List of works by Natalie A. Sims

A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice ⬇️

scientific article published on May 1, 2003

Absence of Calcitriol Causes Increased Lactational Bone Loss and Lower Milk Calcium but Does Not Impair Post-lactation Bone Recovery in Cyp27b1 Null Mice.

scientific article

Adolescent inhalant abuse results in adrenal dysfunction and a hypermetabolic phenotype with persistent growth impairments

scientific article published on 12 September 2018

Adverse effects of valproate on bone: defining a model to investigate the pathophysiology

scientific article published on 12 February 2010

An ethyl-nitrosourea-induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and rickets.

scientific article published on November 2002

Anabolic action of parathyroid hormone (PTH) does not compromise bone matrix mineral composition or maturation

scientific article

Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss

scientific article

Arthritogenic alphaviruses: new insights into arthritis and bone pathology

scientific article

Author Correction: Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

scientific article published on 04 November 2019

Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein

scientific article

Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection

scientific article

Biomechanical testing of the calcified metacarpal articular surface and its association with subchondral bone microstructure in Thoroughbred racehorses.

scientific article

Bone Geometry Is Altered by Follistatin-Induced Muscle Growth in Young Adult Male Mice

scientific article published on 03 March 2021

Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6.

scientific article published on 9 October 2017

Bone: Does anti-sclerostin therapy promote inflammation in rheumatoid arthritis?

scientific article published on 22 April 2016

Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism

scientific article published on 30 August 2019

Building bone with a SOST-PTH partnership

scientific article published on 01 February 2010

Calcitonin physiology, saved by a lysophospholipid.

scientific article

Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

article

Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders

scientific article published on 14 July 2015

Cell-cell signaling: broadening our view of the basic multicellular unit.

scientific article published on 27 July 2013

Cell-specific paracrine actions of IL-6 family cytokines from bone, marrow and muscle that control bone formation and resorption

scientific article

Cellular Processes by Which Osteoblasts and Osteocytes Control Bone Mineral Deposition and Maturation Revealed by Stage-Specific EphrinB2 Knockdown

scientific article published on 01 October 2019

Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification.

scientific article published on 11 January 2016

Ciliary neurotrophic factor inhibits bone formation and plays a sex-specific role in bone growth and remodeling

scientific article

Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization

scientific article published in March 2012

Correction for Chen et al., Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection

scientific article published in December 2015

Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

scientific article published on 27 May 2020

Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

scientific article

Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit

scientific article published on 08 January 2014

Decline in calcitonin receptor expression in osteocytes with age.

scientific article published on 22 April 2014

Delayed development of specific thyroid hormone-regulated events in transthyretin null mice.

scientific article published on 23 October 2012

Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling

scientific article published on 05 June 2019

Differing Effects of Parathyroid Hormone, Alendronate, and Odanacatib on Bone Formation and on the Mineralization Process in Intracortical and Endocortical Bone of Ovariectomized Rabbits

scientific article published on 17 July 2018

Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs

scientific article published on 02 August 2019

Dissociation of bone resorption and bone formation in adult mice with a non-functional V-ATPase in osteoclasts leads to increased bone strength

scientific article (publication date: 2011)

Effect of rapamycin on bone mass and strength in the α2(I)-G610C mouse model of osteogenesis imperfecta.

scientific article

Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance

scientific article published on 13 October 2011

EphB/ephrin-B interactions mediate human MSC attachment, migration and osteochondral differentiation.

scientific article published on 5 November 2010

EphB4 enhances the process of endochondral ossification and inhibits remodeling during bone fracture repair

article

EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis.

scientific article published on 30 June 2014

EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone.

scientific article

GP130 cytokines and bone remodelling in health and disease ⬇️

scientific article published on August 1, 2010

Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone

scientific article published on 6 August 2015

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease

scientific article published on 30 April 2018

Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice.

scientific article

High dose dietary vitamin D3 increases bone mass and strength in mice.

scientific article published on 10 February 2017

Human and Murine Osteocalcin Gene Expression: Conserved Tissue Restricted Expression and Divergent Responses to 1,25-Dihydroxyvitamin D3in Vivo

article

IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis

scientific article published on 28 March 2019

IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy.

scientific article

Implications of osteoblast-osteoclast interactions in the management of osteoporosis by antiresorptive agents denosumab and odanacatib.

scientific article published on March 2014

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

scientific article published on 31 July 2019

Intercellular cross-talk among bone cells: new factors and pathways.

scientific article published on June 2012

Interleukin-6 modulates production of T lymphocyte–derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis

article

Intermittent Fugu parathyroid hormone 1 (1–34) is an anabolic bone agent in young male rats and osteopenic ovariectomized rats

scientific article published on 13 February 2008

Is RANKL inhibition both anti-resorptive and anabolic in rheumatoid arthritis?

scientific article published on 17 November 2015

Isolation and gene expression of haematopoietic-cell-free preparations of highly purified murine osteocytes

scientific article published on 15 November 2014

Isolation, Purification, Generation, and Culture of Osteocytes

scientific article published on 01 January 2019

Lack of sustained response to teriparatide in a patient with adult hypophosphatasia

scientific article published on 20 January 2010

Leukemia inhibitory factor: a paracrine mediator of bone metabolism.

scientific article published on 06 February 2012

Loss of Gsα in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy

scientific article

Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications

scientific article published on 2 November 2017

Macrophages Driving Heterotopic Ossification: Convergence of Genetically-Driven and Trauma-Driven Mechanisms.

scientific article published on 27 November 2017

Model structure and control of bone remodeling: a theoretical study.

scientific article

Molecular mechanisms in coupling of bone formation to resorption.

scientific article published on January 2009

Myokines (muscle-derived cytokines and chemokines) including ciliary neurotrophic factor (CNTF) inhibit osteoblast differentiation

scientific article published on 8 April 2014

Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle.

scientific article published on 26 March 2015

Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts

scientific article published on 22 April 2014

Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

scientific article

Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization

scientific article published in 2021

Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice

scientific article published on 6 December 2017

Osteoclast-derived activity in the coupling of bone formation to resorption.

scientific article

Osteoimmunology: oncostatin M as a pleiotropic regulator of bone formation and resorption in health and disease

scientific article published on 14 May 2014

Overcoming natural Wnt inhibition to optimize therapy

scientific article published on 01 February 2019

Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner.

scientific article

Parthenolide inhibits pro-inflammatory cytokine production and exhibits protective effects on progression of collagen-induced arthritis in a rat model

scientific article published on 2 December 2014

Prepubertal Di-n-Butyl Phthalate Exposure Alters Sertoli and Leydig Cell Function and Lowers Bone Density in Adult Male Mice

scientific article published on 8 April 2016

Prospective histomorphometric and DXA evaluation of bone remodeling in imatinib-treated CML patients: evidence for site-specific skeletal effects.

scientific article published on 8 November 2012

Quantifying the osteocyte network in the human skeleton

scientific article

RANKL/OPG; Critical role in bone physiology.

scientific article published on 04 January 2015

RARγ is a negative regulator of osteoclastogenesis

scientific article published on 20 March 2015

Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment

scientific article published on June 2007

Regulation of cortical and trabecular bone mass by communication between osteoblasts, osteocytes and osteoclasts

scientific article published on 26 May 2014

Response to "Letter to the Editor: On osteocyte density in the human body".

scientific article published on 21 April 2016

Retinoic Acid Receptor γ Activity in Mesenchymal Stem Cells Regulates Endochondral Bone, Angiogenesis, and B Lymphopoiesis

scientific article published on 08 August 2018

Senescent Osteocytes: Do They Cause Damage and Can They Be Targeted to Preserve the Skeleton?

scientific article published on 06 October 2016

Skeletal recovery after weaning does not require PTHrP.

scientific article

Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice.

scientific article

Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo

scientific article

Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis.

scientific article published in July 2004

The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation

scientific article

The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology

scientific article published on 13 August 2020

The Primary Function of gp130 Signaling in Osteoblasts Is To Maintain Bone Formation and Strength, Rather Than Promote Osteoclast Formation

article

The chemokine Cxcl1 is a novel target gene of parathyroid hormone (PTH)/PTH-related protein in committed osteoblasts

scientific article published on 15 January 2009

The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo

scientific article published in August 2010

Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling.

scientific article published on 25 September 2009

Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo

scientific article

Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.

scientific article

VPS35: Two Ways to Recycle the Parathyroid Hormone Receptor (PTH1R) in Osteoblasts

scientific article published on 23 June 2016

Vaginally administered PEGylated LIF antagonist blocked embryo implantation and eliminated non-target effects on bone in mice

scientific article

What is the true nature of the osteoblastic hematopoietic stem cell niche?

scientific article published on August 2009

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

scientific article (publication date: April 2009)

gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation

scientific article published on 16 September 2014

gp130 signaling in bone cell biology: multiple roles revealed by analysis of genetically altered mice.

scientific article published on 03 September 2008

gp130-Mediated Signaling Is Necessary for Normal Osteoblastic Function in Vivo and in Vitro

scientific article published on 14 November 2003

Paulina is supported by:

About Paulina

Help