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List of works by Melanie H. Cobb

A Kinase Divided.

scientific article published on August 2015

A similar ribosomal protein S6 kinase activity is found in insulin-treated 3T3-L1 cells and chick embryo fibroblasts transformed by Rous sarcoma virus

scientific article

A small molecule differentiation inducer increases insulin production by pancreatic β cells

scientific article published on 5 December 2011

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

scientific article

Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.

scientific article

Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.

scientific article published in June 2001

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

scientific article

Activation of MEKK1 by Rho GTPases

scientific article published on January 2006

Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes.

scientific article

Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

scientific article

Activity of the MAP kinase ERK2 is controlled by a flexible surface loop

scientific article published on 01 March 1995

Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3.

scientific article published on 7 December 2012

Bacterial expression of activated mitogen-activated protein kinases

scientific article published on 01 January 2001

Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation

scientific article published on 12 September 2002

Biological Cross-talk between WNK1 and the Transforming Growth Factor β-Smad Signaling Pathway

scientific article published in Journal of Biological Chemistry

Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback ⬇️

scientific article published on December 6, 2010

Catalytic reaction pathway for the mitogen-activated protein kinase ERK2.

scientific article

Cell condition-dependent regulation of ERK5 by cAMP.

scientific article

Characterization of a Protein Kinase that Phosphorylates Serine 189 of the Mitogen-activated Protein Kinase Homolog ERK3

scientific article published in Journal of Biological Chemistry

Characterization of mitogen-activated protein kinase (MAPK) dimers.

scientific article published in November 2006

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

scientific article

Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain

scientific journal article

Context-dependent regulation of NeuroD activity and protein accumulation.

scientific article

Contributions of the Mitogen-activated Protein (MAP) Kinase Backbone and Phosphorylation Loop to MEK Specificity

scientific article published in Journal of Biological Chemistry

Control of Podocyte and Glomerular Capillary Wall Structure and Elasticity by WNK1 Kinase

scientific article published on 01 January 2020

Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways

scientific article

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins ⬇️

scientific article published on November 3, 1997

Crystal structure of domain-swapped STE20 OSR1 kinase domain

scientific article

Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K

scientific journal article

Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension

scientific article published in July 2004

Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

scientific article

Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals

scientific article

Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells

scientific article published on 13 July 2015

Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors

scientific article published on 27 June 2017

Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.

scholarly article

Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism

scientific article published on October 1997

Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK

scientific article

Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses

scientific article published on 01 November 2000

ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter

scientific article

ERK2 enters the nucleus by a carrier-independent mechanism

scientific article

ERK5 signaling gets XIAPed: a role for ubiquitin in the disassembly of a MAPK cascade

scientific article published on 10 July 2014

ERKs Weigh in on Ribosome Mass

scientific article published on 01 November 2001

ERKs, extracellular signal-regulated MAP-2 kinases ⬇️

scientific article published on December 1, 1991

Exposing Contingency Plans for Kinase Networks

scientific article published on 01 December 2010

Expression and characterization of MAP kinases in bacteria.

scientific article published in November 2006

Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs

scientific article published on February 14, 1992

FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST

scientific article published on July 2009

Functional divergence caused by mutations in an energetic hotspot in ERK2

scientific article published on 11 July 2019

G protein-coupled receptors and the regulation of autophagy

scientific article

HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation

scientific article published in May 1998

Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking

scientific article (publication date: 13 July 2001)

Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1

scientific article (publication date: 26 April 2002)

Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.

scientific article

Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells

scientific article published on April 2006

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

scientific article

Insulin-stimulated sodium transport in toad urinary bladder

scientific article published on 01 March 1986

Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity

scientific article

Irreversible inhibition of sodium transport by the toad urinary bladder following photolysis of amiloride analogs

scientific article published on 01 January 1981

Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans.

scientific article published on November 2001

Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades

scientific journal article

Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain

scientific journal article

Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells

scientific article published on February 2016

Lipopolysaccharide-induced tumor necrosis factor-alpha promoter activity is inhibitor of nuclear factor-kappaB kinase-dependent

scientific article published on April 1999

MAP kinase modules: many roads home.

scientific article published on November 2003

MAP kinases

scientific journal article

MAP-ping unconventional protein-DNA interactions.

scientific article

MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases ⬇️

scientific article published on December 19, 1997

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase

scientific journal article

Menin determines K-RAS proliferative outputs in endocrine cells

scientific journal article

Mineralocorticoid-induced membrane proteins in MDCK cells

scientific article published on 01 July 1982

Minireview: Nutrient sensing by G protein-coupled receptors

scientific article

Mitogen-activated protein kinase pathways

scientific article (publication date: April 1997)

Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription

scientific article

Muscarinic control of MIN6 pancreatic β cells is enhanced by impaired amino acid signaling.

scientific article

Mutations in ERK2 Binding Sites Affect Nuclear Entry

scientific article published in Journal of Biological Chemistry

Mxi2 promotes stimulus-independent ERK nuclear translocation

scientific article

NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk

scientific article published on 01 December 1992

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

scientific article

NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas

scientific article

NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM.

scientific article published on 3 April 2013

Off-target effects of MEK inhibitors

scientific article published on 22 July 2013

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases

scientific article published on June 1994

Overview of the Alliance for Cellular Signaling

scientific article

PTMap--a sequence alignment software for unrestricted, accurate, and full-spectrum identification of post-translational modification sites.

scholarly article

Pharmacological inhibitors of MAPK pathways.

scientific article

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

scientific article published on 01 May 2000

Phosphorylation of MAP Kinases by MAP/ERK Involves Multiple Regions of MAP Kinases

scientific article published in Journal of Biological Chemistry

Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation ⬇️

scientific article published on May 15, 1998

Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding.

scientific article published on 07 March 2016

Properties of WNK1 and implications for other family members

scientific article

Protein kinase WNK3 regulates the neuronal splicing factor Fox-1

scientific article

Protein kinases

scientific article published on 01 December 1994

Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.

scientific article

Ras transformation uncouples the kinesin-coordinated cellular nutrient response

scientific article

Reciprocal Signaling between Heterotrimeric G Proteins and the p21-stimulated Protein Kinase

scientific article published in Journal of Biological Chemistry

Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cells

scientific article

Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells

scientific article

Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.

scientific article

Regulation of a third conserved phosphorylation site in SGK1

scientific article published on 09 December 2008

Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells

scientific article

RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity

scientific article published on 27 October 2003

Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome.

scientific article

Scaffolding and protein interactions in MAP kinase modules.

scientific article

Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members

scientific article

Signal control through Raf: in sickness and in health

scientific article published on 06 December 2011

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

scientific article published on 29 January 2016

Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx

scientific article

Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

scientific article

Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway

scientific article published on 25 September 2002

Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3

scientific article published in Journal of Biological Chemistry

Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells

scientific article

TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.

scientific article

TGF-β Regulation by Emilin1: New Links in the Etiology of Hypertension

scientific article published on 01 March 2006

The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (kcat/Km) of CK1α

scientific article published on 10 December 2019

The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.

scientific article published on 06 September 2012

The MAP kinase ERK5 binds to and phosphorylates p90 RSK.

scientific article published on 13 March 2006

The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells

scientific article published in July 1998

The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo

scientific journal article

The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer

scientific article

The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions

scientific article published on 5 January 2004

The insulin receptor and tyrosine protein kinase activity

scientific article published on January 1984

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.

scientific article

The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy

scientific article published on 4 April 2006

The transcriptional ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs

scientific article published on 23 June 2006

Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation

scientific article published on December 2000

WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism

scientific article

WNK1 activates SGK1 to regulate the epithelial sodium channel.

scientific article

WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells

scientific article

WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.

scientific article published on 11 September 2007

WNK1 is required for mitosis and abscission.

scientific article

WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding

scientific article

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

scientific journal article

kin-18, a C. elegans protein kinase involved in feeding

scientific article

p115 Rho GTPase activating protein interacts with MEKK1.

scientific article

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