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List of works by Alan Wells

2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen

scientific article

A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms.

scientific article

A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer

scientific article published on 03 October 2020

A clinical decision support system learned from data to personalize treatment recommendations towards preventing breast cancer metastasis

scientific article published on 08 March 2019

A microphysiological system model of therapy for liver micrometastases

scientific article

Absence of inhibition of cutaneous wound healing in mice by oral doxycycline

scientific article published in September 2003

Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain ⬇️

scientific article

Adult Stem Cell Functioning in the Tumor Micro-Environment.

scientific article published on 25 May 2019

Aging fibroblasts present reduced epidermal growth factor (EGF) responsiveness due to preferential loss of EGF receptors

scientific article

Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling.

scientific article published on 21 January 2010

Aging-related attenuation of EGF receptor signaling is mediated in part by increased protein tyrosine phosphatase activity

scientific article published on October 2003

All-human microphysical model of metastasis therapy

scientific article

Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion

scientific article published on 11 January 2012

An IP-10 (CXCL10)-Derived Peptide Inhibits Angiogenesis ⬇️

scientific article published on July 16, 2012

Assessing Immune Response to SARS-CoV-2 Infection

scientific article published on 11 June 2020

Axl contributes to efficient migration and invasion of melanoma cells

scientific article published in 2023

Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells

scientific article

Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition.

scientific article

CXCR3 in carcinoma progression

scientific article

Calpains as potential anti-cancer targets

scientific article

Cell surface glycoprotein patterns of two EBV-negative lines and their EBV converted sublines

scientific article published in January 1981

Celosia argentea Linn. leaf extract improves wound healing in a rat burn wound model

scientific article published in November 2004

Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR.

scientific article published on September 2005

Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin

scientific article published on 3 April 2007

Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion

scientific article

Comparative mitogenic potencies of EGF and TGF alpha and their dependence on receptor-limitation versus ligand-limitation

scientific article published on 01 July 1998

Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling

scientific article

Counterpoint: developing a clinical pathology curriculum to meet current and future needs

scientific article published on 14 April 2006

Curriculum content and evaluation of resident competency in clinical pathology (laboratory medicine): a proposal

scientific article published on 03 July 2006

Curriculum content and evaluation of resident competency in clinical pathology (laboratory medicine): a proposal

scientific article published on 28 March 2006

Cutting to the chase: calpain proteases in cell motility

scientific article

DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling

scientific article published on September 2004

Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility

scientific article

Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3.

scientific article

Difference in viral binding between two Epstein-Barr virus substrains to a spectrum of receptor-positive target cells

scientific article published in March 1981

Differential in vitro effects of chemotherapeutic agents on primary cultures of human ovarian carcinoma

scientific article

Differentiation of bone marrow mesenchymal stem cells into the smooth muscle lineage by blocking ERK/MAPK signaling pathway

scientific article published on October 2008

Directional motility induced by epidermal growth factor requires Cdc42.

scientific article published on July 2003

Distribution of gelsolin and phosphoinositol 4,5-bisphosphate in lamellipodia during EGF-induced motility

scientific article published on July 2002

E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas.

scientific article

EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness

scientific article published on June 2002

EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells

scientific article published on 01 September 1996

EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation

scientific article

ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair.

scientific article published on 31 July 2008

Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway

scientific article published on March 1999

Engineering epidermal growth factor for enhanced mitogenic potency

scientific article published on December 1996

Engineering liver

scientific article

Epidermal Growth Factor Tethered to β-Tricalcium Phosphate Bone Scaffolds via a High-Affinity Binding Peptide Enhances Survival of Human Mesenchymal Stem Cells/Multipotent Stromal Cells in an Immune-Competent Parafascial Implantation Assay in Mice. ⬇️

scientific article published on 08 July 2016

Epidermal growth factor (EGF) receptor kinase-independent signaling by EGF.

scientific article published on 5 February 2001

Epidermal growth factor (EGF) treatment on multipotential stromal cells (MSCs). Possible enhancement of therapeutic potential of MSC.

scientific article published on 17 February 2010

Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells

scientific article published on 8 September 2005

Epidermal growth factor induces CD44 gene expression through a novel regulatory element in mouse fibroblasts

scientific article published on May 1997

Epidermal growth factor induces acute matrix contraction and subsequent calpain-modulated relaxation

scientific article published on 01 January 2002

Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway

scientific article published on 27 January 2004

Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway

scientific article

Epidermal growth factor receptor-mediated motility in fibroblasts

scientific article published on 01 December 1998

Epstein-Barr virus receptor expression is correlated to cell cycle phase

scientific article published in January 1981

Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma

scientific article

Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer

scientific article published on 12 December 2019

Expression of human, mouse, and rat m-calpains in Escherichia coli and in murine fibroblasts

scientific article published in February 2004

Fatty acid-induced insulin resistance in adipocytes

scientific article published on October 1997

Gene expression patterns in isolated keloid fibroblasts

scientific article published in July 2006

Getting a grip: new insights for cell adhesion and traction

scientific article published on 01 May 2001

Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation

scientific article published in May 2003

Growth factor regulation of proliferation and survival of multipotential stromal cells ⬇️

scientific article published on October 26, 2010

Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition

scientific article

Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance.

scientific article published on 02 October 2011

Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation

scientific article published on 17 December 2014

Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction

scientific article published on 25 March 2011

IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain

scientific article

IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity

scientific article

In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signals

scientific article published on 01 November 1995

Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain.

scientific article

Interferon-γ increases sensitivity to chemotherapy and provides immunotherapy targets in models of metastatic castration-resistant prostate cancer

scientific article published on 22 April 2022

Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts

scientific article

Lack of CXC chemokine receptor 3 signaling leads to hypertrophic and hypercellular scarring

scientific article

Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling.

scientific article

Liver metastases: Microenvironments and ex-vivo models.

scientific article

Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling

scientific article

Localization of epidermal growth factor receptor in hepatocyte nuclei

scientific article published in January 1991

Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins

scientific article

Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells

scientific article

Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells.

scientific article published on 07 July 2016

Matrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasion

scientific article

Matrix control of scarring.

scientific article published on 10 March 2011

Melanoma cell invasiveness is promoted at least in part by the epidermal growth factor-like repeats of tenascin-C.

scientific article published on 6 September 2012

Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.

scientific article published on 23 April 2001

Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis

scientific article (publication date: 18 July 2006)

Modeling of signal-response cascades using decision tree analysis.

scientific article published on May 2005

Modeling the assembly of the multiple domains of α-actinin-4 and its role in actin cross-linking

scientific article published on February 2013

Modulation of osteoblast gap junction connectivity by serum, TNFalpha, and TRAIL.

scientific article published on 23 October 2007

Motility is rate-limiting for invasion of bladder carcinoma cell lines

scientific article published on 01 July 2002

Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells

scientific article published on November 2009

Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts

scientific article published on 3 April 2006

MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock

scientific article

Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility

scientific article

Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease

scientific article

Nuclear Kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells.

scientific article

Ongoing technological revolution. Preface

scientific article published on 01 December 2012

PKCδ localization at the membrane increases matrix traction force dependent on PLCγ1/EGFR signaling

scientific article (publication date: 2013)

PKCδ regulates force signaling during VEGF/CXCL4 induced dissociation of endothelial tubes

scientific article (publication date: 2014)

PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors

scientific article published on 20 November 2006

Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells

scientific article

Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases

scientific article published on 3 September 2011

Pericyte regulation of vascular remodeling through the CXC receptor 3

scientific article

Phosphatidylinositol-4-phosphate 5-kinase-1beta is essential for epidermal growth factor receptor-mediated endocytosis

scientific article

Phospholipase C-gamma1 in tumor progression.

scientific article

Phosphorylation of alpha-actinin 4 upon epidermal growth factor exposure regulates its interaction with actin

scientific article

Preface. Genetics of neurologic and psychiatric diseases

scientific article published in December 2010

Primed fibroblasts and exogenous decorin: potential treatments for subacute vocal fold scar

scientific article published on 01 December 2006

Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to fas ligand.

scientific article published on 17 April 2012

Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis

scientific article published on 20 May 2013

Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells.

scientific article

Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells

scientific article

Proliferative response of fibroblasts expressing internalization-deficient epidermal growth factor (EGF) receptors is altered via differential EGF depletion effect

scientific article published on July 1994

Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells

scientific article published on 20 March 2006

Proteomic analysis of laser microdissected melanoma cells from skin organ cultures.

scientific article

Quantitative comparison of Epstein-Barr virus receptor expression on sIgM and sIgG cell lines and B-cell lymphoma biopsies

scientific article published in January 1982

Receptors for the complement C3d component and the Epstein-Barr virus are quantitatively coexpressed on a series of B-cell lines and their derived somatic cell hybrids

scientific article

STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines

scientific article published on 27 June 2006

Signaling network state predicts twist-mediated effects on breast cell migration across diverse growth factor contexts

scientific article published on 10 August 2011

Signalling shortcuts: cell-surface receptors in the nucleus?

scientific article

Skin tissue repair: Matrix microenvironmental influences

scientific article published on 13 August 2015

Skin wound healing and scarring: fetal wounds and regenerative restitution

scientific article

Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation

scientific article

Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system

scientific article

Statin drugs to reduce breast cancer recurrence and mortality

Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion

scientific article

Statins attenuate outgrowth of breast cancer metastases

scientific article published on 01 October 2018

Surface tethered epidermal growth factor protects proliferating and differentiating multipotential stromal cells from FasL-induced apoptosis.

scientific article

Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells

scientific article

Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function

scientific article published on 26 May 2015

Targeting tumor cell motility as a strategy against invasion and metastasis

scientific article published on 06 April 2013

Tenascin cytotactin epidermal growth factor-like repeat binds epidermal growth factor receptor with low affinity

scientific article

Tenascin-C Signaling in melanoma

scientific article published on January 2015

Tethered epidermal growth factor provides a survival advantage to mesenchymal stem cells

scientific article published on 18 January 2007

The carboxyl tail of alpha-actinin-4 regulates its susceptibility to m-calpain and thus functions in cell migration and spreading ⬇️

scientific article published on March 1, 2013

The challenge of training pathologists in the 21st century

scientific article published on 16 June 2006

The effects of decorin and HGF-primed vocal fold fibroblasts in vitro and ex vivo in a porcine model of vocal fold scarring

scientific article

The goals of resident training in laboratory medicine in combined anatomic pathology/clinical pathology programs: an overview.

scientific article published on June 2007

The influence of tethered epidermal growth factor on connective tissue progenitor colony formation.

scientific article

The matrikine tenascin-C protects multipotential stromal cells/mesenchymal stem cells from death cytokines such as FasL.

scientific article published on May 2013

The mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cells

scientific article

The nuclear accumulation of a variant epidermal growth factor receptor (EGFR) lacking the transmembrane domain requires coexpression of a full-length EGFR.

scientific article

Transplanted fibroblasts prevents dysfunctional repair in a murine CXCR3-deficient scarring model

scientific article published on 10 January 2012

Tyro3 carboxyl terminal region confers stability and contains the autophosphorylation sites

scientific article published on 28 June 2017

Vascular endothelial growth factor (VEGF) and platelet (PF-4) factor 4 inputs modulate human microvascular endothelial signaling in a three-dimensional matrix migration context.

scientific article

Webcasting pathology department conferences in a geographically distributed medical center

scientific article published on July 2004

Workflow Organization in Pathology ⬇️

scientific article published on December 1, 2012

m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate.

scientific article

α-Actinin-4 is required for amoeboid-type invasiveness of melanoma cells

scientific article

α-actinin-4 is essential for maintaining the spreading, motility and contractility of fibroblasts

scientific article

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