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List of works by Michel Bouvier

A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms

scientific article

A Pluridimensional View of Biased Agonism

scientific article

A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells

scientific article

A cyclic peptide mimicking the third intracellular loop of the V2 vasopressin receptor inhibits signaling through its interaction with receptor dimer and G protein

scientific journal article

A human immunodeficiency virus type 1 protease biosensor assay using bioluminescence resonance energy transfer

scientific article published on September 2005

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

scientific article published on 18 April 2017

A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway

scientific article

A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation.

scientific article published on July 1996

A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells

scientific article

Abnormal regulation of the sympathoadrenal system in deoxycorticosterone acetate – salt hypertensive rats

article

Activation of the beta(2)-adrenergic receptor-Galpha(s) complex leads to rapid depalmitoylation and inhibition of repalmitoylation of both the receptor and Galpha(s).

scientific article published on October 1999

Activity of the interferon-induced 2',5'-oligoadenylate synthetase in patients with chronic hepatitis C.

scientific article

Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

scientific article published on 21 August 2003

Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders

scientific article published on July 2004

Agonist stimulation increases the turnover rate of beta 2AR-bound palmitate and promotes receptor depalmitoylation

scientific article published on December 1996

Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways.

scientific article published on 15 July 2009

Agonist-induced formation of unproductive receptor-G12 complexes

scientific article published on 17 August 2020

Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin

scientific article (publication date: 9 November 2001)

An aplysia dopamine1-like receptor: molecular and functional characterization

scientific article published on 29 November 2005

An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling

scientific article

An interview with Michel Bouvier, Ph.D. Interview by Vicki Glaser

scientific article

Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy

scientific article published on 19 September 2017

Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs

scientific article published on 12 June 2019

Appréhender la complexité du vivant à l’ère des « Omiques »

Assembly and signaling of CRLR and RAMP1 complexes assessed by BRET.

scientific article published on 16 May 2007

Association of Treatment with Carvedilol, Bisoprolol and Metoprolol on the Risk of Mortality and Hospital Admission Among Older Adults with Heart Failure

Association of calnexin with wild type and mutant AVPR2 that causes nephrogenic diabetes insipidus.

scientific article published in June 2001

Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response

scientific article published on 16 April 2020

BRET analysis of GPCR oligomerization: newer does not mean better

scientific article published in January 2007

Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy

scientific article published on 24 July 2002

Beta(2)-adrenergic receptor down-regulation. Evidence for a pathway that does not require endocytosis.

scientific article published on October 1999

Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

scientific article

Biased signaling favoring gi over β-arrestin promoted by an apelin fragment lacking the C-terminal phenylalanine

scientific article

Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells

scientific article published in April 2001

Biochemical characterization of beta2-adrenergic receptor dimers and oligomers

scientific article published on January 2003

Bioinactive ACTH causing glucocorticoid deficiency

scientific article

Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing delta-opioid receptors and heterotrimeric G proteins.

scientific article

Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers.

scientific article

Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes

scientific article published on 07 August 2018

Bioluminescence resonance energy transfer-based imaging of protein-protein interactions in living cells

scientific article published on 25 March 2019

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding

scientific article

Bradykinin decreases T-kininogen synthesis in a rat hepatoma cell line: evidence of bradykinin B2-type receptors

scientific article

Building a new conceptual framework for receptor heteromers

scientific article

CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum

scientific article

Ca(2+)-dependent sensitization of adenylyl cyclase activity

scientific article published in June 2001

Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor

scientific article published on 24 February 2007

Cardiac adrenergic receptor effects of carvedilol

scientific article

Cardiomyocytes β-adrenergic receptors are resistants to short-term desensitization

Cellular and subcellular context determine outputs from signaling biosensors ⬇️

scientific article

Chapter 3 Receptor regulation

Characterization of oligomeric human ATP binding cassette transporter A1. Potential implications for determining the structure of nascent high density lipoprotein particles

scientific article

Characterization of the vasorelaxant activity of tyramine and other phenylethylamines in rat aorta

scientific article published on 01 June 1995

Characterization, expression, and hormonal control of a thymic beta 2-adrenergic receptor

scientific journal article

Chemogenetics defines receptor-mediated functions of short chain free fatty acids

scientific article published on 15 April 2019

Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction

scientific article

Chronic β-blockade increases skeletal muscle β-adrenergicreceptor density and enhances contractile force

Combining resonance energy transfer methods reveals a complex between the alpha2A-adrenergic receptor, Galphai1beta1gamma2, and GRK2.

scientific article published on 9 August 2010

Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin-biased agonists.

scientific article published on July 2015

Comparative binding study of rat natriuretic peptide receptor-A.

scientific article

Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways

article published in the Proceedings of the National Academy of Sciences of the United States of America

Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors

scientific article published on 21 November 2012

Conformational rearrangements and signaling cascades involved in ligand-biased mitogen-activated protein kinase signaling through the beta1-adrenergic receptor.

scientific article

Constitutive Agonist-independent CCR5 Oligomerization and Antibody-mediated Clustering Occurring at Physiological Levels of Receptors

scientific article published in Journal of Biological Chemistry

Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow

scientific journal article

Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy

scientific article

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

scientific article

CrossTalk proposal: Weighing the evidence for Class A GPCR dimers, the evidence favours dimers

article

Cys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization

scientific article

Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor

scientific article published on March 1994

Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

scholarly article

Determination of protein-bound palmitate turnover rates using a three-compartment model that formally incorporates [3H]palmitate recycling

scientific article published on September 2004

Development and characterization of pepducins as Gs-biased allosteric agonists

scientific article

Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs

scientific article published on 24 April 2012

Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function

scientific article

Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure

scientific article

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy

scientific article published on 05 August 2019

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis

scientific article

Distinct motifs of neuropeptide Y receptors differentially regulate trafficking and desensitization

scientific article published on 14 December 2007

Distinct receptor domains determine subtype-specific coupling and desensitization phenotypes for human beta1- and beta2-adrenergic receptors

article

Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy

scientific article published on 10 August 2006

Distinct subcellular localization for constitutive and agonist-modulated palmitoylation of the human delta opioid receptor

scientific article published on 4 April 2006

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

scientific article published on 15 August 2016

Dynamic palmitoylation of G-protein-coupled receptors in eukaryotic cells.

scientific article published on January 1995

Dynamic regulation of G-protein coupled receptor palmitoylation: potential role in receptor function.

scientific article published on August 1995

Dysfunction of the beta- and alpha-adrenergic systems in a model of congestive heart failure. The pacing-overdrive dog.

scientific article published in August 1991

Effects of acute and chronic administration of sotalol on the blood pressure and the sympathoadrenal activity of anesthetized deoxycorticosterone acetate – salt hypertensive rats

article

Effects of trandolapril on the sympathetic tone and reactivity in systemic hypertension

article

Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors.

scientific article

Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation

scientific article

Engagement of β-arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation

scientific article published on 9 April 2012

Enhanced sympathoadrenal reactivity to haemorrhagic stress in DOCA-salt hypertensive rats

Espoirs et défis en recherche biomédicale

Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.

scientific article published on 18 December 2017

Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response

scientific article published on 09 September 2019

Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor

scientific journal article

Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis

scientific article published on November 2008

Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors.

scientific article

Expression, regulation, and activity of ABCA1 in human cell lines

scientific article published on April 2003

FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs

scientific article published on 04 December 2018

Free and Conjugated Catecholamines in Plasma and Red Blood Cells of Normotensive and Hypertensive Patients

article by J de Champlain et al published January 1984 in Clinical and Experimental Hypertension

Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats.

scientific article published on 07 August 2017

Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1

scientific article (publication date: 26 October 2007)

Functional characterization of a novel serotonin receptor (5-HTap2) expressed in the CNS of Aplysia californica

scientific article published in January 2002

Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments

scientific article

Functional effects of long-term activation on human beta 2- and beta 3-adrenoceptor signalling

scientific article published on March 1995

Functional rescue of a constitutively desensitized beta2AR through receptor dimerization.

scientific article published on February 1998

Functional rescue of beta-adrenoceptor dimerization and trafficking by pharmacological chaperones

scientific article

Functional rescue of the constitutively internalized V2 vasopressin receptor mutant R137H by the pharmacological chaperone action of SR49059.

scientific article published on 27 May 2004

Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes

scientific article published on 8 November 2011

Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands.

scientific article

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors

scientific article published on 04 December 2018

Functional significance of oligomerization of G-protein-coupled receptors.

scientific article

G protein-coupled receptor modulation with pepducins: moving closer to the clinic

scientific article published on 01 May 2011

G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase

scientific article

G-protein coupling specificity of the human oxytocin receptor

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

scientific article

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.

scientific article

Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity

scientific article

Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

scientific article

Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns

scientific article

Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility

scientific article published on 7 July 2005

Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells.

scientific article published in July 2006

High-throughput screening of G protein-coupled receptor antagonists using a bioluminescence resonance energy transfer 1-based beta-arrestin2 recruitment assay

scientific article published on August 2005

Homo- and hetero-oligomerization of beta-arrestins in living cells

scientific article

Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

scientific article published on February 2004

Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting

scientific article published on 20 May 2004

Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias

article

Identification and characterization of an activating F229V substitution in the V2 vasopressin receptor in an infant with NSIAD.

scientific article

Impedance responses reveal β₂-adrenergic receptor signaling pluridimensionality and allow classification of ligands with distinct signaling profiles

scientific article

Increased apparent norepinephrine release rate in anesthetized DOCA-salt hypertensive rats

scientific article published on January 1985

Increased basal and reactive plasma norepinephrine and epinephrine levels in awake DOCA-salt hypertensive rats

scientific article published on 01 February 1986

Increased pressure on G protein-coupled receptor kinases

scientific article published on May 1997

Increased production of active human beta(2)-adrenergic/G(alphas) fusion receptor in Sf-9 cells using nutrient limiting conditions

scientific article

Increased sympatho-adrenal tone and adrenal medulla reactivity in DOCA-salt hypertensive rats

scientific article

Influence of receptor density on the patterns of beta2-adrenocepter desensitization

scientific article published on May 1997

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

scientific article

Insights into signaling from the β2-adrenergic receptor structure

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers.

scientific article published on March 2007

Inverse agonist activity of beta-adrenergic antagonists.

scientific article published on March 1994

KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABAB Receptor-Induced K+ Currents

scientific article published on 21 December 2016

La recherche académique

Les années 2000

Les années 2010

Ligand bias prevents class equality among beta-blockers.

scientific article published on 27 March 2014

Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors

scientific article published on 24 May 2011

Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation

scientific article published on April 2002

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

scientific article published on 25 September 2018

Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.

scientific article published on 6 November 2017

Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction

scientific article (publication date: 19 April 2016)

Mapping the putative G protein-coupled receptor (GPCR) docking site on GPCR kinase 2: insights from intact cell phosphorylation and recruitment assays

scientific article

Mechanisms involved in adrenergic receptor desensitization.

scientific article published on August 1990

Metaphors, naming and new signaling paradigms by G-protein-coupled receptors

scientific article

Methods to monitor the quaternary structure of G protein-coupled receptors

scientific article

Molecular Biology of Adrenergic Receptors

scientific article published on 01 January 1988

Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1).

scientific article

Molecular determinants of ligand efficacy and potency in GPCR signaling

scientific article published on 21 December 2023

Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET

scientific article

Monitoring agonist-promoted conformational changes of beta-arrestin in living cells by intramolecular BRET.

scientific article

Monitoring ligand-dependent assembly of receptor ternary complexes in live cells by BRETFect

article published in the Proceedings of the National Academy of Sciences of the United States of America

Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer

scientific article (publication date: 14 June 2002)

Monitoring protein-protein interactions in living cells by bioluminescence resonance energy transfer (BRET).

scientific article

Multimerization of Staufen1 in live cells

scientific article

Multiplexing of multicolor bioluminescence resonance energy transfer

scientific article published on December 2010

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

scientific article

Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.

scientific article

Mutation of tyrosine-350 impairs the coupling of the beta 2-adrenergic receptor to the stimulatory guanine nucleotide binding protein without interfering with receptor down-regulation

scientific article published on May 1993

Médecine/Scienceset les passerelles du temps

N-Glycan-dependent and -independent quality control of human δ opioid receptor N-terminal variants

scientific article published on 5 May 2014

Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)

scientific article

New molecular and structural determinants involved in beta 2-adrenergic receptor desensitization and sequestration. Delineation using chimeric beta 3/beta 2-adrenergic receptors.

scientific article published on April 1996

Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome.

scientific article

Nitric oxide modulates beta(2)-adrenergic receptor palmitoylation and signaling

scientific article published on September 1999

Nouveau dialogue entre récepteurs et protéines G trimériques : « une danse à corps enlacés »

scientific article published on 01 November 2007

Novel Screening Paradigms for the Identification of Allosteric Modulators and/or Biased Ligands for Challenging G-Protein-Coupled Receptors

article

Older adults with heart failure treated with carvedilol, bisoprolol, or metoprolol tartrate: risk of mortality

scientific article published on 16 November 2016

Oligomerization of G-protein-coupled transmitter receptors.

scientific article

Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells

scientific article

Oxytocin and Vasopressin V1a and V2 Receptors Form Constitutive Homo- and Heterodimers during Biosynthesis

scientific article published on 23 December 2002

PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.

scientific article published on 20 December 2011

Palmitoylated cysteine 341 modulates phosphorylation of the beta2-adrenergic receptor by the cAMP-dependent protein kinase

scientific article published on August 1996

Palmitoylation of G-protein-coupled receptors: a dynamic modification with functional consequences.

scientific article published on February 1995

Palmitoylation of the V2 vasopressin receptor carboxyl tail enhances beta-arrestin recruitment leading to efficient receptor endocytosis and ERK1/2 activation

scientific article published on 4 August 2003

Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

scientific article published on 05 December 2013

Peptide G protein-coupled receptors meet at Erice

scientific article published in September 1998

Peripheral actions of GPCRs in energy homeostasis: view from the Chair

scientific article published on 8 July 2014

Pharmacologic chaperones as a potential treatment for X-linked nephrogenic diabetes insipidus

scientific article published on 30 November 2005

Pharmacological Chaperones Restore Function to MC4R Mutants Responsible for Severe Early-Onset Obesity

scientific article published on 08 September 2010

Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled Receptors

scholarly article published 15 July 2010

Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential.

scientific article published on 14 November 2017

Pharmacological chaperone action on G-protein-coupled receptors.

scientific article published in October 2004

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

scientific journal article

Pharmacological chaperones: a new twist on receptor folding.

scientific article

Pharmacological chaperones: potential treatment for conformational diseases.

scientific article published in July 2004

Phorbol-ester-induced phosphorylation of the beta 2-adrenergic receptor decreases its coupling to Gs

scientific article

Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization.

scientific article

Phosphorylation-independent desensitization of GABA(B) receptor by GRK4

scientific article

Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14.

scientific article

Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling

scientific article

Primary sequence requirements for S-acylation of beta(2)-adrenergic receptor peptides

scientific article published in June 2001

Probing the Functional Selectivity of β-adrenergic Receptors Reveals New Signaling Modes and Potential Therapeutic Applications

Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes.

scientific article published on 13 August 2006

Propranolol Therapy for Ectopic β-Adrenergic Receptors in Adrenal Cushing's Syndrome

Protein-protein interactions monitored in cells from transgenic mice using bioluminescence resonance energy transfer

scientific article published on 24 March 2010

Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

scientific article published on 01 February 2019

Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells

scientific article

Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo

scholarly article

Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy.

scientific article published on 23 December 2013

Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer

scientific article published on 19 September 2002

Real-time monitoring of receptor and G-protein interactions in living cells.

scientific article

Real-time monitoring of ubiquitination in living cells by BRET.

scientific article

Rebuttal from Michel Bouvier and Terence E. Hébert

Receptor activity-independent recruitment of betaarrestin2 reveals specific signalling modes

scientific article published on 23 September 2004

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.

scientific article

Receptor-regulated interaction of activator of G-protein signaling-4 and Galphai

scientific article

Reciprocal regulation of agonist and inverse agonist signaling efficacy upon short-term treatment of the human delta-opioid receptor with an inverse agonist

scientific article

Recovery of homogeneous and functional beta 2-adrenergic receptors from extracellular baculovirus particles

scientific article published on November 1997

Red blood cell catecholamine levels in normotensive and DOCA-salt hypertensive rats.

scientific article

Regulation of adenylyl cyclase-coupled beta-adrenergic receptors

scientific article published on January 1988

Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor.

scientific article

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

scientific article published in Nature

Reply: beyond receptor dimerization

scientific article published on 01 September 2000

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base

scientific article

Resonance energy transfer approaches in molecular pharmacology and beyond

scientific article published on 16 July 2007

Restructuring G-protein- coupled receptor activation

scientific article

Role of SUMOylation in full antiestrogenicity

scientific article

Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function

scientific article

Roles of G-protein-coupled receptor dimerization

scientific article published on January 2004

Selective activation of the adrenal medulla during acute bilateral carotid occlusion and its modulation by alpha-adrenergic receptors in the rat.

scientific article published on April 1983

Sensory neuron-specific MAS-related gene-X1 receptors resist agonist-promoted endocytosis

scientific article published on 27 April 2010

Short-term inverse-agonist treatment induces reciprocal changes in delta-opioid agonist and inverse-agonist binding capacity.

scientific article published in October 2001

Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling

scientific article published on 8 May 2006

Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling

scientific article

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion

scientific article published in Nature Communications

Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex.

scientific article published on 24 April 2007

Structural and functional aspects of G protein-coupled receptor oligomerization

scientific article published in January 1998

Structural insights into binding specificity, efficacy and bias of a βAR partial agonist

scientific article

Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor

scientific article published on 22 December 2020

Subcellular distribution of GABA(B) receptor homo- and hetero-dimers.

scientific article

Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transfer

scientific article

Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization

scientific article

Subtype-Specific Regulation of the β-Adrenergic Receptors

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

scientific article published on 15 March 2017

TAK-875 is a Partial Agonist of the Free Fatty Acid Receptor GPR40

Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function.

scientific article published on 26 January 2017

Technology combination to address GPCR allosteric modulator drug-discovery pitfalls.

scientific article

The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS).

scientific article published on February 2002

The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects

scientific article published on 27 November 2020

The V2 vasopressin receptor stimulates ERK1/2 activity independently of heterotrimeric G protein signalling

scientific article published on 3 June 2006

The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin.

scientific article

The evasive nature of drug efficacy: implications for drug discovery

scientific article published on 19 July 2007

The experimental power of FR900359 to study Gq-regulated biological processes

scientific article

The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum

scientific article

The human beta 3-adrenergic receptor is resistant to short term agonist-promoted desensitization.

scientific article published on April 1993

The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis

scientific article published in Journal of Biological Chemistry

The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization

scientific article

Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets

scientific article published on 3 June 2016

Translating biased signaling in the ghrelin receptor system into differential in vivo functions

article published in the Proceedings of the National Academy of Sciences of the United States of America

Type 2 diabetes–associated variants of the MT2melatonin receptor affect distinct modes of signaling

Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta-arrestins and AP-2.

scientific article published on 3 August 2007

Unraveling the structural basis of GPCR activation and inactivation ⬇️

scientific article published on May 1, 2013

Upregulation ofα1A-andα1B-Adrenergic Receptor mRNAs in the Heart of Cardiomyopathic Hamsters

VRQ397 (CRAVKY): a novel noncompetitive V2 receptor antagonist

scientific article

Vasopressin Type 2 Receptor V88M Mutation: Molecular Basis of Partial and Complete Nephrogenic Diabetes Insipidus

scientific article published on 08 October 2009

When an Inhibitor Promotes Activity

[19] Crosstalk between tyrosine kinase and G-protein-linked signal transduction systems

médecine/sciences2011

article published in 2011

β-Adrenergic receptor desensitization in the early stage of hereditary cardiomyopathy in hamsters

scientific article published on 01 August 1994

β-Adrenoceptors and dexamethasone synergistically stimulate the expression of the angiotensinogen gene in opossum kidney cells

article

β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.

scientific article published on 8 July 2015

β-Blockers have differential effects on the murine asthma phenotype

scientific article

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