List of works - Emanuela Tolosano

A role for hemopexin in oligodendrocyte differentiation and myelin formation

scientific article

Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development

scientific article published on 23 October 2013

Age-Dependent Effects of Haptoglobin Deletion in Neurobehavioral and Anatomical Outcomes Following Traumatic Brain Injury

scientific article published on 19 July 2016

Alumina-zirconia composites functionalized with laminin-1 and laminin-5 for dentistry: effect of protein adsorption on cellular response.

scientific article

Analysis of the murine phosphoinositide 3-kinase gamma gene

scientific article

Assessment of iron absorption in mice by ICP-MS measurements of 57Fe levels

scientific article published on 19 October 2011

Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.

scientific article published on 24 August 2012

Ciliary Neurotrophic Factor Constitutively Expressed in the Nervous System of Transgenic Mice Protects Embryonic Dorsal Root Ganglion Neurons from Apoptosis

scientific article published on 01 March 1996

Crucial Role of FLVCR1a in the Maintenance of Intestinal Heme Homeostasis

scientific article

Data demonstrating the anti-oxidant role of hemopexin in the heart.

scientific article

Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage

scientific article

Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis

scientific article

Evolving Cell-Based and Cell-Free Clinical Strategies for Treating Severe Human Liver Diseases

scientific article published on 07 February 2020

Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency

scientific article

Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro.

scientific article published on August 2010

Green fluorescent protein as a reporter of gene expression in transgenic mice

scientific article published in May 1997

Haemopexin affects iron distribution and ferritin expression in mouse brain.

scientific article

Haptoglobin modifies the hemochromatosis phenotype in mice

scientific article published on 21 December 2004

Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development

scientific article

Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis.

scientific article published on 11 December 2017

Heme and erythropoieis: more than a structural role.

scientific article published on June 2014

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter

scientific article

Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.

scientific article

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

scientific article published on 08 April 2014

Heme-hemopexin complex attenuates neuronal cell death and stroke damage

scientific article published on 11 March 2009

Hemoglobin - a novel ligand of hepatocyte ectopic F1-ATPase

scientific article published in December 2015

Hemoglobin and heme scavenging.

scientific article

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

scientific article

Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload

scientific journal article

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases

scientific article published on 27 February 2013

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

scientific article published on 16 December 2015

Hemopexin: structure, function, and regulation

scientific article (publication date: April 2002)

Hereditary Ataxia: A Focus on Heme Metabolism and Fe-S Cluster Biogenesis

scientific article published on 26 May 2020

Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice

scientific article published on 21 January 2020

Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1.

scientific article published on 24 February 2014

IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections

scientific article published on 03 February 2017

Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis

scientific article published on May 2015

Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice

scientific article

Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles

scientific article published on 21 June 2018

Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake

scientific article

Lack of haptoglobin affects iron transport across duodenum by modulating ferroportin expression.

scientific article

Long Term Liver Engraftment of Functional Hepatocytes Obtained from Germline Cell-Derived Pluripotent Stem Cells.

scientific article published on 31 August 2015

Microarray and Large-Scale In Silico–Based Identification of Genes Functionally Related to Haptoglobin and/or Hemopexin

article

Mitochondrial Targeting in Neurodegeneration: A Heme Perspective

scholarly article by Veronica Fiorito et al published 18 September 2018 in Pharmaceuticals

Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception

scientific article

Plasma protein haptoglobin modulates renal iron loading

scientific article published on April 2005

Posterior column ataxia with retinitis pigmentosa coexisting with sensory-autonomic neuropathy and leukemia due to the homozygous p.Pro221Ser FLVCR1 mutation.

scientific article published on 2 August 2017

Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells

scientific article published on 16 January 2020

Purinergic Calcium Signals in Tumor-Derived Endothelium

scientific article published on 01 June 2019

Renal cells from spermatogonial germline stem cells protect against kidney injury

scientific article published on 17 October 2013

Role of extracellular matrix molecules in the development of the sodium current in quail mesencephalic neural crest cells

scientific article published in September 1992

Specific expression in brain and liver driven by the hemopexin promoter in transgenic mice

scientific article published in January 1996

Targeting Metabolism to Counteract Tumor Angiogenesis: A Review of Patent Literature

article

The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells

scientific article

The RNA-binding protein ESRP1 promotes human colorectal cancer progression

scientific article published on 28 December 2016

The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation

scientific article published on 20 March 2015

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

scientific article

The murine Y1 receptor 5' upstream sequence directs cell-specific and developmentally regulated LacZ expression in transgenic mice CNS.

scientific article published in October 1998

Therapeutic Approaches to Limit Hemolysis-Driven Endothelial Dysfunction: Scavenging Free Heme to Preserve Vasculature Homeostasis ⬇️

scientific article published on May 27, 2013

List of works by Emanuela Tolosano

A role for hemopexin in oligodendrocyte differentiation and myelin formation

Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development

Age-Dependent Effects of Haptoglobin Deletion in Neurobehavioral and Anatomical Outcomes Following Traumatic Brain Injury

Alumina-zirconia composites functionalized with laminin-1 and laminin-5 for dentistry: effect of protein adsorption on cellular response.

Analysis of the murine phosphoinositide 3-kinase gamma gene

Assessment of iron absorption in mice by ICP-MS measurements of 57Fe levels

Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.

Ciliary Neurotrophic Factor Constitutively Expressed in the Nervous System of Transgenic Mice Protects Embryonic Dorsal Root Ganglion Neurons from Apoptosis

Crucial Role of FLVCR1a in the Maintenance of Intestinal Heme Homeostasis

Data demonstrating the anti-oxidant role of hemopexin in the heart.

Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage

Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis

Evolving Cell-Based and Cell-Free Clinical Strategies for Treating Severe Human Liver Diseases

Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency

Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro.

Green fluorescent protein as a reporter of gene expression in transgenic mice

Haemopexin affects iron distribution and ferritin expression in mouse brain.

Haptoglobin modifies the hemochromatosis phenotype in mice

Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development

Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis.

Heme and erythropoieis: more than a structural role.

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter

Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

Heme-hemopexin complex attenuates neuronal cell death and stroke damage

Hemoglobin - a novel ligand of hepatocyte ectopic F1-ATPase

Hemoglobin and heme scavenging.

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

Hemopexin: structure, function, and regulation

Hereditary Ataxia: A Focus on Heme Metabolism and Fe-S Cluster Biogenesis

Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice

Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1.

IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections

Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis

Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice

Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles

Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake

Lack of haptoglobin affects iron transport across duodenum by modulating ferroportin expression.

Long Term Liver Engraftment of Functional Hepatocytes Obtained from Germline Cell-Derived Pluripotent Stem Cells.

Microarray and Large-Scale In Silico–Based Identification of Genes Functionally Related to Haptoglobin and/or Hemopexin

Mitochondrial Targeting in Neurodegeneration: A Heme Perspective

Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception

Plasma protein haptoglobin modulates renal iron loading

Posterior column ataxia with retinitis pigmentosa coexisting with sensory-autonomic neuropathy and leukemia due to the homozygous p.Pro221Ser FLVCR1 mutation.

Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells

Purinergic Calcium Signals in Tumor-Derived Endothelium

Renal cells from spermatogonial germline stem cells protect against kidney injury

Role of extracellular matrix molecules in the development of the sodium current in quail mesencephalic neural crest cells

Specific expression in brain and liver driven by the hemopexin promoter in transgenic mice

Targeting Metabolism to Counteract Tumor Angiogenesis: A Review of Patent Literature

The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells

The RNA-binding protein ESRP1 promotes human colorectal cancer progression

The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

The murine Y1 receptor 5' upstream sequence directs cell-specific and developmentally regulated LacZ expression in transgenic mice CNS.

Therapeutic Approaches to Limit Hemolysis-Driven Endothelial Dysfunction: Scavenging Free Heme to Preserve Vasculature Homeostasis ⬇️