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List of works by Julie Forman-Kay

15N H/D-SOLEXSY experiment for accurate measurement of amide solvent exchange rates: application to denatured drkN SH3.

scientific article

19F NMR studies of solvent exposure and peptide binding to an SH3 domain

scientific article

1H and 15N resonance assignments and secondary structure of the human thioredoxin C62A, C69A, C73A mutant

scientific article published on September 1992

A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

scientific article

A New Phase in ALS Research

scientific article published in September 2016

A hidden competitive advantage of disorder

scientific article published in Nature

A proton nuclear magnetic resonance assignment and secondary structure determination of recombinant human thioredoxin.

scientific article

A simple in vivo assay for increased protein solubility

scientific article published on September 1999

Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na+ channel

scientific article published on 22 March 2003

Allosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTR

scientific article

An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF(Cdc4) ubiquitin ligase

scientific article (publication date: 3 January 2017)

An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors

scientific article published on 16 May 2017

An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2

scientific article (publication date: 23 June 2006)

Analysis of deuterium relaxation-derived methyl axis order parameters and correlation with local structure

scientific article published in February 1999

Aromatic and methyl NOEs highlight hydrophobic clustering in the unfolded state of an SH3 domain

scientific article

Atomic-level characterization of disordered protein ensembles

scientific article published on 23 January 2007

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

scientific article

Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques

scientific article (publication date: November 1994)

Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation

scientific article (publication date: 17 May 1994)

Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy

scientific article published on 7 October 2015

CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices

scientific article published on 29 July 2007

Calculation of ensembles of structures representing the unfolded state of an SH3 domain.

scientific article

Calculation of residual dipolar couplings from disordered state ensembles using local alignment

scientific article published on 31 May 2008

Characterization of disordered proteins with ENSEMBLE.

scientific article

Characterization of the PilN, PilO and PilP type IVa pilus subcomplex ⬇️

scientific article published on November 18, 2011

Characterization of the hydrodynamic properties of the folding transition state of an SH3 domain by magnetization transfer NMR spectroscopy

scientific article

Characterization of the phosphotyrosine-binding domain of the Drosophila Shc protein

scientific article published in December 1996

Clinical presentation and molecular basis of congenital antithrombin deficiency in children: a cohort study

scientific article published on 29 March 2014

Comparative roles of charge, π, and hydrophobic interactions in sequence-dependent phase separation of intrinsically disordered proteins

scientific article published on 02 November 2020

Comparison of the backbone dynamics of a folded and an unfolded SH3 domain existing in equilibrium in aqueous buffer.

scientific article

Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase

scientific article

Comprehensive NOE characterization of a partially folded large fragment of staphylococcal nuclease Delta131Delta, using NMR methods with improved resolution.

scientific article

Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator

scientific article published on 21 June 2012

Conformations of a Metastable SH3 Domain Characterized by smFRET and an Excluded-Volume Polymer Model

scientific article published in April 2016

Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3.

scientific article

Contributions to protein entropy and heat capacity from bond vector motions measured by NMR spin relaxation

scientific article published in October 1997

Cooperative interactions and a non-native buried Trp in the unfolded state of an SH3 domain

scientific article

Correlation between binding and dynamics at SH2 domain interfaces

article

Correlation between dynamics and high affinity binding in an SH2 domain interaction

scientific article

Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity

scientific article

Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization

scientific article

Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator

scientific article

Differential dynamic engagement within 24 SH3 domain: peptide complexes revealed by co-linear chemical shift perturbation analysis

scientific article

Direct Binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric Coupling between the Binding Site and the NBD1:CL4 Interface

scientific article published on 25 May 2017

Distribution of molecular size within an unfolded state ensemble using small-angle X-ray scattering and pulse field gradient NMR techniques

scientific article

Dramatic stabilization of an SH3 domain by a single substitution: roles of the folded and unfolded states.

scientific article

Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling

scientific article

Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor

scholarly article

Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stability

scientific article published on March 2013

Ensemble modeling of protein disordered states: Experimental restraint contributions and validation ⬇️

scientific article published on November 17, 2011

Entropy and Information within Intrinsically Disordered Protein Regions

scientific article published on 06 July 2019

Finding Our Way in the Dark Proteome

scientific article published on 07 July 2016

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

scientific article

From sequence and forces to structure, function, and evolution of intrinsically disordered proteins

scientific article

High populations of non-native structures in the denatured state are compatible with the formation of the native folded state

scientific article

High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif

scientific article published on July 1997

Hydration and packing along the folding pathway of SH3 domains by pressure-dependent NMR.

scientific article

IDPConformerGenerator: A Flexible Software Suite for Sampling the Conformational Space of Disordered Protein States

scientific article published in 2022

Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome

scientific article

Improved structural characterizations of the drkN SH3 domain unfolded state suggest a compact ensemble with native-like and non-native structure

scientific article

In support of the BMRB.

scientific article published in September 2012

Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface

scientific article published on 24 October 2013

Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination

scientific article

Interplay of buried histidine protonation and protein stability in prion misfolding

scientific article published on 13 April 2017

Liquid-liquid phase separation in cellular signaling systems

scientific article

Measurement of side-chain carboxyl pK(a) values of glutamate and aspartate residues in an unfolded protein by multinuclear NMR spectroscopy

scientific article

Measuring pK(a) values in protein folding transition state ensembles by NMR spectroscopy

scientific article

Megakaryocyte and platelet abnormalities in a patient with a W33C mutation in the conserved SH3-like domain of myosin heavy chain IIA.

scientific article

Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications

scientific article published on 5 February 2016

Molecular structural analysis of a novel and de-novo mutation in the SERPINC1 gene associated with type 1 antithrombin deficiency.

scientific article published on 21 April 2016

Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb

scientific article

NMR Experiments for Studies of Dilute and Condensed Protein Phases: Application to the Phase-Separating Protein CAPRIN1

scientific article published on 21 January 2020

NMR characterization of copper-binding domains 4-6 of ATP7B .

scientific article published on 10 September 2010

NMR dynamics-derived insights into the binding properties of a peptide interacting with an SH2 domain

scientific article

NMR evidence for differential phosphorylation-dependent interactions in WT and DeltaF508 CFTR.

scientific article published on 19 November 2009

NMR spectroscopy to study the dynamics and interactions of CFTR.

scientific article published in January 2011

NMR structure of neuromedin C, a neurotransmitter with an amino terminal CuII-, NiII-binding (ATCUN) motif

scientific article published on 01 June 1997

NMR studies of tandem WW domains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel

scientific journal article

NOE data demonstrating a compact unfolded state for an SH3 domain under non-denaturing conditions.

scientific article

Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition

scientific article published on 19 June 2020

Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide

scientific article

Oxidative Inhibition of Pbp1 Phase Separation

scientific article published on 08 July 2019

Oxygen as a paramagnetic probe of clustering and solvent exposure in folded and unfolded states of an SH3 domain

scientific article

Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles

scientific article published on March 2015

Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia

scientific article

Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation

scientific article published on 01 August 2019

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

scientific article published on 14 February 2019

Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis

scientific article published on 25 January 2012

Pi-Pi contacts are an overlooked protein feature relevant to phase separation

scientific article published on 9 February 2018

Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity

scientific article

Probing the diverse landscape of protein flexibility and binding ⬇️

scientific article published on September 20, 2012

Protein dynamics and conformational disorder in molecular recognition

scientific article published on March 2010

Proteome-wide signatures of function in highly diverged intrinsically disordered regions

scientific article published on 2 July 2019

Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions

scientific article

Relationship between electrostatics and redox function in human thioredoxin: characterization of pH titration shifts using two-dimensional homo- and heteronuclear NMR.

scientific article

Role of CBS and Bateman Domains in Phosphorylation-Dependent Regulation of a CLC Anion Channel

scientific article published on November 2016

Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation

scientific article

Sequence determinants of compaction in intrinsically disordered proteins

scientific article published on May 2010

Sequence-Specific Polyampholyte Phase Separation in Membraneless Organelles ⬇️

scientific article published on 17 October 2016

Sequential assignment of proline-rich regions in proteins: application to modular binding domain complexes

scientific article published on 01 March 2000

Side-chain dynamics of the SAP SH2 domain correlate with a binding hot spot and a region with conformational plasticity

scientific article

Site-specific contributions to the pH dependence of protein stability

scientific article

Solution structure and dynamics of the outer membrane enzyme PagP by NMR.

scientific article

Solution structure of a Nedd4 WW domain-ENaC peptide complex

scientific article

Solution structure of a polypeptide dimer comprising the fourth calcium-binding site of troponin C by nuclear magnetic resonance spectroscopy

article

Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations

scientific article

Structural and Dynamic Characterization of the Phosphotyrosine Binding Region of an Src Homology 2 Domain-Phosphopeptide Complex by NMR Relaxation, Proton Exchange, and Chemical Shift Approaches

scientific article published on 01 September 1995

Structural and dynamic characterization of an SH2 domain-phosphopeptide complex by NMR approaches

scientific article published on 01 November 1995

Structural changes of CFTR R region upon phosphorylation: a plastic platform for intramolecular and intermolecular interactions

scientific article published on 25 July 2013

Structural characterization of folded and unfolded states of an SH3 domain in equilibrium in aqueous buffer.

scientific article

Structural characterization of proteins with an attached ATCUN motif by paramagnetic relaxation enhancement NMR spectroscopy.

scientific article published in October 2001

Structural comparison of the unstable drkN SH3 domain and a stable mutant

scientific article

Structural determinants for high-affinity binding in a Nedd4 WW3* domain-Comm PY motif complex

scientific article published in March 2006

Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators

scientific article

Structural signature of the MYPT1-PP1 interaction.

scientific article published on 10 December 2010

Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays

scientific article

Structural, Functional, and Bioinformatic Studies Demonstrate the Crucial Role of an Extended Peptide Binding Site for the SH3 Domain of Yeast Abp1p

scientific article

Structure and disorder in an unfolded state under nondenaturing conditions from ensemble models consistent with a large number of experimental restraints

scientific article

Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity

scientific article

Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide

scientific article

Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase

scientific article

Studies on the solution conformation of human thioredoxin using heteronuclear nitrogen-15-proton nuclear magnetic resonance spectroscopy

scientific article published on 01 February 1990

Synergy of cAMP and calcium signaling pathways in CFTR regulation

scientific article published on 27 February 2017

Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs

scientific article published on January 2007

The 'dynamics' in the thermodynamics of binding

scientific article published on 01 December 1999

The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer

scientific article

The effect of intrachain electrostatic repulsion on conformational disorder and dynamics of the Sic1 protein

scientific article published on 8 April 2014

The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates

scientific article

Theories for Sequence-Dependent Phase Behaviors of Biomolecular Condensates.

scientific article published on 6 March 2018

Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding

scientific article published on 28 March 2012

Tryptophan solvent exposure in folded and unfolded states of an SH3 domain by 19F and 1H NMR.

scientific article

What's in a name? Why these proteins are intrinsically disordered: Why these proteins are intrinsically disordered

scientific article

c.1058C>T variant in theSERPINC1gene is pathogenic for antithrombin deficiency

article

pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins

scientific article

pH titration studies of an SH2 domain-phosphopeptide complex: unusual histidine and phosphate pKa values.

scientific article

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