List of works - Karine Breckpot

A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice

scientific article

A personalized view on cancer immunotherapy

scientific article

A versatile T cell-based assay to assess therapeutic antigen-specific PD-1-targeted approaches.

scientific article published on 12 June 2018

Activation of Immature Monocyte-Derived Dendritic Cells After Transduction with High Doses of Lentiviral Vectors

scientific article published on 01 June 2007

Activation of monocytes via the CD14 receptor leads to the enhanced lentiviral transduction of immature dendritic cells

scientific article published in June 2004

Adjuvant-Enhanced mRNA Vaccines

scientific article

Adult-Derived Human Liver Stem/Progenitor Cells Infused 3 Days Postsurgery Improve Liver Regeneration in a Mouse Model of Extended Hepatectomy.

scientific article published on 21 September 2016

Anti-human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation

scientific article published on 29 September 2020

Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy

scientific article published on 3 July 2014

Antigen-presenting cell-targeted lentiviral vectors do not support the development of productive T-cell effector responses: implications for in vivo targeted vaccine delivery.

scientific article published on 25 May 2017

Assessing T-cell responses in anticancer immunotherapy: Dendritic cells or myeloid-derived suppressor cells?

scientific article published on 12 September 2013

Attenuated Expression of A20 Markedly Increases the Efficacy of Double-Stranded RNA-Activated Dendritic Cells As an Anti-Cancer Vaccine

scientific article published on 01 January 2009

CD83 expression on dendritic cells and T cells: correlation with effective immune responses

scientific article published on March 2007

Cancer-Associated Myeloid Regulatory Cells

scientific article

Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro.

scientific article published on 21 June 2014

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA.

scientific article published on 4 October 2017

Combinatorial strategies for the induction of immunogenic cell death

scientific article published on 24 April 2015

Consensus guidelines for the detection of immunogenic cell death

scientific article published on October 2014

Contribution of Cardiac Sodium Channel β-Subunit Variants to Brugada Syndrome.

scientific article

Corrigendum: "Combinatorial Strategies for the Induction of Immunogenic Cell Death".

scientific article published on June 2015

Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

scientific article published on 01 October 2018

Dendritic cells differentiated in the presence of IFN-β and IL-3 are potent inducers of an antigen-specific CD8+ T cell response

scientific article published on 21 July 2005

Dendritic cells for active anti-cancer immunotherapy: targeting activation pathways through genetic modification.

scientific article published on December 2009

Design of an Optimized Wilms' Tumor 1 (WT1) mRNA Construct for Enhanced WT1 Expression and Improved Immunogenicity In Vitro and In Vivo

scientific article

Development of the Nanobody display technology to target lentiviral vectors to antigen-presenting cells

scientific article

Downregulation of Stat3 in melanoma: reprogramming the immune microenvironment as an anticancer therapeutic strategy

scientific article published on 27 June 2013

Dynamic bioluminescence imaging for quantitative tumour burden assessment using IV or IP administration of D: -luciferin: effect on intensity, time kinetics and repeatability of photon emission.

scientific article published on 4 January 2008

Electroporation of immature and mature dendritic cells: implications for dendritic cell-based vaccines

scientific article

Epigenetic treatment of multiple myeloma mediates tumor intrinsic and extrinsic immunomodulatory effects

scientific article published on 23 July 2018

Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent

scientific article published on 21 June 2019

Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer

scientific article published in May 2015

Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells

scientific article

Functional T-cell responses generated by dendritic cells expressing the early HIV-1 proteins Tat, Rev and Nef.

scientific article

Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL.

scientific article published on 11 November 2013

Generation of large numbers of dendritic cells in a closed system using Cell Factories.

scientific article published on June 2002

HIV-1 lentiviral vector immunogenicity is mediated by Toll-like receptor 3 (TLR3) and TLR7.

scientific article

Hitchhiking nanoparticles: Reversible coupling of lipid-based nanoparticles to cytotoxic T lymphocytes

scientific article published on 10 November 2015

Human pancreatic duct cells can produce tumour necrosis factor-alpha that damages neighbouring beta cells and activates dendritic cells

scientific article

Identification of new antigenic peptide presented by HLA-Cw7 and encoded by several MAGE genes using dendritic cells transduced with lentiviruses

scientific article published on February 2004

Immune modulation by genetic modification of dendritic cells with lentiviral vectors.

scientific article published on 28 May 2013

Immunogenicity of targeted lentivectors.

scientific article published on February 2014

Induction of antigen-specific CD8+ cytotoxic T cells by dendritic cells co-electroporated with a dsRNA analogue and tumor antigen mRNA.

scientific article published on 2 March 2006

Induction of effective therapeutic antitumor immunity by direct in vivo administration of lentiviral vectors

scientific article published on April 2006

Inhibition of firefly luciferase by general anesthetics: effect on in vitro and in vivo bioluminescence imaging

scientific article (publication date: 2012)

Interference with PD-L1/PD-1 co-stimulation during antigen presentation enhances the multifunctionality of antigen-specific T cells

scientific article published on 9 January 2014

Intralymphatic mRNA vaccine induces CD8 T-cell responses that inhibit the growth of mucosally located tumours

scientific article published on 2 March 2016

Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells.

scientific article published on 11 December 2015

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity

scientific article

Intratumoral delivery of mRNA: Overcoming obstacles for effective immunotherapy

scientific article published on 3 February 2015

Lentiviral vectors for anti-tumor immunotherapy.

scientific article published on December 2008

Lentiviral vectors for cancer immunotherapy: transforming infectious particles into therapeutics.

scientific article published on 22 March 2007

Lentiviral vectors in gene therapy: their current status and future potential

scientific article

Lentiviral vectors: a versatile tool to fight cancer.

scientific article published on May 2013

Lentivirally transduced dendritic cells as a tool for cancer immunotherapy

scientific article published on 01 August 2003

Loss of RASSF4 expression in multiple myeloma promotes RAS-driven malignant progression.

scientific article published on 19 December 2017

MODULATING CO-STIMULATION DURING ANTIGEN PRESENTATION TO ENHANCE CANCER IMMUNOTHERAPY.

scientific article published on September 2012

Messenger RNA-electroporated dendritic cells presenting MAGE-A3 simultaneously in HLA class I and class II molecules.

scientific article published on June 2004

Modulation of regulatory T cell function by monocyte-derived dendritic cells matured through electroporation with mRNA encoding CD40 ligand, constitutively active TLR4, and CD70.

scientific article published on 10 July 2013

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

scientific article

Myeloid-derived suppressor cells reveal radioprotective properties through arginase-induced l-arginine depletion

scientific article published on 10 February 2016

Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages.

scientific article

Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment

scholarly article by Heleen Dewitte et al published December 2014 in Nano Today

Neo-Antigen mRNA Vaccines

scientific article published on 18 December 2020

Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers

scientific article published on 30 March 2017

Noninvasive Imaging of the Immune Checkpoint LAG-3 Using Nanobodies, from Development to Pre-Clinical Use

scientific article published on 29 September 2019

Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy.

scientific article published on 7 June 2018

Optimized dendritic cell-based immunotherapy for melanoma: the TriMix-formula

scientific article

PD-L1/PD-1 Co-Stimulation, a Brake for T cell Activation and a T cell Differentiation Signal

scientific article published on October 2012

PD1 signal transduction pathways in T cells.

scientific article published on 19 April 2017

PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity.

scientific article published on August 2017

Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon

scientific article published on 21 June 2016

Perforin and Granzyme B Expressed by Murine Myeloid-Derived Suppressor Cells: A Study on Their Role in Outgrowth of Cancer Cells

scientific article published on 11 June 2019

Phosphorylated STAT3 physically interacts with NPM and transcriptionally enhances its expression in cancer

scientific article published on 5 May 2014

Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2.

scientific article published on 22 December 2016

Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

scientific article published on 15 February 2012

Preclinical Targeted α- and β--Radionuclide Therapy in HER2-Positive Brain Metastasis Using Camelid Single-Domain Antibodies

scientific article published on 21 April 2020

Preclinical evaluation of invariant natural killer T cells in the 5T33 multiple myeloma model

scientific article

Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function

scientific article

Proinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapy.

scientific article

Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines

scientific article

Retroviral and lentiviral vectors for the induction of immunological tolerance

scientific article published on December 2012

Role of non-classical MHC class I molecules in cancer immunosuppression

scientific article

Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis

scientific article published on January 2011

Selective activation of intracellular signalling pathways in dendritic cells for cancer immunotherapy.

scientific article published on January 2012

Side-by-side comparison of lentivirally transduced and mRNA-electroporated dendritic cells: implications for cancer immunotherapy protocols.

scientific article published on October 2004

Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy

scientific article

Single Domain Antibody-Mediated Blockade of Programmed Death-Ligand 1 on Dendritic Cells Enhances CD8 T-cell Activation and Cytokine Production

scientific article published on 07 August 2019

Targeting Neuropilin-1 with Nanobodies Reduces Colorectal Carcinoma Development

scientific article published on 30 November 2020

Targeting lentiviral vectors for cancer immunotherapy

scientific article

Targeting of human antigen-presenting cell subsets.

scientific article published on 17 July 2013

Targeting the tumor microenvironment to enhance antitumor immune responses

scientific article

The Journey of Virus Engineered Dendritic Cells From Bench to Bedside: A Bumpy Road

scientific article published on 11 September 2018

The Next-Generation Immune Checkpoint LAG-3 and Its Therapeutic Potential in Oncology: Third Time's a Charm

scientific article published on 23 December 2020

The ReNAissanCe of mRNA-based cancer therapy

scientific article published on 29 September 2014

The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy

scientific article published on 22 August 2014

The role of SMAC mimetics in regulation of tumor cell death and immunity

scientific article published on September 2012

The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome

scientific article published on 17 September 2015

Theranostics in immuno-oncology using nanobody derivatives

scientific article published on 15 October 2019

Tumour-associated macrophage-mediated survival of myeloma cells through STAT3 activation.

scientific article published on 15 December 2016

Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression

scientific article published on 31 August 2018

Variegation and silencing in a lentiviral-based murine transgenic model

scientific article

mRNA-based dendritic cell vaccines.

scientific article published on 08 September 2014

mRNA: From a chemical blueprint for protein production to an off-the-shelf therapeutic.

scientific article published on 04 January 2013

mRNA: delivering an antitumor message?

scientific article published on 01 May 2011

List of works by Karine Breckpot

A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice

A personalized view on cancer immunotherapy

A versatile T cell-based assay to assess therapeutic antigen-specific PD-1-targeted approaches.

Activation of Immature Monocyte-Derived Dendritic Cells After Transduction with High Doses of Lentiviral Vectors

Activation of monocytes via the CD14 receptor leads to the enhanced lentiviral transduction of immature dendritic cells

Adjuvant-Enhanced mRNA Vaccines

Adult-Derived Human Liver Stem/Progenitor Cells Infused 3 Days Postsurgery Improve Liver Regeneration in a Mouse Model of Extended Hepatectomy.

Anti-human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation

Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy

Antigen-presenting cell-targeted lentiviral vectors do not support the development of productive T-cell effector responses: implications for in vivo targeted vaccine delivery.

Assessing T-cell responses in anticancer immunotherapy: Dendritic cells or myeloid-derived suppressor cells?

Attenuated Expression of A20 Markedly Increases the Efficacy of Double-Stranded RNA-Activated Dendritic Cells As an Anti-Cancer Vaccine

CD83 expression on dendritic cells and T cells: correlation with effective immune responses

Cancer-Associated Myeloid Regulatory Cells

Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro.

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA.

Combinatorial strategies for the induction of immunogenic cell death

Consensus guidelines for the detection of immunogenic cell death

Contribution of Cardiac Sodium Channel β-Subunit Variants to Brugada Syndrome.

Corrigendum: "Combinatorial Strategies for the Induction of Immunogenic Cell Death".

Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

Dendritic cells differentiated in the presence of IFN-β and IL-3 are potent inducers of an antigen-specific CD8+ T cell response

Dendritic cells for active anti-cancer immunotherapy: targeting activation pathways through genetic modification.

Design of an Optimized Wilms' Tumor 1 (WT1) mRNA Construct for Enhanced WT1 Expression and Improved Immunogenicity In Vitro and In Vivo

Development of the Nanobody display technology to target lentiviral vectors to antigen-presenting cells

Downregulation of Stat3 in melanoma: reprogramming the immune microenvironment as an anticancer therapeutic strategy

Dynamic bioluminescence imaging for quantitative tumour burden assessment using IV or IP administration of D: -luciferin: effect on intensity, time kinetics and repeatability of photon emission.

Electroporation of immature and mature dendritic cells: implications for dendritic cell-based vaccines

Epigenetic treatment of multiple myeloma mediates tumor intrinsic and extrinsic immunomodulatory effects

Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent

Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer

Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells

Functional T-cell responses generated by dendritic cells expressing the early HIV-1 proteins Tat, Rev and Nef.

Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL.

Generation of large numbers of dendritic cells in a closed system using Cell Factories.

HIV-1 lentiviral vector immunogenicity is mediated by Toll-like receptor 3 (TLR3) and TLR7.

Hitchhiking nanoparticles: Reversible coupling of lipid-based nanoparticles to cytotoxic T lymphocytes

Human pancreatic duct cells can produce tumour necrosis factor-alpha that damages neighbouring beta cells and activates dendritic cells

Identification of new antigenic peptide presented by HLA-Cw7 and encoded by several MAGE genes using dendritic cells transduced with lentiviruses

Immune modulation by genetic modification of dendritic cells with lentiviral vectors.

Immunogenicity of targeted lentivectors.

Induction of antigen-specific CD8+ cytotoxic T cells by dendritic cells co-electroporated with a dsRNA analogue and tumor antigen mRNA.

Induction of effective therapeutic antitumor immunity by direct in vivo administration of lentiviral vectors

Inhibition of firefly luciferase by general anesthetics: effect on in vitro and in vivo bioluminescence imaging

Interference with PD-L1/PD-1 co-stimulation during antigen presentation enhances the multifunctionality of antigen-specific T cells

Intralymphatic mRNA vaccine induces CD8 T-cell responses that inhibit the growth of mucosally located tumours

Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells.

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity

Intratumoral delivery of mRNA: Overcoming obstacles for effective immunotherapy

Lentiviral vectors for anti-tumor immunotherapy.

Lentiviral vectors for cancer immunotherapy: transforming infectious particles into therapeutics.

Lentiviral vectors in gene therapy: their current status and future potential

Lentiviral vectors: a versatile tool to fight cancer.

Lentivirally transduced dendritic cells as a tool for cancer immunotherapy

Loss of RASSF4 expression in multiple myeloma promotes RAS-driven malignant progression.

MODULATING CO-STIMULATION DURING ANTIGEN PRESENTATION TO ENHANCE CANCER IMMUNOTHERAPY.

Messenger RNA-electroporated dendritic cells presenting MAGE-A3 simultaneously in HLA class I and class II molecules.

Modulation of regulatory T cell function by monocyte-derived dendritic cells matured through electroporation with mRNA encoding CD40 ligand, constitutively active TLR4, and CD70.

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Myeloid-derived suppressor cells reveal radioprotective properties through arginase-induced l-arginine depletion

Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages.

Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment

Neo-Antigen mRNA Vaccines

Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers

Noninvasive Imaging of the Immune Checkpoint LAG-3 Using Nanobodies, from Development to Pre-Clinical Use

Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy.

Optimized dendritic cell-based immunotherapy for melanoma: the TriMix-formula

PD-L1/PD-1 Co-Stimulation, a Brake for T cell Activation and a T cell Differentiation Signal

PD1 signal transduction pathways in T cells.

PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity.

Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon

Perforin and Granzyme B Expressed by Murine Myeloid-Derived Suppressor Cells: A Study on Their Role in Outgrowth of Cancer Cells

Phosphorylated STAT3 physically interacts with NPM and transcriptionally enhances its expression in cancer

Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2.

Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

Preclinical Targeted α- and β--Radionuclide Therapy in HER2-Positive Brain Metastasis Using Camelid Single-Domain Antibodies

Preclinical evaluation of invariant natural killer T cells in the 5T33 multiple myeloma model

Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function

Proinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapy.