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List of works by Daryl L. Davies

A Pilot Study of the Safety and Initial Efficacy of Ivermectin for the Treatment of Alcohol Use Disorder.

scientific article published on 18 April 2016

A charge pair interaction between Arg282 in transmembrane segment 7 and Asp341 in transmembrane segment 8 of hPepT1.

scientific article published on 29 September 2006

A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors

scientific article

Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution

scientific article published on 15 June 2011

Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders.

scientific article

Benzodiazepine agonist and inverse agonist coupling in GABAA receptors antagonized by increased atmospheric pressure

scientific article

Biophysical evidence for His57 as a proton-binding site in the mammalian intestinal transporter hPepT1.

scientific article

Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors

scientific article published on 22 February 2012

Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice.

scientific article published on 20 June 2015

Contribution of P2X4 receptors to ethanol intake in male C57BL/6 mice

scientific article

Cysteine scanning of transmembrane domain three of the human dipeptide transporter: implications for substrate transport

scientific article published on April 2007

Differential effects of propofol and ethanol on P2X4 receptors expressed in Xenopus oocytes

scientific article published on November 2005

Effects of ethanol on adenosine 5'-triphosphate-gated purinergic and 5-hydroxytryptamine receptors

scientific article published on February 2006

Effects of posttraining ethanol on an appetitive task.

scientific article

Effects of the abused solvent toluene on recombinant P2X receptors expressed in HEK293 cells.

scientific article published on June 2004

Ethanol Is a Fast Channel Inhibitor of P2X4 Receptors ⬇️

scientific article published on January 6, 2011

Ethanol differentially affects ATP-gated P2X(3) and P2X(4) receptor subtypes expressed in Xenopus oocytes

scientific article published on August 2005

Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes

scientific article published on 11 March 2008

Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure

scientific article

Ethanol sensitivity in ATP-gated P2X receptors is subunit dependent

scientific article

Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors

scientific article

Functional role of the intracellular loop linking transmembrane domains 6 and 7 of the human dipeptide transporter hPEPT1

scientific article published on 21 November 2010

Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.

scientific article

Implication of the purinergic system in alcohol use disorders.

scientific article

In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol.

scientific article published in February 1999

Ivermectin reduces alcohol intake and preference in mice.

scientific article

Low-level hyperbaric antagonism of ethanol's anticonvulsant property in C57BL/6J mice

scientific article published in October 1994

Low-level hyperbaric exposure antagonizes locomotor effects of ethanol and n-propanol but not morphine in C57BL mice

scientific article published on June 1995

Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol

scientific article published on 28 March 2015

Molecular targets and mechanisms for ethanol action in glycine receptors

scientific article

Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humans

scientific article

Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism

scientific article

Mutagenesis and cysteine scanning of transmembrane domain 10 of the human dipeptide transporter

scientific article

Oral delivery of ivermectin using a fast dissolving oral film: Implications for repurposing ivermectin as a pharmacotherapy for alcohol use disorder.

scientific article

P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus

scientific article published on August 2016

P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders

scientific article

Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin ⬇️

scientific article published on September 17, 2012

Purinergic type 2 receptors at GABAergic synapses on ventral tegmental area dopamine neurons are targets for ethanol action

scientific article published on 26 June 2008

Recent Advances in the Discovery and Preclinical Testing of Novel Compounds for the Prevention and/or Treatment of Alcohol Use Disorders ⬇️

scientific article published on June 4, 2012

Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors

scientific article published on 12 July 2016

Roles for loop 2 residues of alpha1 glycine receptors in agonist activation.

scientific article published on 25 July 2008

Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors

scientific article published on 29 June 2008

Sex and the Lab: An Alcohol-Focused Commentary on the NIH Initiative to Balance Sex in Cell and Animal Studies.

scientific article published on 07 May 2016

Sociocommunicative and sensorimotor impairments in male P2X4-deficient mice.

scientific article

Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol

scientific article published on 24 October 2013

Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors

scientific article

The importance of animals in advancing research on alcohol use disorders.

scientific article published on April 2015

Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors

scientific article published on 2 July 2013

Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals

scientific article published on 23 March 2016

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