List of works - Frank U. Weiss

A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

scientific article

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

scientific article published on 16 March 2015

A structured weight loss program increases gut microbiota phylogenetic diversity and reduces levels of Collinsella in obese type 2 diabetics: A pilot study

scientific article published on 18 July 2019

A syngeneic orthotopic murine model of pancreatic adenocarcinoma in the C57/BL6 mouse using the Panc02 and 6606PDA cell lines

scientific article published on 30 June 2011

ABO blood type B and fucosyltransferase 2 non-secretor status as genetic risk factors for chronic pancreatitis

article published in 2015

Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis

scientific article published on 14 November 2019

Advances in the etiology of chronic pancreatitis.

scientific article published on September 2010

Angiopoietin-2, a regulator of vascular permeability in inflammation, is associated with persistent organ failure in patients with acute pancreatitis from the United States and Germany.

scientific article published on 11 May 2010

Animal models for investigating chronic pancreatitis.

scientific article published on December 2011

Association analysis of genetic variants in the myosin IXB gene in acute pancreatitis

scientific article

Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis.

scientific article published on 12 May 2016

Cathepsin B gene polymorphism Val26 is not associated with idiopathic chronic pancreatitis in European patients

scientific article published on September 2007

Cathepsin B-mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.

scientific article published on 24 October 2017

Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis.

scientific article published on 11 December 2017

Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.

scientific article published on 10 November 2009

Chronic stress increases experimental pancreatic cancer growth, reduces survival and can be antagonised by beta-adrenergic receptor blockade.

scientific article published on 23 March 2016

Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma

scientific article published on 14 September 2012

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

scientific article

Common variants in the CLDN2 - MORC4 and PRSS1 - PRSS2 loci confer susceptibility to acute pancreatitis

scientific article published on 01 June 2018

Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer

scientific article published on 11 October 2016

Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin

scientific article published on 19 November 2018

Defining chronic pancreatitis with a focus on pathological stress responses.

scientific article

Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent cohorts

scientific article published on 14 September 2017

Development of Pancreatic Cancer: Targets for Early Detection and Treatment.

scientific article published on 22 June 2016

Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil

scientific article published on 7 October 2010

Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice

scientific article published on 30 July 2019

Effect of oral administration of AZD8309, a CXCR2 antagonist, on the severity of experimental pancreatitis.

scientific article published on 14 July 2016

Environmental risk factors for chronic pancreatitis and pancreatic cancer.

scientific article published on 05 July 2011

Extracellular cleavage of E-cadherin by leukocyte elastase during acute experimental pancreatitis in rats.

scientific article published in October 2005

Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study

Functional abdominal pain and discomfort (IBS) is not associated with faecal microbiota composition in the general population

article

Functional characterisation of the CFTR mutations M348V and A1087P from patients with pancreatitis suggests functional interaction between CFTR monomers

scientific article published in May 2009

Gene conversion between cationic trypsinogen (PRSS1) and the pseudogene trypsinogen 6 (PRSS3P2) in patients with chronic pancreatitis

scientific article

Genetic polymorphisms in the UDP-glucuronosyltransferase UGT1A7 gene in patients with acute liver failure after kava-kava consumption

scientific article

Genetic susceptibility factors for alcohol-induced chronic pancreatitis.

scientific article published on 18 June 2015

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis

scientific article

Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogen

scientific article published on 21 November 2001

Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism

scientific article

Hereditäre Pankreatitis

scientific article published on 01 October 2006

Identification of genetic loci associated with Helicobacter pylori serologic status

scientific article published in May 2013

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma

scientific article published on 06 August 2018

Impaired Exocrine Pancreatic Function Associates With Changes in Intestinal Microbiota Composition and Diversity

article

In vivo imaging of pancreatic tumours and liver metastases using 7 Tesla MRI in a murine orthotopic pancreatic cancer model and a liver metastases model

scientific article

Induction of M2-macrophages by tumour cells and tumour growth promotion by M2-macrophages: a quid pro quo in pancreatic cancer

scientific article published on 6 July 2013

Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis

scientific article published on 13 October 2012

Irritable bowel syndrome, mental health, and quality of life: Data from a population-based survey in Germany (SHIP-Trend-0)

scientific article published on 15 November 2018

Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer.

scientific article published on 13 October 2006

Lipase gene fusion: a new route to chronic pancreatitis

scientific article

Liver injury and genetic polymorphisms in the cytochrome P450 and UDP-glucuronosyltransferase genes

scientific article published on 15 December 2015

Local clustering of PRSS1 R122H mutations in hereditary pancreatitis patients from Northern Germany.

scientific article published on 8 August 2008

Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function

scientific article published on 09 November 2020

Metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis.

scientific article published on 20 January 2017

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

scientific article

NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis

scientific article published on 05 October 2019

Novel mechanisms of RTK signal generation

scientific article published on February 1997

Pancreatic cancer risk in hereditary pancreatitis

scientific article

Plasma protein profiling of patients with intraductal papillary mucinous neoplasm of the pancreas as potential precursor lesions of pancreatic cancer

scientific article published on 5 December 2017

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer

scientific article published on 05 December 2011

Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer

scientific article

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas

scientific article published on 09 April 2019

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

scientific article published on February 1996

Specificity of a Polyclonal Fecal Elastase ELISA for CELA3.

scientific article

Spontaneous and sporadic trypsinogen mutations in idiopathic pancreatitis

scientific article published in November 2002

Subdiaphragmatic vagotomy promotes tumor growth and reduces survival via TNFα in a murine pancreatic cancer model.

scientific article

Surgical trauma leads to a shorter survival in a murine orthotopic pancreatic cancer model

scientific article

The PNPLA3 SNP rs738409:G allele is associated with increased liver disease-associated mortality but reduced overall mortality in a population-based cohort

scientific article published on 11 December 2017

The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis

article

Tissue tolerable plasma (TTP) induces apoptosis in pancreatic cancer cells in vitro and in vivo.

scientific article

Toll-like receptor 4 polymorphisms in German and US patients are not associated with occurrence or severity of acute pancreatitis

article

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) improves the innate immune response and enhances survival in murine polymicrobial sepsis

scientific article

Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice

scientific article published on 5 April 2012

Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer.

scientific article published on 12 May 2016

Up-regulation, nuclear import, and tumor growth stimulation of the adhesion protein p120 in pancreatic cancer

scientific article published in April 2003

Variations in trypsinogen expression may influence the protective effect of the p.G191R PRSS2 variant in chronic pancreatitis.

scientific article published in June 2009

List of works by Frank U. Weiss

A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

A structured weight loss program increases gut microbiota phylogenetic diversity and reduces levels of Collinsella in obese type 2 diabetics: A pilot study

A syngeneic orthotopic murine model of pancreatic adenocarcinoma in the C57/BL6 mouse using the Panc02 and 6606PDA cell lines

ABO blood type B and fucosyltransferase 2 non-secretor status as genetic risk factors for chronic pancreatitis

Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis

Advances in the etiology of chronic pancreatitis.

Angiopoietin-2, a regulator of vascular permeability in inflammation, is associated with persistent organ failure in patients with acute pancreatitis from the United States and Germany.

Animal models for investigating chronic pancreatitis.

Association analysis of genetic variants in the myosin IXB gene in acute pancreatitis

Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis.

Cathepsin B gene polymorphism Val26 is not associated with idiopathic chronic pancreatitis in European patients

Cathepsin B-mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.

Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis.

Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.

Chronic stress increases experimental pancreatic cancer growth, reduces survival and can be antagonised by beta-adrenergic receptor blockade.

Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Common variants in the CLDN2 - MORC4 and PRSS1 - PRSS2 loci confer susceptibility to acute pancreatitis

Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer

Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin

Defining chronic pancreatitis with a focus on pathological stress responses.

Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent cohorts

Development of Pancreatic Cancer: Targets for Early Detection and Treatment.

Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil

Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice

Effect of oral administration of AZD8309, a CXCR2 antagonist, on the severity of experimental pancreatitis.

Environmental risk factors for chronic pancreatitis and pancreatic cancer.

Extracellular cleavage of E-cadherin by leukocyte elastase during acute experimental pancreatitis in rats.

Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study

Functional abdominal pain and discomfort (IBS) is not associated with faecal microbiota composition in the general population

Functional characterisation of the CFTR mutations M348V and A1087P from patients with pancreatitis suggests functional interaction between CFTR monomers

Gene conversion between cationic trypsinogen (PRSS1) and the pseudogene trypsinogen 6 (PRSS3P2) in patients with chronic pancreatitis

Genetic polymorphisms in the UDP-glucuronosyltransferase UGT1A7 gene in patients with acute liver failure after kava-kava consumption

Genetic susceptibility factors for alcohol-induced chronic pancreatitis.

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis

Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogen

Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism

Hereditäre Pankreatitis

Identification of genetic loci associated with Helicobacter pylori serologic status

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma

Impaired Exocrine Pancreatic Function Associates With Changes in Intestinal Microbiota Composition and Diversity

In vivo imaging of pancreatic tumours and liver metastases using 7 Tesla MRI in a murine orthotopic pancreatic cancer model and a liver metastases model

Induction of M2-macrophages by tumour cells and tumour growth promotion by M2-macrophages: a quid pro quo in pancreatic cancer

Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis

Irritable bowel syndrome, mental health, and quality of life: Data from a population-based survey in Germany (SHIP-Trend-0)

Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer.

Lipase gene fusion: a new route to chronic pancreatitis

Liver injury and genetic polymorphisms in the cytochrome P450 and UDP-glucuronosyltransferase genes

Local clustering of PRSS1 R122H mutations in hereditary pancreatitis patients from Northern Germany.

Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function

Metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis.

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis

Novel mechanisms of RTK signal generation

Pancreatic cancer risk in hereditary pancreatitis

Plasma protein profiling of patients with intraductal papillary mucinous neoplasm of the pancreas as potential precursor lesions of pancreatic cancer

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer

Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

Specificity of a Polyclonal Fecal Elastase ELISA for CELA3.

Spontaneous and sporadic trypsinogen mutations in idiopathic pancreatitis

Subdiaphragmatic vagotomy promotes tumor growth and reduces survival via TNFα in a murine pancreatic cancer model.

Surgical trauma leads to a shorter survival in a murine orthotopic pancreatic cancer model

The PNPLA3 SNP rs738409:G allele is associated with increased liver disease-associated mortality but reduced overall mortality in a population-based cohort

The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis

Tissue tolerable plasma (TTP) induces apoptosis in pancreatic cancer cells in vitro and in vivo.

Toll-like receptor 4 polymorphisms in German and US patients are not associated with occurrence or severity of acute pancreatitis

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) improves the innate immune response and enhances survival in murine polymicrobial sepsis

Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice

Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer.

Up-regulation, nuclear import, and tumor growth stimulation of the adhesion protein p120 in pancreatic cancer

Variations in trypsinogen expression may influence the protective effect of the p.G191R PRSS2 variant in chronic pancreatitis.