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List of works by John F. Disterhoft

A MRI-compatible system for whisker stimulation ⬇️

scientific article published on 04 February 2012

A fiber optic-based system for behavioral eyeblink measurement in a MRI environment

scientific article published in January 2005

A novel method for precisely timed stimulation of mouse whiskers in a freely moving preparation: application for delivery of the conditioned stimulus in trace eyeblink conditioning

scientific article published on 12 November 2008

A system for quantitative analysis of associative learning. Part 1. Hardware interfaces with cross-species applications.

scientific article

A system for quantitative analysis of associative learning. Part 2. Real-time software for MS-DOS microcomputers

scientific article published on September 1994

AHP reductions in rabbit hippocampal neurons during conditioning correlate with acquisition of the learned response

scientific article published in October 1988

Activity of hippocampal pyramidal neurons during trace eyeblink conditioning

scientific article published in January 1996

Activity profiles of single neurons in caudal anterior cingulate cortex during trace eyeblink conditioning in the rabbit.

scientific article published on 15 May 2003

Activity-induced manganese-dependent MRI (AIM-MRI) and functional MRI in awake rabbits during somatosensory stimulation

scientific article

Acute stress facilitates trace eyeblink conditioning in C57BL/6 male mice and increases the excitability of their CA1 pyramidal neurons

scientific article

Age- and dose-dependent facilitation of associative eyeblink conditioning by D-cycloserine in rabbits ⬇️

scientific article published on December 1, 1997

Age-dependent changes in the immunoreactivity for neurofilaments in rabbit hippocampus

scientific article published in July 1997

Age-related deficits in a forebrain-dependent task, trace-eyeblink conditioning

scientific article

Age-related effects on eyeblink conditioning in the F344 x BN F1 hybrid rat.

scientific article

Age-related loss of calcium binding proteins in rabbit hippocampus

scientific article published on 01 May 1996

Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum

scientific article published in March 2004

Aging-related alterations in the distribution of Ca(2+)-dependent PKC isoforms in rabbit hippocampus

scientific article published in January 2004

Alterations in intrinsic neuronal excitability during normal aging.

scientific article published on June 2007

An analysis of leg position learning in the cockroach yoked control

scientific article published in September 1971

Autophosphorylation of alphaCaMKII downregulates excitability of CA1 pyramidal neurons following synaptic stimulation.

scientific article

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

scientific article

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

scientific article published on 20 December 2006

BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice

scientific article (publication date: 2009)

Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry

scientific article

Behavioral deficits associated with fetal alcohol exposure are reversed by prenatal thyroid hormone treatment: a role for maternal thyroid hormone deficiency in FAE.

scientific article published in October 2005

CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats.

scientific article published on 04 January 2017

Calcium-dependent afterhyperpolarization and learning in young and aging hippocampus.

scientific article

Caudate nucleus in retrieval of trace eyeblink conditioning after consolidation.

scientific article published on February 2013

Caudate nucleus is critically involved in trace eyeblink conditioning

scientific article

Cellular mechanisms for altered learning in aging.

scientific article published on January 2010

Cerebellar cortical degeneration disrupts discrimination learning but not delay or trace classical eyeblink conditioning

scientific article published in October 2000

Comparisons of dorsal and ventral hippocampus cornu ammonis region 1 pyramidal neuron activity during trace eye-blink conditioning in the rabbit.

scientific article

Conditional discrimination learning in patients with bilateral medial temporal lobe amnesia.

scientific article published on December 2003

Conditioning, awareness, and the hippocampus

Connections of the caudal anterior cingulate cortex in rabbit: neural circuitry participating in the acquisition of trace eyeblink conditioning

scientific article

Connections of the rabbit abducens nucleus

scientific article published in February 1985

Cortical barrel lesions impair whisker-CS trace eyeblink conditioning.

scientific article published on January 2007

Cortical involvement in acquisition and extinction of trace eyeblink conditioning

scientific article published in December 2000

Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity.

scientific article published on 20 August 2008

Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2.

scientific article

Dietary nimodipine improves associative learning in aging rabbits

scientific article published in November 1990

Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability

scientific article

Differential responsivity of neurons in perirhinal cortex, lateral entorhinal cortex and dentate gyrus during time-bridging learning

scientific article published on 25 November 2018

Differentiated short latency response increases after conditioning in inferior colliculus neurons of alert rat.

scientific article published in July 1977

Effects of hypothermia and lamotrigine on trace-conditioned learning after global cerebral ischemia in rabbits

scientific article

Electromyography as a recording system for eyeblink conditioning with functional magnetic resonance imaging

scientific article published in October 2002

Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in I M.

scientific article published on 20 August 2007

Exploring prefrontal cortical memory mechanisms with eyeblink conditioning

scientific article published on June 2011

Eyeball retraction latency in the conscious rabbit measured with a new photodiode technique

scientific article published in January 1984

Eyeblink Conditioning and Novel Object Recognition in the Rabbit: Behavioral Paradigms for Assaying Psychiatric Diseases

scientific article

Eyeblink conditioning in the rabbit (Oryctolagus cuniculus) with stimulation of the mystacial vibrissae as a conditioned stimulus

scientific article

Functional MRI of cerebellar activity during eyeblink classical conditioning in children and adults.

scientific article

Functional magnetic resonance imaging in the awake rabbit: a system for stimulus presentation and response detection during eyeblink conditioning

scientific article

Functional magnetic resonance imaging of delay and trace eyeblink conditioning in the primary visual cortex of the rabbit

scientific article published on May 2008

Functional reorganization of a prefrontal cortical network mediating consolidation of trace eyeblink conditioning

scientific article

GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists

scientific article

GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator.

scientific article

Galantamine facilitates acquisition of hippocampus-dependent trace eyeblink conditioning in aged rabbits

scientific article published on January 2004

Galantamine increases excitability of CA1 hippocampal pyramidal neurons.

scientific article published on 20 October 2005

Genetic Ablation of Neural Progenitor Cells Impairs Acquisition of Trace Eyeblink Conditioning

scientific article published on 01 September 2019

Hippocampal lesions impair memory of short-delay conditioned eye blink in rabbits

scientific article published in October 1989

Hippocampal lesions prevent trace eyeblink conditioning in the freely moving rat.

scientific article

Hippocampectomy disrupts auditory trace fear conditioning and contextual fear conditioning in the rat.

scientific article

Hippocampectomy disrupts trace eye-blink conditioning in rabbits

scientific article published in August 2015

Impaired delay eyeblink conditioning in amnesic Korsakoff's patients and recovered alcoholics

scientific article published in October 1995

Impaired eyeblink conditioning and decreased hippocampal volume in PDAPP V717F mice.

scientific article published in December 2002

Increased Excitability of Both Principal Neurons and Interneurons during Associative Learning

scientific article

Increasing SK2 channel activity impairs associative learning

scientific article

Infragranular barrel cortex activity is enhanced with learning.

scientific article published on 13 June 2012

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

scientific article published in October 2006

Intrinsic Excitability Increase in Cerebellar Purkinje Cells after Delay Eye-Blink Conditioning in Mice

scientific article published on 03 February 2020

Intrinsic neuronal excitability is reversibly altered by a single experience in fear conditioning.

scientific article

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes

scientific article

Learning and memory

scientific article published on 01 May 1991

Learning increases intrinsic excitability of hippocampal interneurons

scientific article published on March 2013

Learning, aging and intrinsic neuronal plasticity.

scientific article published on 30 August 2006

Learning-induced afterhyperpolarization reductions in hippocampus are specific for cell type and potassium conductance

scientific article published in January 1990

Learning-induced alterations in hippocampal PKC-immunoreactivity: a review and hypothesis of its functional significance

scientific article published on April 1997

Learning-related postburst afterhyperpolarization reduction in CA1 pyramidal neurons is mediated by protein kinase A

scholarly article

Lesions of the caudal area of rabbit medial prefrontal cortex impair trace eyeblink conditioning

scientific article published in March 1998

Location of rabbit auditory cortex and description of single unit activity

scientific article published on June 1981

Lubeluzole and conditioned learning after cerebral ischemia

scientific article published in August 2003

Mechanisms underlying basal and learning-related intrinsic excitability in a mouse model of Alzheimer's disease

scientific article

Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice

scientific article published on 23 May 2009

Metrifonate treatment enhances acquisition of eyeblink conditioning in aging rabbits

scientific article published on January 1997

Modulation of cholinergic transmission enhances excitability of hippocampal pyramidal neurons and ameliorates learning impairments in aging animals.

scientific article

Neuron activity in rat hippocampus and motor cortex during discrimination reversal

scientific article published on November 1978

Neurotoxic lesions of the dorsal hippocampus disrupt auditory-cued trace heart rate (fear) conditioning in rabbits

scientific article

Nictitating membrane conditioning to tone in the immobilized albino rabbit

scientific article published in November 1977

Nimodipine decreases calcium action potentials in rabbit hippocampal CA1 neurons in an age-dependent and concentration-dependent manner

scientific article published in February 1994

Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning.

scientific article published on December 1990

Pharmacological and molecular enhancement of learning in aging and Alzheimer's disease.

scientific article published on 3 February 2006

Physiological and anatomical studies of associative learning: Convergence with learning studies of W.T. Greenough.

scientific article published on July 2011

Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors.

scientific article

Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats.

scientific article

Receptive fields of single cells from the face zone of the cat rostral dorsal accessory olive

scientific article published in March 1993

Reevaluating hippocampus-dependent learning in FVB/N mice

scientific article

Relation of nimodipine dose and serum concentration to learning enhancement in aging rabbits

scientific article published in May 1994

Remodeling of hippocampal synapses after hippocampus-dependent associative learning

scientific article published in January 2000

Response plasticity of single neurons in rabbit auditory association cortex during tone-signalled learning

scientific article published in August 1982

Robust hippocampal responsivity during retrieval of consolidated associative memory.

scientific article

Slow afterhyperpolarization governs the development of NMDA receptor-dependent afterdepolarization in CA1 pyramidal neurons during synaptic stimulation

scientific article

Spared discrimination and impaired reversal eyeblink conditioning in patients with temporal lobe amnesia

scientific article published in December 2001

Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions.

scientific article published on 30 November 2006

Surface L-type Ca2+ channel expression levels are increased in aged hippocampus

scientific article published on October 2013

Temporal discrimination learning in abstinent chronic alcoholics

scientific article

Temporal discrimination learning in severe amnesic patients reveals an alteration in the timing of eyeblink conditioned responses

scientific article published in February 1999

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

scientific article published in January 2006

The BK-mediated fAHP is modulated by learning a hippocampus-dependent task.

scholarly article

The effect of auditory stimulus rate on [14C]2-deoxyglucose uptake in rabbit inferior colliculus

scientific article

The effects of aging in delay and trace human eyeblink conditioning ⬇️

scientific article published on September 1, 2010

The impact of hippocampal lesions on trace-eyeblink conditioning and forebrain-cerebellar interactions

scientific article (publication date: August 2015)

The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus

scientific article published on 4 September 2015

Trace eyeblink conditioning in abstinent alcoholic individuals: effects of complex task demands and prior conditioning

scientific article

Trace eyeblink conditioning in the freely moving rat: optimizing the conditioning parameters.

scientific article published in October 1999

Trace eyeblink conditioning is hippocampally dependent in mice

scientific article published in January 2004

Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice

scientific article published on 16 May 2005

Vibrissa-signaled eyeblink conditioning induces somatosensory cortical plasticity.

scientific article

Watermaze learning enhances excitability of CA1 pyramidal neurons

scientific article

Where is the trace in trace conditioning?

scientific article published on 15 January 2008

fMRI of visual system activation in the conscious rabbit

scientific article published in September 2000

gamma Isoform-selective changes in PKC immunoreactivity after trace eyeblink conditioning in the rabbit hippocampus

scientific article published in January 1997

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