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List of works by Geert Bultynck

A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum

scientific article published on 21 April 2014

ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells

article

Adenine-nucleotide binding sites on the inositol 1,4,5-trisphosphate receptor bind caffeine, but not adenophostin A or cyclic ADP-ribose

scientific article published on 01 February 1999

Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor

scientific article

Altered Ca(2+) signaling in cancer cells: proto-oncogenes and tumor suppressors targeting IP3 receptors.

scientific article published on 08 December 2012

Alzheimer's disease-associated peptide Aβ42 mobilizes ER Ca(2+) via InsP3R-dependent and -independent mechanisms.

scientific article

BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models

scientific article published on 17 September 2020

Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis

scientific article published on 16 July 2013

Bax inhibitor-1 is a novel IP₃ receptor-interacting and -sensitizing protein

scientific article

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output

scientific article published on 16 April 2019

Bcl-2 binds to and inhibits ryanodine receptors

scientific article published on 24 April 2014

Calcineurin and intracellular Ca2+-release channels: regulation or association?

scientific article published on November 2003

Calcium and connexin-based intercellular communication, a deadly catch?

scientific article published on 31 May 2011

Calmodulin increases the sensitivity of type 3 inositol-1,4, 5-trisphosphate receptors to Ca(2+) inhibition in human bronchial mucosal cells

scientific article published on 01 March 2000

Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis

scientific article

Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling.

scientific article

Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor

scientific article

Connexin 43 hemichannels contribute to cytoplasmic Ca2+ oscillations by providing a bimodal Ca2+-dependent Ca2+ entry pathway

scientific article

Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability

scientific article

Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening.

scientific article published on 02 September 2013

Connexins: sensors and regulators of cell cycling.

scientific article published on 27 August 2010

Constitutive IP signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP receptor disruptor BIRD-2

scientific article published on 13 June 2018

Curcumin affects proprotein convertase activity: elucidation of the molecular and subcellular mechanism

scientific article published on 10 April 2013

Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells

scientific article published on 18 March 2020

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

DLBCL Cells with Acquired Resistance to Venetoclax Are Not Sensitized to BIRD-2 But Can Be Resensitized to Venetoclax through Bcl-XL Inhibition

scientific article published on 21 July 2020

Development of inositol-based antagonists for thed-myo-inositol 1,4,5-trisphosphate receptor

scientific article published in 2011

Effects of the immunosuppressant FK506 on intracellular Ca2+ release and Ca2+ accumulation mechanisms

scientific article published in June 2000

Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes

scientific article published on 28 February 2018

Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs).

scientific article published in January 2017

Endoplasmic-reticulum calcium depletion and disease

scientific article published on June 2011

Endothelial calcium dynamics, connexin channels and blood-brain barrier function.

scientific article published on 10 July 2013

Extracellular and ER-stored Ca contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells

scientific article published on 02 November 2018

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines.

scientific article

IP3, a small molecule with a powerful message

scientific article published on 02 January 2013

IP3Receptors, Mitochondria, and Ca2+Signaling: Implications for Aging ⬇️

scientific article published on 08 March 2011

Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction

scientific article

Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival

scientific article

Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated

scientific article published on December 2011

Intracellular Ca(2+) signaling: A novel player in the canonical mTOR-controlled autophagy pathway

scientific article published on 25 June 2013

Intracellular Ca2+ storage in health and disease: a dynamic equilibrium.

scientific article published on March 2010

Intracellular calcium-releasing channels as cellular targets for immunophilins: a molecular, functional and structural analysis

scientific article published in January 2004

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity

scientific article published on 15 July 2010

Low extracellular Ca2+ conditions induce an increase in brain endothelial permeability that involves intercellular Ca2+ waves

scientific article published on 10 July 2012

MICAL2 is essential for myogenic lineage commitment

scientific article published on 18 August 2020

Manipulating connexin communication channels: use of peptidomimetics and the translational outputs

scientific article published on 11 August 2012

Measurement of intracellular Ca2+ release in intact and permeabilized cells using 45Ca2+

scientific article published in March 2014

Measurement of intracellular Ca2+ release in intact cells using 45Ca2+.

scientific article published on March 2014

Measurement of intracellular Ca2+ release in permeabilized cells using 45Ca2+.

scientific article published on March 2014

Mechanical stimulation-induced calcium wave propagation in cell monolayers: the example of bovine corneal endothelial cells

scientific article published on 16 July 2013

Necroptosis in Immuno-Oncology and Cancer Immunotherapy

scientific article published on 01 August 2020

Negatively charged residues (Asp378 and Asp379) in the last ten amino acids of the C-terminal tail of Cx43 hemichannels are essential for loop/tail interactions

scientific article published on 29 January 2013

Neuronal overexpression of IP₃ receptor 2 is detrimental in mutant SOD1 mice

scientific article

Non-channel functions of connexins in cell growth and cell death

scientific article published on 22 June 2011

Organelle membrane derived patches: reshaping classical methods for new targets

scientific article published on 26 October 2017

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

scientific article

Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum.

scientific article published on 03 August 2010

Pannexins, distant relatives of the connexin family with specific cellular functions?

scientific article published on September 2009

Paracrine signaling through plasma membrane hemichannels

scientific article published on 13 July 2012

Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release

scientific article published on 27 March 2012

Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin

scientific article

Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain.

scientific article

Profiling of the Bcl-2/Bcl-X(L)-binding sites on type 1 IP(3) receptor

scientific article published on 08 October 2012

Regioselective deprotection of orthobenzoates for the synthesis of inositol phosphates.

scientific article published on 6 March 2009

Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins

scientific article

Regulation of connexin- and pannexin-based channels by post-translational modifications.

scientific article published on 17 July 2013

Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation.

scientific article published on 30 May 2009

Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.

scientific article published on 16 December 2008

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

scientific journal article

RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system

scientific article

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings.

scientific article

Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy ⬇️

scientific article published on July 6, 2012

SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System

scientific article published on 12 May 2021

STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function

scientific article published on 4 April 2011

STIM1, but not STIM2, is required for proper agonist-induced Ca2+ signaling

scientific article published on August 2010

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.

scientific article published on 8 November 2012

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.

scientific article published on 5 August 2011

Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease.

scientific article

Suramin and disulfonated stilbene derivatives stimulate the Ca2+-induced Ca2+ -release mechanism in A7r5 cells.

scientific article published on 25 April 2005

Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate.

scientific article

TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis

scientific journal article

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

scientific article

The 12 kDa FK506-binding protein, FKBP12, modulates the Ca(2+)-flux properties of the type-3 ryanodine receptor.

scientific article

The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

scientific article

The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca-Dependent Manner

scientific article published on 30 November 2018

The IP3 receptor–mitochondria connection in apoptosis and autophagy ⬇️

scientific article published on December 10, 2010

The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+.

scientific article

The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity.

scientific article

The contractile system as a negative regulator of the connexin 43 hemichannel.

scientific article published on 04 April 2012

The dual face of connexin-based astroglial Ca(2+) communication: a key player in brain physiology and a prime target in pathology.

scientific article published on 21 April 2014

The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellular calcium wave propagation in corneal endothelial cells

scientific article published on 9 July 2008

The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase.

scientific article

The relative order of IP3 sensitivity of types 1 and 3 IP3 receptors is pH dependent.

scientific article published on July 1999

The role of calmodulin for inositol 1,4,5-trisphosphate receptor function

scientific article

The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyond ⬇️

scientific article published on 06 September 2012

The suppressor domain of inositol 1,4,5-trisphosphate receptor plays an essential role in the protection against apoptosis

scientific article published on 3 February 2006

The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition

scientific article published on 02 August 2016

The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2.

scientific article published on August 2007

Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction

scientific article published on July 2004

Transfer of IP₃ through gap junctions is critical, but not sufficient, for the spread of apoptosis

scientific article published on 25 November 2011

Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery

scientific article published on 23 September 2020

Unraveling the role of polycystin-2/inositol 1,4,5-trisphosphate receptor interaction in Ca signaling

scientific article published on November 2010

Washing out of lipophilic compounds induces a transient increase in the passive Ca(2+) leak in permeabilized A7r5 cells

scientific article

mTOR-Controlled Autophagy Requires Intracellular Ca2+ Signaling ⬇️

scientific article published on April 2, 2013

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