List of works by Michael M. Shen

A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue

scientific article

A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.

scholarly article

A luminal epithelial stem cell that is a cell of origin for prostate cancer

scientific article

A molecular signature predictive of indolent prostate cancer

scientific article published on September 2013

A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration

scientific journal article

A novel PF/PN motif inhibits nuclear localization and DNA binding activity of the ESX1 homeoprotein

scientific article

A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

scientific article published on 11 September 2020

Activator Protein-1 Transcription Factors Are Associated with Progression and Recurrence of Prostate Cancer

scientific article published on 01 April 2008

An early phase of embryonic Dlx5 expression defines the rostral boundary of the neural plate.

scientific article published in October 1998

An unusual gene dosage effect of p27kip1 in a mouse model of prostate cancer.

scientific article

Atg7 cooperates with Pten loss to drive prostate cancer tumor growth

scientific article published on February 2016

B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer

scientific article

Basal Progenitors Contribute to Repair of the Prostate Epithelium Following Induced Luminal Anoikis

scientific article published on 20 April 2016

Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

scientific article published in December 2003

C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons

scientific article published in February 1992

CRISPR/Cas9-Mediated Point Mutation in Nkx3.1 Prolongs Protein Half-Life and Reverses Effects Nkx3.1 Allelic Loss

scientific article published on 17 September 2020

Cancer: The complex seeds of metastasis.

scientific article published in April 2015

Canonical Wnt signaling regulates Nkx3.1 expression and luminal epithelial differentiation during prostate organogenesis.

scientific article published on 29 July 2013

Cell signaling in growth and development: the 11th Annual CABM Symposium, October 8-9, 1997.

scientific article published in June 1998

Cell types of origin for prostate cancer

scientific article

Chromoplexy: a new category of complex rearrangements in the cancer genome

scientific article published on May 2013

Comparative lineage tracing reveals cellular preferences for prostate cancer initiation.

scientific article published on 25 February 2015

Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy

scientific journal article

Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs

scientific article

Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells.

scientific article published in March 2005

Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.

scientific article

Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin

scientific article

Cripto-1 ablation disrupts alveolar development in the mouse mammary gland through a progesterone receptor-mediated pathway.

scientific article

Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy

scientific article published on May 2014

Development and characterization of a novel CD19CherryLuciferase (CD19CL) transgenic mouse for the preclinical study of B-cell lymphomas

scientific article

Diagnostics: The prostate-cancer metabolome

scientific article published in February 2009

Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation

scientific article published on 15 January 2018

Distinct modes of floor plate induction in the chick embryo

scientific article published on 13 August 2003

Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model.

scientific article

ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer.

scientific article published on 05 August 2013

Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice.

scientific article

Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis

scientific journal article

Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies.

scientific article published on March 1994

FGF signaling in prostate tumorigenesis--new insights into epithelial-stromal interactions

scientific article published on 01 December 2007

Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis

scientific journal article

Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors

scientific journal article

From blastocyst to gastrula: gene regulatory networks of embryonic stem cells and early mouse embryogenesis

scientific article

Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis

scientific article

Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A

scientific article published on 20 November 2020

Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport

scientific journal article

HER3 Is an Actionable Target in Advanced Prostate Cancer

scientific article published on 09 November 2021

Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene

scientific journal article

Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks

scientific article published on 01 August 2016

Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks.

scientific article

Identification of differentially expressed genes in mouse development using differential display and in situ hybridization.

scientific article published in May 2001

Illuminating the Properties of Prostate Luminal Progenitors.

scientific article published in December 2015

In situ hybridization reveals co-expression of embryonic and adult alpha globin genes in the earliest murine erythrocyte progenitors

scientific article published on 01 December 1992

Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1

scientific article (publication date: 6 December 2002)

Intra-epithelial non-canonical Activin A signaling safeguards prostate progenitor quiescence

scientific article published on 07 March 2022

Leukemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vitro ⬇️

scientific article published on September 1, 1992

Lineage Plasticity in Cancer Progression and Treatment

scientific article published on 01 December 2017

Luminal cells are favored as the cell of origin for prostate cancer

scientific article

Mash1 expression is induced in neuroendocrine prostate cancer upon the loss of Foxa2.

scientific article published on 11 October 2012

Molecular genetics of prostate cancer.

scientific article

Molecular genetics of prostate cancer: new prospects for old challenges

scientific article

Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development

scientific journal article

Mouse models of prostate carcinogenesis.

scientific article

Msx homeobox genes inhibit differentiation through upregulation of cyclin D1.

scientific article

Msx1 antagonizes the myogenic activity of Pax3 in migrating limb muscle precursors.

scientific article

Murine FGFR-1 is required for early postimplantation growth and axial organization

scientific article published on 01 December 1994

NSD2 is a conserved driver of metastatic prostate cancer progression

scientific article published in Nature Communications

Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate

scientific article published on 23 May 2019

Nkx3.1 controls the DNA repair response in the mouse prostate

scientific article published on 10 December 2015

Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis.

scientific article published in June 2002

Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases

scientific article published in July 2003

Nodal signaling: developmental roles and regulation.

scientific article published on 7 February 2007

Nodal signalling in vertebrate development.

scientific article

Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis

scientific article published on 16 November 2005

Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models.

scientific article

ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm

scientific article

Progenitor cells for the prostate epithelium: roles in development, regeneration, and cancer.

scientific article published on January 2008

Prostate Cancer Research at the Crossroads

scientific article published on 01 July 2019

Prostate Stem Cells and Cancer Stem Cells

scientific article published on 03 June 2019

Prostate organogenesis: tissue induction, hormonal regulation and cell type specification

scientific article published on April 2017

Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway

scientific article published in 2011

Pten inactivation and the emergence of androgen-independent prostate cancer.

scientific article published on July 2007

Regulation of extra-embryonic endoderm stem cell differentiation by Nodal and Cripto signaling

scientific article

Revisiting the concept of cancer stem cells in prostate cancer.

scientific article

Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis

scientific journal article

Roles for Nkx3.1 in prostate development and cancer

scientific journal article

Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis.

scientific article

Single luminal epithelial progenitors can generate prostate organoids in culture.

scientific article

SnapShot: Prostate cancer

scientific article published on September 2013

Sox9 is required for prostate development

scientific journal article

Stem cells in genetically-engineered mouse models of prostate cancer

scientific article

Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity

scientific article

Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo.

scientific article published on 3 October 2007

The EGF-CFC gene family in vertebrate development.

scientific article

The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance

scientific article published on 30 July 2019

The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo

scientific article

The roots of cancer: stem cells and the basis for tumor heterogeneity

scientific article published on 02 October 2012

The trophic role of oligodendrocytes in the basal forebrain.

scientific article published on July 2003

Transdifferentiation as a Mechanism of Treatment Resistance in a Mouse Model of Castration-Resistant Prostate Cancer.

scientific article published on 14 April 2017

Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation

scientific article published on March 2015

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer.

scientific article published in April 2018

Two modes by which Lefty proteins inhibit nodal signaling

scientific journal article

Two nodal-responsive enhancers control left-right asymmetric expression of Nodal.

scientific article published in April 2005

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