List of works - Dagmar Kratky

1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype.

scientific article published on 26 August 2016

25-Hydroxycholesterol regulates cholesterol homeostasis in the murine CATH.a neuronal cell line

scientific article published on 21 January 2013

A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C).

scientific article published on 23 July 2011

A sensitive chemiluminescence method to measure the lipoxygenase catalyzed oxygenation of complex substrates

scientific article

ATGL/CGI-58-Dependent Hydrolysis of a Lipid Storage Pool in Murine Enterocytes

scientific article published on 01 August 2019

Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung

scientific article published on 11 January 2016

Active autophagy but not lipophagy in macrophages with defective lipolysis.

scientific article

Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice

scientific article

Adenovirus-mediated rescue of lipoprotein lipase-deficient mice. Lipolysis of triglyceride-rich lipoproteins is essential for high density lipoprotein maturation in mice

scientific article

Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

scientific article published in 2024

Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis

scientific article

Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis.

scientific article published on September 2012

Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.

scientific article

Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy

scientific article published in June 2009

C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages.

scientific article published on 15 March 2012

Characterization of rat serum amyloid A4 (SAA4): a novel member of the SAA superfamily.

scientific article

Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice

scientific article

Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363

scientific article

Critical role of the peroxisomal protein PEX16 in white adipocyte development and lipid homeostasis

scientific article published on 22 December 2016

Cytosolic lipolysis and lipophagy: two sides of the same coin

scientific article published on 30 August 2017

Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue

scientific article published on 16 August 2003

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

scientific article

Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis

scientific article published in November 2003

Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis.

scientific article

Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase

scientific article

Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells

scientific article published on 31 October 2013

Endothelial and lipoprotein lipases in human and mouse placenta

scientific article published on 8 September 2005

Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity

scientific article

Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue

scientific article published on January 2005

Erratum to: Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis.

scientific article published on 25 May 2013

Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.

scientific article published on 25 May 2015

Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle

scientific article published on 23 January 2002

Impact of Endothelial Lipase on Cholesterol Efflux Capacity of Serum and High-density Lipoprotein

scientific article published on 2 October 2017

Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis

scientific article published on 2 May 2011

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

scientific article published on October 2011

In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake

scientific article published in November 2001

Intestinal GATA4 deficiency induces proximal fibroblast growth factor 15 expression and represses hepatic gluconeogenesis.

scientific article published on 10 July 2013

Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis

scientific article

Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice.

scientific article published on September 2011

Lanifibranor Reduces Inflammation and Improves Dyslipidemia in Lysosomal Acid Lipase-Deficient Mice

scientific article published in 2024

Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance.

scientific article

Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.

scientific article

Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype.

scientific article published on 19 December 2017

Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover

scientific article published on 27 June 2016

Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production.

scientific article published on 9 March 2018

Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice

scientific article published on 06 May 2016

Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis.

scientific article published on 24 January 2018

Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages.

scientific article published on 29 March 2017

Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in low-density lipoprotein receptor knockout mice

scientific article

MiR-206 is expressed in pancreatic islets and regulates glucokinase activity

scientific article published on 24 May 2016

Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice

scientific article

Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice

scientific article

Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro

scientific article published on 09 February 2020

Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo

scientific article

Myristic acid induces proteomic and secretomic changes associated with steatosis, cytoskeleton remodeling, endoplasmic reticulum stress, protein turnover and exosome release in HepG2 cells

scientific article published in June 2018

Neutral cholesterol ester hydrolases in macrophages: still a matter of debate

scientific article published on May 2011

Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors

scientific article published on 7 October 2014

Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo

scientific article published on 10 November 2017

Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism

scientific article published on 23 June 2016

Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases

scientific article published on 30 April 2022

Phospholipid transfer protein is expressed in cerebrovascular endothelial cells and involved in high density lipoprotein biogenesis and remodeling at the blood-brain barrier

scientific article

Pleiotropic regulation of mitochondrial function by adipose triglyceride lipase-mediated lipolysis

scientific article published on July 2013

Pro-angiogenic induction of myeloid cells for therapeutic angiogenesis can induce mitogen-activated protein kinase p38-dependent foam cell formation.

scientific article published on 03 December 2010

Spatially resolved activity-based proteomic profiles of the murine small intestinal lipases

scientific article published on 06 October 2020

Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors.

scientific article

Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol.

scientific article

The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity

scientific article published in Scientific Reports

The role of lipoprotein lipase in adipose tissue development and metabolism

scientific article published in November 2000

Tissue-Specific Landscape of Metabolic Dysregulation during Ageing

scientific article published in 2021

Tissue-specific activity of lipoprotein lipase in skeletal muscle regulates the expression of uncoupling protein 3 in transgenic mouse models

scientific article published on May 2001

Toxicity of oxidized phospholipids in cultured macrophages

scientific article

Transition between acute and chronic hepatotoxicity in mice is associated with impaired energy metabolism and induction of mitochondrial heme oxygenase-1.

scientific article

Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages

scientific article

Tumor-Induced Hyperlipidemia Contributes to Tumor Growth.

scientific article published on 29 March 2016

Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.

scientific article published on 03 May 2013

miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages

scientific article

α/β-hydrolase domain containing protein 15 (ABHD15)--an adipogenic protein protecting from apoptosis.

scientific article

List of works by Dagmar Kratky

1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype.

25-Hydroxycholesterol regulates cholesterol homeostasis in the murine CATH.a neuronal cell line

A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C).

A sensitive chemiluminescence method to measure the lipoxygenase catalyzed oxygenation of complex substrates

ATGL/CGI-58-Dependent Hydrolysis of a Lipid Storage Pool in Murine Enterocytes

Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung

Active autophagy but not lipophagy in macrophages with defective lipolysis.

Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice

Adenovirus-mediated rescue of lipoprotein lipase-deficient mice. Lipolysis of triglyceride-rich lipoproteins is essential for high density lipoprotein maturation in mice

Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis

Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis.

Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.

Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy

C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages.

Characterization of rat serum amyloid A4 (SAA4): a novel member of the SAA superfamily.

Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice

Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363

Critical role of the peroxisomal protein PEX16 in white adipocyte development and lipid homeostasis

Cytosolic lipolysis and lipophagy: two sides of the same coin

Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis

Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis.

Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase

Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells

Endothelial and lipoprotein lipases in human and mouse placenta

Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity

Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue

Erratum to: Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis.

Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.

Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle

Impact of Endothelial Lipase on Cholesterol Efflux Capacity of Serum and High-density Lipoprotein

Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake

Intestinal GATA4 deficiency induces proximal fibroblast growth factor 15 expression and represses hepatic gluconeogenesis.

Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis

Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice.

Lanifibranor Reduces Inflammation and Improves Dyslipidemia in Lysosomal Acid Lipase-Deficient Mice

Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance.

Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.

Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype.

Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover

Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production.

Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice

Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis.

Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages.

Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in low-density lipoprotein receptor knockout mice

MiR-206 is expressed in pancreatic islets and regulates glucokinase activity

Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice

Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice

Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro

Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo

Myristic acid induces proteomic and secretomic changes associated with steatosis, cytoskeleton remodeling, endoplasmic reticulum stress, protein turnover and exosome release in HepG2 cells

Neutral cholesterol ester hydrolases in macrophages: still a matter of debate

Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors

Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo

Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism

Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases

Phospholipid transfer protein is expressed in cerebrovascular endothelial cells and involved in high density lipoprotein biogenesis and remodeling at the blood-brain barrier

Pleiotropic regulation of mitochondrial function by adipose triglyceride lipase-mediated lipolysis

Pro-angiogenic induction of myeloid cells for therapeutic angiogenesis can induce mitogen-activated protein kinase p38-dependent foam cell formation.

Spatially resolved activity-based proteomic profiles of the murine small intestinal lipases

Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors.

Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol.

The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity

The role of lipoprotein lipase in adipose tissue development and metabolism

Tissue-Specific Landscape of Metabolic Dysregulation during Ageing

Tissue-specific activity of lipoprotein lipase in skeletal muscle regulates the expression of uncoupling protein 3 in transgenic mouse models

Toxicity of oxidized phospholipids in cultured macrophages

Transition between acute and chronic hepatotoxicity in mice is associated with impaired energy metabolism and induction of mitochondrial heme oxygenase-1.

Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages

Tumor-Induced Hyperlipidemia Contributes to Tumor Growth.

Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.

miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages

α/β-hydrolase domain containing protein 15 (ABHD15)--an adipogenic protein protecting from apoptosis.