List of works - David K. Cole

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.

scientific article

A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells.

scientific article published on January 2015

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape

scientific article

Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation

scientific article published on 01 July 2021

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining

scientific article

Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs

scientific article

Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses

scientific article published in March 2004

Biochemical, biophysical and preliminary X-ray crystallographic analyses of the fusion core of Sendai virus F protein

scientific article published on 26 August 2004

CD8: adhesion molecule, co-receptor and immuno-modulator.

scientific article

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation

scientific article published on 05 September 2013

Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus

scientific article published in November 2004

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

scientific article

Complex assembly, crystallization and preliminary X-ray crystallographic studies of MHC H-2Kd complexed with an HBV-core nonapeptide

scientific article published on 21 July 2004

Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor

scientific article

Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein

scientific article published in November 2004

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

scientific article published on 9 November 2008

Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance

scientific article published on 2 October 2014

Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding.

scientific article

Crystal structure of HLA-A*2402 complexed with a telomerase peptide

scientific article published in January 2006

Crystallization and preliminary X-ray structural studies of a high-affinity CD8alphaalpha co-receptor to pMHC

scientific article published on 12 February 2005

Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus

scientific article published on 21 May 2004

Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers

scientific article published on 31 July 2008

Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

scientific article published in Journal of Biological Chemistry

Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B27:05- and -B27:02-Mediated Control of HIV-1 Infection

scientific article published on 22 November 2017

Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope

scientific article published on 12 September 2012

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.

scientific article

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide

scientific article published on 17 June 2015

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions

scientific article published in Nature Communications

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.

scientific article published on 10 November 2017

ELISPOT and functional T cell analyses using HLA mono-specific target cells.

scientific article published in September 2009

Engineering and functional evaluation of a single-chain antibody against HIV-1 external glycoprotein gp120.

scientific article

Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers

scientific article published on 9 November 2015

Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors

scientific article published in June 2004

Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor

scientific article

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

scientific article

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

scientific article

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

scientific article published on 16 May 2016

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

scientific article published on 15 August 2016

Human TCR-binding affinity is governed by MHC class restriction

scientific article

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope

scientific article published on 16 October 2019

Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity

scientific article

Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b 214-222 by combinatorial peptide library screening

scientific article published on 06 July 2020

In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.

scientific article published on 11 April 2018

In this issue

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.

scientific article

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

scientific article published on 26 February 2010

Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation

scientific article published on 9 November 2017

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

scientific article

Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection

scientific article published on 7 February 2012

Molecular Basis of a Dominant T Cell Response to an HIV Reverse Transcriptase 8-mer Epitope Presented by the Protective Allele HLA-B*51:01

scientific article

Molecular characterisation of HLA class II binding to the LAG-3 T cell co-inhibitory receptor

scientific article published on 12 September 2020

More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers

scientific article

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

scientific article

Novel TCR-based biologics: mobilising T cells to warm 'cold' tumours

scientific article published on 12 June 2019

P16-56 LB. Novel tetramer technology for the detection of high affinity CD8 T cells

Paediatric non-progression following grandmother-to-child HIV transmission

scientific article published on 08 September 2016

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma

article

Peptide cargo tunes a network of correlated motions in human leucocyte antigens

scientific article published on 05 March 2020

Peptide length determines the outcome of TCR/peptide-MHCI engagement

scientific article

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

scientific article published on 12 March 2018

Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation

scientific article published on 23 July 2009

Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough.

scientific article published on July 2013

Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability.

scientific article

Real-time binding kinetic analyses of the interaction of the dietary stain orange II with dentin matrix

scientific article published on 09 June 2018

Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment

scientific article published on 3 November 2014

SARS coronavirus induces apoptosis in Vero E6 cells

scientific article published on July 2004

Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.

scientific article

Structural and biophysical determinants of αβ T-cell antigen recognition

scientific article published on January 2012

Structural basis for ineffective T-cell responses to MHC anchor residue-improved "heteroclitic" peptides

scientific article

Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

scientific article

T cell Receptor Alpha Variable 12-2 bias in the immunodominant response to Yellow fever virus

scientific article published on 3 October 2017

T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding

scientific article published on 19 February 2008

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions

scientific article

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

scientific article

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones

scientific article published on 27 January 2016

TCR-induced alteration of primary MHC peptide anchor residue

scientific article published on 27 May 2019

TCR/pMHC Optimized Protein crystallization Screen

scientific article published on 15 June 2012

Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies

scientific article published on 13 November 2017

The T cell antigen receptor: the Swiss army knife of the immune system.

scientific article

The impact of HLA class I and EBV latency-II antigen-specific CD8(+) T cells on the pathogenesis of EBV(+) Hodgkin lymphoma

scientific article

The molecular determinants of CD8 co-receptor function

scientific article published on October 2012

The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells

scientific article

The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy

scientific article

The ultimate mix and match: making sense of HLA alleles and peptide repertoires.

scientific article published on 31 March 2015

The versatility of the αβ T-cell antigen receptor

scientific article published on 28 January 2014

Thermal Stability of Heterotrimeric pMHC Proteins as Determined by Circular Dichroism Spectroscopy.

scientific article

Tricks with tetramers: how to get the most from multimeric peptide-MHC.

scientific article published on February 2009

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.

scientific article

VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium

scientific article published on 01 January 2020

List of works by David K. Cole

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.

A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells.

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape

Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation

Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining

Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs

Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses

Biochemical, biophysical and preliminary X-ray crystallographic analyses of the fusion core of Sendai virus F protein

CD8: adhesion molecule, co-receptor and immuno-modulator.

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation

Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

Complex assembly, crystallization and preliminary X-ray crystallographic studies of MHC H-2Kd complexed with an HBV-core nonapeptide

Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor

Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance

Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding.

Crystal structure of HLA-A*2402 complexed with a telomerase peptide

Crystallization and preliminary X-ray structural studies of a high-affinity CD8alphaalpha co-receptor to pMHC

Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus

Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers

Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection

Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.

ELISPOT and functional T cell analyses using HLA mono-specific target cells.

Engineering and functional evaluation of a single-chain antibody against HIV-1 external glycoprotein gp120.

Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers

Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors

Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

Human TCR-binding affinity is governed by MHC class restriction

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope

Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity

Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b 214-222 by combinatorial peptide library screening

In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.

In this issue

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection

Molecular Basis of a Dominant T Cell Response to an HIV Reverse Transcriptase 8-mer Epitope Presented by the Protective Allele HLA-B*51:01

Molecular characterisation of HLA class II binding to the LAG-3 T cell co-inhibitory receptor

More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Novel TCR-based biologics: mobilising T cells to warm 'cold' tumours

P16-56 LB. Novel tetramer technology for the detection of high affinity CD8 T cells

Paediatric non-progression following grandmother-to-child HIV transmission

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma

Peptide cargo tunes a network of correlated motions in human leucocyte antigens

Peptide length determines the outcome of TCR/peptide-MHCI engagement

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation

Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough.

Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability.

Real-time binding kinetic analyses of the interaction of the dietary stain orange II with dentin matrix

Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment

SARS coronavirus induces apoptosis in Vero E6 cells

Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.

Structural and biophysical determinants of αβ T-cell antigen recognition

Structural basis for ineffective T-cell responses to MHC anchor residue-improved "heteroclitic" peptides

Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

T cell Receptor Alpha Variable 12-2 bias in the immunodominant response to Yellow fever virus

T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones

TCR-induced alteration of primary MHC peptide anchor residue

TCR/pMHC Optimized Protein crystallization Screen

Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies

Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B27:05- and -B27:02-Mediated Control of HIV-1 Infection