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List of works by Charles T. Roberts

A cycloheximide-resistant mutant of Tetrahymena pyriformis.

scientific article

A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene

scientific article published on 30 May 2006

A novel insulin-like growth factor (IGF)-independent role for IGF binding protein-3 in mesenchymal chondroprogenitor cell apoptosis

scientific article (publication date: May 2003)

A novel, stable, aqueous glucagon formulation using ferulic acid as an excipient

scientific article published on 24 September 2014

Alterations in peripheral blood lymphocyte cytokine expression in obesity.

scientific article

Altered expression of insulin-like growth factor-I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats

scientific article published in January 1992

Altered expression of the WT1 wilms tumor suppressor gene in human breast cancer

scientific article

Alternative leader sequences in insulin-like growth factor I mRNAs modulate translational efficiency and encode multiple signal peptides

scientific article published on October 1995

Alternative splicing produces messenger RNAs encoding insulin-like growth factor-I prohormones that are differentially glycosylated in vitro

scientific article published on 01 June 1990

Analysis of the human type I insulin-like growth factor receptor promoter region

scientific article published on 01 June 1991

Androgen effects on adipose tissue architecture and function in nonhuman primates.

scientific article

Androgen receptor (AR) expression in AR-negative prostate cancer cells results in differential effects of DHT and IGF-I on proliferation and AR activity between localized and metastatic tumors

scientific article published on November 2004

Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells.

scientific article

Antiproliferative effects of insulin-like growth factor-binding protein-3 in mesenchymal chondrogenic cell line RCJ3.1C5.18. relationship to differentiation stage

scientific article

Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction

scientific journal article

Biochemical stabilization of glucagon at alkaline pH.

scientific article

Cell-autonomous heterogeneity of nutrient uptake in white adipose tissue of rhesus macaques

scientific article

Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression

scientific article published in September 1990

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II.

scientific article published in January 1992

Characterization of a salmon insulin-like growth factor I promoter

scientific article published in October 1994

Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene

scientific article published in June 1990

Components of the IGF system mediate the opposing effects of tamoxifen on endometrial and breast cancer cell growth

scientific article published on 01 January 1995

Comprehensive proteomic analysis of human cervical-vaginal fluid.

scientific article published on 21 March 2007

Comprehensive proteomic analysis of the human amniotic fluid proteome: gestational age-dependent changes

scientific article published on 21 March 2007

Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.

scientific article

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes.

scientific article published on 25 June 2015

Decreased expression of Wilms' tumor gene WT-1 and elevated expression of insulin growth factor-II (IGF-II) and type 1 IGF receptor genes in prostatic stromal cells from patients with benign prostatic hyperplasia

scientific article published on 01 July 1997

Defects in human insulin receptor gene expression

scientific article published on 01 March 1988

Developmental expression of rat insulin-like growth factor-II/mannose 6-phosphate receptor messenger ribonucleic acid

scientific article published in June 1992

Developmental regulation of insulin-like growth factor-I-stimulated glucose transporter in rat brain astrocytes

scientific article published on May 1991

Developmental regulation of rat brain/Hep G2 glucose transporter gene expression

scientific article published in February 1989

Developmental regulation of somatostatin gene expression in the brain is region specific

scientific article published in February 1987

Dexamethasone reduces steady state insulin-like growth factor I messenger ribonucleic acid levels in rat neuronal and glial cells in primary culture

scientific article

Differential Activation of Insulin Receptor Substrates 1 and 2 by Insulin-Like Growth Factor-Activated Insulin Receptors

Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain

scientific article published on 20 October 2005

Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors.

scientific article published on 26 February 2007

Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor

scientific article published on February 1997

Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor

scientific article published on May 1995

Distinct promoters in the rat insulin-like growth factor-I (IGF-I) gene are active in CHO cells

scientific article published in February 1993

Distribution and regulation of rat insulin-like growth factor I messenger ribonucleic acids encoding alternative carboxyterminal E-peptides: evidence for differential processing and regulation in liver

scientific article published on 01 June 1988

Effect of a growth hormone-releasing factor antagonist on compensatory renal growth, insulin-like growth factor-I (IGF-I), and IGF-I receptor gene expression after unilateral nephrectomy in immature rats

scientific article published on 01 May 1992

Effect of growth hormone on levels of differentially processed insulin-like growth factor I mRNAs in total and polysomal mRNA populations

scientific article published on 01 November 1992

Effect of hypoxia on lung, heart, and liver insulin-like growth factor-I gene and receptor expression in the newborn rat.

scientific article published in June 1996

Effect of testosterone on insulin-like growth factor-I (IGF-I) and IGF-I receptor gene expression in the hypophysectomized rat

scientific article published on 01 May 1992

Erythrocyte insulin-like growth factor-L binding in younger and older males

scientific article published on 01 March 1998

Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action

scientific article published on January 1994

Evolutionary origins of intercellular communication systems: implications for mammalian biology

scientific article

Expression and stability of insulin-like growth factor-I (IGF-I) mRNA splicing variants in the GH3 rat pituitary cell line

scientific article published on 01 August 1989

Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes

scientific article published on 01 May 1995

Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells

scientific article published on September 1989

Expression of the genes encoding the insulin-like growth factors and their receptors in the human ovary

scientific article

Expression of the insulin-like growth factor (IGF)-I and -II and the IGF-I and -II receptor genes during postnatal development of the rat ovary

scientific article published on September 1992

Expression, action, and steroidal regulation of insulin-like growth factor-I (IGF-I) and IGF-I receptor in the rat corpus luteum: their differential role in the two cell populations forming the corpus luteum

scientific article published in December 1991

Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes

scientific article published in 1999

Familial short stature caused by haploinsufficiency of the insulin-like growth factor i receptor due to nonsense-mediated messenger ribonucleic acid decay

scientific article published on 24 February 2009

Galactokinase-deficient mutants of Tetrahymena thermophila: selection and characterization.

scientific article published in January 1980

Genetic basis for chamber-specific ventricular phenotypes in the rat infarct model

scientific article published in February 2003

Glucose utilization in a patient with hepatoma and hypoglycemia. Assessment by a positron emission tomography ⬇️

scientific article published on June 1, 1992

Glycosylated fibronectin as a first-trimester biomarker for prediction of gestational diabetes

scientific article published in September 2013

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) treatment of the GH-deficient dwarf rat: differential effects on IGF-I transcription start site expression in hepatic and extrahepatic tissues and lack of effect on type I IGF receptor mRN

scientific article published in May 1994

Growth hormone (GH) status regulates GH receptor and GH binding protein mRNA in a tissue- and transcript-specific manner but has no effect on insulin-like growth factor-I receptor mRNA in the rat.

scientific article published in February 1996

Growth hormone (GH) stimulates insulin-like growth factor-I (IGF-I) and IGF-I-binding protein-3, but not GH receptor gene expression in livers of juvenile rats

scientific article published on 01 August 1993

Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid

scientific article published on 01 October 1995

Hepatic tyrosine-phosphorylated proteins identified and localized following in vivo inhibition of protein tyrosine phosphatases: effects of H2O2 and vanadate administration into rat livers

scientific article published on 01 November 1993

Hormonal regulation of rat hypothalamic neuropeptide mRNAs: effect of hypophysectomy and hormone replacement on growth-hormone-releasing factor, somatostatin and the insulin-like growth factors

scientific article published in March 1991

Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells ⬇️

scientific article published on March 13, 2011

Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily ⬇️

scientific article published on November 25, 1997

Identification of multiple transcription start sites in the human insulin-like growth factor-I gene

scientific article published in June 1991

Identification of novel protein biomarkers of preterm birth in human cervical-vaginal fluid

scientific article published on 21 March 2007

Identification of the insulin-like growth factor binding proteins 5 and 6 (IGFBP-5 and 6) in human breast cancer cells

scientific article published on 01 March 1992

Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation

scientific article published on July 1994

Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains

scientific article published in April 1991

Insulin-like growth factor I (IGF-I): a molecular basis for endocrine versus local action?

scientific article published on May 1991

Insulin-like growth factor I as an intraovarian regulator: basic and clinical implications.

scientific article published on January 1991

Insulin-like growth factor I gene expression by primary cultures of ovarian cells: insulin and dexamethasone dependence

scientific article published on 01 June 1993

Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain

scientific article

Insulin-like growth factor I messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed during development of the rat.

scientific article published in June 1989

Insulin-like growth factor binding protein-5 gene expression is differentially regulated at a post-transcriptional level in retinoic acid-sensitive and resistant MCF-7 human breast carcinoma cells.

scientific article

Insulin-like growth factor receptor gene expression in the rat ovary: divergent regulation of distinct receptor species

scientific article published on 01 December 1991

Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line

scientific article published on October 1992

Insulin-like growth factor-II in nonislet cell tumors associated with hypoglycemia: increased levels of messenger ribonucleic acid

scientific article published on 01 December 1989

Insulin-like growth factor-binding protein enhancement of insulin-like growth factor-I (IGF-I)-mediated DNA synthesis and IGF-I binding in a human breast carcinoma cell line

scientific article published on January 1994

Insulin-like growth factors and their receptors in normal physiology and pathological states

scientific article published on 01 July 1993

Large-scale generation of highly enriched neural stem-cell-derived oligodendroglial cultures: maturation-dependent differences in insulin-like growth factor-mediated signal transduction

scientific article published on February 2007

Live-cell imaging demonstrates rapid cargo exchange between lipid droplets in adipocytes

scientific article

Liver regeneration is associated with increased expression of the insulin-like growth factor-II/mannose-6-phosphate receptor

scientific article published on 01 October 1990

Localization of growth hormone receptor/binding protein messenger ribonucleic acid (mRNA) during rat fetal development: relationship to insulin-like growth factor-I mRNA

scientific article published on 01 October 1995

Luteinizing hormone-releasing hormone antagonists interfere with autocrine and paracrine growth stimulation of MCF-7 mammary cancer cells by insulin-like growth factors

scientific article

Maternal serum biomarkers for risk assessment in gestational diabetes. A potential universal screening test to predict GDM status.

scientific article

Maternal serum glycosylated fibronectin as a point-of-care biomarker for assessment of preeclampsia

scientific article published on 31 July 2014

Mechanisms of glucagon degradation at alkaline pH.

scientific article published on 04 May 2013

Modulation of insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins in endometrial cancer cells by estradiol

scientific article published on 01 June 1995

Molecular aspects of insulin-like growth factors, their binding proteins and receptors

scientific article

Natriuretic peptide signalling: molecular and cellular pathways to growth regulation

scientific article

Nucleotide sequence of a genomic fragment of the rat IGF-I gene spanning an alternate 5' non coding exon

scientific article published on May 1989

Nutritional regulation of insulin-like growth factor-I receptor mRNA levels in growing chickens

scientific article published in June 1996

Nutritional regulation of insulin-sensitive glucose transporter gene expression in rat cardiac muscle

scientific article published in June 1993

Ovarian cycle-specific regulation of adipose tissue lipid storage by testosterone in female nonhuman primates.

scientific article published on 05 September 2013

Paradoxical biological effects of overexpressed insulin-like growth factor-1 receptors in Chinese hamster ovary cells

scientific article published on July 1993

Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group

scientific article

Phylogeny of the insulin-like growth factors (IGFs) and receptors: a molecular approach

scientific article published on August 1993

Plasma distribution and signaling activities of IGF-II precursors.

scientific article

Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene

scientific article published on April 1994

Protective hinge in insulin opens to enable its receptor engagement

scientific article

Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection

scientific article published on January 2007

Proteomic analysis of maternal serum in down syndrome: identification of novel protein biomarkers

scientific article

Proteomic identification of salivary biomarkers of type-2 diabetes

scientific article published on 01 January 2009

Proteomic identification of urinary biomarkers of diabetic nephropathy

scientific article published on 01 March 2007

Purification and properties of galactokinase from Tetrahymena thermophila

scientific article published on 01 July 1982

RNA trafficking by acute myelogenous leukemia exosomes.

scientific article

Rat IGF-I cDNA's contain multiple 5'-untranslated regions

scientific article published in August 1987

Rat ovarian insulin-like growth factor I (IGF-I) gene expression is granulosa cell-selective: 5'-untranslated mRNA variant representation and hormonal regulation

scientific article published on 01 July 1989

Rat ovarian insulin-like growth factor II gene expression is theca-interstitial cell-exclusive: hormonal regulation and receptor distribution

scientific article published on 01 December 1990

Receptors for intercellular messenger molecules in microbes: similarities to vertebrate receptors and possible implications for diseases in man.

scientific article

Regulation of Start Site Usage in the Leader Exons of the Rat Insulin-Like Growth Factor-I Gene by Development, Fasting, and Diabetes ⬇️

scientific article published on November 1, 1991

Regulation of endometrial cancer cell growth by insulin-like growth factors and the luteinizing hormone-releasing hormone antagonist SB-75.

scientific article published on October 1993

Regulation of insulin-like growth factor (IGF) binding protein-5 in the T47D human breast carcinoma cell line by IGF-I and retinoic acid

scientific article published on November 1993

Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element

scientific article published on September 1995

Regulation of insulin-like growth factor I receptor gene expression by the Wilms' tumor suppressor WT1.

scientific article published in January 1996

Regulation of insulin-like growth factor-binding-protein-1, 2, 3, 4, 5, and 6: synthesis, secretion, and gene expression in estrogen receptor-negative human breast carcinoma cells

scientific article published on June 1993

Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells

scientific article published on 01 July 1989

Regulation of rat brain/HepG2 glucose transporter gene expression by phorbol esters in primary cultures of neuronal and astrocytic glial cells

scientific article published on January 1990

Renal IGF-1 mRNA levels are enhanced following unilateral nephrectomy in immature but not adult rats

scientific article published in May 1991

Retinoic acid and estrogen modulation of insulin-like growth factor binding protein-4 gene expression and the estrogen receptor status of human breast carcinoma cells

scientific article

Role of GH and IGF-I in the regulation of IGF-I, IGF-I receptor and IGF binding protein gene expression in the rat spleen

scientific article published on 01 August 1994

Salivary protein glycosylation as a noninvasive biomarker for assessment of glycemia

scientific article published on 10 October 2014

Saw palmetto extract suppresses insulin-like growth factor-I signaling and induces stress-activated protein kinase/c-Jun N-terminal kinase phosphorylation in human prostate epithelial cells

scientific article published on 19 March 2004

Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanes

scientific article published in July 2005

Serum leptin levels, hepatic leptin receptor transcription, and clinical predictors of non-alcoholic steatohepatitis in obese bariatric surgery patients.

scientific article

Sex-specific differences in lipid and glucose metabolism

scientific article

Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency

scientific article

Single tyrosine substitution in the insulin-like growth factor I receptor inhibits ligand-induced receptor autophosphorylation and internalization, but not mitogenesis

scientific article published on November 1995

Stable liquid glucagon formulations for rescue treatment and bi-hormonal closed-loop pancreas

scientific article published on December 2012

Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction in IGF binding proteins

scientific article

Structural and functional analysis of the insulin-like growth factor I receptor gene promoter

scientific article published on October 1, 1992

TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding

scientific article published on 01 July 1989

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.

scientific article

The accumulation of IGF-I in kidneys of streptozotocin-diabetic adult rats is not associated with elevated plasma GH or IGF-I levels

scientific article published on 01 September 1995

The growth hormone-insulin-like growth factor-I axis in chronic kidney disease

scientific article published on 07 September 2007

The insulin-like growth factor I (IGF-I) gene is expressed in chick embryos during early organogenesis

scientific article published in September 1990

The insulin-like growth factor system and cancer

scientific article

Tissue-specific transcription start site usage in the leader exons of the rat insulin-like growth factor-I gene: evidence for differential regulation in the developing kidney

scientific article

Transcription initiation in the two leader exons of the rat IGF-I gene occurs from disperse versus localized sites

scientific article published on 01 April 1991

Transcriptional regulation of insulin-like growth factor-I receptor gene expression in prostate cancer cells

scientific article

Two insulin genes are present in the salmon genome

scientific article published in March 1993

Vesicle trafficking and RNA transfer add complexity and connectivity to cell-cell communication

scientific article

WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation

scientific article published on 19 November 2002

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

scientific article

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