List of works - Anthony R. White

3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases

scientific article published on 01 September 2018

A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease

scientific article published on June 2010

A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5

scientific article published on 16 September 2011

Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with beta-amyloid peptides

scientific article published in March 2003

Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide

scientific article

Advances in the Development of Disease-Modifying Treatments for Amyotrophic Lateral Sclerosis

scientific article published on 19 February 2016

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

scientific article published on 20 May 2013

Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF).

scientific article published in June 2002

Amyloid beta.

scientific article

Amyloidogenicity and neurotoxicity of peptides corresponding to the helical regions of PrP(C).

scientific article published in October 2000

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.

scientific article published on 15 December 2011

Biometals in rare neurodegenerative disorders of childhood.

scientific article published on 25 March 2013

Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease

scientific article

Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease

scientific article

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

scientific article

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex.

scientific article published on 8 October 2010

Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.

scientific article published on 30 August 2016

Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity

scientific article published on 17 November 2007

Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages

scientific article

Conjugation of Transferrin to Azide-Modified CdSe/ZnS Core-Shell Quantum Dots using Cyclooctyne Click Chemistry

scientific article published on 20 September 2012

Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.

scientific article published in January 2002

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.

scientific article published in July 2001

Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies

scientific article published on 22 September 2009

Copper as a key regulator of cell signalling pathways.

scientific article published on 22 May 2014

Copper complexes as therapeutic agents ⬇️

scientific article published on December 20, 2011

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

scientific journal article

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

scientific article

Correlative studies support lipid peroxidation is linked to PrPres propagation as an early primary pathogenic event in prion disease

scientific article published on 05 October 2005

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

scientific article published on 28 April 2006

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

scientific article

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

scientific article

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

scientific article published on 27 October 2011

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

scientific article published on November 2007

Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation

scientific article published in March 2003

Editorial: Metals and neurodegeneration: restoring the balance.

scientific article published on 2 July 2015

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

scientific article published on 28 December 2010

Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS.

scientific article published on 30 June 2016

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates

scientific article published on 27 January 2012

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

scientific article published on 27 July 2016

Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione

scientific article published in May 1999

Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: implications for the mechanism of prion formation

scientific article published in March 1999

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

scientific journal article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

scientific article published on 13 April 2020

Immunotherapeutic approaches in prion disease: progress, challenges and potential directions.

scientific article published on May 2013

Immunotherapy as a therapeutic treatment for neurodegenerative disorders.

scientific article published on November 2003

In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc

scientific article published in November 2005

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

scientific article published on 11 February 2014

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis

scientific article

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

scholarly article

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes

scientific article

Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays

scientific article

Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126.

scientific article

Iron inhibits neurotoxicity induced by trace copper and biological reductants

scientific article published on 3 February 2004

Isolation and growth of a cytopathic agent from multiple sclerosis brain tissue

scientific article published in April 2002

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

scientific article

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

scientific article published on 4 February 2013

Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.

scientific article published on 14 March 2014

Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

scientific article published on 23 April 2010

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes.

scientific article

Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease

scientific article published on August 2007

Membrane-targeted strategies for modulating APP and Abeta-mediated toxicity.

scientific article published on February 2009

Metal homeostasis in Alzheimer's disease

scientific article

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

scientific article (publication date: 2011)

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

scientific article published on 20 August 2002

Metals and Alzheimer's disease.

scientific article published on 3 May 2011

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein

scientific article

Mitochondrial metals as a potential therapeutic target in neurodegeneration

scientific article published on April 2014

Monoclonal antibodies inhibit prion replication and delay the development of prion disease

scientific article published in Nature

Neuroinflammation and copper in Alzheimer's disease.

scientific article

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

scientific article

Neurotoxicity from glutathione depletion is dependent on extracellular trace copper

scientific article published in March 2003

Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation

scientific article published on 15 September 2007

Neurotoxicity of prion peptides on cultured cerebellar neurons

scientific article published in January 2008

Olfactory cell cultures to investigate health effects of air pollution exposure: Implications for neurodegeneration

scientific article published on 19 March 2020

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

scientific article

Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model

scientific article

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

scientific article published on 4 September 2002

Oxidative stress and neurodegeneration

scientific article published on 01 April 2013

Peptide-oligonucleotide hybrids in antisense therapy.

scientific article

Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells

scientific article

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

scientific article

Phosphorylation of hnRNP K controls cytosolic accumulation of TDP-43

Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease

scholarly article

Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

scientific article published on 17 October 2013

Protein Labelling with Versatile Phosphorescent Metal Complexes for Live Cell Luminescence Imaging

scientific article published on 11 August 2015

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes

scientific article published on 26 February 2016

Restoration of intestinal function in an MPTP model of Parkinson's Disease

scientific article published on 29 July 2016

Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation

scientific article

Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

scientific article

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice.

scientific article published on 25 January 2010

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

scientific article (publication date: 9 May 2003)

Subcellular localization of a fluorescent derivative of CuII(atsm) offers insight into the neuroprotective action of CuII(atsm).

scientific article published on 19 September 2011

Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons.

scientific article published in April 2001

Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.

scientific article published in August 1998

Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity.

scientific article published on November 2009

Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway.

scientific article published on 02 May 2011

The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures

scientific article published on 01 November 1999

The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

scientific article

The Potential Impact of Bushfire Smoke on Brain Health

scientific article published on 07 July 2020

The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126.

scientific article

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

scientific article published on 2 April 2012

The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease

scientific article published on 6 July 2007

The role of metals in modulating metalloprotease activity in the AD brain.

scientific article published on 13 February 2008

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.

scientific article published on 19 August 2013

Therapeutic treatment of Alzheimer's disease using metal complexing agents.

scientific article

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

scientific article published on October 2006

Type-I interferons in Parkinson's disease: innate inflammatory response drives fate of neurons in model of degenerative brain disorder: An editorial comment on 'Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by r

scientific article published in April 2017

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

scientific article

X-ray fluorescence microscopic measurement of elemental distribution in the mouse retina with age.

scientific article published on 2 August 2016

Zinc induces depletion and aggregation of endogenous TDP-43.

scientific article

Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.

scientific article

List of works by Anthony R. White

3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases

A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease

A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5

Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with beta-amyloid peptides

Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide

Advances in the Development of Disease-Modifying Treatments for Amyotrophic Lateral Sclerosis

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF).

Amyloid beta.

Amyloidogenicity and neurotoxicity of peptides corresponding to the helical regions of PrP(C).

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.

Biometals in rare neurodegenerative disorders of childhood.

Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease

Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex.

Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.

Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity

Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages

Conjugation of Transferrin to Azide-Modified CdSe/ZnS Core-Shell Quantum Dots using Cyclooctyne Click Chemistry

Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.

Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies

Copper as a key regulator of cell signalling pathways.

Copper complexes as therapeutic agents ⬇️

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

Correlative studies support lipid peroxidation is linked to PrPres propagation as an early primary pathogenic event in prion disease

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation

Editorial: Metals and neurodegeneration: restoring the balance.

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS.

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione

Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: implications for the mechanism of prion formation

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Immunotherapeutic approaches in prion disease: progress, challenges and potential directions.

Immunotherapy as a therapeutic treatment for neurodegenerative disorders.

In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes

Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays

Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126.

Iron inhibits neurotoxicity induced by trace copper and biological reductants

Isolation and growth of a cytopathic agent from multiple sclerosis brain tissue

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.

Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes.

Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease

Membrane-targeted strategies for modulating APP and Abeta-mediated toxicity.

Metal homeostasis in Alzheimer's disease

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

Metals and Alzheimer's disease.

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein

Mitochondrial metals as a potential therapeutic target in neurodegeneration

Monoclonal antibodies inhibit prion replication and delay the development of prion disease

Neuroinflammation and copper in Alzheimer's disease.

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

Neurotoxicity from glutathione depletion is dependent on extracellular trace copper

Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation

Neurotoxicity of prion peptides on cultured cerebellar neurons

Olfactory cell cultures to investigate health effects of air pollution exposure: Implications for neurodegeneration

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

Oxidative stress and neurodegeneration