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List of works by Jesús Giraldo

A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses

scientific article published on 13 November 2017

A genomewide screen for tolerance to cationic drugs reveals genes important for potassium homeostasis in Saccharomyces cerevisiae.

scientific article published on July 2011

A method for the quantification of biased signalling at constitutively active receptors

article

A pH-dependent model of the activation mechanism of the histamine H2 receptor

scientific article published on 01 July 1999

Adrenergic and purinergic components in bisected vas deferens from spontaneously hypertensive rats

scientific article published in October 1999

Advanced age increases chromosome structural abnormalities in human spermatozoa

scientific article

Agonist induction, conformational selection, and mutant receptors

scientific article (publication date: 2 January 2004)

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.

scientific article

Alpha 1-adrenoceptor vasoconstriction in the tail artery during ageing

scientific article published in July 1997

An allosteric modulator to control endogenous G protein-coupled receptors with light.

scientific article published on 31 August 2014

An operational model for GPCR homodimers and its application in the analysis of biased signaling

scientific article published on 9 April 2018

Analysis of agonism at functional prejunctional alpha 2-adrenoceptors of rat vas deferens using operational and null approaches

scientific article published in June 1994

Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand.

scientific article published on 10 July 2017

Angiotensin II type 1/adenosine A 2A receptor oligomers: a novel target for tardive dyskinesia

scientific article

Artificial Intelligence: A Novel Approach for Drug Discovery

scientific article published on 3 July 2019

Assessing receptor affinity for inverse agonists: Schild and Cheng-Prusoff methods revisited.

scientific article published on January 2007

Assessing the (a)symmetry of concentration-effect curves: empirical versus mechanistic models.

scientific article

Can Adding Constitutive Receptor Activity Redefine Biased Signaling Quantification?

scientific article published on 01 February 2019

Changes in electrophysiological properties in the prostatic portion of vas deferens from spontaneously hypertensive rats

scientific article published on 21 September 2002

Characterization of the calcium-mediated response to alkaline stress in Saccharomyces cerevisiae.

scientific article

Chromosomal Instability in Amniocytes From Fetuses of Mothers Who Smoke

scientific article published in The Journal of the American Medical Association

Chromosomal bands affected by acute oil exposure and DNA repair errors

scientific article

Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats

scientific article

Computational analysis of negative and positive allosteric modulator binding and function in metabotropic glutamate receptor 5 (in)activation

scientific article published on 13 May 2014

Conformational analysis of GpA and GpAp in aqueous solution by molecular dynamics and statistical methods

scientific article

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

scientific article

Correction: Rational design of a peptide capture agent for CXCL8 based on a model of the CXCL8:CXCR1 complex

scholarly article in RSC Advances, vol. 8 no. 30, 2018

Coupling of the guanosine glycosidic bond conformation and the ribonucleotide cleavage reaction: implications for barnase catalysis

scientific article published in February 2008

Distinct Dopamine D₂ Receptor Antagonists Differentially Impact D₂ Receptor Oligomerization ⬇️

scientific article published on 04 April 2019

Dynamical Correlations Reveal Allosteric Sites in G Protein-Coupled Receptors

scientific article published on 27 December 2020

Ecophysiological significance of scale-dependent patterns in prokaryotic genomes unveiled by a combination of statistic and genometric analyses

scientific article

Empirical models and Hill coefficients.

scientific article

Enhanced noradrenergic transmission in the spontaneously hypertensive rat anococcygeus muscle

scientific article published on 22 September 2003

Evaluation of Operational Models of Agonism and Allosterism at Receptors with Multiple Orthosteric Binding Sites

scientific article published on 08 November 2019

Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine(2A) receptor homodimers.

scientific article published on 11 March 2009

Exploring the Activation Mechanism of the mGlu5 Transmembrane Domain

scientific article published on 06 March 2020

Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

scientific article published on 05 September 2014

Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill

scientific article published on 29 July 2015

GNAO1 encephalopathy: further delineation of a severe neurodevelopmental syndrome affecting females.

scientific article

Have many estimates of efficacy and affinity been misled? Revisiting the operational model of agonism

scientific article published on 24 June 2016

Head circumference growth function as a marker of neurological impairment in a cohort of microcephalic infants and children

scientific article published on 29 August 2012

Helix 3 acts as a conformational hinge in Class A GPCR activation: An analysis of interhelical interaction energies in crystal structures

scientific article published on 29 October 2015

How inverse can a neutral antagonist be? Strategic questions after the rimonabant issue

scientific article published on 4 May 2010

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals

scientific article published on 19 December 2016

Increased superoxide anion production by interleukin-1beta impairs nitric oxide-mediated relaxation in resistance arteries

scientific journal article

Insights into adenosine A2A receptor activation through cooperative modulation of agonist and allosteric lipid interactions

scientific article published on 16 April 2020

Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4.

scientific article published on January 2011

Label noise in subtype discrimination of class C G protein-coupled receptors: A systematic approach to the analysis of classification errors

scientific article

Mathematical modeling of G protein-coupled receptor function: what can we learn from empirical and mechanistic models?

scientific article published on January 2014

Mechanistic analysis of the function of agonists and allosteric modulators: reconciling two-state and operational models

scientific article published on July 2013

Modeling cooperativity effects in dimeric G protein-coupled receptors.

scientific article published on January 2013

Modeling the binding and function of metabotropic glutamate receptors.

scientific article published on 20 February 2008

Modelling the changes due to the endothelium and hypertension in the alpha-adrenoreceptor-mediated responses of rat aorta

scientific article published in August 1999

Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism

scientific article

On the fitting of binding data when receptor dimerization is suspected

scientific article

Operational models of allosteric modulation: caution is needed

scientific article published on 12 November 2014

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

scientific article published on 11 April 2017

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.

scientific article published on 27 July 2016

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

scientific article published on 23 October 2014

Paternal Age and Numerical Chromosome Abnormalities in Human Spermatozoa

scientific article published on 21 June 2016

Persistence of Breakage in Specific Chromosome Bands 6 Years after Acute Exposure to Oil.

scientific article

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

scientific article

Pharmacological properties of S1RA, a new sigma‐1 receptor antagonist that inhibits neuropathic pain and activity‐induced spinal sensitization ⬇️

scientific article published on August 1, 2012

Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation.

scientific article published on 12 January 2017

Preface

Preface. In cells

scientific article published in January 2013

Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism.

scientific article published on 23 April 2015

Quantifying the allosteric interactions within a G-protein-coupled receptor heterodimer

scientific article

Rational design of a peptide capture agent for CXCL8 based on a model of the CXCL8:CXCR1 complex

scholarly article in RSC Advances, vol. 5 no. 33, 2015

Reducing the n-gram feature space of class C GPCRs to subtype-discriminating patterns

scientific article

Representation Learning for Class C G Protein-Coupled Receptors Classification

article

Revealing the Mechanism of Agonist-Mediated Cannabinoid Receptor 1 (CB1) Activation and Phospholipid-Mediated Allosteric Modulation

scientific article published on 29 May 2019

Role of elastin in spontaneously hypertensive rat small mesenteric artery remodelling

scientific journal article

Selective Protonation of Acidic Residues Triggers Opsin Activation

scientific article published on 17 July 2015

Shift in nucleotide conformational equilibrium contributes to increased rate of catalysis of GpAp versus GpA in barnase

scientific article

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

scientific article published on 7 April 2015

Statistics for the analysis of molecular dynamics simulations: providing P values for agonist-dependent GPCR activation

scientific article published on 17 November 2020

Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions.

scientific article

Synthesis toward Bivalent Ligands for the Dopamine D2 and Metabotropic Glutamate 5 Receptors

scientific article published on 18 September 2018

Systematic Analysis of Primary Sequence Domain Segments for the Discrimination Between Class C GPCR Subtypes.

scientific article published on 19 February 2018

Terminating evolutionary algorithms at their steady state

Text mining and expert curation to develop a database on psychiatric diseases and their genes

scientific article published in January 2017

The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways.

scientific article published on 04 December 2009

The catalytic power of enzymes: conformational selection or transition state stabilization?

scientific article published on 30 March 2006

The effect of the molecular mechanism of G protein-coupled receptor activation on the process of signal transduction ⬇️

scientific article published on September 17, 1997

The influence of alignment-free sequence representations on the semi-supervised classification of class C G protein-coupled receptors: semi-supervised classification of class C GPCRs.

scientific article published on 4 November 2014

The slope parameter and the receptor reserve

scientific article published on 01 November 1998

The structure and activity of membrane receptors: computational simulation of histamine H2-receptor activation

Transient middle cerebral artery occlusion causes different structural, mechanical, and myogenic alterations in normotensive and hypertensive rats

scientific article published on 30 March 2007

Use of the operational model of agonism and [3H]prazosin binding to assess altered responsiveness of α1-adrenoceptors in the vas deferens of spontaneously hypertensive rat

scientific article published on 01 September 1997

Using machine learning tools for protein database biocuration assistance

scientific article published on 05 July 2018

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