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List of works by Benjamin Frey

12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance

scientific journal article

302MO Development of a flow cytometry-based whole-blood prognostic immune signature in metastatic cancer patients treated with immune checkpoint inhibitors

scientific article published in November 2020

A clinician's plea to test glioma patients for CMV.

scientific article published on September 2017

A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer

scientific article published on June 2016

Activation-induced cell death and total Akt content of granulocytes show a biphasic course after low-dose radiation

scientific article published on 01 May 2009

Activator protein 1 shows a biphasic induction and transcriptional activity after low dose X-irradiation in EA.hy.926 endothelial cells

scientific article published on 01 May 2009

After shrinkage apoptotic cells expose internal membrane-derived epitopes on their plasma membranes

scientific article published on 15 December 2006

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

scientific article published on 28 April 2014

Analysis of the immune status from peripheral whole blood with a single-tube multicolor flow cytometry assay

scientific article published on 04 April 2019

AnnexinA5 renders dead tumor cells immunogenic--implications for multimodal cancer therapies.

scientific article

Antitumor immune responses induced by ionizing irradiation and further immune stimulation

scientific article

Application of hyperthermia in addition to ionizing irradiation fosters necrotic cell death and HMGB1 release of colorectal tumor cells

scientific article published on 05 December 2009

Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases

scientific article

Benign painful elbow syndrome. First results of a single center prospective randomized radiotherapy dose optimization trial

scientific article published on 25 August 2012

Benign painful shoulder syndrome: initial results of a single-center prospective randomized radiotherapy dose-optimization trial

scientific article published on 07 November 2012

CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer

scientific article published on 10 January 2022

Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells

scientific article published on July 2010

Cancer Cell Death-Inducing Radiotherapy: Impact on Local Tumour Control, Tumour Cell Proliferation and Induction of Systemic Anti-tumour Immunity

scientific article published in January 2016

Cells under pressure - treatment of eukaryotic cells with high hydrostatic pressure, from physiologic aspects to pressure induced cell death.

scientific article published on January 2008

Chemoradiation Increases PD-L1 Expression in Certain Melanoma and Glioblastoma Cells

scientific article published on 22 December 2016

Chromosome Aberrations in Lymphocytes of Patients Undergoing Radon Spa Therapy: An Explorative mFISH Study

scientific article published on 13 October 2021

Clinically Relevant Radiation Exposure Differentially Impacts Forms of Cell Death in Human Cells of the Innate and Adaptive Immune System

scholarly article by Sylvia E Falcke published in November 2018

Combination of Gas Plasma and Radiotherapy Has Immunostimulatory Potential and Additive Toxicity in Murine Melanoma Cells in Vitro

scientific article published on 18 February 2020

Combination of ionising irradiation and hyperthermia activates programmed apoptotic and necrotic cell death pathways in human colorectal carcinoma cells

scientific article published on 08 November 2010

Combination of ionising radiation with hyperthermia increases the immunogenic potential of B16-F10 melanoma cells in vitro and in vivo

scientific article published on 11 January 2016

Combinations of Radiotherapy with Vaccination and Immune Checkpoint Inhibition Differently Affect Primary and Abscopal Tumor Growth and the Tumor Microenvironment

scientific article published on 9 February 2021

Combined treatment of human colorectal tumor cell lines with chemotherapeutic agents and ionizing irradiation can in vitro induce tumor cell death forms with immunogenic potential

scientific article published on 16 July 2012

Contribution of the immune system to bystander and non-targeted effects of ionizing radiation

scientific article published on 15 October 2013

Decrease of Markers Related to Bone Erosion in Serum of Patients with Musculoskeletal Disorders after Serial Low-Dose Radon Spa Therapy.

scientific article published on 25 July 2017

Defining Metaniches in the Oral Cavity According to Their Microbial Composition and Cytokine Profile

scientific article published on 03 November 2020

Detailed <i>in vitro</i> analyses of the impact of multimodal cancer therapy with hyperthermia and radiotherapy on the immune phenotype of human glioblastoma cells

scientific article published in 2022

Development of a Modular Assay for Detailed Immunophenotyping of Peripheral Human Whole Blood Samples by Multicolor Flow Cytometry

scientific article published on 11 August 2016

Differences of the Immune Phenotype of Breast Cancer Cells after Ex Vivo Hyperthermia by Warm-Water or Microwave Radiation in a Closed-Loop System Alone or in Combination with Radiotherapy

scientific article published on 27 April 2020

Discontinuous induction of X-linked inhibitor of apoptosis in EA.hy.926 endothelial cells is linked to NF-κB activation and mediates the anti-inflammatory properties of low-dose ionising-radiation

scientific article

Dose Reduction to the Swallowing Apparatus and the Salivary Glands by De-Intensification of Postoperative Radiotherapy in Patients with Head and Neck Cancer: First (Treatment Planning) Results of the Prospective Multicenter DIREKHT Trial

scientific article published on 26 February 2020

Early mortality of brain cancer patients and its connection to cytomegalovirus reactivation during radiochemotherapy

scientific article published on 14 February 2020

Editorial to Radiation in Multimodal Tumor Immune Therapies—Mechanisms and Application

scientific article published on 17 July 2021

Editorial: Radiation and the Immune System: Current Knowledge and Future Perspectives

scientific article published in January 2017

Erratum to: Primary glioblastoma multiforme tumors and recurrence: comparative analysis of the danger signals HMGB1, HSP70, and calreticulin

scientific article published on 01 March 2016

Ex vivo- and in vivo-induced dead tumor cells as modulators of antitumor responses.

scientific article published on October 2010

FSRT vs. SRS in Brain Metastases-Differences in Local Control and Radiation Necrosis-A Volumetric Study

scientific article published on 30 September 2020

Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines

scientific article published on 30 March 2014

Frequent occurrence of therapeutically reversible CMV-associated encephalopathy during radiotherapy of the brain

scientific article published on 10 June 2016

Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction.

scientific article

Graphene Oxide Nanosheets for Localized Hyperthermia-Physicochemical Characterization, Biocompatibility, and Induction of Tumor Cell Death

scientific article published on 23 March 2020

High hydrostatic pressure treatment generates inactivated mammalian tumor cells with immunogeneic features

scientific article published on 01 July 2010

How does ionizing irradiation contribute to the induction of anti-tumor immunity?

scientific article published on 25 July 2012

Hyperthermia in combination with X-irradiation induces inflammatory forms of cell death

scientific article published on May 2009

Hypofractionated Irradiation Has Immune Stimulatory Potential and Induces a Timely Restricted Infiltration of Immune Cells in Colon Cancer Tumors.

scientific article published on 08 March 2017

Hypofractionated Radiotherapy Upregulates Several Immune Checkpoint Molecules in Head and Neck Squamous Cell Carcinoma Cells Independently of the HPV Status While ICOS-L Is Upregulated Only on HPV-Positive Cells

scientific article published on 24 August 2021

Identification of 15 lncRNAs Signature for Predicting Survival Benefit of Advanced Melanoma Patients Treated with Anti-PD-1 Monotherapy

scientific article published on 22 April 2021

Identification of novel binding partners (annexins) for the cell death signal phosphatidylserine and definition of their recognition motif

scientific article published on 3 December 2010

Immune biological rationales for the design of combined radio- and immunotherapies

scientific article published on 18 January 2020

Immune modulatory effects of radiotherapy as basis for well-reasoned radioimmunotherapies

scientific article published on 02 March 2018

Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors

scientific article

Immunomodulation by ionizing radiation-impact for design of radio-immunotherapies and for treatment of inflammatory diseases.

scientific article published in November 2017

Immunomodulatory properties and molecular effects in inflammatory diseases of low-dose x-irradiation

scientific article

Impact of radon and combinatory radon/carbon dioxide spa on pain and hypertension: Results from the explorative RAD-ON01 study

scientific article published on 16 February 2018

Implementation of Double Immune Checkpoint Blockade Increases Response Rate to Induction Chemotherapy in Head and Neck Cancer

scientific article published on 19 April 2021

In Vitro Examinations of Cell Death Induction and the Immune Phenotype of Cancer Cells Following Radiative-Based Hyperthermia with 915 MHz in Combination with Radiotherapy

scientific article published on 8 June 2021

Induction of abscopal anti-tumor immunity and immunogenic tumor cell death by ionizing irradiation - implications for cancer therapies.

scientific article published on January 2012

Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE).

scientific article published on 12 August 2008

Insights into the infiltrative behavior of adamantinomatous craniopharyngioma in a new xenotransplant mouse model

scientific article published on 19 May 2014

Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces

scientific article

Interconnection between DNA damage, senescence, inflammation, and cancer.

scientific article published on January 2017

Intra- and Early Postoperative Evaluation of Malperfused Areas in an Irradiated Random Pattern Skin Flap Model Using Indocyanine Green Angiography and Near-Infrared Reflectance-Based Imaging and Infrared Thermography

scientific article published on 8 February 2022

Ionizing radiation reduces the capacity of activated macrophages to induce T-cell proliferation, but does not trigger dendritic cell-mediated non-targeted effects

scientific article published on 21 August 2018

Key mechanisms involved in ionizing radiation-induced systemic effects. A current review.

scientific article published on 11 August 2015

Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy

scientific article published on January 2014

Lectins detect changes of the glycosylation status of plasma membrane constituents during late apoptosis

scientific article published in April 2006

Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis

scientific article published on 14 August 2020

Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function

scientific article published on 01 January 2015

Low dose ionising radiation leads to a NF-κB dependent decreased secretion of active IL-1β by activated macrophages with a discontinuous dose-dependency ⬇️

scientific article published on May 22, 2012

Low- vs. high-dose radiotherapy in Graves' ophthalmopathy: a retrospective comparison of long-term results

scientific article published in October 2021

Low-Dose Irradiation Differentially Impacts Macrophage Phenotype in Dependence of Fibroblast-Like Synoviocytes and Radiation Dose

scientific article published on 14 August 2019

Low-Dose Radiotherapy Ameliorates Advanced Arthritis in hTNF-α tg Mice by Particularly Positively Impacting on Bone Metabolism

scientific article published on 18 September 2018

Low-Dose Radiotherapy Has No Harmful Effects on Key Cells of Healthy Non-Inflamed Joints

scientific article published on 16 October 2018

Low-dose radiotherapy: Mayday, mayday. We've been hit!

scientific article published on 18 December 2018

Microscopy under pressure--an optical chamber system for fluorescence microscopic analysis of living cells under high hydrostatic pressure

scientific article published in February 2006

Mitoxantrone-Loaded Nanoparticles for Magnetically Controlled Tumor Therapy-Induction of Tumor Cell Death, Release of Danger Signals and Activation of Immune Cells

scientific article published on 27 September 2020

Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation

scientific article

Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases

scientific article published on 14 April 2015

Modulation of inflammatory immune reactions by low-dose ionizing radiation: molecular mechanisms and clinical application.

scientific article published on January 2012

Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner

scientific article

Modulation of the immune system by dying cells and the phosphatidylserine-ligand annexin A5.

scientific article published on June 2007

Modulation of the peripheral immune system after low-dose radon spa therapy: Detailed longitudinal immune monitoring of patients within the RAD-ON01 study

scientific article

Modulations in the Peripheral Immune System of Glioblastoma Patient Is Connected to Therapy and Tumor Progression-A Case Report from the IMMO-GLIO-01 Trial

scientific article

Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases

scientific article published on 23 July 2020

Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cells

scientific article published on 10 February 2014

Old and new facts about hyperthermia-induced modulations of the immune system

scientific article published on 12 June 2012

Oligometastatic head and neck cancer: Which patients benefit from radical local treatment of all tumour sites?

scientific article published on 31 March 2021

On PTV definition for glioblastoma based on fiber tracking of diffusion tensor imaging data

scientific article published on 06 January 2020

One-Tube Multicolor Flow Cytometry Assay (OTMA) for Comprehensive Immunophenotyping of Peripheral Blood

scientific article published on 01 January 2019

Oxidation of the alarmin high-mobility group box 1 protein (HMGB1) during apoptosis

scientific article published in May 2009

Peer review analysis in the field of radiation oncology: results from a web-based survey of the Young DEGRO working group

scientific article published on 18 December 2020

Phospholipids: key players in apoptosis and immune regulation.

scientific article

Photopheresis with UV-A light and 8-methoxypsoralen leads to cell death and to release of blebs with anti-inflammatory phenotype in activated and non-activated lymphocytes.

scientific article published on 6 June 2009

Primary glioblastoma multiforme tumors and recurrence : Comparative analysis of the danger signals HMGB1, HSP70, and calreticulin

scientific article published on 8 December 2015

Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90

scientific article published on 27 August 2020

Prospective Evaluation of All-lesion Versus Single-lesion Radiotherapy in Combination With PD-1/PD-L1 Immune Checkpoint Inhibitors

scientific article published on 29 October 2020

Prospective development and validation of a liquid immune profile-based signature (LIPS) to predict response of patients with recurrent/metastatic cancer to immune checkpoint inhibitors

scientific article published in February 2021

Prospective evaluation of the prognostic value of immune-related adverse events in patients with non-melanoma solid tumour treated with PD-1/PD-L1 inhibitors alone and in combination with radiotherapy

scientific article published on 08 October 2020

Proteasome inhibition aggravates tumor necrosis factor-mediated bone resorption in a mouse model of inflammatory arthritis

scientific article published on 01 March 2011

Questionnaire-based detection of immune-related adverse events in cancer patients treated with PD-1/PD-L1 immune checkpoint inhibitors

scientific article published on 24 March 2021

Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages

scientific article published in October 2011

Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses - Pre-Clinical Evidence and Ongoing Clinical Applications

scientific article

Radio-immunotherapy: the focused beam expands.

scientific article

Radiomics to predict outcomes and abscopal response of patients with cancer treated with immunotherapy combined with radiotherapy using a validated signature of CD8 cells

scientific article published on 01 November 2020

Radiotherapy for achillodynia : results of a single-center prospective randomized dose-optimization trial

scientific article published on 21 December 2012

Radiotherapy for benign achillodynia. Long-term results of the Erlangen Dose Optimization Trial.

scientific article published on 14 September 2015

Radiotherapy for benign calcaneodynia: long-term results of the Erlangen Dose Optimization (EDO) trial

scientific article published on 26 March 2014

Radiotherapy for calcaneodynia. Results of a single center prospective randomized dose optimization trial

scientific article published on 28 February 2013

Radiotherapy-Induced Changes in the Systemic Immune and Inflammation Parameters of Head and Neck Cancer Patients

scientific article published on 06 September 2019

Radon Exposure-Therapeutic Effect and Cancer Risk

scientific article published on 30 December 2020

Radon Improves Clinical Response in an Animal Model of Rheumatoid Arthritis Accompanied by Increased Numbers of Peripheral Blood B Cells and Interleukin-5 Concentration

scientific article published on 16 February 2022

Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis

scientific article published on 13 January 2020

Reduced secretion of the inflammatory cytokine IL-1β by stimulated peritoneal macrophages of radiosensitive Balb/c mice after exposure to 0.5 or 0.7 Gy of ionizing radiation

scientific article

Reduction of Elective Radiotherapy Treatment Volume in Definitive Treatment of Locally Advanced Head and Neck Cancer-Comparison of a Prospective Trial with a Revised Simulated Contouring Approach

scientific article published on 11 October 2021

Regulatory T cells protect from local and systemic bone destruction in arthritis.

scientific article published on 17 May 2010

Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus

scientific article published in June 2009

Safety and efficacy of single cycle induction treatment with cisplatin/docetaxel/ durvalumab/tremelimumab in locally advanced HNSCC: first results of CheckRad-CD8

scientific article published on 01 October 2020

Selected anti-tumor vaccines merit a place in multimodal tumor therapies

scientific article published on 9 October 2012

Sodium overload and water influx activate the NALP3 inflammasome

scientific article

Survivin antisense oligonucleotides effectively radiosensitize colorectal cancer cells in both tissue culture and murine xenograft models

scientific article

Sweet clearance: involvement of cell surface glycans in the recognition of apoptotic cells

scientific article published on June 2007

Systemic modulation of stress and immune parameters in patients treated for prostate adenocarcinoma by intensity-modulated radiation therapy or stereotactic ablative body radiotherapy

scientific article published on 09 June 2020

Targeting of drug-loaded nanoparticles to tumor sites increases cell death and release of danger signals

scientific article published on 04 July 2018

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

scientific article published on 24 April 2020

Temporarily increased TGFβ following radon spa correlates with reduced pain while serum IL-18 is a general predictive marker for pain sensitivity

scientific article published on 19 November 2018

The Distribution of Pelvic Nodal Metastases in Prostate Cancer Reveals Potential to Advance and Personalize Pelvic Radiotherapy

scientific article published in 2020

The Effect of Hyperthermia and Radiotherapy Sequence on Cancer Cell Death and the Immune Phenotype of Breast Cancer Cells

scientific article published on 19 April 2022

The Erlangen Dose Optimization Trial for radiotherapy of benign painful shoulder syndrome. Long-term results

scientific article

The Erlangen Dose Optimization trial for low-dose radiotherapy of benign painful elbow syndrome. Long-term results

scientific article published on 16 January 2014

The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia

scientific article published on 05 November 2010

The Influence of Radiation on Bone and Bone Cells-Differential Effects on Osteoclasts and Osteoblasts

scientific article published on 02 September 2020

The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia

scientific article published on 7 June 2016

The immune functions of phosphatidylserine in membranes of dying cells and microvesicles.

scientific article published on 13 October 2010

The immune reaction against allogeneic necrotic cells is reduced in Annexin A5 knock out mice whose macrophages display an anti-inflammatory phenotype.

scientific article

The in vitro immunogenic potential of caspase-3 proficient breast cancer cells with basal low immunogenicity is increased by hypofractionated irradiation

scientific article

The role of annexin A5 in the modulation of the immune response against dying and dead cells

scientific article published on January 2007

Transcriptomes of MPO-Deficient Patients with Generalized Pustular Psoriasis Reveals Expansion of CD4+ Cytotoxic T Cells and an Involvement of the Complement System

scientific article published in December 2021

Tumor Cell-Based Vaccine Generated With High Hydrostatic Pressure Synergizes With Radiotherapy by Generating a Favorable Anti-tumor Immune Microenvironment

scientific article published on 28 August 2019

UVB-irradiated apoptotic cells induce accelerated growth of co-implanted viable tumor cells in immune competent mice.

scientific article published on 8 February 2013

Upregulation of CCR4 in activated CD8 T cells indicates enhanced lung homing in patients with severe acute SARS-CoV-2 infection

scientific article published in June 2021

Whole body low dose irradiation improves the course of beginning polyarthritis in human TNF-transgenic mice

scientific article published on 01 May 2009

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