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List of works by Richard Moriggl

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

scientific article published in August 2016

A Single Amino Acid in the DNA Binding Regions of STAT5A and STAT5B Confers Distinct DNA Binding Specificities

scientific article published in Journal of Biological Chemistry

A detailed protocol for bacterial artificial chromosome recombineering to study essential genes in stem cells

scientific article published on 01 January 2008

A haunted beast: Targeting STAT5BN642H in T-Cell Neoplasia.

scientific article

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis

scientific article

A mouse model to identify cooperating signaling pathways in cancer

article

A novel germline JAK2 mutation in familial myeloproliferative neoplasms

scientific article

A rare castration-resistant progenitor cell population is highly enriched in Pten-null prostate tumours

scientific article

A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling

scientific article

A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5

scientific article

AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis.

scientific article

Acetylation and sumoylation control STAT5 activation antagonistically

scientific article published on July 2012

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.

scientific article published on 15 February 2018

Activated STAT5 confers resistance to intestinal injury by increasing intestinal stem cell proliferation and regeneration

scientific article published on 8 January 2015

Activation of STAT proteins and cytokine genes in human Th1 and Th2 cells generated in the absence of IL-12 and IL-4.

scientific article published in April 1998

Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation

scientific article published on August 1999

Activation of STAT6 is not dependent on phosphotyrosine-mediated docking to the interleukin-4 receptor and can be blocked by dominant-negative mutants of both receptor subunits

scientific article published in January 1998

Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition.

scientific article published on 20 September 2016

Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice

scientific article published on 17 November 2016

Advances in covalent kinase inhibitors

scientific article published on 30 March 2020

Afatinib restrains K-RAS–driven lung tumorigenesis

scientific article published on 01 June 2018

Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation

scientific article

Apoptosis protection by the Epo target Bcl-X(L) allows factor-independent differentiation of primary erythroblasts

scientific article

Autocrine PDGFR signaling promotes mammary cancer metastasis

scientific article

Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression.

scientific article published on 29 May 2017

Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5.

scientific article

Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma

scientific article published on 11 June 2013

Cell Metabolism Control Through O-GlcNAcylation of STAT5: A Full or Empty Fuel Tank Makes a Big Difference for Cancer Cell Growth and Survival ⬇️

scientific article published on 27 February 2019

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation

scientific article

Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy

scientific article published on March 2014

Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia

scientific article

Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia.

scientific article

Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model

scientific article

Combined targeting of STAT3 and STAT5: a novel approach to overcome drug resistance in chronic myeloid leukemia

scientific article published on 8 June 2017

Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells

scientific article published on July 1997

Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias

scientific article published on 12 October 2006

Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice

scientific article published on 23 February 2016

Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

scientific article published on 14 July 2020

Correlation of malignancy parameters in colorectal carcinoma with up- and downstream signalling partners of STAT3.

scientific article

Cytokine receptor-independent, constitutively active variants of STAT5

scientific article published on 01 November 1997

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

scientific article published on October 1996

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

scientific article published on 21 August 2018

Differential roles of cytokine signaling during T-cell development.

scientific article

Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression

scientific article published on May 2007

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis

scientific article

Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis.

scientific article

Diverging fates of cells of origin in acute and chronic leukaemia

scientific article

Dominant negative variants of the SHP-2 tyrosine phosphatase inhibit prolactin activation of Jak2 (janus kinase 2) and induction of Stat5 (signal transducer and activator of transcription 5)-dependent transcription

scientific article published on 01 April 1998

Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells.

scientific article published on 29 November 2017

Editorial: Recovery from chemotherapy depends on STAT1 for replenishment of B lymphopoiesis

Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin

scientific article published on 10 June 2010

Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation

scientific article published on 9 January 2012

Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway

scientific article

Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling.

scientific article

Epigenetic program and transcription factor circuitry of dendritic cell development

scientific article

Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis

scientific article published in Nature Communications

Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR.

scientific article published on May 2006

Evaluation of Stat5 as a potential drug target in bcr/abl-induced leukemias

Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V.

scientific article

First-in-human response of BCL-2 inhibitor venetoclax in T-cell prolymphocytic leukemia.

scientific article published on 27 September 2017

Gadd45gamma is dispensable for normal mouse development and T-cell proliferation

scientific article published on May 2001

Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth

scientific article published on March 2004

Growth-hormone-induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer

article

Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.

scientific article published on 7 October 2016

Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression

scientific article published on 30 October 2018

Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development

scientific article

High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia.

scientific article

Homodimerization of interleukin-4 receptor alpha chain can induce intracellular signaling

scientific article published on September 1996

Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1

scientific article published on 19 September 2017

IGFBP7, a novel tumor stroma marker, with growth-promoting effects in colon cancer through a paracrine tumor-stroma interaction.

scientific article

Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides.

scientific article

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

scientific article published on October 2011

Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer

article

Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

scientific article published on 13 October 2016

Induction of 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13.

scientific article published on January 1999

Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemia

scientific article

Interleukin-6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus.

scientific article published on 6 January 2016

Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction

scientific article published on 4 March 2013

JAK-STAT signaling in cancer: From cytokines to non-coding genome.

scientific article published on 24 June 2016

Jak1 deficiency leads to enhanced Abelson-induced B-cell tumor formation

scientific article published on 06 February 2003

JunB inhibits proliferation and transformation in B-lymphoid cells

scientific article

Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation

scientific article

MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling

scientific article published on June 2016

Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy

scientific article published on 19 April 2007

NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells

scientific article published on 26 August 2015

Natural compound methyl protodioscin protects against intestinal inflammation through modulation of intestinal immune responses

scientific article published on 10 February 2015

New perspectives in stem cell research: beyond embryonic stem cells

scientific article published on April 2011

Nonredundant roles for Stat5a/b in directly regulating Foxp3

scientific article published on 16 January 2007

O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies

scientific article published on 11 January 2017

Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade

scientific article published on 25 June 2008

Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses.

scientific article

Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation

scientific article

PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis

scientific article

PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas

scientific article

Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth

scientific article published on June 2005

Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation

scientific article published on 31 March 2014

Pharmacologic inhibition of STAT5 in acute myeloid leukemia

scientific article published on 2 February 2018

Presence or absence of TGF-beta determines IL-4-induced generation of type 1 or type 2 CD8 T cell subsets

scientific article published on 01 January 1999

Prolactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor

scientific article published on December 1995

Promising new sources for pluripotent stem cells

scientific article published on March 2010

Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.

scientific article published in January 2002

Regulation of the trans-activation potential of STAT5 through its DNA-binding activity and interactions with heterologous transcription factors.

scientific article

Reliable quantification of protein expression and cellular localization in histological sections

scientific article

Reply: To PMID 21725989.

scientific article published on 7 October 2013

SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells

scientific article published on May 2014

STAT1 acts as a tumor promoter for leukemia development

scientific article published on July 2006

STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with the MMP-1 promoter

scientific article published on 17 March 2011

STAT3 regulated ARF expression suppresses prostate cancer metastasis

scientific article published on 22 July 2015

STAT3β is a tumor suppressor in acute myeloid leukemia

scientific article published on 01 July 2019

STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion

scientific article

STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease

scientific article published on 16 January 2017

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease

scientific article

STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output

scientific article

STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia

scientific article

STAT5A/5B-specific expansion and transformation of hematopoietic stem cells.

scientific article published on 6 January 2017

STAT5BN642H drives transformation of NKT cells: a novel mouse model for CD56+ T-LGL leukemia

scientific article published on 09 April 2019

Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice

scientific article

Serine phosphorylation of the Stat5a C-terminus is a driving force for transformation.

scientific article published on June 2011

Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction

scientific article published on April 2007

Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription

scientific article published on November 1997

Src family kinases mediate cytoplasmic retention of activated STAT5 in BCR-ABL-positive cells

scientific article published on 27 August 2012

Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL Leukemia Cells.

scientific article published on 19 March 2015

Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2.

scientific article published on 31 January 2008

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

scientific journal article

Stat5 gene dosage in T cells modulates CD8+T-cell homeostasis and attenuates contact hypersensitivity response in mice

article

Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia

scientific article published on March 2010

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

scientific article

Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.

scientific article

Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.

scientific article

Stat5 tetramer formation is associated with leukemogenesis

scientific article published on 01 January 2005

Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation

scientific article

Steering of carcinoma progression by the YIN/YANG interaction of STAT1/STAT3.

scientific article published on 2 February 2017

Structural and functional consequences of the STAT5BN642H driver mutation.

scientific article published on 7 June 2019

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia

scientific article published on 7 March 2013

Targeting STAT3 and STAT5 in Cancer

scientific article published on 22 July 2020

The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease

The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease

The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma.

scientific article

The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor

scientific article published on January 2009

The different functions of Stat5 and chromatin alteration through Stat5 proteins

scientific article

The first European interdisciplinary ewing sarcoma research summit ⬇️

scientific article

The inhibition of stat5 by a Peptide aptamer ligand specific for the DNA binding domain prevents target gene transactivation and the growth of breast and prostate tumor cells

scientific article published on 20 August 2013

The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain

scientific article published on November 1998

The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth

scientific article published on 12 May 2016

The role of Stat5 transcription factors as tumor suppressors or oncogenes ⬇️

scientific article published on October 20, 2010

The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease

scientific article

The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone.

scientific article published on 13 December 2017

Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens.

scientific article

Variants in STAT5B Associate with Serum TC and LDL-C Levels

article published in 2011

When the guardian sleeps: Reactivation of the p53 pathway in cancer

scientific article published on 17 February 2017

YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model

scientific article published on 8 October 2015

p19(ARF) /p14(ARF) controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma

scientific article published in July 2011

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