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List of works by Hirofumi Akari

A noncanonical mu-1A-binding motif in the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes

scientific article published in February 2012

Accumulation of MAC387+ macrophages in paracortical areas of lymph nodes in rhesus monkeys acutely infected with simian immunodeficiency virus

scientific article published in October 1999

Age-dependent remodeling of peripheral blood CD4+ CD8+ T lymphocytes in cynomolgus monkeys

scientific article published in March 1998

Age-related changes in major lymphocyte subsets in cynomolgus monkeys

scientific article published in July 1998

Age-related increase of peripheral CD4+ CD8+ double-positive T lymphocytes in cynomolgus monkeys: longitudinal study in relation to thymic involution

scientific article published in June 2003

Allele frequency of antiretroviral host factor TRIMCyp in wild-caught cynomolgus macaques (Macaca fascicularis).

scientific article

Antiviral effects of 6-chloro-2',3'-dideoxyguanosine in rhesus monkeys acutely infected with simian immunodeficiency virus

scientific article published on January 1998

Biological characterization of human immunodeficiency virus type 1 and type 2 mutants in human peripheral blood mononuclear cells

scientific article published on January 1992

Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers

scientific article published on 4 November 2015

CD16(+) natural killer cells play a limited role against primary dengue virus infection in tamarins

scientific article published on 3 December 2011

Changes in hematological and serum biochemical parameters in common marmosets (Callithrix jacchus) after inoculation with dengue virus

scientific article

Characterization of Natural Killer Cells in Tamarins: A Technical Basis for Studies of Innate Immunity ⬇️

scientific article published on December 8, 2010

Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection.

scientific article

Cleavage of Gag precursor is required for early replication phase of HIV-1

article

Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expression

scientific article published on February 2004

Common marmoset (Callithrix jacchus) as a primate model of dengue virus infection: development of high levels of viraemia and demonstration of protective immunity

scientific article published on 22 June 2011

Comparative Analysis of Human and Macaque Monkey CD4: Differences in Formaldehyde Lability and Conformation

scientific article published on 01 January 1998

Compatibility of Vpu-like activity in the four groups of primate immunodeficiency viruses

scientific article published on 01 January 1999

Complete inhibition of SIVmac replication by its capsid mutants

scientific article published on January 1998

Cyclophilin A-independent replication of a human immunodeficiency virus type 1 isolate carrying a small portion of the simian immunodeficiency virus SIV(MAC) gag capsid region

scientific article published on November 2001

Demonstration of marmosets (Callithrix jacchus) as a non-human primate model for secondary dengue virus infection: high levels of viraemia and serotype cross-reactive antibody responses consistent with secondary infection of humans

scientific article published on 9 December 2013

Detection of 14 alleles derived from the MHC class I A locus in cynomolgus monkeys

scientific article published on 26 May 2004

Detection of SRV/D shedding in body fluids of cynomolgus macaques and comparison of partial gp70 sequences in SRV/D-T isolates

scientific article published on 26 January 2007

Detection of the cellular membrane proteins on human T cell leukemia virus type I.

scientific article published on January 1995

Differential reactivities of antibodies to HIV and HTLV-I in sera of suspected AIDS and ARC patients.

scientific article published in July 1994

Divergence and diversity of ULBP2 genes in rhesus and cynomolgus macaques

scientific article published on 28 January 2014

Diversity of MHC class I genes in Burmese-origin rhesus macaques

article

Diversity of MHC class I haplotypes in cynomolgus macaques

scientific article published on 01 September 2011

Dual phasic suppression of viral replication following de novo human immunodeficiency virus type 1 (HIV-1) infection in lymphocytes of asymptomatic HIV-1 carriers

scientific article published in April 1997

Dynamics of cellular immune responses in the acute phase of dengue virus infection

scientific article published on 5 February 2013

Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms.

scientific article

Early function of HIV-1 Gag proteins is cell-dependent

scientific article published on July 1998

Effective Delivery of a Lipophilic 6-chloro-2',3'-dideoxyguanosine(6-Cl-ddG) into Rat Lymphoid Tissues

scientific article published on 01 October 1999

Effects of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) in surface lymph nodes of rhesus monkeys (Macaca mulatta) chronically infected with simian immunodeficiency virus (SIVmac239).

scientific article published in October 1997

Effects of SIVmac infection on peripheral blood CD4+CD8+ T lymphocytes in cynomolgus macaques

scientific article published on June 1999

Efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) on an ARC/AIDS rhesus macaque (Macaca mulatta) infected with simian immunodeficiency virus

scientific article published in January 1997

Efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) on rhesus macaque monkeys chronically infected with simian immunodeficiency virus (SIVmac239).

scientific article published in December 1997

Efficient in vivo depletion of CD8(+) T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration

scientific article published on July 2013

Efficient inhibition of SDF-1alpha-mediated chemotaxis and HIV-1 infection by novel CXCR4 antagonists

scientific article published on 24 February 2009

Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C.

scientific article published on 16 July 2007

Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host.

scientific article

Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody

scientific article published on 2 June 2016

Enhancement of human immunodeficiency virus type 1 infectivity by Nef is producer cell-dependent.

scientific article published in October 1998

Epidemiological Surveillance of Lymphocryptovirus Infection in Wild Bonobos.

scientific article published on 12 August 2016

Epidemiological study of zoonoses derived from humans in captive chimpanzees.

scientific article

Exchangeability of accessory Vif and Vpu proteins between various HIV/SIVs (review)

article

Exposure of p19 matrix protein of human T-cell leukemia virus type I (HTLV-I) on the surface of MOLT-4#8 cells after virus adsorption

scientific article published on January 1994

Expression of HIV-1 accessory protein Vif is controlled uniquely to be low and optimal by proteasome degradation

scientific article published on July 2004

Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques

scientific article published on 23 June 2020

Functional analysis of long terminal repeats derived from four strains of simian immunodeficiency virus SIVAGM in relation to other primate lentiviruses

scientific article published in November 1991

Functional domain mapping of HIV-1 Gag proteins

scientific article

Functional roles of HIV accessory proteins for viral replication (review)

article

GBV-B as a pleiotropic virus: distribution of GBV-B in extrahepatic tissues in vivo

scientific article published on 27 January 2007

Gag-CA Q110D mutation elicits TRIM5-independent enhancement of HIV-1mt replication in macaque cells

scientific article

Generation of rhesus macaque-tropic HIV-1 clones that are resistant to major anti-HIV-1 restriction factors.

scientific article published on 21 August 2013

Geographical, genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis)

scientific article

HIV-1 capsid mutants inhibit the replication of wild-type virus at both early and late infection phases

scientific article published in September 1997

High level expression of human immunodeficiency virus type-1 Vif inhibits viral infectivity by modulating proteolytic processing of the Gag precursor at the p2/nucleocapsid processing site

scientific article published on 13 January 2004

Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication ⬇️

scientific article published on January 6, 2012

Host cell-dependent replication of HIV-1 mutants with deletions in gp41 cytoplasmic tail region is independent of the function of Vif

article

Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo.

scientific article published on 29 November 2017

Human immunodeficiency virus type 1 Vif is efficiently packaged into virions during productive but not chronic infection

scientific article

Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications

scientific article

In vitro immortalization of Old World monkey T lymphocytes with Herpesvirus saimiri: its susceptibility to infection with simian immunodeficiency viruses

scientific article published on April 1996

Induction of MHC-IIDR expression on circulating CD8+ lymphocytes in macaques infected with SIVmac239 nef-open but not with its nef-deletion mutant

scientific article published on May 1998

Induction of apoptosis in HEp-2 cells by infection with herpes simplex virus type 2.

scientific article published on January 1998

Induction of apoptosis in Herpesvirus saimiri-immortalized T lymphocytes by blocking interaction of CD28 with CD80/CD86.

scientific article published on September 1999

Induction of humoural and cellular immunity by immunisation with HCV particle vaccine in a non-human primate model.

scientific article

Interaction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor.

scientific article

Intravirion processing of the human immunodeficiency virus type 1 Vif protein by the viral protease may be correlated with Vif function.

scientific article

Isolation and characterization of a highly divergent HIV-2[GH-2]: generation of an infectious molecular clone and functional analysis of its rev-responsive element in response to primate retrovirus transactivators (Rev and Rex)

scientific article (publication date: June 1992)

Isolation and characterization of simian immunodeficiency virus from African white-crowned mangabey monkeys (Cercocebus torquatus lunulatus).

scientific article published on January 1993

Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates

scientific article published on 19 June 2012

Long-Term Persistent GBV-B Infection and Development of a Chronic and Progressive Hepatitis C-Like Disease in Marmosets ⬇️

scientific article published on December 7, 2011

MDM2 is a novel E3 ligase for HIV-1 Vif.

scientific article published on 07 January 2009

MHC-I expression in HTLV-1-positive and -negative cells.

scientific article published in July 2000

Macaque-tropic human immunodeficiency virus type 1: breaking out of the host restriction factors

scientific article published on 09 July 2013

Mapping Region of Human Restriction Factor APOBEC3H Critical for Interaction with HIV-1 Vif.

scientific article published on 20 March 2017

Mapping the genetic determinants of human immunodeficiency virus type 2 for cell tropism and replication efficiency

scientific article published on January 1998

Modification of a loop sequence between alpha-helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV-1) derivative that has simian immunodeficiency virus (SIVmac239) vif and CA alpha-helices 4 and 5 loop improves r

article

Molecular cloning and characterization of the common marmoset huntingtin gene

scientific article published on 24 November 2008

Molecular evolution of immunoglobulin superfamily genes in primates

scientific article published on 10 March 2011

Mutational analysis of human immunodeficiency virus type 1 vif gene

scientific article

Natural selection in the TLR-related genes in the course of primate evolution

article

Naturally occurring amino acid substitutions in the HIV-2 ROD envelope glycoprotein regulate its ability to augment viral particle release.

scientific article published in April 2003

Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation

scientific article

Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen

scientific article published in 2022

New type of Sendai virus vector provides transgene-free iPS cells derived from chimpanzee blood

scientific article

Non-human primate surrogate model of hepatitis C virus infection.

scientific article published on January 2009

Novel mutant human immunodeficiency virus type 1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by random mutagenesis

scientific article published on 20 January 2016

PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

scientific article published on 23 April 2019

Peripheral blood CD4 and CD8 double-positive T cells of rhesus macaques become vulnerable to Simian Immunodeficiency Virus by in vitro stimulation due to the induction of CCR5.

scientific article published on 12 March 2010

Peripheral blood CD4+CD8+ lymphocytes in cynomolgus monkeys are of resting memory T lineage

scientific article published in April 1997

Peripheral blood extrathymic CD4(+)CD8(+) T cells with high cytotoxic activity are from the same lineage as CD4(+)CD8(-) T cells in cynomolgus monkeys

scientific article published on July 2000

Persistent replication of a hepatitis C virus genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus B in a New World monkey

scientific article published on 4 December 2015

Phenotypic changes in peripheral blood monocytes of cynomolgus monkeys acutely infected with simian immunodeficiency virus

scientific article published in September 1998

Prevalence and molecular phylogenetic characterization of Trypanosoma (Megatrypanum) minasense in the peripheral blood of small neotropical primates after a quarantine period

scientific article published in October 2008

Producer cell-dependent requirement of the Nef protein for efficient entry of HIV-1 into cells

scientific article published on September 1998

Prophylaxis of experimental HTLV-I infection in cynomolgus monkeys by passive immunization.

scientific article published in August 1997

Pseudotyping human immunodeficiency virus type 1 by vesicular stomatitis virus G protein does not reduce the cell-dependent requirement of vif for optimal infectivity: functional difference between Vif and Nef.

scientific article published in November 1999

Regulation of cell cycle and apoptosis by human immunodeficiency virus type 1 Vpr.

scientific article published on July 2000

Rev-dependent expression of three species of HIV-1 mRNAs (review).

scientific article

Role of virus-induced apoptosis in a host defense mechanism against virus infection.

scientific article published in August 1998

Selective expression of beta 7 integrin on lymphocytes undergoing apoptosis in lymphoid tissues

scientific article

Seroprevalence of Japanese encephalitis virus infection in captive Japanese macaques (Macaca fuscata).

scientific article published on 19 April 2014

Serotype-specific and cross-reactive neutralizing antibody responses in cynomolgus monkeys after infection with multiple dengue virus serotypes

scientific article published on 16 March 2011

Simian T cell leukemia virus type I-induced malignant adult T cell leukemia-like disease in a naturally infected African green monkey: implication of CD8+ T cell leukemia

scientific article published in March 1998

Simple assay system for detecting human T cell leukemia virus type I-binding cells and its application in titrating binding inhibitory antibodies

scientific article published on November 1993

Suppression of HIV-1 replication in peripheral blood mononuclear cells by fasudil.

scientific article published in February 1998

Susceptibility of HVS-immortalized lymphocytic HSC-F cells to various strains and mutants of HIV/SIV.

scientific article published on May 2003

Systemic biological analysis of the mutations in two distinct HIV-1mt genomes occurred during replication in macaque cells.

scientific article published on 4 February 2013

TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax.

scientific article

TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1.

scientific article

The HIV-1 Vpr displays strong anti-apoptotic activity

scientific article published in July 1998

The Human Immunodeficiency Virus Type 1 Accessory Protein Vpu Induces Apoptosis by Suppressing the Nuclear Factor κB–dependent Expression of Antiapoptotic Factors ⬇️

scientific article published on November 5, 2001

The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B.

scientific article published on 16 February 2001

The non-env tropism of HIV/SIV (Review)

article

ULBP4/RAET1E is highly polymorphic in the Old World monkey.

scientific article published on 7 May 2011

Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex.

scientific article published on 21 November 2005

Vpx and Vpr proteins of HIV-2 up-regulate the viral infectivity by a distinct mechanism in lymphocytic cells

scientific article published on April 2003

nef gene is required for robust productive infection by simian immunodeficiency virus of T-cell-rich paracortex in lymph nodes.

scientific article

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