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List of works by Massimiliano Mazzone

"Active" cancer immunotherapy by anti-Met antibody gene transfer

scientific article

A lifeline for suffocating tissues

scientific article published in Nature

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling

scientific article published in 2023

Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity

scientific article

Altering the intratumoral localization of macrophages to inhibit cancer progression

scientific article published on January 2014

An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity.

scientific article

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

scientific article published on 01 January 2020

Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels

scientific article

Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation

scientific article published on 3 August 2010

Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?

scientific article published on 31 May 2011

B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Kill Pathological Vessels?

scientific article published on 12 June 2020

Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells.

scientific article published on 19 October 2016

Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A

scientific article

Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding

scientific article published in 2023

Building in resistance to endothelial cell death

scientific article published on 01 November 2007

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy

scientific article published in Nature Communications

Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia.

scientific article published on 28 April 2016

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

scientific article

Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth

scientific article published on 16 October 2017

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization

scientific article

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

scientific article published on 16 September 2016

Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival

scientific article published on 2 April 2015

Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia.

scientific article

Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity

article

Genetic Deficiency in Plasma Protein HRG Enhances Tumor Growth and Metastasis by Exacerbating Immune Escape and Vessel Abnormalization

scientific article published on 28 February 2012

Genetic targeting of the kinase activity of the Met receptor in cancer cells

scientific article

Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages

scientific article published on 04 September 2020

Growing tumor vessels: more than one way to skin a cat - implications for angiogenesis targeted cancer therapies.

scientific article published on 22 April 2011

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

scientific article

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

scientific article

Histidine-rich glycoprotein uptake and turnover is mediated by mononuclear phagocytes

scientific article

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

scientific article (publication date: April 2003)

Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia

scientific article published on 01 May 2021

Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling

scientific article published on 05 February 2019

Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency.

scientific article published on 2 April 2015

Impaired Autonomic Regulation of Resistance Arteries in Mice With Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery

scientific article published on 06 July 2010

Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.

scientific article

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

scientific article

Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function

scientific article published on 02 August 2021

Loss of Caveolin-1 in Metastasis-Associated Macrophages Drives Lung Metastatic Growth through Increased Angiogenesis

scientific article published in December 2017

Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.

scientific article

Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury

scientific article published on 8 October 2009

MET is required for the recruitment of anti-tumoural neutrophils

scientific article

MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis

scientific article

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

scientific article

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

scientific article

Macrophage-derived glutamine boosts satellite cells and muscle regeneration

scientific article published on 28 October 2020

Metron factor-1 prevents liver injury without promoting tumor growth and metastasis

scientific article

Novel alternatives for anti-angiogenetic therapy and therapeutic angiogenesis.

scientific article published on January 2010

Overcoming resistance to antiangiogenic therapies

scientific article published on 06 July 2012

PHD1 regulates p53-mediated colorectal cancer chemoresistance.

scientific article published on 19 August 2015

PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner

scientific article

PHD2 regulates arteriogenic macrophages through TIE2 signalling

scientific article published on 25 April 2013

Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma

scientific article published on 10 October 2015

Preclinical and clinical evaluation of MET functions in cancer cells and in the tumor stroma.

scientific article published on 21 March 2016

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy

scientific article

Regulation of angiogenesis by oxygen and metabolism.

scientific article published on February 2009

Renal CD133(+)/CD73(+) progenitors produce erythropoietin under hypoxia and prolyl hydroxylase inhibition

scientific article published on 9 May 2013

Retinoid X receptor suppresses a metastasis-promoting transcriptional program in myeloid cells via a ligand-insensitive mechanism

scientific article published on 18 September 2017

Role and therapeutic potential of VEGF in the nervous system

scientific article published on April 2009

Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.

scientific article published on 13 May 2010

Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

scientific article

Sema3E?Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice.

scientific article published in July 2011

Sema3E–Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice.

scientific article published on 2 December 2013

Semaphorin Signals on the Road of Endothelial Tip Cells ⬇️

scientific article published on August 16, 2011

Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence

scientific article

Sixty shades of oxygen-an attractive opportunity for cancer immunotherapy

scientific article published on August 2015

Sunitinib but not VEGF blockade inhibits cancer stem cell endothelial differentiation

scientific article published on May 2015

Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models

scientific article published on 4 January 2011

Targeting the tumor and its microenvironment by a dual-function decoy Met receptor

scientific article

The "cord of life" serving antiangiogenic therapy

scientific article published in May 2013

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

scientific article published on 28 July 2015

The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation

scientific article published on 2 April 2014

The Met pathway: master switch and drug target in cancer progression

scientific article published on August 2006

The anti-proliferative effect of L-carnosine correlates with a decreased expression of hypoxia inducible factor 1 alpha in human colon cancer cells.

scientific article

The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation

scientific article published on 16 September 2013

The impact of hypoxia on tumor-associated macrophages

scientific article published on 2 August 2016

The therapeutic potential of hepatocyte growth factor to sensitize ovarian cancer cells to cisplatin and paclitaxel in vivo

scientific article published on April 2007

The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment

scientific article published on 5 May 2008

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity.

scientific article published on 23 December 2016

Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.

scientific article

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.

scientific article

Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment.

scientific article published on 22 April 2013

Tumor-associated macrophages: a short compendium

scientific article published on 12 February 2019

Tumour growth inhibition and anti‐metastatic activity of a mutated furin‐resistant Semaphorin 3E isoform ⬇️

scientific article published on January 13, 2012

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

scientific article published on 17 August 2016

Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer

scientific article published on 26 March 2015

VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials

scientific article

Vessel Normalization in the Spot-LIGHT of Cancer Treatment

scientific article published on 07 January 2016

miR-511-3p modulates genetic programs of tumor-associated macrophages

scientific journal article

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