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List of works by Mario Delmar

4965Non-transcriptional disruption of Ca2+i homeostasis and Cx43 function in the right ventricle precedes overt arrhythmogenic cardiomyopathy in PKP2-deficient mice

A 17mer peptide interferes with acidification-induced uncoupling of connexin43.

scientific article published in May 1998

A connexin40 mutation associated with a malignant variant of progressive familial heart block type I

scientific article

A particle-receptor model for the insulin-induced closure of connexin43 channels

scientific article published in July 1998

A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: the carboxyl tail length

scientific article

ARVC/D and the dyad: A long distance relationship?

scientific article published on 21 November 2015

Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc

scientific article published on 14 January 2020

Arrhythmogenic cardiomyopathy and Brugada syndrome: diseases of the connexome

scientific article published on 15 February 2014

Beyond the One Gene-One Disease Paradigm: Complex Genetics and Pleiotropy in Inheritable Cardiac Disorders

scientific article published on 12 August 2019

Bioinformatic analysis of a plakophilin-2-dependent transcription network: implications for the mechanisms of arrhythmogenic right ventricular cardiomyopathy in humans and in boxer dogs

scientific article published on 01 November 2018

Blockade of the Adenosine 2A Receptor Mitigates the Cardiomyopathy Induced by Loss of Plakophilin-2 Expression

scientific article published on 05 December 2018

C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques

scientific article published on 11 October 2007

Cardiac connexins, mutations and arrhythmias.

scientific article

Channels, arrhythmias, and … the search for the impossible?

scientific article published on 09 June 2015

Characterization of an E4031-sensitive potassium current in quiescent AT-1 cells

scientific article published on December 1994

Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping

Characterization of the molecular phenotype of two arrhythmogenic right ventricular cardiomyopathy (ARVC)-related plakophilin-2 (PKP2) mutations

scientific article published on 6 September 2008

Characterization of the pH-dependent Interaction between the Gap Junction Protein Connexin43 Carboxyl Terminus and Cytoplasmic Loop Domains

scientific article published in Journal of Biological Chemistry

Coexpression of connexins 40 and 43 enhances the pH sensitivity of gap junctions: a model for synergistic interactions among connexins

article

Connexin diversity and gap junction regulation by pHi.

scientific article published in January 1999

Connexin diversity: discriminating the message

scientific article published on 01 July 2002

Connexin40 controls endothelial activation by dampening NFκB activation

scientific article published on 22 March 2017

Connexin43 and the regulation of intercalated disc function

scientific article published on 2 November 2011

Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart.

scientific article

Connexin43 regulates sodium current; ankyrin-G modulates gap junctions: the intercalated disc exchanger

scientific article published on 16 December 2011

Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells

scientific article (publication date: 28 September 2007)

Connexins and Disease

scientific article published on 4 August 2017

Culture in Glucose-Depleted Medium Supplemented with Fatty Acid and 3,3',5-Triiodo-l-Thyronine Facilitates Purification and Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes

scientific article published on 9 October 2017

Cx43 CT domain influences infarct size and susceptibility to ventricular tachyarrhythmias in acute myocardial infarction

scientific article published on 20 July 2009

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels

scientific article published on 05 April 2013

Design and characterization of the first peptidomimetic molecule that prevents acidification-induced closure of cardiac gap junctions

scientific article published on 26 June 2010

Desmosome-ion channel interactions and their possible role in arrhythmogenic cardiomyopathy.

scientific article published on 10 March 2012

Desmosomes and the sodium channel complex: implications for arrhythmogenic cardiomyopathy and Brugada syndrome

scientific article (publication date: July 2014)

Disruption of Ca2+i Homeostasis and Connexin 43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in Plakophilin-2-Deficient Mice

scientific article published on 18 July 2019

Dynamics of the background outward current of single guinea pig ventricular myocytes. Ionic mechanisms of hysteresis in cardiac cells

scientific article published in November 1991

Dynamics of the inward rectifier K+ current during the action potential of guinea pig ventricular myocytes

scientific article

Effect of charge substitutions at residue his-142 on voltage gating of connexin43 channels

scientific article

Effects of 2,4-dinitrophenol or low [ATP]i on cell excitability and action potential propagation in guinea pig ventricular myocytes

scientific article published in October 1992

Effects of changes in excitability and intercellular coupling on synchronization in the rabbit sino-atrial node

scientific article published in January 1986

Effects of diacetyl monoxime on the electrical properties of sheep and guinea pig ventricular muscle

scientific article

Electrical uncoupling and impulse propagation in isolated sheep Purkinje fibers.

scientific article

Electrophysiology of single heart cells from the rabbit tricuspid valve

scientific article published in June 1990

Epithelial interactions and local engraftment of lung-resident mesenchymal stem cells

scientific article published on 4 March 2011

Erratum: Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc

scientific article published on 22 February 2016

Evidence for the presence of a free C-terminal fragment of cx43 in cultured cells.

scientific article published in March 2007

Formation of the gap junction nexus: binding partners for connexins

scientific article

Functional Characterization of Connexin43 Mutations Found in Patients With Oculodentodigital Dysplasia

article

Functional demonstration of connexin-protein binding using surface plasmon resonance

scientific article published on January 2001

Gap junction protein Cx37 interacts with endothelial nitric oxide synthase in endothelial cells.

scientific article

Gap junction remodeling in the failing heart: different connexins--different message?

scientific article published on 01 November 2003

Gap junctional channels in adult mammalian sinus nodal cells. Immunolocalization and electrophysiology

scientific article published on August 1, 1992

Gap junctions

scientific article

Gap junctions - guards of excitability

scientific article published on June 2015

Genetically Encoded Voltage Indicators: Mapping Cardiac Electrical Activity Under a New Light

scientific article published on August 2015

Heritable arrhythmia syndromes associated with abnormal cardiac sodium channel function: ionic and non-ionic mechanisms

scientific article published on 06 April 2020

Hetero-domain interactions as a mechanism for the regulation of connexin channels

scientific article published in May 1999

Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk

scientific article

High Incidence of Cardiac Malformations in Connexin40-Deficient Mice

scientific article published on 03 July 2003

Highlights from special issue: junctional targets of skin and heart diseases

scientific article published in February 2014

Identification of a novel peptide that interferes with the chemical regulation of connexin43.

scientific article

Identification of a protein kinase activity that phosphorylates connexin43 in a pH-dependent manner

Immunohistochemical localization of gap junction protein channels in hamster sinoatrial node in correlation with electrophysiologic mapping of the pacemaker region

scientific article published on February 1994

Immunolocalization and expression of functional and nonfunctional cell-to-cell channels from wild-type and mutant rat heart connexin43 cDNA.

scientific article published in June 1992

Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc

scientific article (publication date: 8 July 2011)

Intramolecular interactions mediate pH regulation of connexin43 channels

scientific article

Ionic mechanisms of electronic inhibition and concealed conduction in rabbit atrioventricular nodal myocytes

scientific article published in October 1993

Is the "funny" current funnier than we thought?

scientific article published on April 1994

Kinetics of protein-protein interactions of connexins: use of enzyme linked sorbent assays

scientific article

Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment.

scientific article published on 25 January 2018

Loss of electrical communication, but not plaque formation, after mutations in the cytoplasmic loop of connexin43.

scientific article

Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes

scientific article

Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy

article

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

scientific article

Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype

scientific article

Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart

scientific article published on 31 March 2017

Mitochondrial Dysfunction as Substrate for Arrhythmogenic Cardiomyopathy: A Search for New Disease Mechanisms

scientific article published on 10 December 2019

Modifications in the biophysical properties of connexin43 channels by a peptide of the cytoplasmic loop region

scientific journal article

Molecular composition of the intercalated disc in a spontaneous canine animal model of arrhythmogenic right ventricular dysplasia/cardiomyopathy

scientific article

Multilevel analyses of SCN5A mutations in arrhythmogenic right ventricular dysplasia/cardiomyopathy suggest non-canonical mechanisms for disease pathogenesis

scientific article published in January 2017

Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc

scientific article

Novel pharmacophores of connexin43 based on the "RXP" series of Cx43-binding peptides

scientific article

Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development

scientific journal article

PCP4 regulates Purkinje cell excitability and cardiac rhythmicity

scientific article published on 8 October 2014

PH regulation of connexin43: molecular analysis of the gating particle

scientific article

Phase resetting and entrainment of pacemaker activity in single sinus nodal cells

scientific article published in April 1991

Phosphorylation of connexin43 on serine 306 regulates electrical coupling

scientific article

Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress ⬇️

scientific article published on 21 August 2019

Plakophilin-2 Truncation Variants in Patients Clinically Diagnosed With Catecholaminergic Polymorphic Ventricular Tachycardia and Decedents With Exercise-Associated Autopsy Negative Sudden Unexplained Death in the Young

scientific article published on 01 November 2018

Plakophilin-2 and the migration, differentiation and transformation of cells derived from the epicardium of neonatal rat hearts

scientific journal article

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.

scientific article published on 24 July 2017

Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.

scientific article published on 8 February 2016

Potential new mechanisms of pro-arrhythmia in arrhythmogenic cardiomyopathy: focus on calcium sensitive pathways

scientific article published on 19 January 2017

Protein⁻Protein Interactions with Connexin 43: Regulation and Function.

scientific article published on 10 May 2018

Proton and zinc effects on HERG currents

scientific article

Quantitative proteomics of human heart samples collected in vivo reveal the remodeled protein landscape of dilated left atrium without atrial fibrillation

scientific article published on 14 April 2020

RXP-E: a connexin43-binding peptide that prevents action potential propagation block

scientific article published on 31 July 2008

Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice

scientific article published on 16 November 2011

Reentry in Cardioversion: 'We can see it from here...'.

scientific article published on 10 October 2008

Reevaluation of genetic variants previously associated with arrhythmogenic right ventricular cardiomyopathy integrating population-based cohorts and proteomics data

scientific article published on 19 August 2019

Regulation of cardiovascular connexins by mechanical forces and junctions

scientific article published on 23 April 2013

Regulation of connexin43 protein complexes by intracellular acidification

scientific journal article

Relationship Between Arrhythmogenic Right Ventricular Cardiomyopathy and Brugada Syndrome: New Insights From Molecular Biology and Clinical Implications.

scientific article published on April 2016

Relative contribution of changes in sodium current versus intercellular coupling on reentry initiation in 2-dimensional preparations of plakophilin-2-deficient cardiac cells

scientific article published on July 2011

Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization

scientific article published on 07 March 2012

Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy

scientific article published on 23 November 2012

Role of histidine 95 on pH gating of the cardiac gap junction protein connexin43.

scientific article

Role of the carboxyl terminal of connexin43 in transjunctional fast voltage gating

scientific article published on March 2002

Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts

scientific article published on 17 September 2014

Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.

scientific article published in December 2016

Sequence-specific resonance assignment of the carboxyl terminal domain of Connexin43

scientific article published on 01 July 2002

Single-molecule Localization of Nav1.5 Reveals Different Modes of Reorganization at Cardiomyocyte Membrane Domains

scientific article published on 15 June 2020

Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes

scientific article published on 8 December 2017

Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.

scientific article

Structural and Functional Characterization of A Nav1.5-Mitochondrial Couplon

scientific article published on 21 December 2020

Structural bases for the chemical regulation of Connexin43 channels

scientific article published on May 2004

Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1

scientific journal article

Structure of connexin43 and its regulation by pHi.

scientific article published on August 1997

Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes

scientific article published on 20 July 2011

Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque

scientific article

Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.

scientific article

Super-resolution scanning patch clamp reveals clustering of functional ion channels in adult ventricular myocyte.

scientific article published on 25 February 2013

The carboxyl terminal domain regulates the unitary conductance and voltage dependence of connexin40 gap junction channels

scientific article published in April 2001

The cardiac connexome: Non-canonical functions of connexin43 and their role in cardiac arrhythmias

scientific article published on 7 December 2015

The cardiac desmosome and arrhythmogenic cardiomyopathies: from gene to disease.

scientific article published on September 2010

The intercalated disk as a single functional unit

scientific article published on 01 May 2004

The noncanonical functions of Cx43 in the heart

scientific article published on 24 July 2012

The sodium channel complex at the intercalated disc: Outside the domains of SAP97?

scientific article published on 18 November 2014

The year in arrhythmias--2009: part I.

scientific article published on 24 December 2009

The year in arrhythmias-2009 part II.

scientific article published on 06 January 2010

Transcription factor ETV1 is essential for rapid conduction in the heart

scientific article published on 24 October 2016

UltraRapid communication : coexpression of connexins 40 and 43 enhances the pH sensitivityof gap junctions: A model for synergistic interactions among connexins

scientific article published in May 2000

Ultrastructural changes in cardiac myocytes from Boxer dogs with arrhythmogenic right ventricular cardiomyopathy

scientific article

Ultrastructure of the intercellular space in adult murine ventricle revealed by quantitative tomographic electron microscopy

scientific article

Why publish in the American Journal of Physiology-Heart and Circulatory Physiology?

scientific article published on 16 June 2017

pH-dependent dimerization of the carboxyl terminal domain of Cx43.

scientific article

pH-dependent intramolecular binding and structure involving Cx43 cytoplasmic domains

scientific article published on 31 July 2002

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