List of works - Makoto Urushitani

A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS.

scientific article published on 11 March 2015

Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43)

scientific article published on 4 April 2013

Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy

scientific article published on 8 July 2015

Activated caspase-9 immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy

scientific article published on 21 June 2016

Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish

scientific article published on 16 June 2008

Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl

scientific article published on 9 February 2018

An autopsy case of SOD1-related ALS with TDP-43 positive inclusions

scientific article published on 16 November 2011

Antibody therapy targeting ALS-linked misfolded protein ⬇️

scientific article published on 01 November 2011

Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine

scientific article published on 12 February 2014

Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons

scientific article

CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70.

scientific article published in July 2004

CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.

scientific article published on 11 January 2016

Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model

scientific article

Charcot-Marie-Tooth disease type 2A with an autosomal-recessive inheritance: the first report of an adult-onset disease

scientific article

Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis

scientific article

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

scientific article

Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model

scientific article

Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43.

scientific article

Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: mechanisms of neuroprotective treatment against oxidative stress.

scientific article published in July 1998

Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals.

scientific article

Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death

scientific article published in December 1998

Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory.

scientific article published on 13 October 2015

Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant

scientific article

In vivo detection of amyloid β deposition using ¹⁹F magnetic resonance imaging with a ¹⁹F-containing curcumin derivative in a mouse model of Alzheimer's disease.

scientific article published on 12 April 2011

In vivo evidence of CHIP up-regulation attenuating tau aggregation

scientific article

Induction of protective immunity by vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice

scientific article published on 01 October 2010

Localization of a mutant SOD1 protein in E40K-heterozygous dogs: Implications for non-cell-autonomous pathogenesis of degenerative myelopathy.

scientific article published on 24 October 2016

MRI demonstration of a reversible lesion in cerebral deep white matter in thrombotic thrombocytopenic purpura

scientific article published in February 1996

Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection

scientific article published on 01 November 1998

Miller Fisher-Guillain-Barré overlap syndrome with enhancing lesions in the spinocerebellar tracts

scientific article published on February 1995

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis

scientific article

Multiple Proteinopathies in Familial ALS Cases With Optineurin Mutations.

scientific article published on 20 December 2017

Neuronal over-expression of chromogranin A accelerates disease onset in a mouse model of ALS

scientific article published on 26 October 2010

Neuroprotective effect of cyclic GMP against radical-induced toxicity in cultured spinal motor neurons

scientific article published in August 2000

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.

scientific article published on 27 December 2017

Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons

scientific article published on 01 May 2000

Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis

scientific article published in December 2002

Proteasome dysfunction induces muscle growth defects and protein aggregation.

scientific article

Protection of cultured spinal motor neurons by estradiol

scientific article published on 01 November 2000

Protein misdirection inside and outside motor neurons in Amyotrophic Lateral Sclerosis (ALS): a possible clue for therapeutic strategies

scientific article published on 19 October 2011

Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease

scientific article published on 23 February 2010

Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity.

scientific article published in May 1998

Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43.

scientific article published on March 2010

TDP-43 levels are higher in platelets from patients with sporadic amyotrophic lateral sclerosis than in healthy controls

scientific article published on 20 December 2018

The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial

scientific article published on 21 December 2018

The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS.

scientific article

The role of nitric oxide in amyotrophic lateral sclerosis ⬇️

scientific article published on June 1, 2001

Transglutaminase 2 accelerates neuroinflammation in amyotrophic lateral sclerosis through interaction with misfolded superoxide dismutase 1.

scientific article published on 30 September 2013

Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging

scientific article

Velocity of intraneural blood flow is increased in inflammatory neuropathies: sonographic observation

scientific article published on 25 November 2016

Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation

scientific article published on 29 March 2007

[Future perspectives of immunotherapy against ALS]

scientific article published on 01 November 2009

siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme

scientific article published on January 2004

List of works by Makoto Urushitani

A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS.

Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43)

Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy

Activated caspase-9 immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy

Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish

Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl

An autopsy case of SOD1-related ALS with TDP-43 positive inclusions

Antibody therapy targeting ALS-linked misfolded protein ⬇️

Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine

Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons

CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70.

CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.

Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model

Charcot-Marie-Tooth disease type 2A with an autosomal-recessive inheritance: the first report of an adult-onset disease

Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model

Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43.

Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: mechanisms of neuroprotective treatment against oxidative stress.

Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals.

Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death

Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory.

Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant

In vivo detection of amyloid β deposition using ¹⁹F magnetic resonance imaging with a ¹⁹F-containing curcumin derivative in a mouse model of Alzheimer's disease.

In vivo evidence of CHIP up-regulation attenuating tau aggregation

Induction of protective immunity by vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice

Localization of a mutant SOD1 protein in E40K-heterozygous dogs: Implications for non-cell-autonomous pathogenesis of degenerative myelopathy.

MRI demonstration of a reversible lesion in cerebral deep white matter in thrombotic thrombocytopenic purpura

Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection

Miller Fisher-Guillain-Barré overlap syndrome with enhancing lesions in the spinocerebellar tracts

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis

Multiple Proteinopathies in Familial ALS Cases With Optineurin Mutations.

Neuronal over-expression of chromogranin A accelerates disease onset in a mouse model of ALS

Neuroprotective effect of cyclic GMP against radical-induced toxicity in cultured spinal motor neurons

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.

Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons

Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis

Proteasome dysfunction induces muscle growth defects and protein aggregation.

Protection of cultured spinal motor neurons by estradiol

Protein misdirection inside and outside motor neurons in Amyotrophic Lateral Sclerosis (ALS): a possible clue for therapeutic strategies

Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease

Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity.

Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43.

TDP-43 levels are higher in platelets from patients with sporadic amyotrophic lateral sclerosis than in healthy controls

The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial

The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS.

The role of nitric oxide in amyotrophic lateral sclerosis ⬇️

Transglutaminase 2 accelerates neuroinflammation in amyotrophic lateral sclerosis through interaction with misfolded superoxide dismutase 1.

Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging

Velocity of intraneural blood flow is increased in inflammatory neuropathies: sonographic observation

Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation

[Future perspectives of immunotherapy against ALS]

siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme