List of works by António Francisco Ambrósio

A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion

scientific article published on 01 February 1995

A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss

scientific article published on 01 July 2019

Activation of Adenosine A3 Receptor Inhibits Microglia Reactivity Elicited by Elevated Pressure

scientific article published on 30 September 2020

Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro

scientific article published on 26 August 2015

Adenosine A2A Receptor Blockade Modulates Glucocorticoid-Induced Morphological Alterations in Axons, But Not in Dendrites, of Hippocampal Neurons.

scientific article published on 19 March 2018

Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety

scientific article published on 11 October 2016

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure

scientific article

Adenosine A3 receptor activation is neuroprotective against retinal neurodegeneration.

scientific article published on 18 August 2015

Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro

scientific article

Blockade of microglial adenosine A2A receptor suppresses elevated pressure-induced inflammation, oxidative stress, and cell death in retinal cells

scientific article published on 22 January 2019

Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma.

scientific article

Calcium Dobesilate Is Protective against Inflammation and Oxidative/Nitrosative Stress in the Retina of a Type 1 Diabetic Rat Model.

scientific article published on 10 August 2017

Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes

scientific journal article

Calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion

scientific article published on 19 September 2012

Carbamazepine inhibits L-type Ca2+ channels in cultured rat hippocampal neurons stimulated with glutamate receptor agonists.

scientific article published in September 1999

Caveolin-1-mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype.

scientific article published on 28 March 2017

Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons

scientific article published on 22 June 2007

Choroidal thickness changes stratified by outcome in real-world treatment of diabetic macular edema

scientific article published on 23 July 2018

Cobalt staining of hippocampal neurons mediated by non-desensitizing activation of AMPA but not kainate receptors

scientific article

Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose

scientific journal article

Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases

scientific article

Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus ⬇️

scientific journal article

Diabetes causes transient changes in the composition and phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and interaction with auxiliary proteins in the rat retina

scientific article published on 21 June 2014

Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina

scientific article published on 6 February 2008

Diabetes changes the levels of ionotropic glutamate receptors in the rat retina.

scientific article published on 17 August 2009

Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals

scientific article published on 19 June 2010

Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: implications for axonal transport.

scientific article published on 24 July 2014

Diabetes induces early transient changes in the content of vesicular transporters and no major effects in neurotransmitter release in hippocampus and retina.

scientific article published on 28 January 2011

Diabetic hyperglycemia reduces Ca2+ permeability of extrasynaptic AMPA receptors in AII amacrine cells

scientific article

Differential contribution of L-, N-, and P/Q-type calcium channels to [Ca2+]i changes evoked by kainate in hippocampal neurons

scientific article published on 27 March 2008

Differential contribution of the guanylyl cyclase-cyclic GMP-protein kinase G pathway to the proliferation of neural stem cells stimulated by nitric oxide.

scientific article published on 23 February 2012

Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies

scientific article published on 06 November 2018

Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus.

scientific article

Early calpain-mediated proteolysis following AMPA receptor activation compromises neuronal survival in cultured hippocampal neurons.

scientific article published in December 2004

Effects of 3,4-methylenedioxymethamphetamine administration on retinal physiology in the rat

scientific article

Effects of drugs of abuse on the central neuropeptide Y system

scientific article published on 22 April 2015

Electrochemical Immunosensor for TNFα-Mediated Inflammatory Disease Screening

scientific article published on 18 April 2019

Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation.

scientific article published on 15 May 2017

Elevated Pressure Changes the Purinergic System of Microglial Cells.

scientific article published on 24 January 2018

Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampus

scientific article published on 29 May 2012

Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection

scientific article published on 30 October 2013

Evaluation of neurotoxic and neuroprotective pathways affected by antiepileptic drugs in cultured hippocampal neurons.

scientific article published on 19 September 2013

Evaluation of the impact of diabetes on retinal metabolites by NMR spectroscopy.

scientific article published on November 2010

Extracellular Vesicles and MicroRNA: Putative Role in Diagnosis and Treatment of Diabetic Retinopathy

scientific article published on 04 August 2020

Glia-Mediated Retinal Neuroinflammation as a Biomarker in Alzheimer's Disease.

scientific article

Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases.

scientific article published on 31 January 2017

Heme oxygenase-1 protects retinal endothelial cells against high glucose- and oxidative/nitrosative stress-induced toxicity

scientific article

High glucose and diabetes increase the release of [3H]-D-aspartate in retinal cell cultures and in rat retinas.

scientific article published on 28 February 2006

High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway

scientific article

High glucose changes extracellular adenosine triphosphate levels in rat retinal cultures.

scientific article published on May 2009

High glucose enhances intracellular Ca2+ responses triggered by purinergic stimulation in retinal neurons and microglia

scientific article published on 23 December 2009

High glucose induces caspase-independent cell death in retinal neural cells

scientific article published on 16 December 2006

Impact of Neuroinflammation on Hippocampal Neurogenesis: Relevance to Aging and Alzheimer's Disease.

scientific article

Impact of type 1 diabetes mellitus and sitagliptin treatment on the neuropeptide Y system of rat retina.

scientific article published on 14 February 2018

Impairment of Axonal Transport in Diabetes: Focus on the Putative Mechanisms Underlying Peripheral and Central Neuropathies

scientific article published on 12 July 2018

In Vivo Characterization of Corneal Changes in a Type 1 Diabetic Animal Model

scientific article published on 31 December 2018

Increase of the intracellular Ca2+ concentration mediated by transport of glutamate into rat hippocampal synaptosomes: characterization of the activated voltage sensitive Ca2+ channels.

scientific article published in January 1998

Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy

scientific article

Inhibition of N-,P/Q- and other types of Ca2+ channels in rat hippocampal nerve terminals by the adenosine A1 receptor.

scientific article published in December 1997

Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels.

scientific article published in May 2001

Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline.

scientific article published on 15 December 2015

Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice

scientific article published on 20 November 2019

Involvement of class A calcium channels in the KCl induced Ca2+ influx in hippocampal synaptosomes

scientific article published on 01 October 1995

Long-term exposure to high glucose increases the content of several exocytotic proteins and of vesicular GABA transporter in cultured retinal neural cells.

scientific article published on 30 June 2015

Long-term exposure to high glucose induces changes in the content and distribution of some exocytotic proteins in cultured hippocampal neurons.

scientific article

Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024.

scientific article

Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: role of tight junction proteins and matrix metalloproteinase-9.

scientific article published on 14 July 2011

Methamphetamine-induced nitric oxide promotes vesicular transport in blood-brain barrier endothelial cells.

scientific article published on September 2012

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

scientific article published on 14 May 2020

Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration

scientific article published on 01 June 2020

Microglia sequelae: brain signature of innate immunity in schizophrenia

scientific article published in 2022

Modeling Human Glaucoma: Lessons from the in vitro Models

scientific article published on 13 September 2016

Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats

scientific article published on 26 October 2005

Modulation of Ca2+ channels by activation of adenosine A1 receptors in rat striatal glutamatergic nerve terminals.

scientific article published in December 1996

Modulation of glutamate release from rat hippocampal synaptosomes by nitric oxide.

scientific article published on August 1997

Müller cells do not influence leukocyte adhesion to retinal endothelial cells

scientific article

NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells

scientific journal article

Neuronal nitric oxide synthase proteolysis limits the involvement of nitric oxide in kainate‐induced neurotoxicity in hippocampal neurons ⬇️

scientific article published on May 1, 2003

Neuropeptide Y Receptors Y1and Y2are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture

article

Neuropeptide Y inhibits [Ca2+]i changes in rat retinal neurons through NPY Y1, Y4, and Y5 receptors

scientific article

Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy.

scientific article

Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate.

scientific article published on 16 May 2013

Neuropeptide Y stimulates retinal neural cell proliferation--involvement of nitric oxide

scientific article published in June 2008

Neuropeptide Y system in the retina: From localization to function

scientific article published on 19 March 2015

Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead

scientific article published on 25 March 2020

Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024

scientific article published on 01 October 2000

Neurotoxicity induced by antiepileptic drugs in cultured hippocampal neurons: a comparative study between carbamazepine, oxcarbazepine, and two new putative antiepileptic drugs, BIA 2-024 and BIA 2-093.

scientific article published in December 2004

Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling

scientific article

Nitric oxide inhibits complex I following AMPA receptor activation via peroxynitrite.

scientific article published in September 2004

Nitric oxide modulates sodium vitamin C transporter 2 (SVCT-2) protein expression via protein kinase G (PKG) and nuclear factor-κB (NF-κB).

scientific article published on 31 October 2011

Nitric oxide stimulates the proliferation of neural stem cells bypassing the epidermal growth factor receptor.

scientific article published in July 2010

Obesity and brain inflammation: a focus on multiple sclerosis.

scientific article

Old and new drug targets in diabetic retinopathy: from biochemical changes to inflammation and neurodegeneration

scientific article (publication date: August 2005)

Opening eyes to nanomedicine: Where we are, challenges and expectations on nanotherapy for diabetic retinopathy

scientific article

Protective Effect of a GLP-1 Analog on Ischemia-Reperfusion Induced Blood-Retinal Barrier Breakdown and Inflammation

scientific article published on May 2016

Protective effects of the dipeptidyl peptidase IV inhibitor sitagliptin in the blood-retinal barrier in a type 2 diabetes animal model

scientific article published on 6 January 2012

Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats

scientific article published on 21 November 2018

Regulation of claudins in blood-tissue barriers under physiological and pathological states

scientific article published on 30 May 2013

Retinal texture biomarkers may help to discriminate between Alzheimer's, Parkinson's, and healthy controls

scientific article published on 21 June 2019

Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer's disease: a longitudinal multimodal in vivo study

scientific article published on 13 November 2019

Role of desensitization of AMPA receptors on the neuronal viability and on the [Ca2+]ichanges in cultured rat hippocampal neurons

scientific article published on 01 June 2000

Role of kainate receptor activation and desensitization on the [Ca(2+)](i) changes in cultured rat hippocampal neurons.

scientific article

Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases

scientific article

Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient ischemic injury

scientific article published on 23 November 2015

Sex differences in offspring neurodevelopment, cognitive performance and microglia morphology associated with maternal diabetes: Putative targets for insulin therapy

scientific article published on 19 April 2020

Sildenafil Acutely Decreases Visual Responses in ON and OFF Retinal Ganglion Cells

scientific article

Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy

scientific article published on 13 July 2018

TNF-α signals through PKCζ/NF-κB to alter the tight junction complex and increase retinal endothelial cell permeability

scientific article

Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose

scientific article published on 5 September 2013

The Adenosinergic System in Diabetic Retinopathy

scientific article

The Benefits of Flavonoids in Diabetic Retinopathy

scientific article published on 16 October 2020

The Quadruple Helix-Based Innovation Model of Reference Sites for Active and Healthy Ageing in Europe: The Ageing@Coimbra Case Study.

scientific article

The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer's Disease: Critical Aspects to Unravel

scientific article published on 05 January 2019

The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin ameliorates retinal endothelial cell dysfunction triggered by inflammation.

scientific article published on 29 March 2018

The value of choroidal thickness in diabetic macular oedema is contradictory

scientific article published on 09 July 2020

Therapeutic Opportunities for Caffeine and A2A Receptor Antagonists in Retinal Diseases

scientific article

Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage

scientific article published on 5 October 2017

Viewing the choroid: where we stand, challenges and contradictions in diabetic retinopathy and diabetic macular oedema.

scientific article published on 22 August 2016

c-Src function is necessary and sufficient for triggering microglial cell activation

scientific article

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