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List of works by Wayne I. Lencer

4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models

scientific article

A Cholera Toxin B-subunit Variant That Binds Ganglioside GM1but Fails to Induce Toxicity

scientific article published in Journal of Biological Chemistry

A Single Native Ganglioside GM 1 -Binding Site Is Sufficient for Cholera Toxin To Bind to Cells and Complete the Intoxication Pathway ⬇️

scientific article published on October 30, 2012

A modified cholera toxin B subunit containing an ER retention motif enhances colon epithelial repair via an unfolded protein response

scientific article published on 27 September 2019

A passionate kiss, then run: exocytosis and recycling of IgG by FcRn.

scientific article

A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization

scientific article published on 27 November 2019

A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis.

scientific article published on 9 January 2017

Advances in Evaluation of Chronic Diarrhea in Infants.

scientific article published on 11 April 2018

An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice.

scientific article published on 04 August 2009

Antibodies in the breakdown lane

scientific article published in October 2005

Antigen presentation by intestinal epithelial cells

scientific article published on 01 June 1999

Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia

scientific article published on 03 January 2017

Association of protease activity in Vibrio cholerae vaccine strains with decreases in transcellular epithelial resistance of polarized T84 intestinal epithelial cells

scientific article published on November 2000

Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor.

scientific article published on 06 February 2004

CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection.

scientific article

Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway

scientific article

CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types

scientific article published on 29 September 2016

Characterization of receptor-mediated signal transduction by Escherichia coli type IIa heat-labile enterotoxin in the polarized human intestinal cell line T84.

scientific article

Characterization of the porcine neonatal Fc receptor--potential use for trans-epithelial protein delivery

scientific article

Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways.

scientific article

Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum

scientific article published on 05 March 2010

Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation

scientific article published on 2 March 2003

Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W.

scientific article published on 23 June 2015

Conversion of apical plasma membrane sphingomyelin to ceramide attenuates the intoxication of host cells by cholera toxin

scientific article published on January 2008

Derlin-1 facilitates the retro-translocation of cholera toxin

scientific article

Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling

scientific article published on 30 December 2003

Discovery of dual-action membrane-anchored modulators of incretin receptors

scientific article

Electrophysiological Studies into the Safety of the Anti-diarrheal Drug Clotrimazole during Oral Rehydration Therapy

scientific article (publication date: September 2015)

Endocytosis of cholera toxin by human enterocytes is developmentally regulated

scientific article published on 24 March 2005

Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling

scientific article published on 21 October 2020

Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics

scientific article

FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.

scientific article published on May 2015

Functional analysis of VopF activity required for colonization in Vibrio cholerae.

scientific article

Functional colocalization of water channels and proton pumps in endosomes from kidney proximal tubule.

scientific article

Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin

scientific article

Ganglioside GD1a restores infectibility to mouse cells lacking functional receptors for polyomavirus

scientific article

Ganglioside GM1-mediated transcytosis of cholera toxin bypasses the retrograde pathway and depends on the structure of the ceramide domain.

scientific article published on 24 July 2013

Ganglioside Structure Dictates Signal Transduction by Cholera Toxin and Association with Caveolae-like Membrane Domains in Polarized Epithelia ⬇️

scientific article published on May 18, 1998

Gangliosides are receptors for murine polyoma virus and SV40

scientific article

Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm

scientific article published on 17 September 2003

Glycolipid Crosslinking Is Required for Cholera Toxin to Partition Into and Stabilize Ordered Domains

scientific article published on 30 November 2016

Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury

scientific article

Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells.

scientific article published in June 2004

INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling

scientific article published on 25 October 2018

IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity

scientific article published on 19 October 2006

Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn.

scientific article published on 03 June 2009

Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3.

scientific article published on August 1997

Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathway

scientific article

Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2

scientific article

Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1.

scientific article

Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation.

scientific article

Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic ⬇️

scientific article published on June 1, 1992

Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion

scientific article

Microtubule motors power plasma membrane tubulation in clathrin-independent endocytosis

scientific article published on 27 April 2015

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids.

scientific article published on 31 May 2018

Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules.

scientific article

Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure

scientific article published on 25 April 2006

N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG.

scientific article published on 21 January 2009

Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer.

scientific article

Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

scientific article

Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria

scientific article

Neonatal Fc receptor: from immunity to therapeutics

scientific article

Opening CFTR in the Intestine: Flushing on Demand

scientific article published on 19 March 2016

Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response

scientific article published on 27 February 2004

Patching a leaky intestine

scientific article published on July 2008

Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera Toxin

scientific article published on 01 March 2001

Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation

scientific article published on June 2006

Proteolytic activation of cholera toxin and Escherichia coli labile toxin by entry into host epithelial cells. Signal transduction by a protease-resistant toxin variant.

scientific article published on June 1997

Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway

scholarly article

RETRACTED: The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling

retracted scientific article published on May 2013

Raft trafficking of AB5 subunit bacterial toxins

scientific article

Remodeling of the intestinal brush border underlies adhesion and virulence of an enteric pathogen

scientific article

Research Agenda for Pediatric Gastroenterology, Hepatology and Nutrition: Secretion and Diarrhea: Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundati

scientific article published on 01 January 2002

Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.

scientific article published in April 2018

Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells

scientific article

Retrograde transport of cholera toxin into the ER of host cells.

scientific article published on April 2004

Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate

scientific article published on 2 June 2005

Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation

scientific article

Salmonella pathogenesis: the trojan horse or the New York shuttle?

scientific article

Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells

scientific article

Signal transduction by bacterial proteins.

scientific article

Structural basis for the differential toxicity of cholera toxin and Escherichia coli heat-labile enterotoxin. Construction of hybrid toxins identifies the A2-domain as the determinant of differential toxicity

scientific article published on February 1999

Structured clustering of the glycosphingolipid GM1 is required for membrane curvature induced by cholera toxin

scientific article published on 17 June 2020

Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL

scientific article

The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells

scientific article published on 18 March 2006

The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption

scientific article published on 14 September 2007

The Immunologic Functions of the Neonatal Fc Receptor for IgG ⬇️

scientific article published on September 5, 2012

The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association

scientific article published on November 2002

The intracellular voyage of cholera toxin: going retro.

scientific article published on December 2003

The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity

scientific article

The viral E3 ubiquitin ligase mK3 uses the Derlin/p97 endoplasmic reticulum-associated degradation pathway to mediate down-regulation of major histocompatibility complex class I proteins

scientific article published on 30 January 2006

The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies

scientific article

To translocate or not: that is the problem

scientific article published on September 2011

Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton

scientific article published on 4 August 2004

Transcytosis of cholera toxin subunits across model human intestinal epithelia.

scientific article

Uncoupling of the cholera toxin-G(M1) ganglioside receptor complex from endocytosis, retrograde Golgi trafficking, and downstream signal transduction by depletion of membrane cholesterol

scientific article published on 21 February 2002

Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1.

scientific article published on 23 December 2013

Vibrio cholerae-induced cellular responses of polarized T84 intestinal epithelial cells are dependent on production of cholera toxin and the RTX toxin

scientific article

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