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List of works by Maria Siebes

1996 AUR Memorial Award. Densitometric analysis of eccentric vascular stenoses: comparison of CO2 and iodinated contrast media

scientific article

3D Imaging of vascular networks for biophysical modeling of perfusion distribution within the heart.

scientific article published on 10 December 2012

41 Reduced arterial wave reflection and enhanced LV relaxation contribute to warm-up angina

66 Computergestützte Geometriebestimmung und Berechnung der Druckabfall-Fluß-Verhältnisse von angiograffisch dargestellten Modellstenosen

A novel porous mechanical framework for modelling the interaction between coronary perfusion and myocardial mechanics

scientific article published on 10 December 2011

A quantitative high resolution assessment of myocardial blood flow from contrast-enhanced first-pass magnetic resonance perfusion imaging: microsphere validation in a magnetic resonance compatible free beating explanted pig heart model.

scientific article published on 30 January 2013

A quantitative high resolution voxel-wise assessment of myocardial blood flow from contrast-enhanced first-pass magnetic resonance perfusion imaging: microsphere validation in a magnetic resonance compatible free beating explanted pig heart model

scientific article

Acardiac twinning: High resolution three-dimensional reconstruction of a low resistance case

scientific article published on 21 December 2015

Analysis of Coronary Contrast Agent Transport in Bolus-Based Quantitative Myocardial Perfusion MRI Measurements with Computational Fluid Dynamics Simulations

article

Angiographic analysis of eccentric vascular stenoses: Comparison of CO2 and iodinated contrast medium

article

Arterial hemodynamics and wave analysis in the frequency and time domains: an evaluation of the paradigms

article

Assessment of coronary microvascular resistance in the chronic infarcted pig heart

scientific article

Association between coronary lesion severity and distal microvascular resistance in patients with coronary artery disease.

scientific article

Automated detection of wall and plaque borders in intravascular ultrasound images

Automated segmentation of coronary wall and plaque from intravascular ultrasound image sequences

article

BASAL STENOSIS RESISTANCE INDEX AND INSTANTANEOUS WAVE–FREE RATIO HAVE THE SAME DIAGNOSTIC PERFORMANCE AS FRACTIONAL FLOW RESERVE TO DETECT MYOCARDIAL ISCHEMIA USING MYOCARDIAL PERFUSION IMAGING

Basal stenosis resistance index derived from simultaneous pressure and flow velocity measurements

scientific article published on 01 June 2016

Biomechanical characterization of blood vessel and plaque from intravascular ultrasound images

scholarly article published 1 May 1994

Biomedical Engineering Trends in Europe [Views from the Guest Editors]

Clearance from the mouse brain by convection of interstitial fluid towards the ventricular system

scientific article

Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia

scientific article published on 24 February 2020

Comparison of arterial waves derived by classical wave separation and wave intensity analysis in a model of aortic coarctation

article

Comparison of conventional and CO2 quantitative angiography: fiz or fizzle?

article

Comparison of phase-contrast MR imaging and endovascular sonography for intracranial blood flow velocity measurements.

scientific article published on 10 May 2012

Computed Tomography-Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study

scientific article published on 11 July 2019

Computer assessment of hemodynamic severity of coronary artery stenosis from angiograms

scientific article

Coronary Circulation and Hemodynamics

Coronary Physiology During Exercise and Vasodilation in the Healthy Heart and in Severe Aortic Stenosis.

scientific article published in August 2016

Coronary pressure-flow relations as basis for the understanding of coronary physiology

scientific article published on 10 August 2011

Coronary structure and perfusion in health and disease

scientific article

Coronary wave intensity during the Valsalva manoeuvre in humans reflects altered intramural vessel compression responsible for extravascular resistance

scientific article published on 14 May 2012

Coronary wave intensity in humans: effect of changes in microvascular resistance and hemodynamic conditions

Correction: Fractional flow reserve as a surrogate for inducible myocardial ischaemia

Correlation of hemodynamic events with clinical and pathological observations

scientific article

DIAGNOSTIC ACCURACY OF BASAL STENOSIS RESISTANCE INDEX FOR MYOCARDIAL ISCHEMIA IDENTIFIED BY FRACTIONAL FLOW RESERVE AND IMPLICATIONS OF STENOSIS RESISTANCE INDEX DETERMINED AT SUB–MAXIMALLY ELEVATED CORONARY FLOW RATES

article

Data Communication Pathway for Sensing Guidewire at Proximal Side: A Review

article

Derivative-based edge detection in quantitative coronary angiography is not independent of vessel size

Design and development of an electromechanical ultrasound probe holder for urodynamics testing

scientific article

Detection and quantification methods of monocyte homing in coronary vasculature with an imaging cryomicrotome.

scientific article

Diagnostic Accuracy of Combined Intracoronary Pressure and Flow Velocity Information During Baseline Conditions ⬇️

scientific article published on July 10, 2012

Discordance between pressure drift after wire pullback and intracoronary distal pressure offset affects stenosis physiology appraisal

scientific article published on 18 August 2018

Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis

scientific article published on 28 April 2011

Does the instantaneous wave-free ratio approximate the fractional flow reserve?

scientific article published on 6 February 2013

Effect of Warm-Up Exercise Studied with Wave Intensity Analysis

article

Effect of contrast injection on coronary artery pressure and dimension during angiography

Effect of simultaneous intracoronary guidewires on the predictive accuracy of functional parameters of coronary lesion severity

scientific article published on 12 January 2007

Effect of the Valsalva maneuver on cardiac-coronary interaction assessed by wave intensity analysis

scientific article published in January 2010

Effects of cardiac phase on diameter measurements from coronary cineangiograms

article

Engineering for health.

scientific article published on May 2007

Extraction of Coronary Vascular Tree and Myocardial Perfusion Data from Stacks of Cryomicrotome Images

FRACTIONAL FLOW RESERVE IS UNLIKELY TO BE ABNORMAL IN THE PRESENCE OF HIGH MICROVASCULAR RESISTANCE

article

Fluid Dynamics of a Partially Collapsible Stenosis in a Flow Model of the Coronary Circulation

article

Fluorescent microsphere based measurement of collateral flow in the canine heart suggests overestimation of collateral flow as estimated by coronary wedge pressure

article

Fractional flow reserve as a surrogate for inducible myocardial ischaemia

scientific article published on 11 June 2013

Functional Assessment of Coronary Artery Stenosis by Contrast-Induced Reactive Hyperemia

Functional coronary stenosis severity assessed from the mean pressure gradient-velocity relationship obtained by contrast medium-induced submaximal hyperaemia.

scientific article published in July 2014

Fundamentals in clinical coronary physiology: why coronary flow is more important than coronary pressure

scientific article published on June 2015

Gradient Changes in Porcine Renal Arterial Vascular Anatomy and Blood Flow After Cryoablation

scientific article published on 17 June 2011

Grenzen der metrischen Abbildungsgenauigkeit in der Koronarangiographie

article published in 1984

Head-to-head comparison of basal stenosis resistance index, instantaneous wave-free ratio, and fractional flow reserve: diagnostic accuracy for stenosis-specific myocardial ischaemia

scientific article published on 01 December 2015

Hemodynamic Effects of Epicardial Stenoses

article published in 2017

High-Resolution Spatial Quantification of Coronary Collaterals with an Imaging Cryomicrotome

Hyaluronidase treatment of coronary glycocalyx increases reactive hyperemia but not adenosine hyperemia in dog hearts

scientific article published on 22 July 2005

Hyperemic stenosis resistance index for evaluation of functional coronary lesion severity

scientific article published in July 2002

Identification of coronary collaterals in imaging cryomicrotome datasets

Impact of coronary bifurcation morphology on wave propagation

scientific article published on 08 July 2016

Impact of hyperaemic microvascular resistance on fractional flow reserve measurements in patients with stable coronary artery disease: insights from combined stenosis and microvascular resistance assessment.

scientific article published on 11 April 2014

Improved detection of fluorescently labeled microspheres and vessel architecture with an imaging cryomicrotome

scientific article published on 24 June 2010

Improved regional myocardial perfusion measurement by means of an imaging cryomicrotome

In vitro and in vivo validation of a new dual-sensor 0.014″ guide wire for simultaneous measurement of intracoronary pressure and flow velocity

In vitro study on the pressure drop-flow relationship of a compliant coronary stenosis

Increased diastolic time fraction as beneficial adjunct of alpha1-adrenergic receptor blockade after percutaneous coronary intervention

scientific article

Increased hyperaemic coronary microvascular resistance adds to the presence of myocardial ischaemia.

scientific article published in January 2014

Influence of Branching and Tapering on Intracoronary Pressure and Flow Velocity: Comparison of Axial Measurement Location

Influence of contrast agent dispersion on bolus-based MRI myocardial perfusion measurements: A computational fluid dynamics study

scientific article published on 11 December 2019

Influence of hemodynamic conditions on fractional flow reserve: parametric analysis of underlying model.

scientific article published in October 2002

Influence of increased heart rate and aortic pressure on resting indices of functional coronary stenosis severity.

scientific article published on 13 September 2017

Influence of percutaneous coronary intervention on coronary microvascular resistance index

scientific article published on 20 December 2004

Influence of segmented vessel size due to limited imaging resolution on coronary hyperemic flow prediction from arterial crown volume.

scientific article published on 29 January 2016

Innate collateral segments are predominantly present in the subendocardium without preferential connectivity within the left ventricular wall

Inside Cover: Oxidation Monitoring by Fluorescence Spectroscopy Reveals the Age of Fingermarks (Angew. Chem. Int. Ed. 24/2014)

Intracoronary Hemodynamic Effects of Pressure-Controlled Intermittent Coronary Sinus Occlusion (PICSO): Results from the First-In-Man Prepare PICSO Study

scientific article published on 20 September 2012

Intracoronary and intravenous administration of adenosine achieve comparable maximal hyperemia and stenosis pressure gradient-flow velocity relations

Intracoronary pressure and flow velocity for hemodynamic evaluation of coronary stenoses

scientific article published in September 2003

Intracranial blood-flow velocity and pressure measurements using an intra-arterial dual-sensor guidewire.

scientific article

Investigation of plaque biomechanics from intravascular ultrasound images using finite element modeling

scholarly article

Is myocardial contrast echocardiography ready to assume 'gold standard' status for quantification of collateral flow in humans?

scientific article published on 25 May 2006

Iterative Deblurring of Large 3D Datasets from Cryomicrotome Imaging Using an Array of GPUs

article published in 2013

MINIMAL EFFECT OF COLLATERAL FLOW ON CALCULATION OF CORONARY MICROVASCULAR RESISTANCE WITH INTERMEDIATE AND NON-CRITICAL CORONARY STENOSES

Mathematical model of pressure-related changes in coronary diameter and their effect on the assessment of coronary flow velocity reserve

article

Mathematical model of pressure-related changes in stenosis cross-sectional area during the cardiac cycle

article

Mechanical effect of contrast injection on coronary artery diameter during angiography

Microsphere skimming in the porcine coronary arteries: Implications for flow quantification

scientific article published on 9 May 2015

Microvascular resistance in addition to stenosis resistance best predicts inducible myocardial ischemia

article

Minimal effect of collateral flow on coronary microvascular resistance in the presence of intermediate and noncritical coronary stenoses

scientific article published on 22 June 2012

Model of coronary hemodynamics during radiographic contrast injection

article

Model prediction of subendocardial perfusion of the coronary circulation in the presence of an epicardial coronary artery stenosis

scientific article published on May 2008

Model-Based Vasculature Extraction From Optical Fluorescence Cryomicrotome Images

article

Modelling Parameter Role on Accuracy of Cardiac Perfusion Quantification

Multi-scale parameterisation of a myocardial perfusion model using whole-organ arterial networks.

scientific article

Multicenter core laboratory comparison of the instantaneous wave-free ratio and resting Pd/Pa with fractional flow reserve: the RESOLVE study

scientific article

Myocardial perfusion distribution and coronary arterial pressure and flow signals: clinical relevance in relation to multiscale modeling, a review

scientific article published on 27 July 2013

Necrosis avid near infrared fluorescent cyanines for imaging cell death and their use to monitor therapeutic efficacy in mouse tumor models

scientific article

Optimization of Vascular Casting for Three-Dimensional Fluorescence Cryo-Imaging of Collateral Vessels in the Ischemic Rat Hindlimb.

scientific article published on February 2017

Organization and collateralization of a subendocardial plexus in end-stage human heart failure

scientific article published on 23 October 2009

Oxidation Monitoring by Fluorescence Spectroscopy Reveals the Age of Fingermarks

scientific article published on 21 May 2014

P193High-resolution coronary collateral distribution in the human heart

PERIPHERAL REFLECTED WAVES AUGMENT CORONARY BLOOD FLOW DURING THE VALSALVA MANEUVER

PROGNOSTIC VALUE OF FRACTIONAL FFOW RESERVE AFTER DEFERRAL OF REVASCULARIZATION USING THE 0.75 DEFER OR 0.80 FAME FRACTIONAL FLOW RESERVE CUT-OFF VALUE: CLINICAL IMPLICATIONS OF THE 0.75 – 0.80 FRACTIONAL FLOW RESERVE GREY ZONE

article

Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways.

scientific article published on 15 June 2016

Perfusion and microvascular adaptation in a rabbit model of developing heart failure assessed with a 3D imaging cryomicrotome

article

Perfusion territories subtended by penetrating coronary arteries increase in size and decrease in number toward the subendocardium

scientific article published on 20 December 2013

Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiol

scientific article published on 28 August 2006

Physiological basis and long-term clinical outcome of discordance between fractional flow reserve and coronary flow velocity reserve in coronary stenoses of intermediate severity.

scientific article published on 29 April 2014

Physiological basis of clinically used coronary hemodynamic indices

scientific article

Porcine coronary collateral formation in the absence of a pressure gradient remote of the ischemic border zone

scientific article published on 11 March 2011

Potential and limitations of wave intensity analysis in coronary arteries

article

Precision and reproducibility of quantitative coronary angiography with applications to controlled clinical trials. A sampling study

scientific article

Prompt augmentation in systolic coronary flow velocity and forward coronary wave energy in patients undergoing transcatheter aortic valve implantation

Quantitative Angiography: Experimental Studies On The Representation Of Model Coronary Arteries In Angiographic Films

article published in 1982

Quantitative angiographic assessment of coronary stenoses: problems and pitfalls.

scientific article published in January 1983

Quantitative assessment of magnetic resonance derived myocardial perfusion measurements using advanced techniques: microsphere validation in an explanted pig heart system

scientific article

Rationale of combined intracoronary pressure and flow velocity measurements

scientific article published in January 2002

Response to Michiels et al and Sen et al Regarding Article, “Diagnostic Accuracy of Combined Intracoronary Pressure and Flow Velocity Information During Baseline Conditions: Adenosine-Free Assessment of Functional Coronary Lesion Severity”

Role of fractional and coronary flow reserve in clinical decision making in intermediate coronary lesions

article

Role of plaque inflammation in acute and recurrent coronary syndromes

scientific article published on March 2004

Role of variability in microvascular resistance on fractional flow reserve and coronary blood flow velocity reserve in intermediate coronary lesions.

scientific article

Segmentation of intravascular ultrasound images: a knowledge-based approach

scientific article published in January 1995

Selective subepicardial localization of monocyte subsets in response to progressive coronary artery constriction

scientific article published on 20 May 2016

Single-wire pressure and flow velocity measurement to quantify coronary stenosis hemodynamics and effects of percutaneous interventions

scientific article published in February 2004

Sources of error in quantitative coronary angiography

scientific article published in August 1993

Synergistic Adaptations to Exercise in the Systemic and Coronary Circulations That Underlie the Warm-Up Angina Phenomenon

scientific article published in November 2012

TCT-616 Quantification of the Functional Status of the Coronary Microvasculature Distal to Coronary Stenoses by Means of the Hyperemic Microvascular Resistance Index Does Not Require Correction for Collateral Flow Contribution

article

TCT-633 Discordance of Coronary Flow Velocity Reserve With Fractional Flow Reserve Originates From Microvascular Involvement in Coronary Artery Disease

article

TCT-634 Diagnostic accuracy of basal stenosis resistance index (BSR) is higher than that of instantaneous wave-free ratio (iFR): validation of basal stenosis resistance index in an independent cohort of simultaneous pressure and flow measurements

article

THE MECHANISM OF SYMPTOMS IN AORTIC STENOSIS: NOVEL INSIGHTS FROM INTRACORONARY MEASUREMENTS DURING EXERCISE

article published in 2015

Temporal dissociation between the minimal distal-to-aortic pressure ratio and peak hyperemia during intravenous adenosine infusion

scientific article published on 17 February 2017

The angiographical stenotic flow reserve compared to intracoronary hemodynamic parameters for evaluation of coronary lesion severity

The future of collateral artery research

scientific article published on February 2014

The impact of scaled boundary conditions on wall shear stress computations in atherosclerotic human coronary bifurcations.

scientific article

The importance of combined pressure and flow velocity measurements to evaluate the hemodynamic effect of percutaneous coronary interventions

article by Maria Siebes et al published March 2003 in Journal of the American College of Cardiology

The importance of microvascular resistance in restoration of coronary perfusion after percutaneous coronary intervention

The prognostic value of combined intracoronary pressure and blood flow velocity measurements after deferral of percutaneous coronary intervention

article

The role of biofluid mechanics in the assessment of clinical and pathological observations: sixth International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008 Pasadena, California

scientific article published on 20 January 2010

Theoretical models for coronary vascular biomechanics: progress & challenges

scientific article (publication date: 2011)

Transcatheter Replacement of Stenotic Aortic Valve Normalizes Cardiac-Coronary Interaction by Restoration of Systolic Coronary Flow Dynamics as Assessed by Wave Intensity Analysis

scientific article published on April 2016

Transmural distribution and connectivity of coronary collaterals within the human heart.

scientific article published on 30 June 2016

Variability in measures of coronary lumen dimensions using quantitative coronary angiography

scientific article published in October 1993

Virtual physiological human 2016: translating the virtual physiological human to the clinic

Visualisation of intramural coronary vasculature by an imaging cryomicrotome suggests compartmentalisation of myocardial perfusion areas.

scientific article

WAVE SPEED IN THE HUMAN CORONARY ARTERY DOES NOT DECREASE WITH VASODILATION: EXTENDING THE LIMITS OF VALIDITY OF THE SINGLE–POINT TECHNIQUE FOR WAVE INTENSITY ANALYSIS

Wave speed in human coronary arteries is not influenced by microvascular vasodilation: implications for wave intensity analysis

article

Windkesselness of coronary arteries hampers assessment of human coronary wave speed by single-point technique

scientific article published on 30 May 2008

[Hemodynamics of coronary stenoses]

scientific article

euHeart: personalized and integrated cardiac care using patient-specific cardiovascular modelling

scientific article published on April 2011

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