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List of works by Bernhard Lüscher

4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10

scientific article published on 20 June 2018

A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions

scientific article

A peptide-based target screen implicates the protein kinase CK2 in the global regulation of caspase signaling

scientific article published on 10 May 2011

A role for the p34cdc2 kinase and phosphatases in the regulation of phosphorylation and disassembly of lamin B2 during the cell cycle

scientific article published in April 1991

A selenium-based click AdoMet analogue for versatile substrate labeling with wild-type protein methyltransferases

scientific article published on 30 April 2012

ADP-Ribosylation, a Multifaceted Posttranslational Modification Involved in the Control of Cell Physiology in Health and Disease

scientific article published on 27 November 2017

AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

scientific article published on 25 February 2020

ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation.

scientific article

Acetylation of the c-MYC oncoprotein is required for cooperation with the HTLV-1 p30(II) accessory protein and the induction of oncogenic cellular transformation by p30(II)/c-MYC.

scientific article

Activation of human B cells. Comparison of the signal transduced by IL-4 to four different competence signals.

scientific article published in December 1989

Activity-based assay for human mono-ADP-ribosyltransferases ARTD7/PARP15 and ARTD10/PARP10 aimed at screening and profiling inhibitors.

scientific article published on 26 February 2013

Analysis of Myc/Max/Mad network members in adipogenesis: inhibition of the proliferative burst and differentiation by ectopically expressed Mad1.

scientific article published on June 2000

Analysis of the DNA-binding activities of Myc/Max/Mad network complexes during induced differentiation of U-937 monoblasts and F9 teratocarcinoma cells

scientific article published on 01 August 1997

Analysis of the Max-binding protein MNT in human medulloblastomas

scientific article published in September 1999

Assessment of Intracellular Auto-Modification Levels of ARTD10 Using Mono-ADP-Ribose-Specific Macrodomains 2 and 3 of Murine Artd8

scientific article published on 01 January 2018

Biosynthesis and maturation of the Lyt-2/3 molecular complex in mouse thymocytes

scientific article published on 01 September 1985

Biosynthesis of casein kinase II in lymphoid cell lines

scientific article published on March 1994

C-MYC expression in medulloblastoma and its prognostic value.

scientific article published in September 2000

C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter

scientific article published on September 1996

CD73/Ecto-5′-Nucleotidase Protects Against Vascular Inflammation and Neointima Formation

scientific article published on 24 April 2006

Casein kinase II as a potentially important enzyme concerned with signal transduction

scientific article published on January 1988

Casein kinase II in signal transduction and cell cycle regulation

scientific article published on November 1993

Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis

scientific article

Caspase-dependent cleavage of the mono-ADP-ribosyltransferase ARTD10 interferes with its pro-apoptotic function

scientific article published on 13 February 2013

Caspase-dependent regulation and subcellular redistribution of the transcriptional modulator YY1 during apoptosis

scientific article

Cell growth inhibition by the Mad/Max complex through recruitment of histone deacetylase activity

scientific article published on 01 June 1997

Cell surface glycoproteins involved in the stimulation of interleukin 1-dependent interleukin 2 production by a subline of EL4 thymoma cells. II. Structure, biosynthesis, and maturation

scientific article published on 01 December 1985

Cetuximab induces eme1-mediated DNA repair: a novel mechanism for cetuximab resistance

scientific article published on March 2014

Characterization of a human TSPY promoter.

scientific article published on August 2005

Characterization of the transcriptional regulator YY1. The bipartite transactivation domain is independent of interaction with the TATA box-binding protein, transcription factor IIB, TAFII55, or cAMP-responsive element-binding protein (CPB)-binding

scientific article published on 01 January 1997

Control of the Physical and Antimicrobial Skin Barrier by an IL-31-IL-1 Signaling Network.

scientific article published on 04 March 2016

Cytokine-induced inhibition of Myc activity in monocytic cells.

scientific article published on January 1997

Cytokines and inflammation

scientific article published on 23 February 2012

Cytokines and the skin barrier.

scientific article published on 26 March 2013

DNA binding of Myc/Max/Mad network complexes to oligonucleotides containing two E box elements: c-Myc/Max heterodimers do not bind DNA cooperatively.

scientific article

Development of a stabilized form of the regulatory CK2beta subunit that inhibits cell proliferation

scientific article published on 06 August 2007

Differential effects by Mad and Max on transformation by cellular and viral oncoproteins

scientific article published on August 3, 1995

Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62.

scientific article

Effects of a ceramide-containing water-in-oil ointment on skin barrier function and allergen penetration in an IL-31 treated 3D model of the disrupted skin barrier

scientific article published on 20 July 2018

Endotoxin tolerance in mast cells, its consequences for IgE-mediated signalling, and the effects of BCL3 deficiency

scientific article published on 3 July 2017

Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

scientific article published on 15 October 2020

Enhanced Sampling Approach to the Induced-Fit Docking Problem in Protein–Ligand Binding: The Case of Mono-ADP-Ribosylation Hydrolase Inhibitors

scientific article published on 24 November 2021

Enzymatic site-specific functionalization of protein methyltransferase substrates with alkynes for click labeling

scientific article published on 01 July 2010

Expanding functions of intracellular resident mono‐ADP‐ribosylation in cell physiology ⬇️

scientific article published on May 28, 2013

Expression and regulation of protein kinase CK2 during the cell cycle

scientific article published on January 1999

Expression of mad, mxi1, max and c-myc during induced differentiation of hematopoietic cells: opposite regulation of mad and c-myc

scientific article published on 01 April 1994

Function and regulation of the mono-ADP-ribosyltransferase ARTD10.

scientific article published on January 2015

Function and regulation of the transcription factors of the Myc/Max/Mad network

scientific article (publication date: 17 October 2001)

GAR22β regulates cell migration, sperm motility, and axoneme structure

scientific article

Gastroprotective peptide trefoil factor family 2 gene is activated by upstream stimulating factor but not by c-Myc in gastrointestinal cancer cells.

scientific article published on November 2002

H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1.

scientific article published on 6 November 2009

Hematopoietic stem and progenitor cell proliferation and differentiation requires the trithorax protein Ash2l

scientific article published on 04 June 2019

IL-31 expression by inflammatory cells is preferentially elevated in atopic dermatitis

IL-31 regulates differentiation and filaggrin expression in human organotypic skin models

scientific article

ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53

scientific article published on 10 April 2015

Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators

scientific article published on 01 March 1998

Identification of casein kinase II phosphorylation sites in Max: effects on DNA-binding kinetics of Max homo- and Myc/Max heterodimers

scientific article (publication date: December 1993)

Identification of new substrates of cyclin-activated kinases in breast cancers

scientific article published in January 2001

Inhibition of SIRT2 suppresses hepatic fibrosis

scientific article published on 28 April 2016

Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene

scientific article published on 12 November 2007

Inhibition of proliferation and apoptosis by the transcriptional repressor Mad1. Repression of Fas-induced caspase-8 activation

scientific article

Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2).

scientific article published on 25 September 2015

Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M

scientific article

Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation

scientific article

Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation.

scientific article published on 20 December 2015

Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization

scientific article published on 18 October 2016

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.

scientific article published on 11 July 2016

JAK1/3-inhibition preserves epidermal morphology in full thickness 3D skin models of atopic dermatitis and psoriasis

article

Learning how to read ADP-ribosylation

scientific article published in October 2009

MAD1 and its life as a MYC antagonist: an update.

scientific article published on 13 September 2011

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.

scientific article published on 10 March 2013

Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation.

scientific article published on 05 June 2013

Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity

scientific article published on 19 February 2007

Mad1 function in cell proliferation and transcriptional repression is antagonized by cyclin E/CDK2.

scientific article published on 18 February 2005

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

scientific article

Mitosis-specific phosphorylation of the nuclear oncoproteins Myc and Myb.

scientific article published on August 1992

Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin

scientific article published on 2 March 2018

Molecular simulation-based structural prediction of protein complexes in mass spectrometry: the human insulin dimer

scientific article

Mutational analysis of the carboxy-terminal casein kinase II phosphorylation site in human c-myc

scientific article published on January 1990

Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation

scientific article published on April 1990

Myc and Max associate in vivo

scientific article

Myc/Max/Mad regulate the frequency but not the duration of productive cell cycles ⬇️

scientific article published on November 21, 2001

Negative charge at the casein kinase II phosphorylation site is important for transformation but not for Rb protein binding by the E7 protein of human papillomavirus type 16.

scientific article published on June 1991

Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription.

scientific article

Overlap of the gene encoding the novel poly(ADP-ribose) polymerase Parp10 with the plectin 1 gene and common use of exon sequences

scientific article published on July 2005

PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1

scientific article published on 19 June 2019

PARP10 (ARTD10) modulates mitochondrial function

scientific article published on 2 January 2018

Paradox of sonic hedgehog (SHH) transcriptional regulation: Alternative transcription initiation overrides the effect of downstream promoter DNA methylation

scientific article published on April 2011

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

scientific article

Phosphorylation during mitosis: How many kinases are out there? ⬇️

scientific article published on November 15, 2011

Phosphorylation of casein kinase II by p34cdc2 in vitro and at mitosis

scientific article published on July 1992

Phosphorylation of the transcription factor YY1 by CK2α prevents cleavage by caspase 7 during apoptosis

scientific article

Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential.

scientific article published in December 1993

Players in ADP-ribosylation: Readers and Erasers

scientific article published on 19 April 2016

Posttranslational regulation of Myc function in response to phorbol ester/interferon-gamma-induced differentiation of v-Myc-transformed U-937 monoblasts.

scientific article published in June 1999

Progress in the function and regulation of ADP-Ribosylation

scientific article published on 24 May 2011

Proteins encoded by the c-myc oncogene: analysis of c-myc protein degradation

scientific article published on 01 January 1986

Proteins of the Myc network: essential regulators of cell growth and differentiation.

scientific article published on January 1996

Regulation of NF-κB signalling by the mono-ADP-ribosyltransferase ARTD10

scientific article

Regulation of cell growth by the Myc-Max-Mad network: role of Mad proteins and YY1.

scientific article published on January 1997

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.

scientific article

Regulation of gene transcription by the oncoprotein MYC.

scientific article published on 28 December 2011

Regulation of sirtuin function by posttranslational modifications

scientific article published on 28 February 2012

Regulation of the MAD1 promoter by G-CSF.

scientific article published on 18 January 2008

Regulation of transcription factors c-Myc, Max, and c-Myb by casein kinase II.

scientific article published on January 1994

Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules

scientific article published on June 1997

Repression of in vivo growth of Myc/Ras transformed tumor cells by Mad1.

scientific article published on January 2002

Revisiting a selection of target genes for the hematopoietic transcription factor c-Myb using chromatin immunoprecipitation and c-Myb knockdown

scientific article

SH3TC2, a protein mutant in Charcot-Marie-Tooth neuropathy, links peripheral nerve myelination to endosomal recycling

scientific article

SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310

scientific article

Signaling by IL-31 and functional consequences

scientific article

Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage.

scientific article published on 22 September 2016

Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP.

scientific article

Structural prediction of the interaction of the tumor suppressor p27KIP1 with cyclin A/CDK2 identifies a novel catalytically relevant determinant

scientific article

Studying the Role of AMPK in Autophagy.

scientific article

Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

scientific article published on October 2008

Successful omalizumab treatment in chronic spontaneous urticaria is associated with lowering of serum IL-31 levels

scientific article

Sulfoximines as ATR inhibitors: Analogs of VE-821.

scientific article

Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc

article

TGFβ1 enhances MAD1 expression and stimulates promoter-bound Pol II phosphorylation: basic functions of C/EBP, SP and SMAD3 transcription factors

scientific article

Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity

scientific article published on 22 July 2009

The CCNY (cyclin Y)-CDK16 kinase complex: a new regulator of autophagy downstream of AMPK

scientific article published on 29 July 2020

The E7 protein of human papillomavirus type 16 is phosphorylated by casein kinase II

scientific article published on 01 October 1989

The Mad side of the Max network: antagonizing the function of Myc and more.

scientific article

The Mad1 transcription factor is a novel target of activin and TGF-beta action in keratinocytes: possible role of Mad1 in wound repair and psoriasis

scientific article

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

scientific article published on 21 December 2011

The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases

scientific article published on 2 February 2017

The golden hamster aphrodisin gene. Structure, expression in parotid glands of female animals, and comparison with a similar murine gene

scientific article published in January 1999

The human T-cell leukemia virus type-1 p30II protein activates p53 and induces the TIGAR and suppresses oncogene-induced oxidative stress during viral carcinogenesis

scientific article published on 17 February 2018

The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification

scientific article published on 29 April 2014

The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site

scientific article published on 2 March 2006

The psoriasis-associated IL-17A induces and cooperates with IL-36 cytokines to control keratinocyte differentiation and function

scientific article

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

scientific article

The transcription factor YY1 is a substrate for Polo-like kinase 1 at the G2/M transition of the cell cycle

scientific article

The world according to MYC. Conference on MYC and the transcriptional control of proliferation and oncogenesis

scientific article published on 16 November 2007

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

scientific article published on 26 January 2010

Transcriptional activity of GLI1 is negatively regulated by protein kinase A.

scientific article published on July 2000

Tumorigenic N-terminal deletions of c-Myb modulate DNA binding, transactivation, and cooperativity with C/EBP

scientific article published on 01 November 2001

Ultraviolet B radiation and reactive oxygen species modulate interleukin-31 expression in T lymphocytes, monocytes and dendritic cells

scientific article published on 17 October 2011

Y-box protein 1 mediates PDGF-B effects in mesangioproliferative glomerular disease

scientific article published on 10 August 2005

YY1 binding to a subset of p53 DNA-target sites regulates p53-dependent transcription.

scientific article

YY1 can inhibit c-Myc function through a mechanism requiring DNA binding of YY1 but neither its transactivation domain nor direct interaction with c-Myc

scientific article

Yersinia enterocolitica YopT and Clostridium difficile toxin B induce expression of GILZ in epithelial cells

scientific article

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