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List of works by Jason M Haugh

A bipolar clamp mechanism for activation of Jak-family protein tyrosine kinases

scientific article

A unified model for signal transduction reactions in cellular membranes

scientific article published on February 2002

Active EGF receptors have limited access to PtdIns(4,5)P(2) in endosomes: implications for phospholipase C and PI 3-kinase signaling.

scientific article published on January 2002

Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase

scientific article

Analysis of reaction-diffusion systems with anomalous subdiffusion

scientific article published in July 2009

Analysis of receptor internalization as a mechanism for modulating signal transduction

scientific article published in November 1998

Are Filopodia Privileged Signaling Structures in Migrating Cells?

scientific article

Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration

scientific article published on 19 September 2014

Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility.

scientific article published on 23 October 2013

Biophysics: Cells get in shape for a crawl

scientific article published in Nature

Cell population-based model of dermal wound invasion with heterogeneous intracellular signaling properties.

scientific article published on 26 April 2008

Cell regulation: a time to signal, a time to respond

scientific article published on July 2012

Cells see the light to bring signaling under control ⬇️

scientific article published on September 29, 2011

Combinatorial Signal Transduction Responses Mediated by Interleukin-2 and -4 Receptors in a Helper TH2 Cell Line

scientific article published on September 2008

Computational models of tandem SRC homology 2 domain interactions and application to phosphoinositide 3-kinase.

scientific article published on 20 January 2008

Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

scientific article

Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation

scientific article

Deactivation of a negative regulator: a distinct signal transduction mechanism, pronounced in Akt signaling

scientific article

Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation

scientific article published on 04 June 2019

Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing

scientific article

Development of a tandem affinity phosphoproteomic method with motif selectivity and its application in analysis of signal transduction networks

scientific article

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet

scientific article published on 05 July 2014

Directional persistence of cell migration coincides with stability of asymmetric intracellular signaling

scientific article

Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway

scientific article published on March 1999

F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling

scientific article

Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein.

scientific article

GMFβ controls branched actin content and lamellipodial retraction in fibroblasts.

scientific article

In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling.

scientific article

Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts

scientific article

Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation

scientific article published on 9 January 2017

Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts

scientific article published on 18 July 2003

Lamellipodia are crucial for haptotactic sensing and response

scientific article published on 12 May 2016

Live-Cell Fluorescence Microscopy with Molecular Biosensors: What Are We Really Measuring? ⬇️

scientific article published on May 2, 2012

Localization of receptor-mediated signal transduction pathways: the inside story.

scientific article published on September 2002

Mathematical model of human growth hormone (hGH)-stimulated cell proliferation explains the efficacy of hGH variants as receptor agonists or antagonists

scientific article published in September 2004

Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions

scientific article published in October 2000

Mechanisms of gradient sensing and chemotaxis: conserved pathways, diverse regulation.

scientific article

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

scientific article published on 07 April 2020

Membrane-binding/modification model of signaling protein activation and analysis of its control by cell morphology

scientific article published on 6 April 2007

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism

scientific article

On the cross-regulation of protein tyrosine phosphatases and receptor tyrosine kinases in intracellular signaling.

scientific article published in September 2004

Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling

scientific article published on 05 May 2020

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk

scientific article published on 17 February 2009

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk.

scientific article

Poly(vinylmethylsiloxane) elastomer networks as functional materials for cell adhesion and migration studies.

scientific article published on March 2011

Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways

scientific article

Quantitative analysis of B-lymphocyte migration directed by CXCL13

scientific article published on August 2016

Quantitative analysis of phosphoinositide 3-kinase (PI3K) signaling using live-cell total internal reflection fluorescence (TIRF) microscopy

scientific article published on 2 December 2013

Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts

scientific article published on 28 November 2005

Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly

scientific article

Quantitative models of signal transduction networks: How detailed should they be?

scientific article

Reactions on cell membranes: comparison of continuum theory and Brownian dynamics simulations.

scientific article published on August 2005

Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics

article

Semi-autonomous wound invasion via matrix-deposited, haptotactic cues

scientific article published in 2023

Signal transduction at point-blank range: analysis of a spatial coupling mechanism for pathway crosstalk

scientific article published on 23 May 2008

Signaling pathways that control cell migration: models and analysis ⬇️

scientific article published on March 1, 2011

Spatial analysis of 3' phosphoinositide signaling in living fibroblasts, III: influence of cell morphology and morphological Polarity.

scientific article

Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups.

scientific article

Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments.

scientific article

Spatial sensing in fibroblasts mediated by 3' phosphoinositides

scientific article

Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells

scientific article

Structure-based kinetic models of modular signaling protein function: focus on Shp2.

scientific article published on 5 January 2007

Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network.

scientific article

Systemic perturbation of the ERK signaling pathway by the proteasome inhibitor, MG132.

scientific article

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