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List of works by Massimiliano Mazzone

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

scientific article (publication date: April 2003)
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels

scientific article
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

scientific article
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

scientific article
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

scientific article
Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.

scientific article
Role and therapeutic potential of VEGF in the nervous system

scientific article published on April 2009
Regulation of angiogenesis by oxygen and metabolism.

scientific article published on February 2009
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

scientific article
Targeting the tumor and its microenvironment by a dual-function decoy Met receptor

scientific article
Tumour hypoxia causes DNA hypermethylation by reducing TET activity

scientific article published on 17 August 2016
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population

scientific article
Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?

scientific article published on 31 May 2011
VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials

scientific article
MET is required for the recruitment of anti-tumoural neutrophils

scientific article
Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

scientific article
miR-511-3p modulates genetic programs of tumor-associated macrophages

scientific journal article
Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity

scientific article
Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment.

scientific article published on 22 April 2013
Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

scientific article
Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury

scientific article published on 8 October 2009
Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

scientific article
The Met pathway: master switch and drug target in cancer progression

scientific article published on August 2006
The impact of hypoxia on tumor-associated macrophages

scientific article published on 2 August 2016
Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models

scientific article published on 4 January 2011
Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity

article
Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.

scientific article published on 13 May 2010
The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity.

scientific article published on 23 December 2016
Growing tumor vessels: more than one way to skin a cat - implications for angiogenesis targeted cancer therapies.

scientific article published on 22 April 2011
The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation

scientific article published on 16 September 2013
The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment

scientific article published on 5 May 2008
Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy

scientific article
Tumour growth inhibition and anti‐metastatic activity of a mutated furin‐resistant Semaphorin 3E isoform

scientific article published on January 13, 2012
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis

scientific article
Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence

scientific article
Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation

scientific article published on 3 August 2010
The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

scientific article published on 28 July 2015
FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

scientific article published on 16 September 2016
Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.

scientific article
Overcoming resistance to antiangiogenic therapies

scientific article published on 06 July 2012
Impaired Autonomic Regulation of Resistance Arteries in Mice With Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery

scientific article published on 06 July 2010
Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A

scientific article
PHD1 regulates p53-mediated colorectal cancer chemoresistance.

scientific article published on 19 August 2015
"Active" cancer immunotherapy by anti-Met antibody gene transfer

scientific article
PHD2 regulates arteriogenic macrophages through TIE2 signalling

scientific article published on 25 April 2013
Genetic targeting of the kinase activity of the Met receptor in cancer cells

scientific article
Genetic Deficiency in Plasma Protein HRG Enhances Tumor Growth and Metastasis by Exacerbating Immune Escape and Vessel Abnormalization

scientific article published on 28 February 2012
Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency.

scientific article published on 2 April 2015
Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia.

scientific article published on 28 April 2016
Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization

scientific article

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