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List of works by David J. Segal

A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications

scientific article

Active integration: new strategies for transgenesis.

scientific article published on 6 March 2007

Adding fingers to an engineered zinc finger nuclease can reduce activity

scientific article published on 11 May 2011

Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.

scientific article

Author Correction: Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance.

scientific article

Bacteria herald a new era of gene editing

scientific article published on 29 January 2013

Beyond the genome and into the clinic.

scientific article published on 30 October 2012

Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing.

scientific article

Conformational elasticity can facilitate TALE-DNA recognition

scientific article published on January 2014

Custom zinc-finger nucleases for use in human cells

scientific article published in October 2005

DNA sequence-enabled reassembly of the green fluorescent protein

scientific article published in August 2005

Design, construction and in vitro testing of zinc finger nucleases

scientific article published in January 2006

Designing transcription factor architectures for drug discovery.

scientific article published on 31 August 2004

Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing

scientific article published on 01 April 2022

Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors

scientific article (publication date: 3 August 2001)

Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors

scientific article

Endonuclease-induced, targeted homologous extrachromosomal recombination in Xenopus oocytes.

scientific article

Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins

scientific article

Exploring the suitability of RanBP2-type Zinc Fingers for RNA-binding protein design

scientific article published on 21 February 2019

Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites

scientific article published on February 2004

Genome engineering at the dawn of the golden age.

scientific article published on 20 May 2013

Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing

scientific article

Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?

scientific article published on 01 September 2013

Live-Animal Epigenome Editing: Convergence of Novel Techniques

scientific article published on 22 May 2019

Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance

scientific article published on 8 November 2017

Modular Assembly of RanBP2-Type Zinc Finger Domains to Target Single-Stranded RNA

scientific article published on 19 April 2012

New Insights into DNA Recognition by Zinc Fingers Revealed by Structural Analysis of the Oncoprotein ZNF217

scientific article

Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

scientific article published on 30 April 2020

Quantitative analysis of TALE-DNA interactions suggests polarity effects.

scientific article published on 13 February 2013

Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker

scientific article published on 3 March 2009

SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation

scientific article

Seeing genetic and epigenetic information without DNA denaturation using sequence-enabled reassembly (SEER).

scientific article published in January 2010

Sequence-enabled reassembly of beta-lactamase (SEER-LAC): a sensitive method for the detection of double-stranded DNA.

scientific article published on March 2006

Site-directed genome modification: nucleic acid and protein modules for targeted integration and gene correction.

scientific article

Site-specific detection of DNA methylation utilizing mCpG-SEER.

scientific article published in August 2006

Split beta-lactamase sensor for the sequence-specific detection of DNA methylation

scientific article published on 8 August 2007

Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA.

scientific article published on 11 August 2006

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

scientific article

Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA.

scientific article published on 05 May 2009

Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain

scientific article published on 14 February 2018

The functional significance of common polymorphisms in zinc finger transcription factors

scientific article

The generation of zinc finger proteins by modular assembly.

scientific article

The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders

scientific article

The prospects for designer single-stranded RNA-binding proteins ⬇️

scientific article published on February 27, 2011

The protein-binding potential of C2H2 zinc finger domains

scientific article published on 20 February 2008

The use of zinc finger peptides to study the role of specific factor binding sites in the chromatin environment.

scientific article

Toward a general approach for RNA-templated hierarchical assembly of split-proteins

scientific article published on August 2010

Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

scientific article

Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome

scientific article published on 27 January 2020

Uranyl acetate as a direct inhibitor of DNA-binding proteins

scientific article published on 14 April 2007

Zinc-finger nucleases transition to the CoDA ⬇️

scientific article published on 01 January 2011

dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression.

scientific article published on September 2017

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