List of works - Patrick A. Lewis

A Tangled Web – Tau and Sporadic Parkinson's Disease ⬇️

scientific article published on December 27, 2010

A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

scientific article published in March 2002

Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance

scientific article

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution

scientific article

Assaying the kinase activity of LRRK2 in vitro.

scientific article

Cancer and neurodegeneration: between the devil and the deep blue sea.

scientific article

Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation

scientific article published on 01 August 2006

Computational analysis of the LRRK2 interactome

scientific article

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research

scientific article

DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA

scientific article

Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease ⬇️

scientific article published on October 1, 2012

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases ⬇️

scientific article published on 05 June 2013

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies

scientific article published on 16 May 2013

Emerging pathways in genetic Parkinson's disease

scientific article published in December 2008

Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2.

scientific article published on December 2008

Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study

scientific article published on 13 June 2017

Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides

scientific article

Familial frontotemporal dementia associated with a novel presenilin-1 mutation

scientific article

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus

scientific article

GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1.

scientific article

GTP binding controls complex formation by the human ROCO protein MASL1

scientific article

Gene expression in the Parkinson's disease brain ⬇️

scientific article published on December 3, 2011

Genetic and phenotypic characterization of complex hereditary spastic paraplegia

scientific article published on 23 May 2016

Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia

scientific article published on 26 July 2019

Genetic, structural, and molecular insights into the function of ras of complex proteins domains.

scientific article published on 26 June 2014

Improving Wikipedia verifiability with AI

scientific article published on 19 October 2023

Inhibition of LRRK2 kinase activity stimulates macroautophagy

scientific journal article

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

scientific article published on 10 July 2012

James Parkinson: the man behind the shaking palsy.

scientific article published on January 2012

LRRK2 and human disease: a complicated question or a question of complexes?

scientific article published on 17 January 2012

LRRK2: Cause, Risk, and Mechanism ⬇️

scientific article published on January 1, 2013

Leucine rich repeat kinase 2: a paradigm for pleiotropy

scientific article published on 11 June 2019

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

scientific article

Mad fly disease.

scientific article published on January 2007

Mutations in LRRK2 amplify cell-to-cell protein aggregate propagation: a hypothesis.

scientific article published on 29 March 2018

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

scientific article published on 23 August 2011

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

scientific article

Parkinson's disease: From human genetics to clinical trials

scientific article published in September 2015

Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue

scientific article

Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

scientific journal article

Pierre D. and the first photographs of Parkinson's disease

scientific article published on 24 January 2020

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

scientific article

Rare variants in LRRK1 and Parkinson's disease

scientific article

Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity

scientific article published on April 2006

Reply to: "Light and Shade in Patrick Lewis et al's Paper on the First Photographs of Parkinson's Disease"

scientific article published on 01 October 2020

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

scientific article

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

scientific article

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy

scientific article

The R1441C mutation alters the folding properties of the ROC domain of LRRK2.

scientific article

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

scientific article

The function of ROCO proteins in health and disease.

scientific article published on March 2009

The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis.

scientific article published in October 2007

The presenilin 1 C92S mutation increases abeta 42 production.

scientific article published in October 2000

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

scientific article (publication date: 12 October 2016)

α-Synuclein mutations cluster around a putative protein loop

scientific article

List of works by Patrick A. Lewis

A Tangled Web – Tau and Sporadic Parkinson's Disease ⬇️

A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution

Assaying the kinase activity of LRRK2 in vitro.

Cancer and neurodegeneration: between the devil and the deep blue sea.

Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation

Computational analysis of the LRRK2 interactome

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research

DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA

Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease ⬇️

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases ⬇️

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies

Emerging pathways in genetic Parkinson's disease

Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2.

Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study

Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides

Familial frontotemporal dementia associated with a novel presenilin-1 mutation

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus

GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1.

GTP binding controls complex formation by the human ROCO protein MASL1

Gene expression in the Parkinson's disease brain ⬇️

Genetic and phenotypic characterization of complex hereditary spastic paraplegia

Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia

Genetic, structural, and molecular insights into the function of ras of complex proteins domains.

Improving Wikipedia verifiability with AI

Inhibition of LRRK2 kinase activity stimulates macroautophagy

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

James Parkinson: the man behind the shaking palsy.

LRRK2 and human disease: a complicated question or a question of complexes?

LRRK2: Cause, Risk, and Mechanism ⬇️

Leucine rich repeat kinase 2: a paradigm for pleiotropy

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

Mad fly disease.

Mutations in LRRK2 amplify cell-to-cell protein aggregate propagation: a hypothesis.

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Parkinson's disease: From human genetics to clinical trials

Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue

Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

Pierre D. and the first photographs of Parkinson's disease

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

Rare variants in LRRK1 and Parkinson's disease

Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity

Reply to: "Light and Shade in Patrick Lewis et al's Paper on the First Photographs of Parkinson's Disease"

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy

The R1441C mutation alters the folding properties of the ROC domain of LRRK2.

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

The function of ROCO proteins in health and disease.

The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis.

The presenilin 1 C92S mutation increases abeta 42 production.

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

α-Synuclein mutations cluster around a putative protein loop