THE G0/G1, TRANSITION

article

Genome-wide analysis of the rat colon reveals proximal-distal differences in histone modifications and proto-oncogene expression

scientific article published on 22 October 2013

Homeostatic responses of colonic LGR5+ stem cells following acute in vivo exposure to a genotoxic carcinogen

scientific article published on 30 December 2015

Host-microbe interactions in the neonatal intestine: role of human milk oligosaccharides.

scientific article published on May 2012

Identification of actively translated mRNA transcripts in a rat model of early-stage colon carcinogenesis.

scientific article published on 20 October 2009

Imaging inflammation in mouse colon using a rapid stage-scanning confocal fluorescence microscope

scientific article

In vivo formation of polyphosphoinositide isomers and association with progression of murine polycystic kidney disease

article

Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid.

scientific article

Incorporation of a dietary omega 3 fatty acid impairs murine macrophage responses to Mycobacterium tuberculosis

scientific article

Inhibition of growth and linoleate-enhanced metastasis of a transplantable mouse mammary tumor by indomethacin

scientific article published in December 1988

Insight into hypoxia tolerance in cowpea bruchid: metabolic repression and heat shock protein regulation via hypoxia-inducible factor 1.

scientific article

Interactions of phospholipase D and cytochrome P450 protein stability

scientific article published in August 2004

Interactive effects of fatty acid and butyrate-induced mitochondrial Ca²⁺ loading and apoptosis in colonocytes

scientific article published on 11 May 2011

Interference with Protein Kinase C-Related Signal Transduction in Vascular Smooth Muscle Cells by Benzo[a]pyrene

scientific article published on 01 April 1995

Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes

scientific article published on January 2011

Long-Chain n-3 Fatty Acids Attenuate Oncogenic KRas-Driven Proliferation by Altering Plasma Membrane Nanoscale Proteolipid Composition

article

Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells

scientific article published on 10 August 2020

Mechanisms by Which Pleiotropic Amphiphilic n-3 PUFA Reduce Colon Cancer Risk

scientific article

Mechanistic insights into the role of microRNAs in cancer: influence of nutrient crosstalk.

scientific article

Metabolism and function of skin lipids

scientific article published on January 1988

Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities

scientific article

Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential for murine CD4(+) T cell metabolic activation.

scientific article published on 24 July 2014

Modulation of Protein Kinase C-Related Signal Transduction by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exhibits Cell Cycle Dependence

article

Mouse peritoneal macrophage prostaglandin E1 synthesis is altered by dietary gamma-linolenic acid

scientific article published on 01 August 1992

Non-invasive analysis of intestinal development in preterm and term infants using RNA-Sequencing

scientific article

Noninvasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas

scientific article published on 26 May 2009

Noninvasive molecular fingerprinting of host-microbiome interactions in neonates

scientific article

Noninvasive stool-based detection of infant gastrointestinal development using gene expression profiles from exfoliated epithelial cells.

scientific article

Oncogenic ras alters sensitivity of mouse colonocytes to butyrate and fatty acid mediated growth arrest and apoptosis

scientific article published in December 2002

Personalized Nutrition Using Microbial Metabolite Phenotype to Stratify Participants and Non-Invasive Host Exfoliomics Reveal the Effects of Flaxseed Lignan Supplementation in a Placebo-Controlled Crossover Trial

scientific article published on 13 June 2022

Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility.

scientific article

Proapoptotic effects of dietary (n-3) fatty acids are enhanced in colonocytes of manganese-dependent superoxide dismutase knockout mice.

scientific article published on 20 May 2009

Prostaglandin profile and synthetic capacity of the colon: comparison of tissue sources and subcellular fractions

scientific article published in February 1992

Protein kinase C isoforms in human and rat colonic mucosa.

scientific article published in August 1994

Protein kinase C zeta isoform is critical for mitogenic signal transduction

scientific article published on August 1993

Purified dietary n-3 polyunsaturated fatty acids alter diacylglycerol mass and molecular species composition in concanavalin A-stimulated murine splenocytes

scientific article

Quantification of human intestinal gene expression profiles using exfoliated colonocytes: a pilot study

article

Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis

scientific article published on 3 December 2008

Rapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk

scientific article

Recent advances in the field of nutritional immunology.

scientific article

Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice

scientific article published on May 2008

Relationship among colonocyte proliferation, differentiation, and apoptosis as a function of diet and carcinogen

article

Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavones.

scientific article published on 23 March 2018

Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes.

scientific article

Targeted overexpression of inducible 6-phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and inflammatory responses.

scientific article

Th17 cell accumulation is decreased during chronic experimental colitis by (n-3) PUFA in Fat-1 mice.

scientific article published on 30 November 2011

The Induction of Proliferative Vascular Smooth Muscle Cell Phenotypes by Benzo(a)pyrene Is Characterized by Up-Regulation of Inositol Phospholipid Metabolism and c-Ha-ras Gene Expression

article

Upregulation of p21Waf1/Cip1 expression in vivo by butyrate administration can be chemoprotective or chemopromotive depending on the lipid component of the diet

scientific article published on 20 June 2008

Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer.

scientific article published on 16 October 2008

Utilization of dihomo-gamma-linolenic acid (8,11,14-eicosatrienoic acid) by murine peritoneal macrophages

scientific article published in April 1988

Utilization of gammalinolenic acid by mouse peritoneal macrophages

scientific article published on October 1991

fat-1 transgene expression prevents cell culture-induced loss of membrane n-3 fatty acids in activated CD4+ T-cells

scientific article published on 31 October 2008

n-3 Fatty acids uniquely affect anti-microbial resistance and immune cell plasma membrane organization

scientific article

n-3 PUFA and membrane microdomains: a new frontier in bioactive lipid research.

scientific article

n-3 PUFAs reduce T-helper 17 cell differentiation by decreasing responsiveness to interleukin-6 in isolated mouse splenic CD4⁺ T cells

scientific article

n-3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization

scientific article published on 19 October 2011

n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation.

scientific article published on April 2012

n-3 polyunsaturated fatty acids suppress the localization and activation of signaling proteins at the immunological synapse in murine CD4+ T cells by affecting lipid raft formation

scientific article

n-3 polyunsaturated fatty acids--physiological relevance of dose.

scientific article

n3 PUFAs reduce mouse CD4+ T-cell ex vivo polarization into Th17 cells

scientific article published on 17 July 2013

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